Meta-Analysis of the Diagnostic Efficacy of the Luminex xTAG Respiratory Viral Panel FAST v2 Assay for Respiratory Viral Infections

Xu-Guang Guo,Li-Min Xie,Xin Yin,Tian-Ao Xie,Jian-Wen Su,Qin Huang,Jing-Hao Zhang,Yin-Fei Huang 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.1

Purpose: Acute respiratory viral infections pose significant morbidity and mortality, making it essential to diagnose respiratory viral infections rapidly. In this study, the diagnostic efficacy of the Luminex xTAG Respiratory Virus Panel (RVP) FAST v2 test was evaluated on respiratory viral infections. Materials and Methods: Information was retrieved from electronic databases, including Embase, Web of Science, PubMed, and Cochrane Library, for systematic review. Studies that fulfilled predefined inclusion criteria were included. After the extraction of information, statistical software was utilized for quality evaluation, data analysis, and assessment of publication bias. Results: Eighty groups in fourfold tables from nine articles were included to perform statistical analyses. Therein, the mean specificity and mean sensitivity of Luminex xTAG RVP FAST v2 test for the detection of respiratory viral infections were 0.99 (0.98–0.99) and 0.88 (0.87–0.90), respectively. Additionally, the negative and positive likelihood ratios were 0.14 (0.11–0.19) and 87.42 (61.88–123.50), respectively. Moreover, the diagnostic odds ratio and area under the curve of summary receiver operating characteristic were 714.80 and 0.9886, respectively. Conclusion: The Luminex xTAG RVP FAST v2 test could be a reliable and rapid diagnostic method for multiple respiratory viral infections.

18F-fluorodeoxyglucose PET/CT as an independent predictor for patients with hepatocellular carcinoma combined with major portal vein tumor thrombus

Xu-Guang Hu,Xue-Yin Shen,Jin-Niang Nan,In-Gyu Kim,Joon-Kee Yoon,Sung-Yeon Hong,Mi-Na Kim,Bong-Wan Kim,Hee-Jung Wang 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.1

Purpose: Hepatocellular carcinoma (HCC) patients with major portal vein tumor thrombosis (mPVTT) complications were generally characterized by extremely poor prognoses. The aim of this study was to explore the role of 18F-fluorodeoxyglucose (18F-FDG) PET/CT imaging in predicting HCC complicated by mPVTT. Methods: Five hundred one HCC patients received surgery in our hospital during November 2008 to December 2014, among which 32 patients (6.4%) were diagnosed as HCC complicated by mPVTT. Six cases were excluded for reasons of complex medical conditions, including 2 cases of salvage liver transplantation, 2 cases of re-resection, 1 case of mPVTT combined with inferior vina cava tumor thrombosis, and 1 case of residual portal vein tumor thrombosis. Ultimately, 26 cases were enrolled in this study. The maximal tumor standardized uptake value (SUVmax) was identified as a predictive factor and detected. The univariate and multivariate regression analyses were performed to identify the prognostic factors for recurrence-free survival (RFS) and overall survival (OS) of HCC patients complicated by mPVTT. Results: Our results showed that the median OS was 16 months. The 1-, 3-, and 5-year cumulative OS was 55.6%, 31.7%, and 31.7%, respectively. The multivariate regression analysis revealed that SUVmax ≥ 4.65 was the only independent risk factor for RFS and OS. Conclusion: SUVmax was an independent predictor for RFS and OS of patients suffering from both HCC and mPVTT. L ow SUVmax could serve as an effective factor for selecting candidates with low recurrence risks and for helping with improving patient survival after surgical resection.

