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Laporte, Ste´phane A.,Miller, William E.,Kim, Kyeong-Man,Caron, Marc G. 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
β-Arrestins, proteins involved in the turn-off of G protein-coupled receptor (GPCR) activation, bind to the β_2-adaptin subunit of the clathrin adaptor AP-2. The interaction of β_2-adaptin with β-Arrestin involves critical arginine residues in the C-terminal domain of β-Arrestin and plays an important role in initiating clathrin-mediated endocytosis of the β_2-adrenergic receptor(β_2AR) (Laporte, S. A., Oakley, R. H., Holt, J. A., Barak, L. S., and Caron, M. G. (2000) J. Biol. Chem. 276, 23120-23126). However, the β-arrestin-binding site in β_2-adaptin has not been identified, and little is known about the role of β-arrestin/AP-2 interaction in the endocytosis of other GPCRs. Using in vitro binding assays, we have identified two glutamate residues (Glu-849 and Glu-902) in β_2-adaptin that are important in β-arrestin binding. These residues are located in the platform subdomain of the C terminus β_2-adaptin, where accessory/adapter endocytic proteins for other classes of receptors interact, distinct from the main site where clathrin interact. The functional significance of the β-arrestin/AP-2/clathrin complex in the endocytosis of GPCRs such as the β_2AR and vasopressin type Ⅱ receptor was evaluated using mutant constructs of the β_2-adaptin C terminus containing either the clathrin and the β-arrestin binding domains or the β-arrestin-binding domain alone. When expressed in human embryonic kidney 293 cells, both constructs acted as dominant negatives inhibiting the agonist-induced internalization of the β_2AR and the vasopressin type Ⅱ receptor. In addition, although the β_2-adaptin construct containing both the clathrin and β-arrestin binding domains was able to block the endocytosis of transferrin receptors, a β_2-adaptin construct capable of assoociating with β-arrestin but lacking its high affinity clathrin interaction did not interfere with transferrin receptor endocytosis. These results suggest that the interaction of β-arrestin with β_2-adaptin represents a selective endocytic trigger for several members of the GPCR family.
Determination of the orders generated by a cyclic cubic unit that are Galois invariant
Lee, Jun Ho,Louboutin, Sté,phane R. Elsevier 2015 Journal of number theory Vol.148 No.-
<P><B>Abstract</B></P> <P>Let <I>ϵ</I> be a totally real cubic algebraic unit. Assume that the cubic number field Q ( ϵ ) is Galois. In this situation, it is natural to ask when the cubic order Z [ ϵ ] is invariant under the action of the Galois group Gal ( Q ( ϵ ) / Q ) . It seems that this natural problem has never been looked at. We give an answer to this problem (e.g., we show that if <I>ϵ</I> is totally positive, then this happens in only 12 cases).</P>
Nonlinear ion dynamics in Hall thruster plasma source by ion transit-time instability
Lim, Youbong,Choe, Wonho,Mazouffre, Sté,phane,Park, Jae Sun,Kim, Holak,Seon, Jongho,Garrigues, L IOP PUBLISHING 2017 PLASMA SOURCES SCIENCE AND TECHNOLOGY Vol.26 No.3
<P>High-energy tail formation in an ion energy distribution function (IEDF) is explained in a Hall thruster plasma with the stationary crossed electric and magnetic fields whose discharge current is oscillated at the ion transit-time scale with a frequency of 360 kHz. Among ions in different charge states, singly charged Xe ions (Xe<SUP>+</SUP>) have an IEDF that is significantly broadened and shifted toward the high-energy side, which contributes to tail formation in the entire IEDF. Analytical and numerical investigations confirm that the IEDF tail is due to nonlinear ion dynamics in the ion transit-time oscillation.</P>
A pivotal role of GSK-3 in synaptic plasticity
Bradley, Clarrisa A.,Peineau, Sté,phane,Taghibiglou, Changiz,Nicolas, Celine S.,Whitcomb, Daniel J.,Bortolotto, Zuner A.,Kaang, Bong-Kiun,Cho, Kwangwook,Wang, Yu Tian,Collingridge, Graham L. Frontiers Media S.A. 2012 Frontiers in molecular neuroscience Vol.5 No.-
<P>Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.</P>
Marie Alfrede Mvondo,Jessica Darelle Ekenfack,Ste´phane Minko Essono,Harding Saah Namekong,Charline Florence Awounfack,Matthias W. Laschke,Dieudonne´ Njamen 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.6
High prevalence of endometriosis was reported in Asian women as a result of their traditionally high intake of soy foods during infancy. Soy is widely used in infant feeding after weaning from breast milk or cow milk. This study thus aimed to determine to what extent soy intake before puberty may contribute to the development of endometriosis. For this purpose, immature (6-week old) female rats were fed with various soy formulas (0%, 10%, 20%, 30%, 40%, 50%, and 60%). Normal control animals were fed with a soy-free diet. At 13 weeks of age, animals (except the normal control) underwent a transplantation surgery to establish endometriosis. Estradiol valerate and oxytocin were used to induce pelvic pain. Endometrial implant levels of glutathione (GSH) and malondialdehyde (MDA) allowed estimating tissue oxidative status. Physiological ovarian function was assessed by histological analysis of ovaries. Results showed that soy-fed animals grew faster than animals receiving a soy-free diet (P < .001). In animals supplemented with more than 10% of soy, the intensity of pelvic pain increased (P < .001) as well as the volume of ectopic foci. In addition, tissue levels of MDA and GSH increased (P < .001). The ovarian function was altered and the number of luteinized unruptured follicles increased. In conclusion, although animals supplemented with soy at the prepubertal stage displayed a good growth performance, regular soy consumption may promote the development and progress of endometriosis in adulthood, especially when soy content in food is more than 10%.
