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( Won Ki Hong ),( Moon Young Kim ),( Soon Koo Baik ),( Seung Yong Shin ),( Jung Min Kim ),( Yong Seok Kang ),( Yoo Li Lim ),( Young Ju Kim ),( Youn Zoo Cho ),( Hye Won Hwang ),( Jin Hyung Lee ),( Myeo 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.4
Background/Aims: Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. Methods: LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. Results: A strong positive correlation between LSM and HVPG was observed in the overall population (r2=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. Conclusions: LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.
Yoo, Zoo-Won,Kim, Nam-Sun,Lee, Dong-Sun Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.2
The aroma component of Hallabong peel has been characterized by GC-MS with two different extraction techniques: solid-phase trapping solvent extraction (SPTE) and headspace solid-phase microextraction (HSSPME). Aroma components emitted from Hallabong peel were compared with those of other citrus varieties: lemon, orange and grapefruit by SPTE and GC-MS. d-Limonene (96.98%) in Hallabong was the main component, and relatively higher peaks of cis- ${\beta}$-ocimene, valencene and -farnesene were observed. Other volatile aromas, such as sabinene, isothujol and ${\delta}$-elemene were observed as small peaks. Also, principal components analysis was employed to distinguish citrus aromas based on their chromatographic data. For HSSPME, the fiber efficiency was evaluated by comparing the partition coefficient ($K_{gs}$Kgs) between the HS gaseous phase and HS-SPME fiber coating, and the relative concentration factors (CF) of the five characteristic compounds of the four citrus varieties. 50/30 ${\mu}$m DVB/CAR/PDMS fiber was verified as the best choice among the four fibers evaluated for all the samples.
Dong-Sun Lee,Mi-Jin Jung,Zoo-Won Yoo,Sun-Neo Lee,Nam-Sun Kim 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
Headspace hanging drop liquid phase micro-extraction (HS-HD-LPME) is studied as a novel solvent-based sample pretreatment method for floral volatile aroma compounds. This paper reports on application of the HS-HD-LPME combined with GC-MS for the analysis of linalool component emitted from evening primrose flowers. The effect of several variables on the method performance was investigated. Additionally, the separation of enantiomers on a cyclodextrin capillary column was performed to identify chirality of ()-linalool component. Since the unsurpassed volume of a few micro-liters of solvent is used, there is minimal waste or exposure to toxic organic solvents. This method enables to combine extraction, enrichment, clean-up, and sample introduction into a single step prior to the chromatographic process.
Kim, Nam-Sun,Jung, Mi-Jin,Yoo, Zoo-Won,Lee, Sun-Neo,Lee, Dong-Sun Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
Headspace hanging drop liquid phase micro-extraction (HS-HD-LPME) is studied as a novel solvent-based sample pretreatment method for floral volatile aroma compounds. This paper reports on application of the HSHD- LPME combined with GC-MS for the analysis of linalool component emitted from evening primrose flowers. The effect of several variables on the method performance was investigated. Additionally, the separation of enantiomers on a cyclodextrin capillary column was performed to identify chirality of (−)-linalool component. Since the unsurpassed volume of a few micro-liters of solvent is used, there is minimal waste or exposure to toxic organic solvents. This method enables to combine extraction, enrichment, clean-up, and sample introduction into a single step prior to the chromatographic process.
SPTE 및 GC-MS를 이용한 한국산 및 중국산 생강의 향미 특성 분석
유주원,김남선,김건,이동선 서울여자대학교 자연과학연구소 2005 자연과학연구논문집 Vol.17 No.-
Volatile flavor components of the Korean and the Chinese ginger (Zingiber officinale Roscoe) have been studied in this paper. The accurate characterization of the flavors from the ginger rhizomes was carried out by head space solid phase trapping-solvent extraction (SPTE) and gas chromatography-ion trap mass spectrometry. Predominant compounds of the Korean ginger flavors are zingiberene, β-phellandrene, camphene, β-sequiphellandrene and α-farnesene, whereas those of the Chinese ginger flavors are β-phellandrene, camphene, zingiberene and α-farnesene. In addition, α-pinene, α-curcumene, β-pinene and β-bisabolene are also found as minor compounds of ginger flavors. A new finding in this work is that limonene, β-sesquiphellandrene, germacrene D, and zingiberene are critical index to distinguish the origin between the Korean ginger and the Chinese ginger.