Segmentectomy 8 for Hepatocellular Carcinoma Applied with Synapse Vincent 3D for Preoperative Evaluation

( Xu-guang Hu ),( Hee-jung Wang ),( Bong-wan Kim ),( Sung-yeon Hong ),( Xue-yin Shen ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The Glission pedicle of anterior section is complexity and there was no detailed description on patterns of the 3rd order of Glission branch. This presentation is attempt to describe the patterns of the 3rd order of Glission branch in right anterior sectionwith SYNAPSE VINCENT 3D and present two video clip of segmentectomy 8 which applied with SYNAPSE VINCENT 3D for preoperative evaluation. Methods: A total of 106 preoperative multi detector-row computed tomography (MDCT) images were obtained from the donors of adult living donor liver transplantation and the 3D images were reconstructed by SYNAPSE VINCENT medical imaging system. The patterns of the 3rd order of Glission branch in right anterior section were investigated using SYNAPSE VINCENT medical imaging system. Results: After analysis the patterns of the 3rd order of anterior Glission pedicle, we classified the right anterior Glission pedicle into four types. Type A: cranial-caudal type (49 cases, 46.2%); Type B: ventral-dorsal type (14 cases, 13.2%); Type C: Radial type (37 cases, 34.9%); Type D: The right anterior Glission pedicles have sliding branch to/from posterior branch (6 cases, 5.7%). Two video clip of segmentectomy 8 will be shown. The dye injection and Glissionian technique were applied seperatively and the procedure were evaluate by preoperative SYNAPSE VINCENT 3D. Conclusions: The detailed description of the 3rd branch of anterior Glission pedicle enriched our understanding of Couinaud segmental anatomy. Preoperative SYNAPSE VINCENT 3D is helpful for anatomic evaluation of liver resection especially segmentectomy.

Novel Classification for Right Posterior Portal Vein (RPPV) Evaluated by SYNAPSE VINCENT

( Xu-guang Hu ),( Ingyu Kim ),( Sung Yeon Hong ),( Xue-yin Shen ),( Mina Kim ),( Bong-wan Kim ),( Hee-jung Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: There was no consensus on right posterior section (RPS) graft was a routine option for adult living donor liver transplantation (LDLT). The main reason for it was that the vascular pedicles of the RPS graft which was the second order branches were complicated. And there was no deep and detailed description of the patterns of the 2^nd, 3^rd portal branch in RPS. The present study is an attempt to describe the patterns of the 2^nd, 3^rd portal branch in RPPV. Methods: Between November 2008 and January 2017, a total of 106 preoperative liver multidetector-row computed tomography (MDCT) images were obtained from the donor and the 3D images were reconstructed by SYNAPSE VINCENT medical imaging system. The patterns of the 2^nd, 3^rd portal branch of the RPPV were investigated using SYNAPSE VINCENT medical imaging system. Results: We classified the RPPV into four types. Type A: the RPPV have a common trunk (more than 5mm) with two main 3^rd order branch (36 cases, 34%); Type B: there was no common trunk with two main 2^nd order branch (16 cases, 15%); Type C: there was one major common trunk with multiple 3^rd order branch (48 cases, 45.3%); Type D: the right posterior section have sliding branches to/from anterior portal vein (6 cases, 5.7%). The median length of the type A portal trunk was 12.35mm (range 5.0mm-28.7mm). In the present study, there were 16 cases of right posterior sector (RPS) graft which were selected by volumetry-Based criteria. There was only one RPS graft has multiple portal veins opening. Conclusions: The Couinaud segment was not always supplied with one inflow portal pedicle. In the present study, there were 52 cases (Type A and B, 49%) which one segment has only one inflow portal pedicle. Others, 54 cases which one segment have two or more 3rd inflow portal pedicle. RPPV type C and D could not apply with anatomic segmentectomy, only the systematic resection is possible.

