Robust Invariant Features for Object Recognition, Pose Estimation and Topological Navigation

Zhe Lin,In So Kweon 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2005 International Journal of Assistive Robotics and Me Vol.6 No.1

  We present a new robust image feature detector for the object recognition and vision based mobile robot navigation. The proposed algorithm extracts highly robust and repeatable features based on the key idea of tracking and grouping multi-scale interest points and selecting a unique representative structure with the strongest response in both spatial and scale domains. Weighted Zernike moments are used as the local descriptor for feature representation. The experimental results and performance evaluation show that our feature detector has high repeatability and invariance to large scale, viewpoint and illumination changes. The efficiency and usefulness of the proposed feature detection method are also confirmed by the excellent performance on object recognition and mobile robot indoor navigation.

Different fates of oocytes with DNA double-strand breaks in vitro and in vivo

Lin, Fei,Ma, Xue-Shan,Wang, Zhen-Bo,Wang, Zhong-Wei,Luo, Yi-Bo,Huang, Lin,Jiang, Zong-Zhe,Hu, Meng-Wen,Schatten, Heide,Sun, Qing-Yuan Taylor Francis 2014 Cell Cycle Vol.13 No.17

Flatbands and Emergent Ferromagnetic Ordering in Fe3Sn2 Kagome Lattices

Lin, Zhiyong,Choi, Jin-Ho,Zhang, Qiang,Qin, Wei,Yi, Seho,Wang, Pengdong,Li, Lin,Wang, Yifan,Zhang, Hui,Sun, Zhe,Wei, Laiming,Zhang, Shengbai,Guo, Tengfei,Lu, Qingyou,Cho, Jun-Hyung,Zeng, Changgan,Zhan American Physical Society 2018 Physical Review Letters Vol.121 No.9

Prolyl endopeptidase remodels macrophage function as a novel transcriptional coregulator and inhibits fibrosis

Lin Shuang-Zhe,Wu Wei-Jie,Cheng Yu-Qing,Zhang Jian-Bin,Jiang Dai-Xi,Ren Tian-Yi,Ding Wen-Jin,Liu Mingxi,Chen Yuan-Wen,Fan Jian-Gao 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Macrophages are immune cells crucial for host defense and homeostasis maintenance, and their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The transcriptional regulation in macrophage is indispensable for fine-tuning of macrophage functions, but the details have not been fully elucidated. Prolyl endopeptidase (PREP) is a dipeptidyl peptidase with both proteolytic and non-proteolytic functions. In this study, we found that Prep knockout significantly contributed to transcriptomic alterations in quiescent and M1/M2-polarized bone marrow-derived macrophages (BMDMs), as well as aggravated fibrosis in an experimental nonalcoholic steatohepatitis (NASH) model. Mechanistically, PREP predominantly localized to the macrophage nuclei and functioned as a transcriptional coregulator. Using CUT&Tag and co-immunoprecipitation, we found that PREP was mainly distributed in active cis-regulatory genomic regions and physically interacted with the transcription factor PU.1. Among PREP-regulated downstream genes, genes encoding profibrotic cathepsin B and D were overexpressed in BMDMs and fibrotic liver tissue. Our results indicate that PREP in macrophages functions as a transcriptional coregulator that finely tunes macrophage functions, and plays a protective role against liver fibrosis pathogenesis.

복합상업시설 내부가로 계획특성 경향 분석

림철(Lin Zhe),송병준(Song, Byung-Joon),주범(Chu Beom) 한국실내디자인학회 2014 한국실내디자인학회논문집 Vol.23 No.4

The internal streets of mixed-use commercial complexes, which are the extension of urban streets, are being changed from a mediating space aiming at movement to a staying-type space according to the change of mixed-use commercial complexes. And function as a resting place of user with court and plaza, and act as an urban public space, and accommodate an activity arising from the gathering of many people. As a result, a role of new relaxation and community space is played in the center of the city. And the aspect of publicness is brought into relief. Hence, this study is intended to examine the characteristics that the internal streets of mixed-use commercial complexes have, and furthermore, it is intended to show the planning characteristics in the contemporary mixed-use commercial complexes. With regard to the method of research, first, space configuration and role of internal streets was examined according to the change of mixed-use commercial complexes on the basic of precedent research and literature review. And the internal streets of mixed-use commercial complexes were classified into doorway part, traffic line, and open space. And the characteristics of internal streets in the mixed-use commercial complexes through the concept of architectural `publicness` were derived as accessibility, amenity, perceptibility, openness, connectivity and symbolism. The internal streets of mixed-use commercial complexes should be changed by the space planning to secure continuity with the city on the basis of accessibility and connectivity and to reinforce visual openness in the internal streets in order to improve amenity and perceptibility, accordingly the mixed-use commercial complexes will be also born again as symbolic public space in the city. Variously changing elements to improve publicness very importantly act on the planning of internal streets in the mixed-use commercial complexes, and therefore researches should be continuously carried out.

