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3D8 scFv 형질전환 돼지 개발 및 PRRS 저항성 평가
이휘철 ( Hwi-cheul Lee ),이건섭 ( Gunsup Lee ),김지윤 ( Ji-yoon Kim ),양현 ( Hyeon Yang ),이보람 ( Bo Ram Lee ),박미령 ( Mi-ryung Park ),황인설 ( In-sul Hwang ),이풍연 ( Poongyeon Lee ),변승준 ( Sung-june Byun ),김원일 ( Won-il K 한국동물위생학회 2020 한국동물위생학회지 (KOJVS) Vol.43 No.4
In this study, we have developed 3D8 scFv transgenic pig (TG) by microinjection of fertilized one-cell pig zygotes (2.17%). The effect of 3D8 scFv TG on porcine reproductive and respiratory syndrome virus (PRRSV) resistance were evaluated through PRRSV VR2332 (1×10 <sup>3</sup> TCID<sub>50</sub>/mL) challenge and transmission experiments. As a result, the average daily weight gain (ADWG) of TG increased compared to the wild type pigs (WT) in PRRSV challenge groups and the serum viremia levels of the TG was significantly lower than of WT on the 7 day and 21 day after infection, meaning that the viral shedding was suppressed by 3D8 scFv expression. These results suggest that the expression of 3D8 scFv in pig could suppress spreading of infected virus to pigs sharing a room.
Study on IL-5 Inhibitory Activity of Novel Chromenone Derivatives
Eeda Venkateswararao,Vinay K. Sharma,Ki-Cheul Lee,Eunmiri Roh,Youngsoo Kim,Sang-Hun Jung 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-
A novel series of chromenone analogs were synthesized and evaluated for their inhibitory activity against interleukin-5. Among them compounds 5-(cyclohexylmethoxy)-N-(4-hydroxy-3-(hydroxymethyl)phenyl)-4-oxo-4H-chromene-3-carboxamide (8e, 54% inhibition at 30 μM) and ethyl 3-(5-(cyclohexylmethoxy)- 4-oxo-4H-chromene-3-carboxamido)benzoate (8g, 62% inhibition at 30 μM) showed the most potent activity. The SAR activity of these chromenones indicated that the bulky substituents at ring B increases the inhibition against IL-5 though none of the compound showed potent inhibition. The reason for less activity of the chromenones 8a-h may be due to the rigidity of amine linkage.
Interleukin-5 저해 활성 chalcone 화합물의 유효 입체 구조
이기철,김민석,P. Thanigaimalai,Vinay K. Sharma,박경래,김영수,정상헌 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-
Interleukin(IL)-5 appears to be one of the main proinflammatory mediators among the growing number of cytokines and chemokines that induce eosinophilic inflammation. Previously, our group synthesized a number of chalcone derivatives to determine their inhibitory activity against IL-5. However, the structure-activity relationship (SAR) of these chalcones was somewhat unclear, robably due to presence of three free rotatable bonds. To further, explore the SAR of these chalcones, we synthesized eight 2-(benzylidene)-2,3-dihydroinden-1-ones and 2- benzylidene)-3,4-dihydronaphthalen-1(2H)-ones 6 and evaluated for their inhibitory activity against IL-5. These rigidified chalcones 6 exhibited very weak inhibitory activity against IL-5 compared to chalcones 2. The structures of 6 closely resemble to the stretched conformations of chalcone 2, not effective conformation for the inhibition on IL-5 function.