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RISS 인기검색어
- 검색키워드
- 저자 : Zhang Huifeng (검색결과 8 건)
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Zhang, Yan,Huang, Huifeng,Zhang, Yun,Liao, Nansheng The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.3
Purpose: To investigate the clinical value of serum miR-221-3p and miR-122-5p expression levels in the diagnosis and prognosis of gastric cancer. Materials and Methods: Serum samples from 141 gastric cancer cases (gastric cancer group), 110 gastric polyps (gastric polyp group), and 75 healthy people (healthy control) were used to detect miR-221-3p and miR-122-5p expression using real-time reverse transcription polymerase chain reaction. Results: Serum miR-221-3p expression was significantly higher in the gastric cancer group than in the gastric polyp group, and it was significantly lower than that before operation. The miR-221-3p expression was significantly higher in the death group than in the survival group. The proliferation and migration ability significantly increased and the apoptosis rate significantly decreased by miR-221-3p transfection in gastric cancer cells. In contrast, the function of miR-122-5p in gastric cancer cells was opposite of miR-221-3p. Serum miR-221-3p expression was negatively correlated with that of miR-122-5p in gastric cancer. Serum miR-221-3p and miR-122-5p expressions were significantly correlated with the degree of differentiation, tumor, node, metastasis stage, lymph node metastasis, and invasion depth. miR-221-3p and miR-122-5p expression levels were independent prognostic factors for postoperative gastric cancer. In the diagnosis and predicting prognosis of gastric cancer, receiver operating characteristic analysis revealed that the area under curve of combined detection of serum miR-221-3p and miR-122-5p expression had a greater diagnostic effect than either single maker. Conclusions: The miR-221-3p and miR-122-5p are involved in the development of gastric cancer, and they have important clinical values in gastric cancer diagnosis and prognosis.
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Utilization of electron beam to modulate electron injection over Schottky barrier
Qi Zhang,Junjie Qi,Yunhua Huang,Huifeng Li,Xin Li,Ruoshui Wang,Yue Zhang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Modulation of electron injection over Schottky barrier was realized by employing electron beam irradiation on the metal/ZnO-nanowire contact. The structure revealed a good response to the illumination at a scanning frequency of 0.1 Hz, which can be enhanced by increasing bias and decreased with the increase of electron beam energy. These phenomena can be attributed to the Schottky barrier formed at the metal/ZnO-nanowire interface which limits the electron transport across the contact. The electron beam irradiation gives rise to high efficiency of electron injection over the barrier, while the interplay between charge discreteness, coherent scattering, and Coulomb interaction may reduce the conductivity.
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Xinjiang Wei,Huifeng Zhang,Lei Guo 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.5
This note is concerned with a saturating composite disturbance-observer-based control (DOBC) and H∞ control for a class of discrete time-delay systems with nonlinearity and disturbances. The disturbances are supposed to include two parts. One in the input channel is generated by an exogenous system with uncertainty, which can represent the harmonic signals with modeling perturbations. The other is supposed to have the bounded H₂norm, which can represent parametric uncertainties and external disturbance existing in the controlled object. The design approaches of reduced-order disturbance observer are presented for the estimation of the disturbance. By composite control law with saturation, the disturbances can be rejected and attenuated, simultaneously, the desired dynamic performances can be guaranteed for discrete time-delay systems with known and unknown nonlinear dynamics, respectively. Simulation for a flight control system is provided to show the effectiveness of the proposed scheme compared with the previous schemes.
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Chen Shiming,Zhang Huifeng 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.13 No.3
The interaction between steel tube and concrete core is the key design considerations for concrete-filled steel tube columns. In a concrete-filled steel tube (CFST) column, the steel tube provides confinement to the concrete core which permits the composite action among the steel tube and the concrete. Due to construction faults and plastic shrinkage of concrete, the debonding separation at the steel-concrete interface weakens the confinement effect, and hence affects the behaviour and bearing capacity of the composite member. This study investigates the axial loading behavior of the concrete filled circular steel tube columns with debonding separation. A three-dimensional nonlinear finite element model of CFST composite columns with introduced debonding gap was developed. The results from the finite element analysis captured successfully the experimental behaviours. The calibrated finite element models were then utilized to assess the influence of concrete strength, steel yield stress and the steel-concrete ratio on the debonding behaviour. The findings indicate a likely significant drop in the load carrying capacity with the increase of the size of the debonding gap. A design formula is proposed to reduce the load carrying capacity with the presence of debonding separation.
