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Spectroscopic and theoretical studies of jet‐cooled 3‐cyanoindole ammonia clusters in the gas phase
Min Ahreum,Kim Jiwon,Moon Cheol Joo,Ahn Ahreum,Park Juhyeon,Choi Myong Yong 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.5
The structural information of 3-cyanoindole ammonia cluster, 3CI (NH3)1, in molecular beams was investigated in the gas phase. We obtained UV–UV holeburning spectrum (UV–UV HB) to determine the number of conformers present in the molecular beams and examine their spectral features. As a result, single conformer of 3CI (NH3)1 was observed in the mass-selected one-color resonant two-photon ionization (1C-R2PI) spectroscopy. The origin band of 3CI (NH3)1 in the R2PI spectrum is redshifted by 122 and 71 cm1 compared to those of the 3CI monomer and 3CI 1:1 water cluster, 3CI (H2O)1, respectively. The fully optimized geometries, relative energies, transition energies, binding energies, and electrostatic potential (ESP) of the 3CI monomer, 3CI (H2O)1, and 3CI (NH3)1 clusters were calculated at the B3LYP and TD-B3LYP methods with the 6-311++(d,p) basis set. The observed spectra are compared with the predictions of time-dependent density functional theory calculations.
Lee, Ahreum,Kim, Yong C.,Baek, Keumjin,Alam, Jehan,Choi, Yun S.,Rheu, Yaeeun,Shin, Yoo Jin,Kim, Sungtae,Kim, Hyun-Duck,Song, Yeong W.,Choi, Youngnim TaylorFrancis 2018 Virulence Vol.9 No.1
<P><B>ABSTRACT</B></P><P>Autoantibodies against alpha-enolase (ENO1) are often detected in various infectious and autoimmune diseases. Anti-ENO1 antibody titers were reported to be associated with the severity of periodontitis in patients with rheumatoid arthritis. Because the enolase of the periodontal pathogen <I>Treponema denticola</I> (TdEno) has the highest homology with ENO1 among the enolases of human-associated bacteria, we hypothesized that anti-ENO1 autoantibodies produced during the immune response to TdEno may contribute to the progression of periodontitis and tested it in human and mouse systems. In human subjects with healthy periodontium or chronic periodontitis, a strong positive correlation between the levels of anti-TdEno and anti-ENO1 antibodies was observed. In addition, the purified anti-TdEno antibodies recognized ENO1 as well as TdEno in a dot blot, confirming the cross-reactivity between TdEno and ENO1. However, anti-ENO1 antibody titers were not associated with the severity of periodontitis. To further investigate the role of TdEno in the production of anti-ENO1 antibodies and the progression of periodontitis, mice received an oral gavage of <I>P. gingivalis</I> alone, subcutaneous immunization with TdEno alone, or both <I>P. gingivalis</I> oral gavage and TdEno immunization. Immunization with TdEno induced not only anti-TdEno but also anti-mouse Eno1 (mEno1) antibodies and increased the expression of TNFα in the gingival tissues. However, alveolar bone loss was not increased by TdEno immunization. In conclusion, autoreactive anti-ENO1/mEno1 antibodies that are produced as byproducts during the antibody response to TdEno play a minimal role in the progression of periodontitis in the absence of rheumatoid arthritis.</P>
Min, Ahreum,Moon, Cheol Joo,Ahn, Ahreum,Lee, Ji Hoon,Kim, Seong Keun,Choi, Myong Yong Elsevier 2016 Chemical physics letters Vol.658 No.-
<P>Mass-selected resonant two-photon ionization (R2PI) and UV-UV hole-burning, and infrared-dip spectra of 5-cyanoindole (5CI) and its water clusters, 5CI-(H2O)(n) (n =1 and 2) were measured. Although, the structures of 5CI-(H2O)(1-2) are similar to those of 3CI-(H2O)1-2, the photofragmentation behaviors of the two systems are quite different due to the L-a-L-b state energy lowering and higher binding energies of 5CI-(H2O)(1-2) compared to those of 3CI-(H2O)(1-2). Especially for the case of 50-(I-120)2 cluster, shortening excited-state lifetime of 5CI-(H2O)(2) causes the broad background in the R2PI spectrum of 5CI-(H2O)(2). (C) 2016 Elsevier B.V. All rights reserved.</P>
Choi Youngha,Jung Se Yong,Park Jung Min,Suh Junghwan,Shin Eun Jung,Chae Hyun Wook,Kim Ho-Seong,Kwon Ahreum 대한소아내분비학회 2023 Annals of Pediatirc Endocrinology & Metabolism Vol.28 No.2
Thyroid hormone plays a vital role in regulating human metabolism. They affect the functions of major organs, such as the brain, liver, skeletal muscle, and heart. Hypothyroidism can lead to dilated cardiomyopathy and decreased heart function. In this report, we describe a case of a teenage boy who developed dilated cardiomyopathy due to hypothyroidism and was considered to undergo heart transplantation. Levothyroxine monotherapy was initiated but produced no improvement. Thereafter, a combination therapy of liothyronine and levothyroxine was administered, and heart function was gradually restored; he recovered completely after 6 months. Cardiac myocytes respond more specifically to liothyronine than to levothyroxine. Therefore, we suggest that liothyronine and levothyroxine combination therapy should be considered rather than levothyroxine monotherapy for hypothyroidism accompanied by heart disease.