Simulation analysis and evaluation of decontamination effect of different abrasive jet process parameters on radioactively contaminated metal

Zhong Lin,Deng Jian,Zuo Zhe-wen,Huang Can-yu,Chen Bo,Lei Lin,Lei Ze-yong,Lei Jie-heng,Zhao Mu,Hua Yun-fei 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.11

A new method of numerical simulating prediction and decontamination effect evaluation for abrasive jet decontamination to radioactively contaminated metal is proposed. Based on the Computational Fluid Dynamics and Discrete Element Model (CFD-DEM) coupled simulation model, the motion patterns and distribution of abrasives can be predicted, and the decontamination effect can be evaluated by image processing and recognition technology. The impact of three key parameters (impact distance, inlet pressure, abrasive mass flow rate) on the decontamination effect is revealed. Moreover, here are experiments of reliability verification to decontamination effect and numerical simulation methods that has been conducted. The results show that: 60Co and other homogeneous solid solution radioactive pollutants can be removed by abrasive jet, and the average removal rate of Co exceeds 80%. It is reliable for the proposed numerical simulation and evaluation method because of the well goodness of fit between predicted value and actual values: The predicted values and actual values of the abrasive distribution diameter are Ф57 and Ф55; the total coverage rate is 26.42% and 23.50%; the average impact velocity is 81.73 m/s and 78.00 m/s. Further analysis shows that the impact distance has a significant impact on the distribution of abrasive particles on the target surface, the coverage rate of the core area increases at first, and then decreases with the increase of the impact distance of the nozzle, which reach a maximum of 14.44% at 300 mm. It is recommended to set the impact distance around 300 mm, because at this time the core area coverage of the abrasive is the largest and the impact velocity is stable at the highest speed of 81.94 m/s. The impact of the nozzle inlet pressure on the decontamination effect mainly affects the impact kinetic energy of the abrasive and has little impact on the distribution. The greater the inlet pressure, the greater the impact kinetic energy, and the stronger the decontamination ability of the abrasive. But in return, the energy consumption is higher, too. For the decontamination of radioactively contaminated metals, it is recommended to set the inlet pressure of the nozzle at around 0.6 MPa. Because most of the Co elements can be removed under this pressure. Increasing the mass and flow of abrasives appropriately can enhance the decontamination effectiveness. The total mass of abrasives per unit decontamination area is suggested to be 50 g because the core area coverage rate of the abrasive is relatively large under this condition; and the nozzle wear extent is acceptable

A Large Scale System Model-Order Reduction Method Based on SVD-Krylov

Zhe Yan,Fangming Lu,lin Zhou 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10

A SVD-Krylov method for large scale MIMO(multi-input multi-output) system model-order reduction is proposed in this paper. Its aim is to combined the singular value decomposition(SVD)and Krylov methods by retaining the best feature that can be applied for solving some problems for the large scale system model-order reduction. The method matches the first r Markov parameters and minimizes the error in the remaining ones in the least-squares sense. The reduced model is asymptotically stable, matches a certain number of moments, and minimizes a weighted error in the discrete time case. The effectiveness of the proposed approaches is tested by the Iss (international space station)model that in the SLICOT library, getting the frequency-response, the error and the error bounds of different order reduced model. The result shows that the proposed method is efficiently.

Synthesis and Biological Evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one Derivatives as Acetylcholinesterase Inhibitors

Zhe Jin,Liu Yang,Si-Jie Liu,Jian Wang,Shuo Li,Huang-Quan Lin,David Chi Cheong Wan,Chun Hu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10

Acetylcholinesterase (AChE) inhibitors played an important role in developing a cure for Alzheimer’ s disease. In order to study on the influence of modifications at different groups and side chains on the AChE inhibitory ability and the active sites of 7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives, fourteen 3,6-diaryl-7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives were designed and synthesized. The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive control drug. Most of the target compounds exhibited more than 50% inhibition at 10 μM. Some target compounds showed strong inhibition against AChE. The molecular fields analysis and preliminary structureactivity relationships are discussed.

Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study

Zhe-Bin Yu,Die Li,Xue-Yu Chen,Pei-Wen Zheng,Hong-Bo Lin,Meng-Ling Tang,Ming-Juan Jin,Jian-Bing Wang,Kun Chen 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.3

Background: Increasing evidence has shown that visit-to-visit variability (VVV) of blood pressure (BP) is associated with an increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate the impact of VVV of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the risk of CVD among patients with type 2 diabetes mellitus (T2DM) in China. Methods: We conducted a retrospective cohort study of 10,163 T2DM patients who were not previously diagnosed with CVD from January 2008 to December 2012 in Ningbo, China. The VVV of BP was calculated using five metrics, including standard deviation (SD), coefficient of variation (CV), variation independent of mean, average real variability, and successive variability (SV) of measurements, obtained over a 24-month measurement period. Hazard ratios and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression models for the associations of variability in BP with risk of CVD. Results: A total of 894 CVD events were observed during a median follow-up of 49.5 months. The hazard ratio in the highest quintile of SD of SBP was 1.24 (95% CI, 1.01 to 1.52) compared with patients in the lowest quintile. The association between higher VVV of DBP and risk of CVD was not consistent across different metrics and sensitivity analyses. Conclusion: Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings.

Requirement of the isocitrate lyase gene ICL1 for VPS41-mediated starvation response in Cryptococcus neoformans

Zhe Xu,Yafei Zhi,Jianzhang Dong,Benfeng Lin,Di Ye,Xiaoguang Liu 한국미생물학회 2016 The journal of microbiology Vol.54 No.7

Cryptococcus neoformans is a major cause of fungal meningitis in individuals with impaired immunity. Our previous studies have shown that the VPS41 gene plays a critical role in the survival of Cryptococcus neoformans under nitrogen starvation; however, the molecular mechanisms underlying VPS41-mediated starvation response remain to be elucidated. In the present study, we show that, under nitrogen starvation, VPS41 strongly enhanced ICL1 expression in C. neoformans and that overexpression of ICL1 in the vps41 mutant dramatically suppressed its defects in starvation response due to the loss of VPS41 function. Moreover, targeted deletion of ICL1 resulted in a dramatic decline in viability of C. neoformans cells under nitrogen deprivation. Taken together, our data suggest a model in which VPS41 up-regulates ICL1 expression, directly or indirectly, to promote survival of C. neoformans under nitrogen starvation.