MiNDSTEp differential photometry of the gravitationally lensed quasars WFI 2033-4723 and HE 0047-1756: microlensing and a new time delay

Giannini, E.,Schmidt, R. W.,Wambsganss, J.,Alsubai, K.,Andersen, J. M.,Anguita, T.,Bozza, V.,Bramich, D. M.,Browne, P.,Calchi Novati, S.,Damerdji, Y.,Diehl, C.,Dodds, P.,Dominik, M.,Elyiv, A.,Fang, X. EDP Sciences 2017 Astronomy and astrophysics Vol.597 No.-

Growth, structure and physical properties of single crystals of pure and Pb-doped Bi-based high Tc superconductors

E. Giannini,R. Gladyshevskii,N. Clayton,N. Musolino,V. Garnier,A. Piriou,R. Flu¨kiger 한국물리학회 2008 Current Applied Physics Vol.8 No.2

Single crystals of (Bi1xPbx)2Sr2Ca2Cu3O10+d (x = 0 and 0.16) (sizes up to 3 · 2 · 0.1 mm3) have been grown by means of a newly developed ‘‘vapour-assisted travelling solvent floating zone’’ technique (VA-TSFZ). Post-annealing under high pressure of O2 (up to 10 MPa at T = 500 C) was applied to enhance Tc (up to 111 K) and improve the homogeneity of the crystals (DTc 6 1 K). The structure of both Pb-free and Pb-doped Bi-2223 was refined for the first time from single crystal X-ray diffraction (XRD) data. The unit cell of the average structure is pseudo-tetragonal with a = 5.4210(7), b = 5.4133(6) and c = 37.010(7)A ˚ , and a = 5.395(1), b = 5.413(1) and c = 37.042(11)A ˚ , for the Pb-free and the Pb-doped phase, respectively. An incommensurate modulation in the direction of one of the short cell vectors has been defined (q 0.21 a*), however, the structure can be conveniently described in a supercell with a fivefold volume (a = 27.105(4) A ˚ ). With respect to the ‘‘non-modulated’’ structure, one additional oxygen atom for ten initial O was found to be inserted into the BiO layers. The superconducting anisotropy of Bi-2223 was found to be 50, from measurements of the lower critical field. The anisotropy of Bi-2223 is significantly reduced compared to that of Bi-2212, and this accounts for the enhanced irreversibility fields in Bi-2223. Furthermore, Bi-2223 has a higher critical current density, and a reduced magnetic relaxation rate compared to Bi-2212, which are both signatures of more effective pinning in Bi-2223 due to its reduced anisotropy. Single crystals of (Bi1xPbx)2Sr2Ca2Cu3O10+d (x = 0 and 0.16) (sizes up to 3 · 2 · 0.1 mm3) have been grown by means of a newly developed ‘‘vapour-assisted travelling solvent floating zone’’ technique (VA-TSFZ). Post-annealing under high pressure of O2 (up to 10 MPa at T = 500 C) was applied to enhance Tc (up to 111 K) and improve the homogeneity of the crystals (DTc 6 1 K). The structure of both Pb-free and Pb-doped Bi-2223 was refined for the first time from single crystal X-ray diffraction (XRD) data. The unit cell of the average structure is pseudo-tetragonal with a = 5.4210(7), b = 5.4133(6) and c = 37.010(7)A ˚ , and a = 5.395(1), b = 5.413(1) and c = 37.042(11)A ˚ , for the Pb-free and the Pb-doped phase, respectively. An incommensurate modulation in the direction of one of the short cell vectors has been defined (q 0.21 a*), however, the structure can be conveniently described in a supercell with a fivefold volume (a = 27.105(4) A ˚ ). With respect to the ‘‘non-modulated’’ structure, one additional oxygen atom for ten initial O was found to be inserted into the BiO layers. The superconducting anisotropy of Bi-2223 was found to be 50, from measurements of the lower critical field. The anisotropy of Bi-2223 is significantly reduced compared to that of Bi-2212, and this accounts for the enhanced irreversibility fields in Bi-2223. Furthermore, Bi-2223 has a higher critical current density, and a reduced magnetic relaxation rate compared to Bi-2212, which are both signatures of more effective pinning in Bi-2223 due to its reduced anisotropy.

