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Anti-osteoporotic Effects of Sericin-Calcium Conjugate in Ovariectomized Rats
Ehn-Kyoung Choi, Dongsun Park, So-Young Choi , Yun-Hui Yang, Seock-Yeon Hwang, Seongho Yeon, Jeong-Yong Lee, Ill-Hwa Kim, Yun-Bae Kim, Hyun-Gu Kang1 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.2
This study was conducted in order to evaluate the effect of sericin-calcium (SC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after ovariectomy (OVX), Sprague-Dawley rats were divided randomly into three groups: sham-operated group (Sham), ovariectomized group, and SC-treatment group (OVX+SC). Rats in the OVX+SC group were given drinking water containing 0.07% SC for eight weeks. Bone breaking force, mineralization, and blood parameters related to bone metabolism were analyzed. In OVX animals, blood concentration of 17β-estradiol showed a significant decrease, while osteocalcin and type I collagen C-terminal telopeptides (CTx) showed an increase. Breaking force of femurs as well as bone mineral density (BMD), ash, calcium, and phosphorus in femurs showed a significant decrease following OVX. Treatment with SC (0.07% in drinking water) resulted not only in remarkable restoration of the decreased 17β-estradiol and increased osteocalcin and CTx concentrations, but also led to recovery of decreased femoral breaking force, BMD, ash, calcium, and phosphorus. It is suggested that SC effectively improves bone density by preventing bone turnover-mediated osteocalcin, CTx, and minerals, and that it could be a potential candidate for use in therapy or prevention of post-menopausal osteoporosis.
Animal Models of Periventricular Leukomalacia
Ehn-Kyoung Choi,Dongsun Park,Tae Kyun Kim,Sun Hee Lee,Dae-Kwon Bae,Goeun Yang,Yun-Hui Yang,Jangbeen Kyung,Dajeong Kim,Woo Ryoung Lee,Jun-Gyo Suh,Eun-Suk Jeong,Seung U. Kim,Yun-Bae Kim 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.2
Periventricular leukomalacia, specifically characterized as white matter injury, in neonates is strongly associated with the damage of pre-myelinating oligodendrocytes. Clinical data suggest that hypoxiaischemia during delivery and intrauterine or neonatal infection-inflammation are important factors in the etiology of periventricular leukomalacia including cerebral palsy, a serious case exhibiting neurobehavioral deficits of periventricular leukomalacia. In order to explore the pathophysiological mechanisms of white matter injury and to better understand how infectious agents may affect the vulnerability of the immature brain to injury, novel animal models have been developed using hypoperfusion, microbes or bacterial products (lipopolysaccharide) and excitotoxins. Such efforts have developed rat models that produce predominantly white matter lesions by adopting combined hypoxia-ischemia technique on postnatal days 1-7, in which unilateral or bilateral carotid arteries of animals are occluded (ischemia) followed by 1-2 hour exposure to 6-8% oxygen environment (hypoxia). Furthermore, low doses of lipopolysaccharide that by themselves have no adverse-effects in 7-day-old rats, dramatically increase brain injury to hypoxicischemic challenge, implying that inflammation sensitizes the immature central nervous system. Therefore, among numerous models of periventricular leukomalacia, combination of hypoxia-ischemialipopolysaccharide might be one of the most-acceptable rodent models to induce extensive white matter injury and ensuing neurobehavioral deficits for the evaluation of candidate therapeutics.
Skin whitening and anti-wrinkle activities of white rose petal extracts
JIEUN CHOI,EUN SUK AN,YOUNG-HWAN BAN,YESEUL CHA,HAIYU GUO,JI YOUNG LEE,NU RY HAN,EUN SANG CHO,EUN SU JEON,DA WOOM SEO,JUNG-MIN YON,HAE CHEON IM,JAE KWON CHOI,YOON BOK LEE,EHN-KYOUNG CHOI,YUN-BAE KIM 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08
( Jae Kwon Choi ),( Yoon Bok Lee ),( Kyun Hee Lee ),( Hae Cheon Im ),( Yun Bae Kim ),( Ehn Kyoung Choi ),( Seong Soo Joo ),( Su Kil Jang ),( Nam Soo Han ),( Chung Ho Kim ) 한국응용생명화학회 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.2
The extract of white rose petals has an antioxidant effect and can be used to treat allergic disease. The purpose of this study was to identify optimal conditions for extracting antioxidative compounds from white rose petals with 2,2-diphenyl-1- picrylhydrazyl scavenging activities. A response surface methodology based on a central composite design was used to investigate the effects of three independent variables: ethanol concentration (X1), extraction temperature (X2), and extraction time (X3). The estimated optimal conditions for obtaining phenolic compounds with antioxidant activities were as follows: ethanol concentration of 42% (X1), extraction time of 80 min (X3), and extraction temperature of 75oC (X2). The estimated optimal conditions for obtaining flavonoid compounds with antioxidant effects were an ethanol concentration of 41% (X1), extraction time of 119 min (X3), and an extraction temperature of 75oC (X2). Under these conditions, predicted response values for the phenolic and flavonoid contents were 243.5 mg gallic acid equivalent/g dry mass and 19.93 mg catechin equivalent (CE)/g dry mass, respectively.
Tae-Su Kim,Ehn-Kyoung Choi,Jihyun Kim,Kyungha Shin,Sung-Pyo Lee,Youngjin Choi,Joseph H. Jeon,Yun-Bae Kim 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.3
Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×10<SUP>9</SUP> CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.
Increased Nephrotoxicity after Combined Administration of Melamine and Cyanuric Acid in Rats
Dongsun Park,Tae Kyun Kim,Young Jin Choi,Sun Hee Lee,Dae-Kwon Bae,Goeun Yang,Yun-Hui Yang,Seong Soo Joo,Ehn-Kyoung Choi,Byeongwoo Ahn,Jong-Choon Kim,Kil-Soo Kim,Yun-Bae Kim 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.1
Renal toxicity by melamine in combination with cyanuric acid (1:1) was investigated. Male rats were orally administered melamine plus cyanuric acid (5, 50 or 400 ㎎/㎏ each) for 3 days. In contrast to a negligible effect by melamine alone (50 ㎎/㎏, a no-observed-adverse-effect-level: NOAEL), coadministration with cyanuric acid markedly increased the concentrations of blood urea nitrogen and creatinine, as well as kidney weight. A high dose (400 ㎎/㎏) of melamine plus cyanuric acid induced more severe kidney toxicity. The increased blood parameters for kidney toxicity and organ weight lasted longer than 4 days. Combined treatment with melamine and cyanuric acid (50?400 ㎎/㎏ each) resulted in many gold-brown crystals and toxic lesions in renal tubules, which were not observed in animals treated with melamine alone (50 mg/kg). These results indicate that only a 3-day exposure to melamine in combination with cyanuric acid causes severe renal damage, even at a NOAEL for melamine found in a 13-week toxicity study. Therefore, it is suggested that the tolerable daily intake or regulatory/management levels of melamine need to be re-considered for cases of co-exposure with cyanuric acid.
Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng
Young-Hwan Ban,Yeseul Cha,Jieun Choi,Eun Suk An,Ji Young Lee,Nu Ry Han,Da Woom Seo,Gooyoung Jung,Da-Hye Jeong,Man Hee Rhee,Ehn-Kyoung Choi,Yun-Bae Kim 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg3 improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.