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GPU-ACCELERATED SPECKLE MASKING RECONSTRUCTION ALGORITHM FOR HIGH-RESOLUTION SOLAR IMAGES
Yanfang Zheng,Xuebao Li,Huifeng Tian,Qiliang Zhang,Chong Su,Lingyi Shi,Ta Zhou 한국천문학회 2018 Journal of The Korean Astronomical Society Vol.51 No.3
The near real-time speckle masking reconstruction technique has been developed to accelerate the processing of solar images to achieve high resolutions for ground-based solar telescopes. However, the reconstruction of solar subimages in such a speckle reconstruction is very time-consuming. We design and implement a new parallel speckle masking reconstruction algorithm based on the Compute Unified Device Architecture (CUDA) on General Purpose Graphics Processing Units (GPGPU). Tests are performed to validate the correctness of our program on NVIDIA GPGPU. Details of several parallel reconstruction steps are presented, and the parallel implementation between various modules shows a significant speed increase compared to the previous serial implementations. In addition, we present a comparison of runtimes across serial programs, the OpenMP-based method, and the new parallel method. The new parallel method shows a clear advantage for large scale data processing, and a speedup of around 9 to 10 is achieved in reconstructing one solar subimage of 256$\times$256 pixels. The speedup performance of the new parallel method exceeds that of OpenMP-based method overall. We conclude that the new parallel method would be of value, and contribute to real-time reconstruction of an entire solar image.
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Zhaoxia Wang,Zhenxing Zhang,Yanling Guo,Huifeng Shui,Guoqi Liu,Tianbo Jin,Huijie Wang 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods: We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. Results: Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p< 0.05). When the RTLs were categorized into tertiles, we found that the lowest RTL was significantly associated with increased breast cancer risk compared with the highest RTL (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.40–3.90; p=0.001). Subgroup analyses indicated that risk of breast cancer was also significantly increased in the lowest RTL compared with the highest RTL in age >40 years (OR, 2.41; 95% CI, 1.31–4.43; p=0.005), body mass index ≤24 kg/m2 (OR, 2.81; 95% CI, 1.55–5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63–9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p= 0.011). Conclusion: Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.
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Nansheng Liao,Yan Zhang,Huifeng Huang,Yun Zhang 대한위암학회 2019 Journal of gastric cancer Vol.19 No.3
Purpose: To investigate the clinical value of serum miR-221-3p and miR-122-5p expressionlevels in the diagnosis and prognosis of gastric cancer. Materials and Methods: Serum samples from 141 gastric cancer cases (gastric cancergroup), 110 gastric polyps (gastric polyp group), and 75 healthy people (healthy control) wereused to detect miR-221-3p and miR-122-5p expression using real-time reverse transcriptionpolymerase chain reaction. Results: Serum miR-221-3p expression was significantly higher in the gastric cancer groupthan in the gastric polyp group, and it was significantly lower than that before operation. The miR-221-3p expression was significantly higher in the death group than in the survivalgroup. The proliferation and migration ability significantly increased and the apoptosis ratesignificantly decreased by miR-221-3p transfection in gastric cancer cells. In contrast, thefunction of miR-122-5p in gastric cancer cells was opposite of miR-221-3p. Serum miR-221-3p expression was negatively correlated with that of miR-122-5p in gastric cancer. SerummiR-221-3p and miR-122-5p expressions were significantly correlated with the degree ofdifferentiation, tumor, node, metastasis stage, lymph node metastasis, and invasion depth. miR-221-3p and miR-122-5p expression levels were independent prognostic factors forpostoperative gastric cancer. In the diagnosis and predicting prognosis of gastric cancer,receiver operating characteristic analysis revealed that the area under curve of combineddetection of serum miR-221-3p and miR-122-5p expression had a greater diagnostic effectthan either single maker. Conclusions: The miR-221-3p and miR-122-5p are involved in the development of gastriccancer, and they have important clinical values in gastric cancer diagnosis and prognosis.
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