Multi-criteria retrieval of CAD assembly models

Lupinetti, Katia,Giannini, Franca,Monti, Marina,Pernot, Jean-Philippe Society for Computational Design and Engineering 2018 Journal of computational design and engineering Vol.5 No.1

Being able to reuse existing design knowledge is of major interest to help designers during the creation of new products. This is true at the level of the parts and even more at the level of the assemblies of multiple parts. Meaningful information and knowledge can be extracted from existing geometric models and associated data and metadata, as well as from the processes followed to define them. This paper proposes a method to characterize and structure CAD assembly models to enable the retrieving of similar models from a database. A framework has been devised for the retrieval of globally and/or partially similar assembly models according to multiple user-specified search criteria. It is based on an assembly descriptor, called the Enriched Assembly Model, which is an attributed graph that encodes all the required data automatically extracted from the geometry and structure of the CAD models. The data are organized in four layers: structural, assembly interface, shape and statistic layers. Starting from a real CAD model or from an abstract query model, the algorithm retrieves models from the database by solving a matching problem. The matching between two assembly models is translated into the problem of finding a subisomorphism between two EAMs. The layered organization of the EAM allows partially defined queries, which can be further refined. The effectiveness of the proposed approach is illustrated with results obtained from the developed software prototype.

Multi-criteria retrieval of CAD assembly models

Katia Lupinetti,Franca Giannini,Marina Monti,Jean-Philippe Pernot 한국CDE학회 2018 Journal of computational design and engineering Vol.5 No.1

Being able to reuse existing design knowledge is of major interest to help designers during the creation of new products. This is true at the level of the parts and even more at the level of the assemblies of multiple parts. Meaningful information and knowledge can be extracted from existing geometric models and associated data and metadata, as well as from the processes followed to define them. This paper proposes a method to characterize and structure CAD assembly models to enable the retrieving of similar models from a database. A framework has been devised for the retrieval of globally and/or partially similar assembly models according to multiple user-specified search criteria. It is based on an assembly descriptor, called the Enriched Assembly Model, which is an attributed graph that encodes all the required data automatically extracted from the geometry and structure of the CAD models. The data are organized in four layers: structural, assembly interface, shape and statistic layers. Starting from a real CAD model or from an abstract query model, the algorithm retrieves models from the database by solving a matching problem. The matching between two assembly models is translated into the problem of finding a subisomorphism between two EAMs. The layered organization of the EAM allows partially defined queries, which can be further refined. The effectiveness of the proposed approach is illustrated with results obtained from the developed software prototype.

Sentinel node mapping in endometrial cancer

Giorgio Bogani,Andrea Giannini,Enrico Vizza,Francesco Raspagliesi,Violante Di Donato 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1

Nodal status is one of the most important prognostic factors for patients with apparentearly stage endometrial cancer. The role of retroperitoneal staging in endometrial cancer iscontroversial. Nodal status provides useful prognostic data, and allows to tailor the needof postoperative treatments. However, two independent randomized trials showed thatthe execution of (pelvic) lymphadenectomy increases the risk of having surger y-relatedcomplication without improving patients’ outcomes. Sentinel node mapping aims toachieve data regarding nodal status without increasing morbidity. Sentinel node mappingis the removal of first (clinically negative) lymph nodes draining the uterus. Several studiessuggested that sentinel node mapping is not inferior to lymphadenectomy in identif yingpatients with nodal disease. More importantly, thorough ultrastaging sentinel node mappingallows the detection of low volume disease (micrometastases and isolated tumor cells), thatare not always detectable via conventional pathological examination. Therefore, the adoptionof sentinel node mapping guarantees a higher identification of patients with nodal diseasethan lymphadenectomy. Further evidence is needed to assess the value of various adjuvantstrategies in patients with low volume disease and to tailor those treatments also on the basisof the molecular and genomic characterization of endometrial tumors.

Acquired Hepatocerebral Degeneration in the Absence of Portosystemic Shunting

Giovanni Caranci,Christian Cordano,Edoardo Giannini,Fabio Bandini 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Megaprosthesis Reconstruction of the Proximal Femur following Bone Tumour Resection: When Do We Need the Cup?

( Riccardo Zucchini ),( Andrea Sambri ),( Michele Fiore ),( Claudio Giannini ),( Davide Maria Donati ),( Massimiliano De Paolis ) 대한고관절학회 2021 Hip and Pelvis Vol.33 No.3

Purpose: Reconstruction of the proximal femur after tumour resection can be performed with proximal femoral endopros-theses (PFE). Many studies have reported that bipolar hemiarthroplasty (BHA) reduce the risk of dislocation after oncological resections. However, progressive cotyloiditis which might require acetabular resurfacing (total hip arthroplasty [THA]) has been reported. The aim of this study is to compare the results of BHA and THA after proximal femur resection. Materials and Methods: A total of 104 consecutive patients affected by primary (n=52) and metastatic (n=52) bone tumours were included. Ninety patients underwent BHA and 14 patients underwent THA. Complications were recorded and classified according to the Henderson classification. At final follow-up, patients with the implant in site were functionally evaluated with modified Harris hip score (HHS). Results: The mean follow-up was 50 months (range, 2-171 months). Twenty-four (23.1%) patients developed major complications. Eleven (12.2%) BHA required acetabular resurfacing. Patients affected by primary bone tumours showed an increased risk of THA conversion (P=0.042). A reduced risk was observed in patients younger than 35 years (P=0.043) and in those older than 65 years (P=0.033). Dislocation occurred in four case (3.8%), in particular after THA (P=0.021). At final follow-up, 93 patients had the prosthesis in site (80 BHA and 13 THA). Mean postoperative HHS was 70 (range, 30-90). Conclusion: The risk of dislocation is lower for bipolar endoprosthesis compared to THA. However cotyloiditis and acetabular resurfacing might occurred.

