http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Zimeng Li (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Li Deng,Wenpeng Jia,Wen Zheng,Hao Liu,Degang Jiang,Zimeng Li,Yu Tian,Wenling Zhang,Jingquan Liu 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-
Ni–Al layered double hydroxides (Ni–Al LDHs) are adopted as an electrorheological (ER) materialascribed to their special layered structure, ample polarizable groups and good dispersibility. Themagnetite nanoparticles (Fe3O4 NPs) are utilized as classical magnetorheological (MR) materials onaccount of their excellent paramagnetic property. In this work, we report the rational design of highperformanceER/MR materials by integrating the structural merits of Fe3O4 NPs onto a binary layeredstructure system. The obtained Fe3O4/Ni–Al LDH NCs dispersed in silicone oil displayed appealing dualER/MR performances. The work opens a new path toward novel stimuli-responsive materials forindustrial applications.
-
Haiyan Xu,Zimeng Shao,Zhijie Wang,Libin Cai,Zhen Li,Xinzheng Jiang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.3
This paper intends to obtain a sub-level classification of fully weathered red sandstone rock mass during the Cretaceous period based on physical property indices. An automatic prediction system for mechanical properties of rock mass is also established in which the values of rock mass grade and mechanical properties can be returned when physical indices are given. In this study, water content, relative compaction, and fine content, which are relatively easy to measure on tunnel sites, are selected as physical property indices, while cohesion, internal friction angle, and compression modulus, which affect mechanical strength, are taken as mechanical indices. For the convenience of analysis, rock mass of different physical states is divided into 18 different combinations based on the results of lab tests and rock mass stability of each state is evaluated using a stability evaluation criterion we put forward. The numerical simulation of tunnel excavation is further carried out for determining the sub-level classification. A decision tree model is applied for further studying the relationship between physical and mechanical indices to ensure accurate prediction. The result shows that the prediction system works with high accuracy and can be used for engineering reference for fully weathered red sandstone rock mass.
-
Shuilin Shen,Zimeng Zhang,Haixiao Huang,Jing Yang,Xinyue Tao,Zhengjie Meng,Hao Ren,Xueming Li 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Immunogenic cell death (ICD) induced by different cancer treatments has been widely evaluated to recruit immune cells and trigger the specific antitumor immunity. However, cancer associated fibroblasts (CAFs) can hinder the invasion of immune cells and polarize the recruited monocytes to M2-type macrophages, which greatly restrict the efficacy of immunotherapy (IT). Methods In this study, an injectable hydrogel induced by copper (Cu) has been designed to contain antibody of PD-L1 and nitric oxide (NO) donor. The therapeutic efficacy of hydrogel was studied in 4T1 cells and CAFs in vitro and 4T1 tumor-bearing mice in vivo. The immune effects on cytotoxic T lymphocytes, dendritic cells (DCs) and macrophages were analyzed by flow cytometry. Enzyme-linked immunosorbent assay, immunofluorescence and transcriptome analyses were also performed to evaluate the underlying mechanism. Results Due to the absorbance of Cu with the near-infrared laser irradiation, the injectable hydrogel exhibits persistent photothermal effect to kill cancer cells. In addition, the Cu of hydrogel shows the Fenton-like reaction to produce reactive oxygen species as chemodynamic therapy, thereby enhancing cancer treatment and amplifying ICD. More interestingly, we have found that the released NO can significantly increase depletion of CAFs and reduce the proportion of M2-type macrophages in vitro. Furthermore, due to the amplify of ICD, injectable hydrogel can effectively increase the infiltration of immune cells and reverse the immunosuppressive tumor microenvironment (TME) by regulating CAFs to enhance the therapeutic efficacy of anti-PD-L1 in vivo. Conclusions The ion induced self-assembled hydrogel with NO could enhance immunotherapy via amplifying ICD and regulating CAFs. It provides a novel strategy to provoke a robust antitumor immune response for clinical cancer immunotherapy.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
