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THE ELEVENTH AND TWELFTH DATA RELEASES OF THE SLOAN DIGITAL SKY SURVEY: FINAL DATA FROM SDSS-III
Alam, Shadab,Albareti, Franco D.,Prieto, Carlos Allende,Anders, F.,Anderson, Scott F.,Anderton, Timothy,Andrews, Brett H.,Armengaud, Eric,Aubourg, É,ric,Bailey, Stephen,Basu, Sarbani,Bautista, J IOP Publishing 2015 The Astrophysical journal Supplement series Vol.219 No.1
<P>The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg(2) of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg(2) of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg(2); 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra.</P>
Jensen, Helene H.,Login, Fré,dé,ric H.,Park, Ji-Young,Kwon, Tae-Hwan,Nejsum, Lene N. Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Aberrant levels of aquaporin-5 (AQP5) expression have been observed in several types of cancer, including breast cancer, where AQP5 overexpression is associated with metastasis and poor prognosis. In cultured cancer cells, AQP5 facilitates cell migration and activates Ras signaling. Both increased cell migration and Ras activation are associated with cancer metastasis, but so far it is unknown if AQP5 also affects these processes <I>in vivo</I>. Therefore, we investigated if high AQP5 expression in breast cancer tissue correlated with increased activation of Ras and of Rac1, which is a GTPase also involved in cell migration. This was accomplished by immunohistochemical analysis of invasive ductal carcinoma of breast tissue sections from human patients, followed by qualitative and quantitative correlation analysis between AQP5 and activated Ras and Rac1. Immunohistochemistry revealed that activation of Ras and Rac1 was positively correlated. There was, however, no correlation between high AQP5 expression and activation of Ras, whereas a nonsignificant, but positive, tendency between the levels of AQP5 and activated Rac1 levels was observed. In summary, this is the first report that correlates AQP5 expression levels to downstream signaling partners in breast cancer tissue sections. The results suggest Rac1 as a potential downstream signaling partner of AQP5 <I>in vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Subcellular AQP5 localization is altered in human breast cancer. </LI> <LI> Correlation analysis of GTPase activation and AQP5 in human breast cancer. </LI> <LI> Positive tendency for correlation between Rac-GTP and AQP5 in human breast cancer. </LI> <LI> Ras-GTP and Rac1-GTP positively correlated in human breast cancer. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Tunneling decay of self-gravitating vortices
Dupuis, É,ric,Gobeil, Yan,Lee, Bum-Hoon,Lee, Wonwoo,MacKenzie, Richard,Paranjape, Manu B.,Yajnik, Urjit A.,Yeom, Dong-han,Gwak, B.,Kang, G.,Kim, C.,Kim, H.-C.,Lee, C.-H.,Lee, J.,Lee, S.,Lee, W. EDP Sciences 2018 The European Physical Journal Conferences Vol.168 No.-
<P>We investigate tunneling decay of false vortices in the presence of gravity, in which vortices are trapped in the false vacuum of a theory of scalar electrodynamics in three dimensions. The core of the vortex contains magnetic flux in the true vacuum, while outside the vortex is the appropriate topologically nontrivial false vacuum. We numerically obtain vortex solutions which are classically stable; however, they could decay via tunneling. To show this phenomenon, we construct the proper junction conditions in curved spacetime. We find that the tunneling exponent for the vortices is half that for Coleman-de Luccia bubbles and discuss possible future applications.</P>
Ronald J.A. Wanders,Gepke Visser,Sacha Ferdinandusse,Frédéric M. Vaz,Riekelt H. Houtkooper 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.3
Mitochondrial fatty acid (FA) oxidation deficiencies represent a genetically heterogeneous group of diseases in humans caused by defects in mitochondrial FA beta-oxidation (mFAO). A general characteristic of all mFAO disorders is hypoketotic hypoglycemia resulting from the enhanced reliance on glucose oxidation and the inability to synthesize ketone bodies from FAs. Patients with a defect in the oxidation of long-chain FAs are at risk to develop cardiac and skeletal muscle abnormalities including cardiomyopathy and arrhythmias, which may progress into early death, as well as rhabdomyolysis and exercise intolerance. The diagnosis of mFAO-deficient patients has greatly been helped by revolutionary developments in the field of tandem mass spectrometry (MS) for the analysis of acylcarnitines in blood and/or urine of candidate patients. Indeed, acylcarnitines have turned out to be excellent biomarkers; not only do they provide information whether a certain patient is affected by a mFAO deficiency, but the acylcarnitine profile itself usually immediately points to which enzyme is likely deficient. Another important aspect of acylcarnitine analysis by tandem MS is that this technique allows high-throughput analysis, which explains why screening for mFAO deficiencies has now been introduced in many newborn screening programs worldwide. In this review, we will describe the current state of knowledge about mFAO deficiencies, with particular emphasis on recent developments in the area of pathophysiology and treatment.
DYNAMICS AND AFTERGLOW LIGHT CURVES OF GAMMA-RAY BURST BLAST WAVES WITH A LONG-LIVED REVERSE SHOCK
Uhm, Z. Lucas,Zhang, Bing,Hascoë,t, Romain,Daigne, Fré,dé,ric,Mochkovitch, Robert,Park, Il H. IOP Publishing 2012 The Astrophysical journal Vol.761 No.2
<P>We perform a detailed study on the dynamics of a relativistic blast wave with the presence of a long-lived reverse shock (RS). Although a short-lived RS has been widely considered, the RS is believed to be long-lived as a consequence of a stratification expected on the ejecta Lorentz factors. The existence of a long-lived RS causes the forward shock (FS) dynamics to deviate from a self-similar Blandford-McKee solution. Employing the 'mechanical model' that correctly incorporates the energy conservation, we present an accurate solution for both the FS and RS dynamics. We conduct a sophisticated calculation of the afterglow emission. Adopting a Lagrangian description of the blast wave, we keep track of an adiabatic evolution of numerous shells between the FS and RS. An evolution of the electron spectrum is also followed individually for every shell. We then find the FS and RS light curves by integrating over the entire FS and RS shocked regions, respectively. Exploring a total of 20 different ejecta stratifications, we explain in detail how a stratified ejecta affects its blast wave dynamics and afterglow light curves. We show that, while the FS light curves are not sensitive to the ejecta stratifications, the RS light curves exhibit much richer features, including steep declines, plateaus, bumps, re-brightenings, and a variety of temporal decay indices. These distinctive RS features may be observable if the RS has higher values of the microphysics parameters than the FS. We discuss possible applications of our results in understanding the gamma-ray burst afterglow data.</P>
THE BARYON OSCILLATION SPECTROSCOPIC SURVEY OF SDSS-III
Dawson, Kyle S.,Schlegel, David J.,Ahn, Christopher P.,Anderson, Scott F.,Aubourg, É,ric,Bailey, Stephen,Barkhouser, Robert H.,Bautista, Julian E.,Beifiori, Alessandra,Berlind, Andreas A.,Bhardw IOP Publishing 2013 The Astronomical journal Vol.145 No.1
High-precision photometry by telescope defocussing - VI. WASP-24, WASP-25 and WASP-26
Southworth, J.,Hinse, T. C.,Burgdorf, M.,Calchi Novati, S.,Dominik, M.,Galianni, P.,Gerner, T.,Giannini, E.,Gu, S.- H.,Hundertmark, M.,Jorgensen, U. G.,Juncher, D.,Kerins, E.,Mancini, L.,Rabus, M.,Ric Oxford University Press 2014 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.444 No.1