Molecular classification of hepatocellular adenoma: A single-center experience

Xue-Yin Shen,Xu-Guang Hu,Young-Bae Kim,Mi-Na Kim,Sung-Yeon Hong,Bong-Wan Kim,Hee-Jung Wang 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.2

Backgrounds/Aims: Hepatocellular adenoma (HCA) is a rare benign tumor that has a risk of malignant transformation into hepatocellular carcinoma (HCC) and bleeding. The aim of this study was to analyze the characteristics of HCA by performing molecular classification. Methods: We retrospectively collected data from nine patients who were diagnosed with HCA from 1995 to 2016. The patients underwent liver surgery due to the existence of clinical symptoms. Immunohistochemical (IHC) staining was performed to classify the subgroups of HCA. Results: Four patients with both β-catenin and inflammation were classified as β-IHCA. Two patients were defined as β-HCA. Two patients were classified as HHCA. Only one patient was defined as IHCA. None of the patients had unclassified HCA. Seven of nine patients had a malignant transformation. By comparing the characteristics of HCA between two groups, we found the mean tumor size in the malignant transformation group was greater than the non-malignant transformation group. Conclusions: Taken together, the mean tumor size and activation of catenin β1 mutation status might be the risk factors for the malignant transformation of HCA into HCC. Moreover, IHCA without the catenin β1 mutation could also have a possibility of malignant transformation into HCC.

Effect of synthesis conditions on the particle size and morphology of YAG powder

Jie-Guang Song,Fang Wang,Ming-Han Xu,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2

Yttrium aluminum garnet (YAG) is currently a widely applied structural and functional material. To prepare highperformance YAG ceramics we prepared pure YAG powder, after calcining the precursor at 1100 ºC, by co-precipitation with ammonia as the precipitant and aluminum nitrate as well as yttrium nitrate as raw materials. The preparation conditions for the YAG precursor were a pH of 9, a titration rate of 10 ml/ minute and a reaction time of 60 minutes. The mean paricle size of the YAG powder was 11ìm. The mean particle size for the YAG powder increased with an increase in the pH and at a higher pH the YAG particles were more irregular in shape. The mean particle size and particle size distribution range of the YAG powder increased with an increase in the titration rate. For the YAG powder with a higher mean particle size, the particle size distribution range was wider but the size of most YAG particles was still small and the YAG particles were nearly spherical.

Can we delineate preoperatively the right and ventral margins of caudate lobe of the liver?

Xue-Yin Shen,Hee-Jung Wang,Bong-Wan Kim,Sung-Yeon Hong,Mi-Na Kim,Xu-Guang Hu 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.97 No.3

Purpose: Complete removal of the caudate lobe, which is sometimes necessary, is accomplished via isolated caudate lobectomy or hepatectomy that includes the caudate lobe. It is impossible, however, to confirm the right and ventral margins of the caudate lobe by preoperative imaging. This study was undertaken to determine whether we could identify the right and ventral margins of the caudate lobe preoperatively using Synapse 3D visualization software. Methods: Ninety-four preoperative 3-dimensional (3D) computed tomographic images (1-mm slices) of the liver from candidate donors were examined. The images of the caudate lobe were subjected to a counter-staining method according to Synapse 3D to delineate their dimensions. We first examined whether the right margin of the caudate lobe exceeded the plane formed by the root of the right hepatic vein (RHV) and the right side of the inferior vena cava (IVC). Second, we determined whether the ventral margin of the caudate lobe exceeded the plane formed by the root of the middle hepatic vein (MHV) and the root of the RHV. Results: For the right margin, 17 cases (18%) exceeded the RHV-IVC plane by a mean of 10.2 mm (range, 2.4–27.2 mm). For the ventral margin, 28 cases (30%) exceeded the MHV-RHV plane by a mean of 17.4 mm (range, 1.2–49.1 mm). Conclusion: Evaluating the anatomy of caudate lobe using Synapse 3D preoperatively could be helpful for more precise anatomical resection of the caudate lobe.