Color and Brightness Tuning in Heteronuclear Lanthanide Terephthalate Coordination Polymers
Haquin, Victor,Etienne, Mael,Daiguebonne, Carole,Freslon, Sté,phane,Calvez, Guillaume,Bernot, Kevin,Le Pollè,s, Laurent,Ashbrook, Sharon E.,Mitchell, Martin R.,Bü,nzli, Jean‐,Cla WILEY‐VCH Verlag 2013 European journal of inorganic chemistry Vol.2013 No.20
<P><B>Abstract</B></P><P>Heteronuclear lanthanide terephthalate coordination polymers with the general chemical formula [Ln<SUB>2–2<I>x</I></SUB>Ln′<SUB>2<I>x</I></SUB>(bdc)<SUB>3</SUB>(H<SUB>2</SUB>O)<SUB>4</SUB>]<SUB>∞</SUB>, for which bdc<SUP>2–</SUP> symbolizes benzene‐1,4‐dicarboxylate (or terephthalate) and Ln and Ln′ represent trivalent rare earth ions, were synthesized and structurally characterized. Analysis of the Y/Lu compounds by <SUP>89</SUP>Y and <SUP>13</SUP>C solid‐state NMR spectroscopy was carried out, and the results support the hypothesis of randomly distributed lanthanide ions. The spectroscopic and colorimetric properties of this family of compounds were investigated in detail. The resulting data demonstrate that this series of compounds presents highly tunable luminescence properties and clearly indicate that intermetallic deactivation processes play an important role in the emission mechanism. Playing with intermetallic distances allows one to tune the color and the brightness of the lanthanide emission in these coordination polymers.</P>
Robust two-level system control by a detuned and chirped laser pulse
Jo, Hanlae,Lee, Han-gyeol,Gué,rin, Sté,phane,Ahn, Jaewook American Physical Society 2017 Physical review. A Vol.96 No.3
<P>We propose and demonstrate a robust control scheme by an ultrafast nonadiabatic chirped laser pulse, designed for targeting coherent superpositions of two-level systems. Robustness against power fluctuation is proved by our numerical study and a proof-of-principle experiment performed with femtosecond laser interaction on cold atoms. They exhibit for the final driven dynamics a cusp on the Bloch sphere, corresponding to a zero curvature of fidelity. This solution is particularly simple and thus applicable to a wide range of potential applications.</P>
The JAK/STAT Pathway Is Involved in Synaptic Plasticity
Nicolas, Cé,line ,S.,Peineau, Sté,phane,Amici, Mascia,Csaba, Zsolt,Fafouri, Assia,Javalet, Charlotte,Collett, Valerie ,J.,Hildebrandt, Lars,Seaton, Gillian,Choi, Sun-Lim,Sim, Su-Eo Cell Press 2012 Neuron Vol.73 No.2
<▼1><P><B>Summary</B></P><P>The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.</P></▼1><▼2><P>The authors demonstrate a new neuronal function for the JAK/STAT pathway in the induction of NMDA-receptor-dependent long-term depression (NMDAR-LTD) in the hippocampus.</P></▼2>
Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
Smith, Matthew R.,Saad, Fred,Chowdhury, Simon,Oudard, Sté,phane,Hadaschik, Boris A.,Graff, Julie N.,Olmos, David,Mainwaring, Paul N.,Lee, Ji Youl,Uemura, Hiroji,Lopez-Gitlitz, Angela,Trudel, G&e New England Journal of Medicine 2018 The New England journal of medicine Vol.378 No.15
<P>Among men with nonmetastatic castration-resistant prostate cancer, metastasis-free survival and time to symptomatic progression were significantly longer with apalutamide than with placebo.</P>