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A vueltas con las maneras de narrar de Galdós hacia fin de siglo
Francisco Estévez 한국스페인어문학회 2010 스페인어문학 Vol.0 No.57
Pese a los numerosos y valiosos estudios que existen sobre el escritor, faltan aún trabajos que analicen el sutil estilode Benito Pérez Galdós. En este trabajo se analiza el fragmento inicial de donde realiza el retrato de uno de los personajes más famosos del autor se intenta ahondar en el estudio de sus recursos estilísticos-constructivos.
Mireya Esbeiddy Cha´vez-Magdaleno,Ramse´s Ramo´n Gonza´lez-Estrada,Anelsy Ramos-Guerrero,Maribel Plascencia-Jatomea,Porfirio Gutie´rrez-Martı´nez 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.6
Preventive and curative activity of postharvest treatments with chitosan nanoparticles (CS) and chitosan biocomposites loaded with pepper tree essential oil (CSPEO) against anthracnose were evaluated on Avocado (Persea americana) cv. Hass artificially inoculated in rind wounds. After 10 days of storage significant preventive and curative activity against Colletotrichum gloeosporioides was observed with the absence of internal damage by applying CS and CS-PEO. Quality parameters like water losses and firmness changes were assessed on fruit treated. CS and CS-PEO were effective to reduce water losses and firmness losses.
Romagnoli, Romeo,Baraldi, Pier Giovanni,Lopez-Cara, Carlota,Cruz-Lopez, Olga,Carrion, Maria Dora,Kimatrai Salvador, Maria,Bermejo, Jaime,Est?vez, Sara,Est?vez, Francisco,Balzarini, Jan,Brancale, Andre Wiley-VCH 2011 CHEMMEDCHEM Vol.6 No.10
<P>Induction of apoptosis is a promising strategy that could lead to the discovery of new molecules active in cancer chemotherapy. This property is generally observed when cells are treated with agents that target microtubules, dynamic structures that play a crucial role in cell division. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. A new class of inhibitors of tubulin polymerization based on the 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan molecular skeleton, with the amino group placed at different positions on the benzene ring, were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell-cycle effects. The methoxy substitution pattern on the benzene portion of the benzo[b]furan moiety played an important role in affecting antiproliferative activity. In the series of 5-amino derivatives, the greatest inhibition of cell growth occurred if the methoxy substituent is placed at the C6 position, whereas C7 substitution decreases potency. The most promising compound in this series is 2-(3',4',5'-trimethoxybenzoyl)-3-methyl-5-amino-6-methoxybenzo[b]furan (3 h), which inhibits cancer cell growth at nanomolar concentrations (IC(50) =16-24 nM), and interacts strongly with tubulin by binding to the colchicine site. Sub-G(1) apoptotic cells in cultures of HL-60 and U937 cells were observed by flow cytometric analysis after treatment with 3 h in a concentration-dependent manner. We also show that compound 3 h induces apoptosis by activation of caspase-3, -8, and -9, and this is associated with cytochrome c release from mitochondria. The introduction of an α-bromoacryloyl group increased antiproliferative activity with respect to the parent amino derivatives.</P>
Ibraikulov, Olzhas A.,Ngov, Chheng,Chá,vez, Patricia,Bulut, Ibrahim,Heinrich, Benoî,t,Boyron, Olivier,Gerasimov, Kirill L.,Ivanov, Dimitri A.,Swaraj, Sufal,Mé,ry, Sté,phane,Lecl The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.25
<P>The recently reported high power conversion efficiencies achieved in fluorinated polymer:fullerene solar cells have been accounted for by the presence of face-on oriented polymer backbones that enable charge transport towards the collecting electrodes. In this work, we demonstrate that, in contrast to the results of a number of reports, the face-on polymer orientation is due to the bulky side chains, rather than to aggregation in solution. This conclusion is supported by a comparative study of polymers having similar conjugated backbones but different number of fluorine atoms and different number and type of alkyl side chains. While the latter are primarily introduced to tune polymer solubility, the present in-depth thin-film morphology investigation shows that increasing the chain bulkiness favors formation of crystalline lamellae with face-on oriented backbones, independently of the degree of fluorination. By contrast, introduction of fluorine atoms is found to substantially enhance the π-stacking interactions that remain invariably strong upon blending of the polymer with fullerene. Our results demonstrate that, for the polymer family under investigation, fluorination and functionalization by bulky alkyl side chains are both needed for reaching power conversion efficiencies above 10%.</P>
Paulo A. Augusto,Teresa Castelo-Grande,Pedro Augusto,A.M. Est?vez,Domingos Barbosa 한국물리학회 2007 Current Applied Physics Vol.7 No.3
The theoretical principles of MAGCLATMsusceptibility, are presented for the magnetic particles. An empirical coecient (TCG2) is introduced in the equations of movement toaccount for deviations between experimental and theoretical values.
Paulo A. Augusto,Teresa Castelo-Grande,Pedro Augusto,Domingos Barbosa,A.M. Est?vez 한국물리학회 2007 Current Applied Physics Vol.7 No.3
A new device, MAGCLATMoped by the authors. In a previous article the equations of movement for non-magnetic particles in this new device were analyzed and inthis paper the limiting conditions set by the dierent variables and equations of movement are presented for the case of the non-magneticparticles. The knowledge of these limiting conditions is important as they set the boundaries within which we may manipulate theMAGCLATM’s operating and design variables.