Effect of the sintering technology on the properties of fired brick from quartz sands

Jie-Guang Song,Fang Wang,Xiao-Bo Bai,Da-Ming Du,Yin-Yan Ju,Ming-Han Xu,Gang-Chang Ji 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.4

River sands as low grade natural raw materials are used to prepare the fired brick to replace clay fired bricks, which aims to save land resources and use low grade natural resources to realize high cost performance. In this paper, the effect of sintering technology of bricks on their performance is discussed. The compressive strength of fired bricks is first increased and then decreased with an increase in the sintering temperature, the compressive strength of bricks prepared by the isostatic compaction shaping is higher than that of bricks prepared by the plastic shaping under the same conditions. The compressive strength of bricks reaches 28 MPa when sintered at 1150 oC by using a 20MPa isostatic compaction shaping method. The compressive strength of bricks is first increased and then decreased by prolonging the holding time, the compressive strength of bricks reaches 28.9MPa when sintered at 1150 oC for 2 h.

Central-Located Massive Tumor With Inflow And Outflow Reconstruction For Massive Hepatectomy - A Case Report

( Xue-yin Shen ),( Xu-guang Hu ),( Sung-yeon Hong ),( Bong-wan Kim ),( Hee-jung Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Right trisectionectomy was the most effective curative treatment with massive tumor located in the right lobe especially central location of liver. Due to the compressing or even invasion from huge tumor to main branches of portal vein, hepatic vein and bile duct, adequate consideration of inflow and outflow reconstruction during surgery was needed and vessels acquired from cadaveric donor or artificial should be prepared preoperatively. Methods: We present the case of a 59-year-old man who found a 10 cm malignant mass in the right lobe with the invasion of right anterior portal vein, right hepatic vein and middle hepatic vein. By performing right portal vein embolization, left lateral section volume was increased from 26.5% to 37.3%, satisfy the condition of right trisectionectomy. Outflow reconstruction was performed using pericardium, which was acquired from previous cadaveric donor. Results: The recovery process was smooth, patient was discharged in POD 58 without any complication, Conclusions: Preoperatively, sufficient consideration of using allograft to perform inflow or outflow reconstruction is needed in patient with vascular invasion. Postoperatively, regular hepatic mesenteric doppler F/U is needed. Usage of allograft is limited in the hospital where cadaveric donor liver transplantation is feasible. Thus, artificial graft should be prepared in the vascular invasion cases.

The 7th/8th American Joint Committee on Cancer and the Modified Union for International Cancer Control Staging System for Hepatocellular Carcinoma

김인규,Xu-Guang Hu,왕희정,김봉완,홍성연,Xue-Yin Shen 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.2

Purpose: Although many staging systems have been proposed for hepatocellular carcinoma (HCC), there is no globally acceptedsystem due to the extreme heterogeneity of the disease. We aimed to compare the results of the 7th/8th American Joint Committeeon Cancer (AJCC) and the modified Union for International Cancer Control (mUICC) staging systems in patients with HCC. Materials and Methods: We collected data from 792 patients who underwent hepatic resection at our center. The Kaplan-Meiermethod was used to determine disease-free survival and overall survival. To evaluate homogeneity, ‘-2 log likelihood’ was calculatedusing Cox proportional hazards regression. To measure discriminatory ability, the linear trend chi method and the Cochran-Armitage test for trend were used. The ability to accurately predict survival was verified by cross-validation analysis. Results: Kaplan-Meier curves for disease-free survival and overall survival showed mUICC to be superior to the 7th/8th AJCC. The homogeneity test indicated that mUICC was the best for both disease-free survival and overall survival. In the discriminatoryability test, the chi-square value of mUICC was the best for disease-free survival, while the 7th AJCC had the best value for overallsurvival. In the cross-validation analysis, all three staging systems had significant predictive power. Conclusion: mUICC seemed to be superior to the 7th/8th AJCC after analyzing the data of our surgical patients, although thegeographic heterogeneity of HCC might result in differences between the staging systems. We believe that, while the three stagingsystems allow for the clear stratification of patients into prognostic groups, mUICC may be more appropriate in HCC.