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Yusung Choi,Thuy-Vy Pham,Xuan-Lan Mai,Quoc-Ky Truong,Thi-Anh-Tuyet Le,Thi-Ngoc-Van Nguyen,Gunhee Lee,Jong-Seong Kang,Woongchon Mar,김경호 한국분석과학회 2019 분석과학 Vol.32 No.5
Over the past decades, chiral switch of the proton pump inhibitors (PPIs) has been received widespread attention in therapeutic advantages as well as pharmaceutical analysis. In present study, the influence of cyclodextrins (CDs) on the chiral separation of four common PPIs (lansoprazole, omeprazole, pantoprazole, and rabeprazole) was investigated. The results demonstrated that capillary electrophoresis (CE) with dual CDs as a chiral selector system is a possible and promising method for the enantioseparation of these PPIs. Rabeprazole, which is the most challenging and acid-labile candidate among four PPIs, was selected for further development of the technique. To optimize CE condition, the effects of capillary parameters and background electrolytes on the enantioseparation were investigated. Finally, the best chiral separation was acheived by using sulfobutyl ether-β-CD, and γ-CD as dual chiral selectors. The developed CE method not only provided the effective chiral separation but also showed the good stability of rabeprazole. The proposed method was successfully validated according to the International Conference on Harmonization guideline and effectively applied to determine rabeprazole enantiomers in commercial rabeprazole tablets, with recoveries ranging from 97.17 % to 103.29 % of the label content.
Choi, Yusung,Pham, Thuy-Vy,Mai, Xuan-Lan,Truong, Quoc-Ky,Le, Thi-Anh-Tuyet,Nguyen, Thi-Ngoc-Van,Lee, Gunhee,Kang, Jong-Seong,Mar, Woongchon,Kim, Kyeong Ho The Korean Society of Analytical Science 2019 분석과학 Vol.32 No.5
Over the past decades, chiral switch of the proton pump inhibitors (PPIs) has been received widespread attention in therapeutic advantages as well as pharmaceutical analysis. In present study, the influence of cyclodextrins (CDs) on the chiral separation of four common PPIs (lansoprazole, omeprazole, pantoprazole, and rabeprazole) was investigated. The results demonstrated that capillary electrophoresis (CE) with dual CDs as a chiral selector system is a possible and promising method for the enantioseparation of these PPIs. Rabeprazole, which is the most challenging and acid-labile candidate among four PPIs, was selected for further development of the technique. To optimize CE condition, the effects of capillary parameters and background electrolytes on the enantioseparation were investigated. Finally, the best chiral separation was acheived by using sulfobutyl ether-${\beta}$-CD, and ${\gamma}$-CD as dual chiral selectors. The developed CE method not only provided the effective chiral separation but also showed the good stability of rabeprazole. The proposed method was successfully validated according to the International Conference on Harmonization guideline and effectively applied to determine rabeprazole enantiomers in commercial rabeprazole tablets, with recoveries ranging from 97.17 % to 103.29 % of the label content.
질적 지표에 의거한 최근 10년간 학습장애 집단 실험 연구 동향 분석 및 학습장애 연구에 주는 시사점 연구
허유성 ( Yusung Heo ),박윤 ( Youn Park ),장은미 ( Eunmee Jang ),최은순 ( Eunsoon Choi ),양안숙 ( Annsook Yang ),김태강 ( Taegang Kim ) 한국특수교육문제연구소 2010 특수교육저널 : 이론과 실천 Vol.11 No.1
본 연구는 지난 10년간 학습장애 학생을 대상으로 수행한 집단 실험ㆍ준실험 연구에 대한 체계적인 분석을 통하여 연구 동향을 분석하고, 과학적 연구에 대한 질적 기준을 얼마나 충족시키고 있는가를 분석하였다. 연구 결과, 첫째, 학습장애 관련 연구의 경우 우선 집단 실험ㆍ준실험 연구의 비중이 낮은 것으로 나타났다. 증거기반 교수법을 강조하는 현 상황에서 보면 보다 많은 실험ㆍ준실험 연구가 필요함을 보여준다. 둘째, 학습장애 정의에 대한 명료화와 이에 대한 근거 제시가 부족한 것으로 나타났다. 셋째, 연구 대상자들에 대한 정보 제공에서 반복 연구가 가능해야 함을 고려해보면 대상자 기술의 풍부성이 미흡한 것으로 나타났다. 넷째, 무선배치를 활용한 연구가 비교적 낮게 나타났는데, 이는 추후 국가 및 연구기관의 지원을 높여 학습장애 연구의 규모를 확장하여 보다 강한 증거가 가능한 연구 수행이 필요하다는 것을 보여준다. 다섯째, 실험 집단의 정보는 다른 영역에 비해 비교적 충실히 제공하는 것으로 나타났다. 그러나 중재충실도에 대한 정보가 부족하고, 비교집단에 대한 기술이 매우 제한적인 것으로 나타났다. 그 외에 중재수행자에 대한 정보, 연구 도구, 자료 수집 및 분석에 대한 내용을 분석하였다. 