Radial access for percutaneous coronary procedure: relationship between operator expertise and complications

Simona Susanu,Marco Angelillis,Cristina Giannini,Rossella Binella,Anna Matteoni,Rita Bellucci,Sandro Balestri,Nicola Ferrara,Federico Falchi,Giuliano Micheletti,Anna Sonia Petronio 대한응급의학회 2018 Clinical and Experimental Emergency Medicine Vol.5 No.2

Objective The aim of this study was to investigate (1) whether the learning curve of new catheterization laboratory operators increases the incidence of complications of transradial access during percutaneous coronary interventions and (2) whether manual compression with a two-step approach is safe and efficient for radial access hemostasis. Methods We performed a prospective study with all consecutive patients who underwent a coronary diagnostic or intervention procedure with radial access. The primary end point was a composite of pulseless radial artery of the wrist and hematoma evaluated after 24 hours. The secondary end point of efficacy was defined as the presence of bleeding or hematoma after 30 seconds. Results From March 2016 to June 2016, 150 consecutive patients, of whom 147 underwent coronary angiography and/or percutaneous coronary intervention through radial access, were included in the present study. The primary end point was present in 33%, but pulseless radial artery of the wrist was present only in 5.3%. We found that the incidence of primary end point was statistically different according to the number of puncture attempts, with a cutoff of two punctures with blood. The secondary end point of safety was present only in 4.7% of the cases. Conclusion Radial access is feasible and safe even if performed by training physicians. Manual compression with early evaluation after 30 seconds is a safe technique for managing the radial access after sheath removal.

Insulin resistance and type 2 diabetes in children

Valeria Castorani,Nella Polidori,Cosimo Giannini,Annalisa Blasetti,Francesco Chiarelli 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.4

Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. Both environmental (lack of physical activity, excess nutritional intake, sedentary lifestyle) and genetic factors contribute to this global epidemic. The growing prevalence of T2D in youth is also associated with a consistently increased incidence of metabolic and cardiovascular complications. Insulin resistance (IR), i.e., whole-body decreased glucose uptake in response to physiological insulin levels, determines impaired glucose homeostasis and it is recognized as cardinal trigger of T2D and cardiovascular disease in both adults and children. In particular, IR and beta-cell dysfunction lead to the persistent hyperglycemia which characterizes T2D. Indeed, both pathological states influence each other and presumably play a crucial, synergistic role in the pathogenesis of T2D, although the precise mechanisms are not completely understood. However, beta-cell dysfunction and IR induce impaired glucose metabolism, thus leading to the progression to T2D. Therefore, understanding the mechanisms correlated with the decline of beta-cell function and IR is crucial in order to control, prevent, and treat T2D in youth. This review focuses on the current knowledge regarding IR and T2D in children and adolescents and showcases interesting opportunities and stimulating challenges for the development of new preventative approaches and therapeutic strategies for young patients with T2D.

p53 Codon 72 Genetic Polymorphism in Asthmatic Children: Evidence of Interaction With Acid Phosphatase Locus 1

Patrizia Saccucci,Alberto Verrotti,Cosimo Giannini,Marcello Verini,Francesco Chiarelli,Anna Neri,Andrea Magrini 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.3

Several lines of evidence are implicating an increased persistence of apoptotic cells in patients with asthma. This is largely due to a combination ofinhibition, or defects in the apoptotic process and/or impaired apoptotic cell removal mechanisms. Among apoptosis-inducing genes, an importantrole is played by p53. In the present study, we have investigated the possible relationship between p53 codon 72 polymorphism and asthma and theinteraction with ACP1, a genetic polymorphism involved in the susceptibility to allergic asthma. We studied 125 asthmatic children and 123 healthysubjects from the Caucasian population of Central Italy. p53 codon 72 and ACP1 polymorphisms were evaluated using a restriction fragment lengthpolymorphism-polymerase chain reaction (RFLP-PCR) method. There is a statistically significant association between p53 codon 72 polymorphismand allergic asthma: Arg/Arg genotype is more represented in asthmatic patients than in controls (P=0.018). This association, however, is presentin subjects with low ACP1 activity A/A and A/B only (P=0.023). The proportion of children with A/A and A/B genotype carrying Arg/Arg genotype issignificantly high in asthmatic children than in controls (OR=1.941, 95% C.I. 1.042-3.628). Our finding could have important clinical implications sincethe subjects with A/A and A/B genotypes of ACP1 carrying Arg/Arg genotype are more susceptible to allergic asthma than Pro/Pro genotype.