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의약품의 Solid Lipid Nanoparticle의 제조 및 용출특성
유혜종,김길수 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6
Solid lipid nanoparticles(SLN) are particulate systems for parenteral drug administration and suitable for controlled release. SLN were prepared by homogenization process. Dispersion at increased temperature (molten lipid) was performed to yield SLN loaded with lipophilic drugs. Tetracaine base, lidocaine base, prednisolone, methyltestosterone and ethinylestradiol were used as model drugs to access the loading capacity and to study the release behavior. To investigate production parameters(lipids, surfactant concentration, homogenizing rpm) in the formation of SLN, particle size was performed by laser diffraction analysis. The mean particle size of SLN with stearic acid or trilaurin was below 1 micron. By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN. Methyltestosterone or ethinylestradiol loaded SLN showed a distinctly prolonged release over a few days.
유은아,김정수,민혜기 誠信女子大學校 1998 硏究論文集 Vol.36 No.-
성신여자대학교 교내 및 주변 음식점의 물이 음용수로써 적합한지의 여부를 검사하였다. 검수 속의 금속 및 중금속이온은 원자흡수분광법을, 무기 음이온은 이온쌍 크로마토그래피법을, 그리고 휘발성 유기물질은 Purge & Trap과 기체크로마토그래피법을 각각 이용하여 분석하였으며 물속에 들어 있는 대장균과 일반세균의 검출은 계절별로 실시하였다. 교내 검수 결과 대부분의 경우 금속 및 중금속 이온, 무기물 음이온, 휘발성 유기물질들은 환경부에서 제시한 기준치 이하로 검출되었으며 세균의 경우 일반 세균의 양은 기준치를 약간 넘는 양이었으나 대장균은 검출되지 않았다. 정수기를 통과한 물인 경우 일반 세균의 수가 감소한 것으로 보아 정수기의 필터만 잘 관리한다면 일반 세균까지도 제거할 수 있다는 장점을 나타내었다. 학교 주변의 경우도 대부분 기준치 이하로 존재하였으나 세균검사의 경우 여름철로 들어서서는 일반 세균의 검출수도 많아졌으며 특히 대장균이 검출된 경우도 있었다. Analysis of drnking water in and around Sungshin Women's University was carried out using Atomic absorption spectrometer for metal and heavy metal ion, Ion pair chromatography system for inorganic anions, and Purge & Trap and Gas chromatography system for volatile organic compounds. In addition we also measured the drinking water for bacteria and coli each season. Most chemical species in the school's drinking water tested below the maximum levels suggested by Korea's Ministry of Environment. Moreover, the number of bacterial colony is just above the suggested levels and there is no detection of coli. Around school the results were almost identical; however in the summer, some of the sampling water showed coli and an increase of bacterial colonies. The most significant result is there is much less or no detection of bacteria and coli in drinking water from clean sources than in water from unclean sources.
Yoo Jung Lee,Eun Hye Yang,Yoon Hee Jo,Soo Han Choi,Hye Won Yoo,Ha Young Cho,Min Jung Kwak,Su Jung Park,Kyung Hee Park,Young Mi Kim 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.2
Purpose: The purpose of our study was to evaluate the usefulness of the BiofireFilmArray Meningitis/Encephalitis (FA ME) panel and identify factors associated with positive FA ME panel results. Methods: We retrospectively analyzed the medical records of 129 patients (45 children, 84 adults) with central nervous system infections and FA ME panel test results. We compared the results of the FA ME panel and the diagnostic yield between pediatric and adult patients with positive and negative FA ME panel results. Positive FA ME panel results were compared with conventional microbiological testing. Results: Forty-three patients (33.3%) had positive results on the FA ME panel. The detected pathogens were enterovirus (n=17, 39.5%), varicella zoster virus (n=10, 23.3%), herpes simplex virus-2 (n=2, 16.3%), herpes simplex virus-1 (n=2, 4.7%), human parechoviruses (n=2), Cryptococcus neoformans/gattii (n=2), Streptococcus agalactiae (n=1, 2.3%), Streptococcus pneumoniae (n=1), and Haemophilus influenzae (n=1). The time to detection of the FA ME panel (4.9±6.6 hours) was significantly shorter than that of conventional culture (77.4±48.2 hours) (P=0.005). Fever was more common in the positive FA ME group than in the negative FA ME group (81.4% vs. 41.9%) and in pediatric patients than in the adult patients (93.3% vs. 34.5%) (P<0.001 for both). The detection rate of the FA ME panel was higher in pediatric patients than in adult patients (55.8% vs. 22.6%, P<0.001). Conclusion: The FA ME panel improves the diagnostic rate in patients with suspected central nervous system infections, with potential favorable implications for the quality of management and prognosis.
