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Meta-analysis identifies a <i>MECOM</i> gene as a novel predisposing factor of osteoporotic fracture
Hwang, Joo-Yeon,Lee, Seung Hun,Go, Min Jin,Kim, Beom-Jun,Kou, Ikuyo,Ikegawa, Shiro,Guo, Yan,Deng, Hong-Wen,Raychaudhuri, Soumya,Kim, Young Jin,Oh, Ji Hee,Kim, Youngdoe,Moon, Sanghoon,Kim, Dong-Joon,Ko BMJ Publishing Group Ltd 2013 Journal of medical genetics Vol.50 No.4
<P><B>Background</B></P><P>Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.</P><P><B>Methods</B></P><P>Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study.</P><P><B>Results</B></P><P>In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (<I>rs784288</I> in the <I>MECOM</I> gene) that showed genome-wide significance (p=3.59×10<SUP>−8</SUP>; OR 1.39). RNA interference revealed that a <I>MECOM</I> knockdown suppresses osteoclastogenesis.</P><P><B>Conclusions</B></P><P>Our findings provide new insights into the genetic architecture underlying OF in East Asians.</P>
단삼(Salvia miltiorrhiza) 추출물의 암세포 증식 억제 효과에 관한 연구
정국찬(Guo Can Cheng),이지영(Ji-Young Lee),김동청(Dong Chung Kim),서성옥(Sung-Ock Suh),황우익(Woo-Ik Hwang) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.4
본 연구에서는 단삼(Salvia miltiorrhiza)의 추출물이 인체 결장암세포인 HT-29, 간암세포인 HepG2 및 직장암세포인 HRT-18의 증식에 미치는 영향을 in vitro에서 확인하였다. 암세포의 배양액에서 단삼의 수용성 추출물과 에탄올 추출물의 암세포 증식억제효과는 농도에 비례하며 에탄올 추출물에서 더 효과적이었다. 이를 토대로 단삼의 에탄올 추출물의 급성독성, 수명연장 및 고형암형성억제를 살펴보기 위해 in vivo 실험을 하였다. 급성독성실험결과 대조군의 15일째의 평균체중은 32.3 g이었고 실험군은 31.6 g으로 정상적인 상태를 유지하였으며, 흰쥐의 육종암세포인 sarcoma-180를 접종한 mouse의 수명연장실험결과 대조군에 비해 61%의 수명연장 효과가 있음을 관찰하였다. 고형암억제 실험 결과에서도 대조군에 비해 에탄올 추출물 처리군이 35%의 고형암 형성 억제능을 나타내었다.<br/> 따라서 단삼의 에탄올 추출물 중에는 in vitro와 in vivo 실험을 통해 항암활성을 갖는 성분이 존재하며, 이 성분은 유효한 항암제로 개발될 수 있으리라 사료된다. This study was performed to evaluate the antitumor activities of water and ethanol (EtOH) extract of Salvia miltiorrhiza in vitro and in vivo. The proliferation of the human hepatoma (HepG2), rectum cancer (HRT-18) and colon cancer (HT-29) cells was inhibited by administration of extracts in a dose- dependent manner. Particularly, EtOH extract inhibited proliferation of the cells more effectively than water extract did. The morphology of cells induced by EtOH extract was characterized by reduction of cell size and deformation. Oral administration of the EtOH extract (3 mg/head) to tumor-bearing mice inhibited the tumor (sarcoma-180) growth by 35% and prolonged their survival rate by 61%. The EtOH extract was shown to be nontoxic at 37.5 mg/head/day on the acute toxicity test. These studies suggest that the EtOH extract of Salvia miltiorrhiza may have antitumor activity in vitro and in vivo.