본 연구 결과는 향후 학습장애 실험ㆍ준실험 연구를 수행하고자 하는 연구자가 고려해야 할 요소를 제공하고, 또한 보다 강한 증거기반 교수법을 선택하는 기준을 제공할 수 있을 것이다. The purpose of this study was to analyze the last 10-year group experimental or quasi-experimental studies for student with LD based on quality indicators. The results of this study indicated that the group experimental and quasi-experimental researches were limited in numbers considering the current importance of evidence-based practices in special education. Second, they did not provide clear definition of LD with reliable references. It makes hard to replicate the studies. Third, they did not provide enough data for the participants that enable future replication studies. Fourth, the studies that employed random assignment were limited in numbers. It indicated that more large scale of studies should be implemented. Fifth, they provided relatively detail information on the interventions of experimental groups, however, the descriptions of comparison groups were not enough to replicate them. In addition, many studies skipped the reports on implementation fidelity. This study included the analysis of intervention implementers, measurements, data collection, and analysis.
Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules
( Jiyoung Ahn ),( Yusung Choi ),( Eric Lawrence Simpson ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.2
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. In contrast to biologics, small molecules are similar to conventional pharmacologic chemical agents used as drugs and are generally prepared by chemical synthesis. Unlike biologics, these drugs often are taken orally or formulated for topical use. The purpose of this review is to summarize the efficacy and safety of the current topical and systemic new therapies in AD by reviewing recently published papers on therapies currently in phase 2 or 3 clinical trials. In this review, it is important to note the characteristics of the study population, the primary endpoints, and whether or not there was concomitant topical therapy allowed. These study design elements may significantly alter the results of studies and should be taken into account. Targeted therapy help push AD treatment into a new era of personalized medicine. (Ann Dermatol 33(2) 101 ∼107, 2021)
Therapeutic New Era for Atopic Dermatitis: Part 1. Biologics
( Jiyoung Ahn ),( Yusung Choi ),( Eric Lawrence Simpson ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.1
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. We are currently experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. Recently, advances in translational research have challenged the traditional AD pathogenesis paradigm of AD being solely a Th2-dominant disease. Other immune pathways seem to play a role in the complex AD pathophysiology, although the clinical relevance of these additional immune pathway abnormalities is unclear. Type 1, type 22, and type 17 pathway activation (with related cytokines/chemokines) have been demonstrated in the skin and blood of AD patients. Type 2 (interleukin [IL]-4, IL-13), IL-31, and type 22 (IL-22) pathway cytokines are increased in AD acute lesions. IL-22 induces both an epidermal hyperplasia at the onset of acute AD and a marked increase in the terminal differentiation S100 genes. This understanding of pathogenesis corresponds to a historic increase in therapeutic development in AD. The extreme clinical heterogeneity and the chronic progression of AD establish the need for newer, safer, and more effective treatments, control the disease, and improve the quality of life of affected patients. (Ann Dermatol 33(1) 1∼10, 2021)
Xuan-Lan Mai,Yusung Choi,Quoc-Ky Truong,Thi-Ngoc-Van Nguyen,Sang Beom Han,Kyeong Ho Kim 한국분석과학회 2020 분석과학 Vol.33 No.4
Separation of basic compounds using reverse phase chromatography on a silica-based stationary phase represents a major challenge, because of the interaction between the cationic sites of the basic compounds with the anionic silanols of the stationary phase. This study presents a simple, reliable, and organic solvent - free liquid chromatographic method for the determination of terbutaline and salbutamol, in which a room temperature ionic liquid (RTIL) is used as mobile phase additive. We investigated various mobile phase parameters affecting the retention of the two compounds, such as types and concentration of RTILs and, pH of the mobile phase were investigated. The developed method was validated according to International Conference on Harmonization (ICH) guidelines and successfully applied effectively to determine salbutamol sulfate in pharmaceutical preparations.