A Case of Codeine Induced Anaphylaxis via Oral Route
Yoo, Hye-Soo,Yang, Eun-Mi,Kim, Mi-Ae,Hwang, Sun-Hyuk,Shin, Yoo-Seob,Ye, Young-Min,Nahm, Dong-Ho,Park, Hae-Sim The Korean Academy of Asthma, Allergy and Clinical 2014 Allergy, Asthma & Immunology Research Vol.6 No.1
<P>Codeine is widely prescribed in clinical settings for the relief of pain and non-productive coughs. Common adverse drug reactions to codeine include constipation, euphoria, nausea, and drowsiness. However, there have been few reports of serious adverse reactions after codeine ingestion in adults. Here, we present a case of severe anaphylaxis after oral ingestion of a therapeutic dose of codeine. A 30-year-old Korean woman complained of the sudden onset of dyspnea, urticaria, chest tightness, and dizziness 10 minutes after taking a 10-mg dose of codeine to treat a chronic cough following a viral infection. She had previously experienced episodes of asthma exacerbation following upper respiratory infections, and had non-atopic rhinitis and a food allergy to seafood. A skin prick test showed a positive response to 1-10 mg/mL of codeine extract, with a mean wheal size of 3.5 mm, while negative results were obtained in 3 healthy adult controls. A basophil histamine release test showed a notable dose-dependent increase in histamine following serial incubations with codeine phosphate, while there were minimal changes in the healthy controls. Following a CYP2D6 genotype analysis, the patient was found to have the CYP2D6*1/*10 allele, indicating she was an intermediate metabolizer. An open label oral challenge test was positive. To the best of our knowledge, this is the first report of a patient presenting with severe anaphylaxis after the ingestion of a therapeutic dose of codeine, which may be mediated by the direct release of histamine by basophils following exposure to codeine.</P>
Permissive Hyperglycemia in Extremely Low Birth Weight Infants
Yoo, Hye Soo,Ahn, So Yoon,Lee, Myung Sook,Han, Young Mi,Sung, Se In,Chang, Yun Sil,Park, Won Soon The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.3
<P>The aim of this study is to evaluate the outcomes of permissive hyperglycemia up to < 300 mg/dL in extremely-low-birth-weight infants (ELBWIs). We retrospectively reviewed the medical records of 260 live-born ELBWIs at Samsung Medical Center between 2004 and 2008, grouped according to peak blood glucose level and management during the first 14 days of life. The groups were normoglycemia (N), blood glucose ≤ 200 mg/dL; permissive hyperglycemia (P), blood glucose 201-299 mg/dL without insulin treatment; treated hyperglycemia (T), blood glucose ≥ 300 mg/dL with insulin. Only 15% of patients were grouped as N, with 39% as P and 46% as T. Although P had lower birth weight, P had a similar daily calorie and glucose intake as well as urine output compared to N. There was no significant correlation between blood glucose level and urine output on day 7. Compared to N, P showed faster weight gain and similar mortality, morbidities, and long-term neurological outcomes. Permissive hyperglycemia up to < 300 mg/dL without insulin treatment during the first 14 days of life is not associated with osmotic diuresis or increased mortality or morbidities, suggesting that it is not detrimental in ELBWIs.</P>
Preoperative Meniscus: Pitfalls and Traps to Avoid
Hye Jin Yoo,Kyung Nam Ryu,Ji Seon Park,Wook Jin,So Young Park,Hye Jin Kang,Hyun Soo Kim,Gene Hyuk Kwon 대한영상의학회 2022 대한영상의학회지 Vol.83 No.3
To accurately interpret knee MRI, it is important not only to know the basic meniscal anatomy but also to distinguish it from that under pathological conditions. Thus, it would be helpful to know the normal meniscus variants (false positives) that could be mistaken for meniscal tears, and tears that could easily be missed and incorrectly diagnosed as normal (false negatives). False positives include synovial recesses, meniscal flounce, the relationship between the popliteus tendon and lateral meniscus, transverse ligament, the anterior root of the meniscus, and meniscofemoral ligament. False negatives include focal radial tears, flap tears, posterior root tears, meniscocapsular separation, and discoid meniscal tears. In this pictorial essay, we reviewed the imaging data obtained in the aforementioned cases.