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( Da-hye Ju ),( Sang Jin Ha ),( Hyeyeon Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: The aim of the current study was to examine the prevalence and time interval of metabolic syndrome development among women with hypertensive disorders of pregnancy compared to those of women with a normal delivery using big data analysis of a customized database using a National Health Insurance System data registry and to compare the prevalence of MS components between the HDP group and the normal delivery group. Methods: Data from 2002 to 2012 from the National Health Insurance Research Database in Korea was used to compare women diagnosed with HDP with those with a normal singleton pregnancy. The women who had medical checkups between 2009 and 2016 were assessed for MS. Using the customized DB, we conducted a trajectory analysis of MS development in our cohort. Results: Between 2002 and 2012, there were a total of 4723541 deliveries. Among the women who were analyzed, a total of 305919 underwent a medical examination from 2009 to 2016. MS was diagnosed in 47459 cases (22%). MS was found in 20.3% of the women in the normal group and 37.1% of the women in the HDP group. The time to MS development in women who had experienced pregnancy complicated by HDP was significantly shorter than that of women who did not experience HDP (6.6 ± 3.4 years vs 8.2 ± 3.4 years, p<0.0001). Women with a history of HDP had significantly increased odds of developing MS (OR 1.23; 95% CI, 1.12-1.35) and elevated systolic blood pressure strongly contributed the increased odds of developing MS in the HDP group (OR 1.644; 95% CI, 1.610-1.678). Conclusion: Our findings suggest that HDP increases the risk of MS development in later life and that MS develops in a shorter period of time in women with HDP than in those with a normal delivery. Women with HDP should be intensively checked for the components of MS.
재발성 또는 지속성 상피성 난소암에서의 Docetaxel 요법의 효용성 및 독성
주다혜 ( Da Hye Ju ),김용만 ( Yong Man Kim ),김민균 ( Min Gyun Kim ),김유진 ( Eu Gene Kim ),김대연 ( Dae Yeon Kim ),서대식 ( Dae Sik Seo ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.11
목적: Paclitaxle-platinum 병합요법 치료 후, 재발하거나 반응이 없는 상피성 난소암에서 docetaxel 단독 및 병합 요법의 치료에 대한 효과 및 독성을 알아보고자 하였다. 연구 방법: 1989년 5월부터 2006년 12월까지 서울아산병원에서 재발성 혹은 지속성 상피성 난소암 환자 중 docetaxel 단독 요법 및 다른 항암제와의 병합 요법을 받은 40명의 환자를 대상으로 하였다. Docetaxel 요법은 docetaxel 75 mg/m2 단독 요법이나 docetaxel과 platinum (carboplatin AUC5 또는 cisplatin 75 mg/m2)을 1 일째 투여하는 병합 요법으로 하여 3~4주 간격으로 시행하였다. 치료 효과는 RECIST criteria와 CA-125 response criteria 정의에 따라 평가하였다. 약제 독성은 NCI Common Toxicity Criteria에 따라 평가하였다. 결과: 20명은 RECIST criteria를 기준으로, 20명은 CA-125 response criteria의 정의에 따라 평가하였다. 전체 반응률은 35% (14/40)이었고, 완전 반응은 11명 (27.5%)이었으며, 부분 반응은 3명 (7.5%)이었다. 40명의 재발성 난소암의 환자들의 평균 치료 반응 기간은 11.29개월 (4~20.7개월), 평균 병의 진행 기간은 6.91개월 (1~23개월)이었다. Platinum sensitivity에서 반응군에서는 38.7%, 저항군에서는 22.2%의 반응률을 보여 통계적으로 유의하지 않았으나 (p=0.776) 반응군에서 더 높은 반응률을 보였다. 한편 이전 3회 이상의 치료를 받은 군에서 그렇지 않은 군보다 통계적으로 유의하게 낮은 반응률을 보였다 (p=0.022). 가장 흔한 약제 독성은 탈모와 위장관계 독성이었으며, 가장 심각한 약제 독성은 골수 억제 반응이었다. 결론: 초회 치료로 paclitaxel-platinum 병용 요법을 사용 한 재발성 또는 지속성 상피성 난소암 환자에서 docetaxel은 효과와 독성 면에서 2차 치료약제로 고려할 만한 약제이다. Objective: The aim of this study is to determine the efficacy and toxicity of docetaxel in patients with recurrent or persistent epithelial ovarian cancer, previously treated with paclitaxel and platinum combination chemotherapy. Methods: Forty patients with recurrent or persistent epithelial ovarian cancer, had been treated with docetaxel combination chemotherapy at Asan Medical Center from May 1989 to December 2006. They received docetaxel (75 mg/m2) only or docetaxel (75 mg/m2) and platinum (carboplatin AUC5 or cisplatin 75 mg/m2) on day 1. The administration was repeated every 3 or 4 weeks. The response of patients was evaluated with CA-125 response criteria and RECIST criteria. The toxicities were defined according to the NCI common toxicity criteria. Results: Twenty patients had been evaluated by RECIST criteria and twenty patients had been evaluated by CA-125 response criteria. The overall response rate was 35% (14/40). Eleven patients were belonged to complete response (CR), and three patients were belonged to partial response (PR). The mean response duration (RD) was 11.29 months (4 to 20.7 months) and the mean time to progression (TTP) was 6.91 months (1 to 23 months). The response rate in the platinum-sensitive patients was 38.7% but in the platinum-resistant patients was 22.2%. The platinum-sensitive patients showed more favorable response rate, but that was not significant statistically. Heavily treated group, more than three prior regimens were used, had poor outcome. The common toxicities were alopecia and gastrointestinal toxicities (anorexia and nausea). Bone marrow suppression was the most serious drug toxicity, however, it was tolerable. Conclusion: The docetaxel is a considerable 2nd line chemotherapy with acceptable efficacy and toxicity in patients with recurrent or persistent epithelial ovarian cancer previously treated with paclitaxel and platinum combination chemotherapy.
