안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성

안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.

중국 국유기업과 외국투자기업 간의 파급효과에 관한 실증분석

전미홍(Mei Hong Zhen),강다연(Da Yeon Kang),전영서(Young Seo Jeon) 한양대학교 아태지역연구센터 2014 중소연구 Vol.37 No.4

Since the 1990s, the global economy is developing rapidly and the independent development of the country is impossible. Opening economy has been the best choice for all the developing countries and developedixcountries. Therefore foreign investors into the chinese market has brought the great impact on the domestic economy. This paper uses panel model to estimate the spillover effect between foreign investment enterprises and Chinese national enterprises, endogenously. Eight industry out of Chinese manufacturing industry as an object, regressing analysis according to the panel model from 2001 to 2012. According to the results of the empirical analysis, there is a complementary relationship between chinese national enterprises and foreign investment enterprises in China. The growth of foreign investment enterprises capital promote the increasing of chinese national enterprise production volume. In addition, the development of chinese national enterprise capital also promote the rising of foreign investment enterprise production volume.

New Gene Cluster from Thermophile Bacillus fordii MH602 for Conversion of DL-5-Substituted Hydantoins to L-Amino Acids

Yan Zhen Mei,Yong Min Wan,Bing Fang He,Han Jie Ying,Ping Kai Ouyang 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.12

Correlation of the size and shape of the solid particles in synovial fluid and knee joint disease

Zhen-Gang Zha,Cheng-Can Yao,Mei Tu,Yao-Xiong Huang 한국물리학회 2007 Current Applied Physics Vol.7 No.s1

The shape and size of solid particles and their distribution in synovial uid were observed and determined as functions of knee jointdiseases by using a multi-dimensional microscope. The results show that there is a close correlation between them, so that the measurement of the parameters might offer a reliable method for diagnosing joint diseases at an early stage and their prognosis.

Terrabacter ginsengisoli sp. nov., isolated from ginseng cultivating soil

Mei-Fang Jin,Xiao-Tian Quan,주베르,Qing-Zhen Liu,Hong Shan Yu,임완택 한국미생물학회 2018 The journal of microbiology Vol.56 No.5

A Gram-positive, strictly aerobic, nonmotile, yellowish, coccus- rod-shaped bacterium (designated Gsoil 653T) isolated from ginseng cultivating soil was characterized using a polyphasic approach to clarify its taxonomic position. The strain Gsoil 653T exhibited optimal growth at pH 7.0 on R2A agar medium at 30°C. Phylogenetic analysis based on 16S rRNA gene sequence similarities, indicated that Gsoil 653T belongs to the genus Terrabacter of the family Humibacillus, and was closely related to Terrabacter tumescens DSM 20308T (98.9%), Terrabacter carboxydivorans PY2T (98.9%), Terrabacter terrigena ON10T (98.8%), Terrabacter terrae PPLBT (98.6%), and Terrabacter lapilli LR-26T (98.6%). The DNA G + C content was 70.5 mol%. The major quinone was MK-8(H4). The primary polar lipids were phosphatidylglycerol, diphosphatidylglycerol, phosphatidyl-ethanolamine. The predominant fatty acids were iso-C15:0, iso-C16:0, iso-C14:0, and anteiso-C15:0, as in the case of genus Terrabacter, thereby supporting the categorization of strain Gsoil 653T. However, the DNA-DNA relatedness between Gsoil 653T and closely related strains of Terrabacter species was low at less than 31%. Moreover, strain Gsoil 653T could be both genotypically and phenotypically distinguished from the recognized species of the genus Terrabacter. This isolate, therefore, represents a novel species, for which the name Terrabacter ginsengisoli sp. nov. is proposed with the type strain Gsoil 653T (= KACC 19444T = LMG 30325T).

Chinese “female force” in an “American Factory” : Women’s identity formation in an English reading club

Zhen Troy Chen,La-Mei Chen 이화여자대학교 한국여성연구원 2021 Asian Journal of Women's Studies(AJWS) Vol.27 No.2

This paper investigates the mediated narratives and identity construction of a reading club of female workers in call centers of multinational corporations in Dalian China, where the discourse of an empowering ‘female force’ has been popularized and scrutinized on Chinese social media. These professional workers manage and construct their emerging middle-class identities through embodied experiences and mediated discourses fostered by an English reading club that is both online and offline. Responding to recent critiques of neoliberal feminism in the Chinese context, this study uses a mixed-method approach to unpack the complex processes of these women’s identity construction and performance through participatory reading practices. This includes ethnographic participant observation in offline reading club activities, in-depth interviews, and a discourse analysis of mediated narratives on social media (WeChat). We argue that Chinese working women’s identity construction and performance are shaped by complex intersections of class, nation, gender and workplace/institutions, where their encounters are in flux, given the changing neoliberal globalization process after China’s four-decade long opening up reform. This study challenges and extends the critique of neoliberal feminism and finds evidence of agency and tactical engagement whereby female workers negotiate their emerging middle-class identities and forge possible solidarities within a networked workplace. 本文着眼“女子力”话语调查分析了大连软件园某全球呼叫中心英文读书会中 女性的媒介化话语和身份认同构建过程。本文对身份认同理论进行创新尝 试,提出“社会性过渡自我”,阐释职业女性身份认同构建和展演过程的多重 制约因素,挑战并发展了对新自由主义女性主义的批判。本文指出在研究中 国女性权利实践时不能陷入历史的虚无,她们运用科技、职场、公共领域等 资源,策略性运用资本制造的潮流话语构建“网络化职场”,达成互助团结。