Kim, Ji-Hoon,Song, Chang Eun,Kang, In-Nam,Shin, Won Suk,Zhang, Zhi-Guo,Li, Yongfang,Hwang, Do-Hoon Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.5
A new conjugated copolymer, poly{4,8-bis(triisopropylsilylethynyl)benzo[1,2-b:4,5-b']dithiophene-alt-4,7- bis(5-thiophen-2-yl)-5,6-difluoro-2-(heptadecan-9-yl)-2H-benzo[d][1,2,3]triazole} (PTIPSBDT-DFDTBTz), is synthesized by Stille coupling polycondensation. The synthesized polymer has a band gap energy of 1.9 eV, and it absorbs light in the range 300-610 nm. The hole mobility of a solution-processed organic thin-film transistor fabricated using PTIPSBDT-DFDTBTz is $3.8{\times}10^{-3}cm^2V^{-1}s^{-1}$. Bulk heterojunction photovoltaic cells are fabricated, with a conventional device structure of ITO/PEDOT:PSS/polymer:$PC_{71}BM$/Ca/Al ($PC_{71}BM$ = [6,6]-phenyl-$C_{71}$-butyric acid methyl ester); the device shows a power conversion efficiency (PCE) of 2.86% with an open-circuit voltage ($V_{oc}$) of 0.85 V, a short-circuit current density ($J_{sc}$) of 7.60 mA $cm^{-2}$, and a fill factor (FF) of 0.44. Inverted photovoltaic cells with the structure ITO/ethoxylated polyethlyenimine/ polymer:$PC_{71}BM/MoO_3$/Ag are also fabricated; the device exhibits a maximum PCE of 2.92%, with a $V_{oc}$ of 0.89 V, a $J_{sc}$ of 6.81 mA $cm^{-2}$, and an FF of 0.48.
Yin Guo Nan,Kim Do-Kyun,Kang Ji In,Im Yebin,Lee Dong Sun,Han Ah-reum,옥지연,Choi Min-Ji,Kwon Mi-Hye,Limanjaya Anita,Jung Saet-Byel,Yang Jimin,Min Kwang Wook,Yun Jeongwon,Koh Yongjun,Park Jong-Eun,Hwang D 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications. One prevalent complication is diabetic erectile dysfunction (ED), which is more severe and more resistant to treatment than nondiabetic ED. The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1) is a modulator of TGF-β-mediated angiogenesis and has been proposed as a biomarker for a variety of diseases, including DM. Here, we found that the adhesion GPCR latrophilin-2 (LPHN2) is a TGF-β-independent receptor of LRG1. By interacting with LPHN2, LRG1 promotes both angiogenic and neurotrophic processes in mouse tissue explants under hyperglycemic conditions. Preclinical studies in a diabetic ED mouse model showed that LRG1 administration into the penile tissue, which exhibits significantly increased LPHN2 expression, fully restores erectile function by rescuing vascular and neurological abnormalities. Further investigations revealed that PI3K, AKT, and NF-κB p65 constitute the key intracellular signaling pathway of the LRG1/LPHN2 axis, providing important mechanistic insights into LRG1-mediated angiogenesis and nerve regeneration in DM. Our findings suggest that LRG1 can be a potential new therapeutic option for treating aberrant peripheral blood vessels and neuropathy associated with diabetic complications, such as diabetic ED.
지역정체성을 고려한 도시재생 문화공간의 맥락적 디자인 특성에 관한 연구 - 서울시 비전2030, 근현대건축자산을 활용한 문화공간 조성을 중심으로 -
강지연(Kang, Ji-Yeon),문예림(Mun, Ye-Rim),고홍국(Gao, Hong-Guo),황연숙(Hwang, Yeon-Sook) 한국실내디자인학회 2023 한국실내디자인학회 학술대회논문집 Vol.25 No.3
The city of Seoul carried out Vision 2030, Culture Citizen City Seoul to rejuvenate old facilities and unused spaces and transform them into cultural venues. The city did so by leveraging modern and contemporary architectural assets to promote the cultural characteristics of the local area in urban revitalization. During this process, contextual design played a pivotal role. The objective of this study is to investigate cases of the regeneration of modern and contemporary architectural assets from a contextual design perspective and provide a design direction to enhance future value within the local community. The theoretical concepts related to regional identity and contextual design in urban revitalization were investigated and used to derive characteristics and analytical frameworks based on prior research. On-site investigations for selected case studies were used in order to draw conclusions. Our results are as follows. In the restoration and enhancement of modern and contemporary architectural landmarks, the preservation of historical significance achieved through the establishment of exhibition spaces, was prominently observed. The project effectively conveyed the unique stories of the local area through exhibitions or experiential programs, while providing an accessible cultural infrastructure. Further to this, the revitalization was achieved through a harmonious design that did not disrupt the surrounding environment. However, there was a need for spaces to enhance community engagement among local residents and visitors.
