Registry-based stroke research in Taiwan: past and future

Cheng-Yang Hsieh,Darren Philbert Wu3,,Sheng-Feng Sung 한국역학회 2018 Epidemiology and Health Vol.40 No.-

Stroke registries are observational databases focusing on the clinical information and outcomes of stroke patients. They play an important role in the cycle of quality improvement. Registry data are collected from real-world experiences of stroke care and are suitable for measuring quality of care. By exposing inadequacies in performance measures of stroke care, research from stroke registries has changed how we manage stroke patients in Taiwan. With the success of various quality improvement campaigns, mortality from stroke and recurrence of stroke have decreased in the past decade. After the implementation of a nationwide stroke registry, researchers have been creatively expanding how they use and collect registry data for research. Through the use of the nationwide stroke registry as a common data model, researchers from many hospitals have built their own stroke registries with extended data elements to meet the needs of research. In collaboration with information technology professionals, stroke registry systems have changed from web-based, manual submission systems to automated fill-in systems in some hospitals. Furthermore, record linkage between stroke registries and administrative claims databases or other existing databases has widened the utility of registry data in research. Using stroke registry data as the reference standard, researchers have validated several algorithms for ascertaining the diagnosis of stroke and its risk factors from claims data, and have also developed a claims-based index to estimate stroke severity. By making better use of registry data, we believe that we will provide better care to patients with stroke.

아시아 횡단철도의 경제적 효과 분석 : 중국 동북 3성을 중심으로

구종순,여희정,동무성 한국관세학회 2009 관세학회지 Vol.10 No.1

The paper explores economic effects of the Trans-Asian Railway North Corridor(TAR-NC) in the Northeast regions of China. The 3 Northeast regions, called Dongbeisan Sheng(3 provinces composed of Liaoning Sheng, Helongjiang Sheng, Jilin Sheng) possess natural resources and form a large regional economic block. In the 2000's the Chinese government has led a development policy of land transport via TAR-NC. Volumes transported by rail from origin/destination stations such as Erlianhaote, Suifenhe, Arasankou, Manzhouli are significantly increasing. Furthermore, by the fact that the Russian government plans to reduce railway tariffs and the Chinese government reforms laws related to container transport to increase competitiveness of the TAR-NC as an international railway route, the TAR-NC will offer a better package of services such as transit times, tariffs to attract shippers and compete against well-established shipping lines. Europe is the second export/import trade partner for the 3 Northeast regions. The reduced transit times and tariffs offered by the railway route for land movements of containers will enhance the competitiveness of products of the regions in the European market.

From an Authoritarian Party-State to a Democratic and Competitive Party System

Wu, Wen Cheng 서강대학교 동아연구소 1988 東亞 硏究 Vol.- No.15

6-Alkylsalicylic Acid Analogues Inhibit In Vitro ATPase Activity of Heat Shock Protein 90

Cheng-Zhu Wu,An Na Moon,Oksik Choi,Sun-Young Kang,Jung Joon Lee,황방연,김영호,Hong-Sub Lee,홍영수,이동호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.12

The molecular chaperone heat shock protein 90 (Hsp90) is responsible for maintaining the correct folding and stability of many signaling proteins. It is a promising target of cancer therapeutics and several other diseases, including neurodegenerative disease, nerve injuries, inflammation, and infection. In an effort to identify new Hsp90 inhibitors from natural sources using an in vitro ATPase inhibition assay, two 6-alkylsalicylic acid analogues, salaceyin A and B were identified from the culture extract of Streptomyces. Salaceyin A and B exhibited moderate ATPase inhibitory activities with IC50 values of 68.3 and 65.2 μM, respectively. Binding of salaceyins to human Hsp90α was examined by competition binding experiments with ATPSepharose beads. However, the compounds exhibited no degradation activity of Hsp90 client proteins, Her2, c-Raf, or Akt.

An Optimized Control Method Based on Dual Three-Level Inverters for Open-end Winding Induction Motor Drives

Wu, Di,Su, Liang-Cheng,Wu, Xiao-Jie,Zhao, Guo-Dong The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.2

An optimized space vector pulse width modulation (SVPWM) method with common mode voltage elimination and neutral point potential balancing is proposed for an open-end winding induction motor. The motor is fed from both of the ends with two neutral point clamped (NPC) three-level inverters. In order to eliminate the common mode voltage of the motor ends and balance the neutral point potential of the DC link, only zero common mode voltage vectors are used and a balancing control factor is gained from calculation in the strategy. In order to improve the harmonic characteristics of the output voltages and currents, the balancing control factor is regulated properly and the theoretical analysis is provided. Simulation and experimental results show that by adopting the proposed method, the common mode voltage can be completely eliminated, the neutral point potential can be accurately balanced and the harmonic performance for the output voltages and currents can be effectively improved.