Aryl diester들에 존재하는 methoxycarbonylmethylester group의 상대적 반응성에 관한 연구
정혜진, 채수연, 표수진, 김다미,이유빈, 최의진, 김진주, 남궁성건 서울여자대학교 자연과학연구소 2016 자연과학연구논문집 Vol.28 No.-
The aryl diesters (1-3) and (8A) were prepared to investigate efficiency of methoxycarbonylmethyl (MCM) group as both protecting group specific for carboxylic acids and activating group for several functional group transformation reactions. MCM ester was very stable under strongly acidic condition and easily deprotected to its acid under mild basic condition. MCM ester of diclofenac (5B) proved to be one of activated esters through base-promoted cyclization reaction. MCM ester was also effective for transesterification reaction and reduction under the presented reaction conditions. Finally, MCM ester was not reactive to pri- and sec-aliphatic amines.
P-10 : Role of Polypyrimide Tract-Binding Protein in HCV RNA Replication
( Hye Soo Son ),( Bo Kyoung Kim ),( Da Hui Ahn ),( Eun Ju Baek ),( Jeong Hoon Park ),( Kyung Soo Chang ) 대한임상병리사협회 2008 임상미생물검사학회 발표자료집 Vol.2008 No.-
Background : Translation initiation of the hepatitis C virus (HCV) is regulated by an internal ribosome entry site (IRES) which requires polypyrimidine tractbinding protein (PTB), which binds to the 5``-untranslated region (UTR) and the 3``-UTR and the end of the core coding region of HCV RNA, for its function. Aims of this Study are to determine the role of PTB in HCV replication. Methods : siRNA technology was used to specifically knockdown the PTB expression in the cell. We determined whether down-expression of PTB affects the EMCV IRES-mediated translation, and examined whether interferon (IFN) down-regulates PTB expression. Results : In this study, we discovered that the level of PTB expression was efficiently decreased by PTB-specific siRNA. PTB knockdown expression by siRNA significantly reduced the efficiency of cell colony formation induced by HCV RNA replication. PTB siRNA resulted in a significant reduction of PTB expression and therein HCV RNA replication in a subgenomic HCV replicon-bearing Huh7 cell line, suggesting that PTB is required for efficient HCV replication in vivo. Result: PTB siRNA does not significantly affect the efficiency of the EMCV IRES-mediated translation. IFN-α resulted in an inhibition of PTB expression, suggesting a potential mechanism by which IFN inhibits HCV replication. Discussion : PTB siRNA efficiently knockdowns the level of PTB expression and subsequently resulted in a significant reduction of HCV RNA replication, indicating that PTB is required for efficient HCV RNA replication in vivo. It appears that IFN-α inhibits PTB expression, suggesting that inhibition of HCV replication by IFN might be due to suppression of cellular proteins that are required for HCV RNA replication.
Da-Hye Kim,Ji-Yeon Kim,Ju Hee Rhee,Jong-Yeol Lee,Sun-Hyung Lim 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
The red or purple color of radish (Raphanus sativus L.) taproots is due to anthocyanins, which have nutritional and aesthetic value, as well as antioxidant properties. Moreover, the varied patterns and levels of anthocyanin accumulation in radish roots make them an interesting system for studying the transcriptional regulation of anthocyanin biosynthesis. The R2R3 MYB domain transcription factor RsMYB1 is a key positive regulator of anthocyanin biosynthesis in radish. Here, we isolated an allele of RsMYB1, named RsMYB1<SUP>Short</SUP>, in radish cultivars with white taproots. The RsMYB1<SUP>Short</SUP> allele carries a 4-bp insertion in the first exon compared with the wild-type allele RsMYB1<SUP>Full</SUP>; this insertion is predicted to introduce an alternative translation start site and may thus generate a shorter protein with an N-terminal truncation of the DNA-binding domain. RsMYB1 <SUP>Full</SUP> and RsMYB1 <SUP>Short</SUP> interacted with their cognate partner TRANSPARENT TESTA 8 (RsTT8) in a yeast two-hybrid assay and localized to the nucleus in Arabidopsis protoplasts. Transient co-overexpression of genomic or cDNA sequences for RsMYB1<SUP>Full</SUP>, but not RsMYB1<SUP>Short</SUP>, with RsTT8 promoted pigment accumulation in radish cotyledons and tobacco (Nicotiana tabacum) leaves and activated transcription of anthocyanin biosynthetic genes in tobacco leaves. Co-expressing RsTT8 and RsMYB1<SUP>Full</SUP>, but not RsMYB1<SUP>Short</SUP>, also transactivated the promoters for the anthocyanin biosynthetic genes CHALCONE SYNTHASE and DIHYDROFLAVONOL 4-REDUCTASE in transient activation assays. We designed a molecular marker for RsMYB1<SUP>Short</SUP> genotyping and revealed that this allele is common in white radish cultivars, underscoring the importance of variation at the RsMYB1 locus in anthocyanin accumulation in radish taproots.