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Zihua Liu,Hao Zhou,Hao Fang,Mingxi Zhou 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.6
Perforated plates have been widely used to attenuate harmful noise. An impedance tube was used to evaluate the sound absorption capacities of four cases of dual perforated plates with multiple apertures traversed by bias flow. The radius of small holes on the plates was 1.0 mm, and the radii of large holes were 1.5 mm, 2.0 mm, 2.5 mm, and 3.0 mm, respectively. The effects of the frequency and amplitude of the incident sound wave, the cavity depths, and the bias flow velocity on the sound attenuation effect of these cases were experimentally studied. The maximum sound absorption coefficient of dual perforated plates with the large difference in hole size was 0.93. On the other hand, the dual plates with the small aperture difference is more adaptable to the change of the bias flow velocity, and the maximum sound absorption coefficient was close to 1.
Yang Meng,Mingxi Yang,Xinchan Liu,Weixian Yu,Bai Yang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3
Multifunctional photoluminescent (PL) nanomaterials have attracted considerable interest in terms of their potential applications in the field of clinical medicine. Carbon dots (CDs), as emerging optical nanomaterials, are promising in various fields including biological imaging, drug transport and nerve tracing. However, little research has investigated on bone tissue engineering as of now. In this study, a new kind of bifunctional Zn2+-doped carbon dots (Zn-CDs) has been synthesized by a one-step hydrothermal method, Zn-CDs show effective fluorescent imaging and induce osteoblastic differentiation abilities in vitro. Moreover, compared with the raw material, Zn-CDs exhibited more effective osteoblastic differentiation promoting capability. Overall, the biocompatible nanomaterial Zn-CDs show potential to be used as a promising novel nanodrug for bone loss therapy and also a monitor of cell variation by fluorescence imaging.
Improving efficiency of remote data audit for cloud storage
( Kuan Fan ),( Mingxi Liu ),( Andwenbo Shi ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.4
The cloud storage service becomes a rising trend based on the cloud computing, which promotes the remote data integrity auditing a hot topic. Some research can audit the integrity and correctness of user data and solve the problem of user privacy leakage. However, these schemes cannot use fewer data blocks to achieve better auditing results. In this paper ,we figure out that the random sampling used in most auditing schemes is not well apply to the problem of cloud service provider (CSP) deleting the data that users rarely use, and we adopt the probability proportionate to size sampling (PPS) to handle such situation. A new scheme named improving audit efficiency of remote data for cloud storage is designed. The proposed scheme supports the public auditing with fewer data blocks and constrains the server's malicious behavior to extend the auditing cycle. Compared with the relevant schemes, the experimental results show that the proposed scheme is more effective.
Hao Zhou,Zihua Liu,Hao Fang,Chengfei Tao,Mingxi Zhou,Liubin Hu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.11
Perforated plates have been widely used in combustors to attenuate harmful sounds. In this study, the acoustic absorption capability of plates with heterogeneously distributed holes under bias flow was evaluated in an impedance tube, and the sound attenuation effect of each plate located in the liquid fuel combustor inlet section was experimentally studied. The perforated plate with heterogeneously distributed large holes showed the best control effect under the designed experimental conditions. After control, the peak dynamic pressure in the chamber and plenum decreased by 90 % and 75 %, respectively, and the reduction in the heat release fluctuation was 60 %. When the primary air flow rate deviated from the optimal value, the plate with large holes still reduced the pressure amplitude in the chamber by approximately 70 %. It was also found that installing the perforated plate with a back cavity had the dual effect of gaining and damping combustion instability.
Lin Shuang-Zhe,Wu Wei-Jie,Cheng Yu-Qing,Zhang Jian-Bin,Jiang Dai-Xi,Ren Tian-Yi,Ding Wen-Jin,Liu Mingxi,Chen Yuan-Wen,Fan Jian-Gao 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Macrophages are immune cells crucial for host defense and homeostasis maintenance, and their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The transcriptional regulation in macrophage is indispensable for fine-tuning of macrophage functions, but the details have not been fully elucidated. Prolyl endopeptidase (PREP) is a dipeptidyl peptidase with both proteolytic and non-proteolytic functions. In this study, we found that Prep knockout significantly contributed to transcriptomic alterations in quiescent and M1/M2-polarized bone marrow-derived macrophages (BMDMs), as well as aggravated fibrosis in an experimental nonalcoholic steatohepatitis (NASH) model. Mechanistically, PREP predominantly localized to the macrophage nuclei and functioned as a transcriptional coregulator. Using CUT&Tag and co-immunoprecipitation, we found that PREP was mainly distributed in active cis-regulatory genomic regions and physically interacted with the transcription factor PU.1. Among PREP-regulated downstream genes, genes encoding profibrotic cathepsin B and D were overexpressed in BMDMs and fibrotic liver tissue. Our results indicate that PREP in macrophages functions as a transcriptional coregulator that finely tunes macrophage functions, and plays a protective role against liver fibrosis pathogenesis.