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Binshtok, Alexander M.,Gerner, Peter,Oh, Seog Bae,Puopolo, Michelino,Suzuki, Suzuko,Roberson, David P.,Herbert, Teri,Wang, Chi-Fei,Kim, Donghoon,Chung, Gehoon,Mitani, Aya A.,Wang, Ging Kuo,Bean, Bruce American Society of Anesthesiologists, Inc. 2009 Anesthesiology Vol.111 No.1
BACKGROUND:: Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establishment of the QX-314–mediated block would limit clinical utility. Because TRPV1 channels are also activated by lidocaine, the authors tested whether lidocaine can substitute for capsaicin to introduce QX-314 into nociceptors through TRPV1 channels and produce selective analgesia. METHODS:: Lidocaine (0.5% [17.5 mm], 1% [35 mm], and 2% [70 mm]) alone, QX-314 (0.2% [5.8 mm]) alone, and a combination of the two were injected subcutaneously and adjacent to the sciatic nerve in rats and mice. Mechanical and thermal responsiveness were measured, as was motor block. RESULTS:: Coapplication of 0.2% QX-314 with lidocaine prolonged the nociceptive block relative to lidocaine alone, an effect attenuated in TRPV1 knockout mice. The 0.2% QX-314 alone had no effect when injected intraplantary or perineurally, and it produced only weak short-lasting inhibition of the cutaneous trunci muscle reflex. Perisciatic nerve injection of lidocaine with QX-314 produced a differential nociceptive block much longer than the transient motor block, lasting 2 h (for 1% lidocaine) to 9 h (2% lidocaine). Triple application of lidocaine, QX-314, and capsaicin further increased the duration of the differential block. CONCLUSIONS:: Coapplication of lidocaine and its quaternary derivative QX-314 produces a long-lasting, predominantly nociceptor-selective block, likely by facilitating QX-314 entry through TRPV1 channels. Delivery of QX-314 into nociceptors by using lidocaine instead of capsaicin produces sustained regional analgesia without nocifensive behavior.
Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line
Irene Flickinger,Barbara C Rütgen,Wilhelm Gerner,Ivana Calice,Alexander Tichy,Armin Saalmüller,Miriam Kleiter 대한수의학회 2013 JOURNAL OF VETERINARY SCIENCE Vol.14 No.2
To evaluate radiosensitivity and the effects of radiation on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the canine oral melanoma cell line, TLM 1,cells were irradiated with doses of 0, 2, 4, 6, 8 and 10 Gray (Gy). Survival rates were then determined by a MTT assay, while vascular endothelial growth factor receptor (VEGFR)-1 and -2expression was measured by flow cytometry and apoptotic cell death rates were investigated using an Annexin assay. Additionally, a commercially available canine VEGF ELISA kit was used to measure VEGF. Radiosensitivity was detected in TLM 1 cells, and mitotic and apoptotic cell death was found to occur in a radiation dose dependent manner. VEGF was secreted constitutively and significant up-regulation was observed in the 8 and 10 Gy irradiated cells. In addition, a minor portion of TLM 1 cells expressed vascular endothelial growth factor receptor (VEGFR)-1 intracellularly. VEGFR-2was detected in the cytoplasm and was down-regulated following radiation with increasing dosages. In TLM 1 cells,apoptosis plays an important role in radiation induced cell death. It has also been suggested that the significantly higher VEGF production in the 8 and 10 Gy group could lead to tumour resistance.
High-precision photometry by telescope defocussing - VI. WASP-24, WASP-25 and WASP-26
Southworth, J.,Hinse, T. C.,Burgdorf, M.,Calchi Novati, S.,Dominik, M.,Galianni, P.,Gerner, T.,Giannini, E.,Gu, S.- H.,Hundertmark, M.,Jorgensen, U. G.,Juncher, D.,Kerins, E.,Mancini, L.,Rabus, M.,Ric Oxford University Press 2014 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.444 No.1
Flux and color variations of the doubly imaged quasar UM673
Ricci, D.,Elyiv, A.,Finet, F.,Wertz, O.,Alsubai, K.,Anguita, T.,Bozza, V.,Browne, P.,Burgdorf, M.,Calchi Novati, S.,Dodds, P.,Dominik, M.,Dreizler, S.,Gerner, T.,Glitrup, M.,Grundahl, F.,Hardis, S.,Ha EDP Sciences 2013 Astronomy and astrophysics Vol.551 No.-
Transits and starspots in the WASP-6 planetary system
Tregloan-Reed, J.,Southworth, J.,Burgdorf, M.,Novati, S. C.,Dominik, M.,Finet, F.,Jorgensen, U. G.,Maier, G.,Mancini, L.,Prof, S.,Ricci, D.,Snodgrass, C.,Bozza, V.,Browne, P.,Dodds, P.,Gerner, T.,Harp Oxford University Press 2015 Monthly notices of the Royal Astronomical Society Vol.450 No.2