DISCOVERY OF GAMMA-RAY EMISSION FROM THE SUPERNOVA REMNANT Kes 17 WITH <i>FERMI</i> LARGE AREA TELESCOPE

Wu, J. H. K.,Wu, E. M. H.,Hui, C. Y.,Tam, P. H. T.,Huang, R. H. H.,Kong, A. K. H.,Cheng, K. S. IOP Publishing 2011 ASTROPHYSICAL JOURNAL LETTERS - Vol.740 No.1

<P>We report the discovery of GeV emission at the position of supernova remnant Kes 17 by using the data from the Large Area Telescope on board the Fermi Gamma-ray Space Telescope. Kes 17 can be clearly detected with a significance of similar to 12 sigma in the 1-20 GeV range. Moreover, a number of gamma-ray sources were detected in its vicinity. The gamma-ray spectrum of Kes 17 can be described well by a simple power law with a photon index of Gamma similar to 2.4. Together with the multiwavelength evidence for its interactions with the nearby molecular cloud, the gamma-ray detection suggests that Kes 17 is a candidate acceleration site for cosmic rays.</P>

Synthesis of 2-Alkynyl Substituted 4'-Thioadenosine Derivatives and Their Binding Affinities at the Adenosine Receptors

Cheng-Wu Liang,최원준,정낙신 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.8

On the basis of high binding affinity of 2-hexynyl-N6-methyladenosine and N6-substituted-4'-thioadenosine derivatives at the A3 adenosine receptor (AR), novel 2-alkynyl-substituted-N6-methyl-4'-thioadenosine derivatives, combining the characteristics of two classes of nucleosides were designed and synthesized from D-gulonic γ-lactone via palladium-catalyzed cross coupling reaction as a key step. Among compounds tested, only compound 3b showed moderate binding affinity at the human A3 adenosine receptor without binding affinities at other subtypes.

CAD-Based Pose Estimation for Random Bin-Picking of Multiple Objects Using a RGB-D Camera

Cheng-Hei Wu,Sin-Yi Jiang,Kai-Tai Song 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

In this paper, we propose a CAD-based 6-DOF pose estimation design for random bin-picking of multiple different objects using a Kinect RGB-D sensor. 3D CAD models of objects are constructed via a virtual camera, which generates a point cloud database for object recognition and pose estimation. A voxel grid filter is suggested to reduce the number of 3D point cloud of objects for reducing computing time of pose estimation. A voting-scheme method was adopted for the 6-DOF pose estimation a swell as object recognition of different type objects in the bin. Furthermore, an outlier filter is designed to filter out bad matching poses and occluded ones, so that the robot arm always picks up the upper object in the bin to increase pick up success rate. A series of experiments on a Kuka 6-axis robot revels that the proposed system works satisfactorily to pick up all random objects in the bin. The average recognition rate of three different type objects is 93.9% and the pickup success rate is 89.7%.

SEARCH FOR PULSED γ-RAY EMISSION FROM GLOBULAR CLUSTER M28

Wu, J. H. K.,Hui, C. Y.,Wu, E. M. H.,Kong, A. K. H.,Huang, R. H. H.,Tam, P. H. T.,Takata, J.,Cheng, K. S. IOP Publishing 2013 ASTROPHYSICAL JOURNAL LETTERS - Vol.765 No.2

<P>Using the data from the Large Area Telescope on board the Fermi Gamma-ray Space Telescope, we have searched for gamma-ray pulsations from the direction of the globular cluster M28 (NGC 6626). We report the discovery of a signal with a frequency consistent with that of the energetic millisecond pulsar (MSP) PSR B1821-24 in M28. A weighted H-test test statistic of 28.8 is attained, which corresponds to a chance probability of similar to 10(-5) (4.3 sigma detection). With a phase-resolved analysis, the pulsed component is found to contribute similar to 25% of the total observed gamma-ray emission from the cluster. However, the unpulsed level provides a constraint for the underlying MSP population and the fundamental plane relations for the scenario of inverse Compton scattering. Follow-up timing observations in radio/X-ray are encouraged to further investigate this periodic signal candidate.</P>

ORBITAL-PHASE-DEPENDENT γ-RAY EMISSIONS FROM THE BLACK WIDOW PULSAR

Wu, E. M. H.,Takata, J.,Cheng, K. S.,Huang, R. H. H.,Hui, C. Y.,Kong, A. K. H.,Tam, P. H. T.,Wu, J. H. K. IOP Publishing 2012 The Astrophysical journal Vol.761 No.2

<P>We report on evidence for orbital phase dependence of the gamma-ray emission from the PSR B1957+20 black widow system using data from the Fermi Large Area Telescope. We divide an orbital cycle into two regions: one containing the inferior conjunction and the other containing the rest of the orbital cycle. We show that the observed spectra for the different orbital regions are fitted by different functional forms. The spectrum of the orbital region containing the inferior conjunction can be described by a power law with an exponential cutoff (PLE) model, which also gives the best-fit model for the orbital phase without the inferior conjunction, plus an extra component above similar to 2.7 GeV. The emission above 3 GeV in this region is detected with a similar to 7 sigma confidence level. The gamma-ray data above similar to 2.7 GeV are observed to be modulated at the orbital period at the similar to 2.3 sigma level. We anticipate that the PLE component dominant below similar to 2.7 GeV originates from the pulsar magnetosphere. We also show that inverse Compton scattering of the thermal radiation of the companion star off a 'cold' ultrarelativistic pulsar wind can explain the extra component above similar to 2.7 GeV. The black widow pulsar PSR B1957+20 may be a member of a new class of object, in the sense that the system is showing gamma-ray emission with both magnetospheric and pulsar wind origins.</P>