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An in vitro cellular analysis of the radical scavenging efficacy of chitooligosaccharides
Mendis, Eresha,Kim, Moon-Moo,Rajapakse, Niranjan,Kim, Se-Kwon Elsevier 2007 Life sciences Vol.80 No.23
<P><B>Abstract</B></P> <P>Despite extensive study on biological activities of chitosan and chitooligosaccharides (COS), there is no experimental evidence available as to COS mediated inhibition of free radical damage in cellular oxidizing systems. In this study, radical scavenging efficacies of different molecular weight bearing COS were assessed and their intracellular radical scavenging effects were tested employing B16F1, murine melanoma cell line. The results exhibited appreciable suppression in occurrence of intracellular radical species in the presence of low molecular weight bearing COS (<1 kDa) confirming low molecular weight is important for observed activities in biological systems. However, DNA oxidation carried out in the presence of COS clearly exhibited that COS exert protective effect on oxidative damage of purified genomic DNA regardless of molecular weight. Low molecular weight bearing COS was observed to be successively participated in suppression of NF-κB gene promoter activity suggesting its capability to prevent oxidative stress related disease complications. Moreover, induction of intracellular glutathione (GSH) level in the presence of COS promoted the effectiveness of COS to act against cellular oxidative stress.</P>
Effect of spongin derived from Hymeniacidon sinapium on bone mineralization
Kim, Moon-Moo,Mendis, Eresha,Rajapakse, Niranjan,Lee, Sang-Hoon,Kim, Se-Kwon Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of Biomedical Materials Research Part B Vol. No.
<P>Marine sponges have been known to provide a source of novel bone and cartilage replacements because of their secondary metabolites and specific skeleton structures. In particular, it has been reported that spongin as a component of fibrous skeleton, pseudokeratin, neurokeratin, horny protein, and collagen-like protein in sponges can be used in several biomedical applications including osteoarthritis (OA). However, the pharmacological mechanism of action of spongin remains obscure. In this study, it was investigated whether spongin derived from Hymeniacidon sinapium can promote bone mineralization of osteoblast-like MG-63 cells. Our present study provides the first evidence that spongin is effective in activating bone mineralization. Furthermore, spongin increased ALP activity, collagen synthesis, and osteocalcin secretion in addition to bone mineralization in osteoblastic cells in vitro. In addition, it was demonstrated that spongin exerted the inhibitory effect on production of inflammatory mediators such as TNF-α, IL-1β, and PGE<SUB>2</SUB> in macrophage, RAW264.7 cells. These results suggest that the anti-inflammatory effect of spongin derived from Hymeniacidon sinapium can play a critical role in bone mineralization of osteoblast-like MG-63 cells. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009</P>
Laurencia okamurai Extract Containing Laurinterol Induces Apoptosis in Melanoma Cells
Moon-Moo Kim,Eresha Mendis,김세권 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Laurinterol is a marine sesquiterpene that has been known to have antimicrobial activity. The purpose of thisstudy is to investigate the effect of Laurencia okamuraiextract containing laurinterol (LOEL) on induction of apoptosis inmelanoma cells (B16F1). Anticancer activity of LOEL against melanoma cells was shown in a dose-dependent manner by the1-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. It was for the first time found that LOEL exhibitedan excellent effect on the induction of apoptosis as determined by DNA fragmentation, terminal deoxynucleotidyl transferase-mediated dUTP in situnick-end labeling assay, cell cycle analysis, and measurement of activities of several caspases inmelanoma cells. It was also demonstrated that transcriptional activation of p53, a tumor suppressor gene, and activation ofp21 promoter by LOEL were involved in the induction of apoptosis by reporter gene assay. In particular, western blot analy-sis confirmed that LOEL above 5 .g/mL significantly increased the expression level of phospho-p53, the active form. Theseresults indicate that LOEL can induce apoptosis through a p53-dependent pathway in melanoma cells.