Yuan, Yu-Guo,Zhang, Shimin,Hwang, Ji-Yoon,Kong, Il-Keun Hindawi 2018 Oxidative medicine and cellular longevity Vol.2018 No.-
<P>Silver nanoparticles (AgNPs) are widely used metal nanoparticles in health care industries, particularly due to its unique physical, chemical, optical, and biological properties. It is used as an antibacterial, antiviral, antifungal, and anticancer agent. Camptothecin (CPT) and its derivatives function as inhibitors of topoisomerase and as potent anticancer agents against a variety of cancers. Nevertheless, the combined actions of CPT and AgNPs in apoptosis in human cervical cancer cells (HeLa) have not been elucidated. Hence, we investigated the synergistic combinatorial effect of CPT and AgNPs in human cervical cancer cells. We synthesized AgNPs using sinigrin as a reducing and stabilizing agent. The synthesized AgNPs were characterized using various analytical techniques. The anticancer effects of a combined treatment with CPT and AgNPs were evaluated using a series of cellular and biochemical assays. The expression of pro- and antiapoptotic genes was measured using real-time reverse transcription polymerase chain reaction. The findings from this study revealed that the combination of CPT and AgNPs treatment significantly inhibited cell viability and proliferation of HeLa cells. Moreover, the combination effect significantly increases the levels of oxidative stress markers and decreases antioxidative stress markers compared to single treatment. Further, the combined treatment upregulate various proapoptotic gene expression and downregulate antiapoptotic gene expression. Interestingly, the combined treatment modulates various cellular signaling molecules involved in cell survival, cytotoxicity, and apoptosis. Overall, these results suggest that CPT and AgNPs cause cell death by inducing the mitochondrial membrane permeability change and activation of caspase 9, 6, and 3. The synergistic cytotoxicity and apoptosis effect seems to be associated with increased ROS formation and depletion of antioxidant. Certainly, a combination of CPT and AgNPs could provide a beneficial effect in the treatment of cervical cancer compared with monotherapy.</P>
Lee, Hyeon Jun,Guo, Er-Jia,Min, Taewon,Hwang, Seung Hyun,Lee, Su Yong,Dorr, Kathrin,Lee, Jaekwang,Jo, Ji Young Tsinghua Press, co-published with Springer-Verlag 2018 NANO RESEARCH Vol.11 No.7
<P>Atomic movement under application of external stimuli (i.e., electric field or mechanical stress) in oxide materials has not been observed due to a lack of experimental methods but has been well known to determine the electric polarization. Here, we investigated atomic movement arising from the ferroelectric response of BiFeO3 thin films under the effect of an electric field and stress in real time using a combination of switching spectroscopy, time-resolved X-ray microdiffraction, and in situ stress engineering. Under an electric field applied to a BiFeO3 film, the hysteresis loop of the reflected X-ray intensity was found to result from the opposing directions of displaced atoms between the up and down polarization states. An additional shift of atoms arising from the linearly increased dielectric component of the polarization in BiFeO3 was confirmed through gradual reduction of the diffracted X-ray intensity. The electric-field-induced displacement of oxygen atoms was found to be larger than that of Fe atom for both ferroelectric switching and increase of the polarization. The effect of external stress on the BiFeO3 thin film, which was controlled by applying an electric field to the highly piezoelectric substrate, showed smaller atomic shifts than for the case of applying an electric field to the film, despite the similar tetragonality.</P>
Bae, Woo Kyun,Lee, Ji Hee,Lee, Sang Joon,Park, Myong Suk,Hwang, Jun Eul,Shim, Hyun Jeong,Cho, Sang Hee,Guo, Ding-Ding,Cho, Chong-Su,Park, In-Kyu,Chung, Ik Joo American Scientific Publishers 2011 Journal of Nanoscience and Nanotechnology Vol.11 No.2
<P>Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.</P>