배귀석,Ahreum Choi,여준모,김종남,Jaeyong Song,Eun Joong Kim,장문백 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.1
Objective: To examine the effects of Rhodobacter sphaeroides (R. sphaeroides) supplementation as a direct-fed microbial (DFM) on rumen fermentation in dairy cows and on coenzyme Q10 (CoQ10) transition into milk, an in vitro rumen simulation batch culture and an in vivo dairy cow experiment were conducted. Methods: The characteristics of in vitro ruminal fermentation were investigated using rumen fluids from six cannulated Holstein dairy cows at 2 h post-afternoon feeding. A control treatment was included in the experiments based on a typified total mixed ration (TMR) for lactating dairy cows, which was identical to the one used in the in vivo study, plus R. sphaeroides at 0.1%, 0.3%, and 0.5% TMR dry matter. The in vivo study employed six ruminally cannulated lactating Holstein cows randomly allotted to either the control TMR (C-TMR) treatment or to a diet supplemented with a 0.5% R. sphaeroides culture (S-TMR, dry matter basis) ad libitum. The presence of R. sphaeroides was verified using denaturing gradient gel electrophoresis (DGGE) applied to the bacterial samples obtained from the in vivo study. The concentration of CoQ10 in milk and in the supernatant from the in vitro study was determined using high performance liquid chromatography. Results: The results of the in vitro batch culture and DGGE showed that the concentration of CoQ10 significantly increased after 2 h of R. sphaeroides supplementation above 0.1%. When supplemented to the diet of lactating cows at the level of 0.5%, R. sphaeroides did not present any adverse effect on dry matter intake and milk yield. However, the concentration of CoQ10 in milk dramatically increased, with treated cows producing 70.9% more CoQ10 than control cows. Conclusion: The CoQ10 concentration in milk increased via the use of a novel DFM, and R. sphaeroides might be used for producing value-added milk and dairy products in the future.
포제한약재의 최종당화산물 생성 억제 활성 및 항산화 효과
이아름 ( Ahreum Lee ),권오준 ( Ojun Kwon ),최준영 ( Joonyoung Choi ),노성수 ( Seong-soo Roh ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.3
Objectives: Advanced glycation end product (AGEs) is combine formation of glucose and protein. AGEs and reactive oxygen species are potential therapeutic targets for the various disease such as diabetic complications, renal injury, skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from 40 Korean medicines and 5 heating-processed Korean medicines. Methods: AGEs formation inhibitory activities of Korean medicines measured using bovine serum albumin (BSA), glucose, and fructose. Then, five effective Korean medicines were selected and heated with 30% ethanol. The AGEs inhibitory activities of heated Korean medicine were measured compared with not-heated Korean medicines. The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2`-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. Furthermore, we examined total phenol and flavonoids contents. Results: Scutellariae Radix, Corni Fructus, Persimmon Fruit, Paeoniae Radix, Mori Folium respectively reduced AGEs production. Morever, heating-processed Scutellariae Radix has AGEs inhibitory activities better than not-processed Scutellariae Radix. Heating- processed Scutellariae Radix scavenged DPPH and ABTS effectively and IC50 of DPPH and ABTS radical scavenging activity of Heat processed Scutellariae Radix were 15.47±0.26 ㎍/㎖ and 12.07±1.23 ㎍/㎖. It caused heat processing methods of Scutellariae Radix up regulated total phenol and flavonoids contents (26.68±0.01 to 46.15±0.10, 20.30±0.38 to 64.20 ±0.52). Conclusion: It has AGEs inhibitory activities that 20 kind of medicinal plants of 40 medicinal plants. Especially, heat processed Scutellariae Radix has excellent AGEs inhibitory activities and antioxidant effect.
Induction of anti-aquaporin 5 autoantibodies by molecular mimicry in mice
Lee, Ahreum,Choi, Youngnim 대한구강생물학회 2020 International Journal of Oral Biology Vol.45 No.4
Molecular mimicry is the most common mechanism that breaches self-tolerance. We previously identified autoantibodies to aquaporin-5 (AQP5) in the sera of patients with Sjögren's syndrome and found that the aquaporin of Prevotella melaninogenica (PmAqp), an oral commensal, is highly homologous to human AQP5. This study aimed to test whether PmAqp can induce anti-AQP5 autoantibodies via molecular mimicry. From the amino acid sequence of PmAqp, an immunizing peptide; i.e., PmE-L, was designed, which contained both the B cell epitope "E" and T cell epitope. C57BL/6 and BALB/c mice were subcutaneously immunized with linear or cyclic forms of PmE-L emulsified in incomplete Freund's adjuvant. The concentrations of the antibodies in sera were measured using enzyme-linked immunosorbent assays. Both linear and cyclic PmE-L induced high levels of antibodies against not only the immunized peptides but also autoantibodies against AQP5E and antibodies against PmE, a Pm homolog of AQP5E. In C57BL/6 mice; however, the cyclic form of PmE-L was more efficient than the linear form in inducing autoantibodies against AQP5E that contained a cyclic epitope. The levels of anti-PmE antibodies and anti-AQP5E autoantibodies showed a strong positive correlation (r = 0.95, p < 0.0005), suggesting molecular mimicry. Collectively, the mice produced anti-AQP5E autoantibodies in response to a PmAqp-derived peptide. This model proved to be useful for studying the mechanisms of autoantibody production by molecular mimicry.