Glaucocalyxin A Activates FasL and Induces Apoptosis Through Activation of the JNK Pathway in Human Breast Cancer Cells

Li, Mei,Jiang, Xiao-Gang,Gu, Zhen-Lun,Zhang, Zu-Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

This study was conducted to analyze the molecular mechanisms responsible for anti-proliferation effects of glaucocalyxin A in cultured MCF-7 and Hs578T breast cancer cells. The concentration that reduced cell viability to 50% (IC50) after 72 h treatment was derived and potential molecular mechanisms of anti-proliferation using the IC50 were investigated as changes in cell cycle arrest and apoptosis. Gene and protein expression changes related to apoptosis were investigated by semi-quantitative RT-PCR and western blotting, respectively. Involvement of phosphorylated mitogen-activated protein kinases and JNK signaling in regulation of these molecules was characterized by western blotting. Cell viability decreased in a concentration-dependent manner and the IC50 was determined as $1{\mu}M$ in MCF-7 and $4{\mu}M$ in Hs578T cell. Subsequently, we demonstrated that the GLA-induced MCF-7 and Hst578T cell death was due to cell cycle arrest at the G2/M transition and was associated with activation of the c-jun N-terminal kinase (JNK) pathway. We conclude that GLA has the potential to inhibit the proliferation of human breast cancer cells through the JNK pathway and suggest its application forthe effective therapy for patients with breast cancer.

Horse Oil Mitigates Oxidative Damage to Human HaCaT Keratinocytes Caused by Ultraviolet B Irradiation

Piao, Mei Jing,Kang, Kyoung Ah,Zhen, Ao Xuan,Kang, Hee Kyoung,Koh, Young Sang,Kim, Bong Seok,Hyun, Jin Won MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.6

<P>Horse oil products have been used in skin care for a long time in traditional medicine, but the biological effects of horse oil on the skin remain unclear. This study was conducted to evaluate the protective effect of horse oil on ultraviolet B (UVB)-induced oxidative stress in human HaCaT keratinocytes. Horse oil significantly reduced UVB-induced intracellular reactive oxygen species and intracellular oxidative damage to lipids, proteins, and DNA. Horse oil absorbed light in the UVB range of the electromagnetic spectrum and suppressed the generation of cyclobutane pyrimidine dimers, a photoproduct of UVB irradiation. Western blotting showed that horse oil increased the UVB-induced Bcl-2/Bax ratio, inhibited mitochondria-mediated apoptosis and matrix metalloproteinase expression, and altered mitogen-activated protein kinase signaling-related proteins. These effects were conferred by increased phosphorylation of extracellular signal-regulated kinase 1/2 and decreased phosphorylation of p38 and c-Jun N-terminal kinase 1/2. Additionally, horse oil reduced UVB-induced binding of activator protein 1 to the matrix metalloproteinase-1 promoter site. These results indicate that horse oil protects human HaCaT keratinocytes from UVB-induced oxidative stress by absorbing UVB radiation and removing reactive oxygen species, thereby protecting cells from structural damage and preventing cell death and aging. In conclusion, horse oil is a potential skin protectant against skin damage involving oxidative stress.</P>

Emodin-Provoked Oxidative Stress Induces Apoptosis in Human Colon Cancer HCT116 Cells through a p53-Mitochondrial Apoptotic Pathway

Xie, Mei-Juan,Ma, Yi-Hua,Miao, Lin,Wang, Yan,Wang, Hai-Zhen,Xing, Ying-Ying,Xi, Tao,Lu, Yuan-Yuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Emodin, a natural anthraquinone isolated from the traditional Chinese medicine Radix rhizoma Rhei, can induce apoptosis in many kinds of cancer cells. This study demonstrated that emodin induces apoptosis in human colon cancer HCT116 cells by provoking oxidative stress, which subsequently triggers a p53-mitochondrial apoptotic pathway. Emodin induced mitochondrial transmembrane potential loss, increase in Bax and decrease in Bcl-2 expression and mitochondrial translocation and release of cytochrome c to cytosol in HCT116 cells. In response to emodin-treatment, ROS increased rapidly, and subsequently p53 was overexpressed. Pretreatment with the antioxidant NAC diminished apoptosis and p53 overexpression induced by emodin. Transfecting p53 siRNA also attenuated apoptosis induced by emodin, Bax expression and mitochondrial translocation being reduced compared to treatment with emodin alone. Taken together, these results indicate that ROS is a trigger of emodin-induced apoptosis in HCT116 cells, and p53 expression increases under oxidative stress, leading to Bax-mediated mitochondrial apoptosis.

Effect of Low-fat Diet on Breast Cancer Survival: a Meta-analysis

Xing, Mei-Yuan,Xu, Su-Zhen,Shen, Peng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Background: Even though many studies have examined the possible effect of low-fat diet on breast cancer survival, the relationship remains unclear. Objectives: To summarize the current evidence about the effect of post-diagnostic low-fat diet on recurrence and all-cause mortality of breast cancer. Methods: We conducted a search of Pubmed, Embase, Web of Science, and Cochrane Library and as a result two randomized controlled trials (RCT) and one large multi-center prospective cohort study with 9,966 breast cancer patients were included in this report. Results: Post-diagnostic low-fat diet reduced risk of recurrence of breast cancer by 23% (HR=0.77, 95%CI 0.63 to 0.94, P=0.009) and all cause mortality of breast cancer by 17% (HR=0.83, 95%CI 0.69 to 1.00, P=0.05). Conclusions: This meta-analysis suggested the post-diagnostic low-fat diet can improve breast cancer survival by reducing risk of recurrence. However, more trials of the relationship between low-fat diet and allcause mortality of breast cancer are still needed.