Melé,ndez-Ló,pez, Samuel G.,Herdman, Scott,Hirata, Ken,Choi, Min-Ho,Choe, Youngchool,Craik, Charles,Caffrey, Conor R.,Hansell, Elisabeth,Chá,vez-Munguí,a, Bibiana,Chen, Yen Tin American Society for Microbiology 2007 EUKARYOTIC CELL Vol.6 No.7
<B>ABSTRACT</B><P>Cysteine proteinases are key virulence factors of the protozoan parasite <I>Entamoeba histolytica</I>. We have shown that cysteine proteinases play a central role in tissue invasion and disruption of host defenses by digesting components of the extracellular matrix, immunoglobulins, complement, and cytokines. Analysis of the <I>E. histolytica</I> genome project has revealed more than 40 genes encoding cysteine proteinases. We have focused on <I>E. histolytica</I> cysteine proteinase 1 (EhCP1) because it is one of two cysteine proteinases unique to invasive <I>E. histolytica</I> and is highly expressed and released. Recombinant EhCP1 was expressed in <I>Escherichia coli</I> and refolded to an active enzyme with a pH optimum of 6.0. We used positional-scanning synthetic tetrapeptide combinatorial libraries to map the specificity of the P1 to P4 subsites of the active site cleft. Arginine was strongly preferred at P2, an unusual specificity among clan CA proteinases. A new vinyl sulfone inhibitor, WRR483, was synthesized based on this specificity to target EhCP1. Recombinant EhCP1 cleaved key components of the host immune system, C3, immunoglobulin G, and pro-interleukin-18, in a time- and dose-dependent manner. EhCP1 localized to large cytoplasmic vesicles, distinct from the sites of other proteinases. To gain insight into the role of secreted cysteine proteinases in amebic invasion, we tested the effect of the vinyl sulfone cysteine proteinase inhibitors K11777 and WRR483 on invasion of human colonic xenografts. The resultant dramatic inhibition of invasion by both inhibitors in this human colonic model of amebiasis strongly suggests a significant role of secreted amebic proteinases, such as EhCP1, in the pathogenesis of amebiasis.</P>
Rocí,o Crystabel Ló,pez-Gonzá,lez,Yara Suhan Juá,rez-Campusano,José,Luis Rodrí,guez-Chá,vez,Guillermo Delgado-Lamas,Sofí,a Marí,a Arvizu Medrano,Ramó,n Á,lv 한국식물병리학회 2021 Plant Pathology Journal Vol.37 No.1
Blue mold caused by Penicillium expansum is one of the most significant postharvest diseases of apples. Some microorganisms associated with the surface of ripen- ing apples possess the ability to inhibit the growth of P. expansum. However, the existing literature about their colonization in the stages before ripening is not explored in depth. This study aims to characterize the antagonistic capacity of bacterial populations from five fruit development stages of ‘Royal Gala’ apples. The re- sults have shown that the density of the bacterial popu- lations decreases throughout the ripening stages of fruit (from 1.0 × 105 to 1.1 × 101 cfu/cm2). A total of 25 bacte- rial morphotypes (corresponding to five genera identi- fied by 16S RNA) were differentiated in which Bacillus stood out as a predominant genus. In the in vitro an- tagonism tests, 10 Bacillus strains (40%) inhibited the mycelial growth of P. expansum from 30.1% to 60.1%, while in fruit bioassays, the same strains reduced the fruit rot ranging from 12% to 66%. Moreover, the bacterial strains with antagonistic activity increased in the ripening fruit stage. B. subtilis subsp. spiziennii M24 obtained the highest antagonistic activity (66.9% of rot reduction). The matrix-assisted laser desorption ioniza- tion-time of flight mass spectrometry analysis revealed that bacteria with antagonistic activity produce anti- fungal lipopeptides from iturin and fengycin families.
Jorge Chávez,Omar Jiménez Alemán,Martín Flores Martínez,Héctor J. Vergara‑Hernández,Luis Olmos,Pedro Garnica‑González,Didier Bouvard 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.2
The design and fabrication of a bilayer Ti6Al4V–Ti6Al4V/30Ta component were performed by using the powder metallurgyprocess and solid-state sintering as the consolidation step. Phase change and sintering densifcation of the component werestudied by dilatometry. The addition of 30 vol% of Ta to the Ti6Al4V matrix had a noticeable efect over the microstructuraland mechanical properties of the alloy, which showed decrements of up to 12.2 and 21.5% in nano-hardness and elastic modulus, respectively. The decrement of these properties strongly afected the wear and corrosion performance of the component. Special attention was focused on the intermediate zone between layers denoted by a transition zone, which presented betterwear response because of the properties and microstructure caused by the gradient difusion of Ta. Ti6Al4V/30Ta alloyshowed an improved corrosion behaviour compared to Ti6Al4V alloy, decreasing 2.4 times their susceptibility to corrosionand about two orders of magnitude their corrosion rate. The bilayer component in this study is proposed as an alternative todecrease the consumption of expensive materials with improved properties.