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Pengxiang Li,Mingzhou Bai,Zijun Wei,Xin Li,Hai Shi 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.8
With the increase in the use of high-speed trains, karst collapse disasters have become increasingly prominent during the construction and operation of railway projects. To study the propagation characteristics of vibration wave caused by single and double railways in karst area, as well as the influence of sinkholes on the stability of the roadbed, a coupling model of vehicle-track-subgrade (including underlying sinkhole) considering track irregularity was established based on the geological engineering characteristics of a karst site. The results show that the subgrade stability is controlled by multiple factors related to the upper load, the stability of the caves, and the soil state; increasing the upper load of the track further develops the sinkhole and has a negative effect on the subgrade stability. The amplitude of vertical dynamic displacement on the subgrade surface can reach 1.31 mm under the superimposed effect of the vibration of double railways, which is approximately 50% higher than that of a single railway. Under the long-term cumulative effect of train vibrations, the sinkholes grow faster in dynamic displacement amplitude than the roadbed surface, and will lead to abrupt displacement of subgrade surface.
Yanmin Shen,He Wang,Zijun Liu,Weikun Li,Yuhua Liu,Jingjing Li,Hong-Liang Wei,Huayun Han 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
A new type of water-retaining, slow-release fertilizer (WSF) based on double-network hydrogels wasfabricated via the ion-crosslinking of sodium carboxymethyl cellulose and the free radical polymeriza-tion of polymerizable β-cyclodextrin (MAH-CD), polyethylene glycol dimethacrylate (PEGDA), acrylamide(AM), and acrylic acid (AA) with urea-loaded halloysite as an additive. The effects of the AM to AAmonomer ratio, the halloysite content, the AlCl3 content and the MAH-CD content on the swelling ratiowere studied. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), andthermogravimetric analysis (TGA) were applied to characterize the structure and properties of the WSF. The swelling behavior and water retention capacity of the fertilizer were investigated using a classicgravimetric method. The experimental results indicated that the presence of halloysite nanotubes clearlyadjusted the swelling and release properties of the WSF. Kinetic modeling indicated that the swellingmechanism and slow release behavior were consistent with a Fickian diffusion mechanism. Form theconsiderations of its properties and raw materials, the fertilizer developed here has a good prospect ofapplication and extension.
Shen Tianli,Wu Yunhua,Wang Xingjie,Wang Zijun,Li Enmeng,Zhou Cancan,Yue Chenyang,Jiang Zhengdong,Wei Guangbing,Lian Jie,Xu Qinhong,Li Xuqi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Peritoneal adhesions (PAs) are a serious complication of abdominal surgery and negatively affect the quality of life of millions of people worldwide. However, a clear molecular mechanism and a standard therapeutic strategy for PAs have not been established. Here, we developed a standardized method to mimic the pathological changes in PAs and found that sirtuin 3 (SIRT3) expression was severely decreased in adhesion tissues, which was consistent with our bioinformatics analysis and patient adhesion tissue analysis. Thus, we hypothesized that activating SIRT3 could alleviate postsurgical PAs. Sirt3-deficient (Sirt3−/−) mice exhibited many more PAs after standardized abdominal surgery. Furthermore, compared with wild-type (Sirt3+/+) mice, Sirt3-deficient (Sirt3−/−) mice showed more prominent reactive oxygen species (ROS) accumulation, increased levels of inflammatory factors, and exacerbated mitochondrial damage and fragmentation. In addition, we observed NLRP3 inflammasome activation in the adhesion tissues of Sirt3−/− but, not Sirt3+/+ mice. Furthermore, mesothelial cells sorted from Sirt3−/− mice exhibited impaired mitochondrial bioenergetics and redox homeostasis. Honokiol (HKL), a natural compound found in several species of the genus Magnolia, could activate SIRT3 in vitro. Then, we demonstrated that treatment with HKL could reduce oxidative stress and the levels of inflammatory factors and suppress NLRP3 activation in vivo, reducing the occurrence of postsurgical PAs. In vitro treatment with HKL also restored mitochondrial bioenergetics and promoted mesothelial cell viability under oxidative stress conditions. Taken together, our findings show that the rescue of SIRT3 by HKL may be a new therapeutic strategy to alleviate and block postsurgical PA formation.
Xu, Sheng,Yan, Zheng,Jang, Kyung-In,Huang, Wen,Fu, Haoran,Kim, Jeonghyun,Wei, Zijun,Flavin, Matthew,McCracken, Joselle,Wang, Renhan,Badea, Adina,Liu, Yuhao,Xiao, Dongqing,Zhou, Guoyan,Lee, Jungwoo,Chu American Association for the Advancement of Scienc 2015 Science Vol.347 No.6218
<P><B>Popping materials and devices from 2D into 3D</B></P><P>Curved, thin, flexible complex three-dimensional (3D) structures can be very hard to manufacture at small length scales. Xu <I>et al.</I> develop an ingenious design strategy for the microfabrication of complex geometric 3D mesostructures that derive from the out-of-plane buckling of an originally planar structural layout (see the Perspective by Ye and Tsukruk). Finite element analysis of the mechanics makes it possible to design the two 2D patterns, which is then attached to a previously strained substrate at a number of points. Relaxing of the substrate causes the patterned material to bend and buckle, leading to its 3D shape.</P><P><I>Science</I>, this issue p. 154; see also p. 130</P><P>Complex three-dimensional (3D) structures in biology (e.g., cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life. Compelling opportunities exist for analogous 3D architectures in human-made devices, but design options are constrained by existing capabilities in materials growth and assembly. We report routes to previously inaccessible classes of 3D constructs in advanced materials, including device-grade silicon. The schemes involve geometric transformation of 2D micro/nanostructures into extended 3D layouts by compressive buckling. Demonstrations include experimental and theoretical studies of more than 40 representative geometries, from single and multiple helices, toroids, and conical spirals to structures that resemble spherical baskets, cuboid cages, starbursts, flowers, scaffolds, fences, and frameworks, each with single- and/or multiple-level configurations.</P>