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Optimal Diversity-Multiplexing Tradeoff of MIMO Multi-way Relay Channel
Yuping Su,Ying Li 한국전자통신연구원 2013 ETRI Journal Vol.35 No.5
A MIMO multi-way relay channel with full data exchange in which K users exchange messages with each other via the help of a single relay is considered. For the case in which each link is quasi-static Rayleigh fading and the relay is full-duplex, the fundamental diversity-multiplexing tradeoff (DMT) is investigated, and we show that a compress-and-forward relay protocol can achieve the optimal DMT.
PCDH8 protects MPP+-induced neuronal injury in SH-SY5Y cells by inhibiting MAPK pathway
Wei Huaming,Wu Yuping,Zhuang Huanxia,Su Hongyi 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background Parkinson's disease (PD) is a common degenerative disease of the nervous system in the elderly. Objectives To investigate the eff ect of protocadherin 8 (PCDH8) on PD and explore the underlying mechanism. Results PCDH8 was down-regulated in PD. Silencing PCDH8 inhibited cell viability, increased cell cytotoxicity and apoptosis, but overexpression of PCDH8 acted the opposed eff ects. Then, silencing PCDH8 increased the levels of IL-1β, IL-8, TNF-α and ROS production, but decreased SOD and CAT activity, while up-regulation of PCDH8 acted the opposed eff ects. In addition, down-regulation of PCDH8 activated MAPK pathway, but up-regulation of PCDH8 inhibited MAPK pathway. Furthermore, in SH-SY5Y cells treated by MPP + , SB203580 reversed cell injuries induced by silencing PCDH8. Conclusion PCDH8 was down-regulated in PD, and PCDH8 protected MPP + -induced neuronal injury in SH-SY5Y cells via inhibiting MAPK pathway.
Duan, Jin-Ao,Wang, Liuying,Qian, Shihui,Su, Shulan,Tang, Yuping 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.8
A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraceae), along with ten known compounds, including atractylenolide II (2), $\varphi$-taraxasteryl acetate (3), taraxerol acetate (4), $\beta$-sitosterol (5), stigmasterol (6), $\beta$-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-$\beta$-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and an isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.
Jiachen Shi,Qiuling Ma,Wenting Su,Congyan Liu,Huangqin Zhang,Yuping Liu,Xiaoqi Li,Xi Jiang,Chang Ge,Fei Kong,Yan Chen,Ding Qu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration. Methods In this study, the effervescent cannabidiol solid dispersion-doped dissolving microneedles (Ef/CBD-SD@ DMNs) composed of the combined effervescent components (CaCO3 & NaHCO3) and CBD-based solid dispersion (CBD-SD) were facilely fabricated by the “one-step micro-molding” method for boosted transdermal and tumoral delivery of cannabidiol (CBD). Results Upon pressing into the skin, Ef/CBD-SD@DMNs rapidly produce CO2 bubbles through proton elimination, significantly enhancing the skin permeation and tumoral penetration of CBD. Once reaching the tumors, Ef/CBD-SD@ DMNs can activate transient receptor potential vanilloid 1 (TRPV1) to increase Ca2+ influx and inhibit the downstream NFATc1-ATF3 signal to induce cell apoptosis. Additionally, Ef/CBD-SD@DMNs raise intra-tumoral pH environment to trigger the engineering of the tumor microenvironment (TME), including the M1 polarization of tumor-associated macrophages (TAMs) and increase of T cells infiltration. The introduction of Ca2+ can not only amplify the effervescent effect but also provide sufficient Ca2+ with CBD to potentiate the anti-melanoma efficacy. Such a “one stone, two birds” strategy combines the advantages of effervescent effects on transdermal delivery and TME regulation, creating favorable therapeutic conditions for CBD to obtain stronger inhibition of melanoma growth in vitro and in vivo. Conclusions This study holds promising potential in the transdermal delivery of CBD for melanoma therapy and offers a facile tool for transdermal therapies of skin tumors.
Jin-ao Duan,Liuying Wang,Shihui Qian,Shulan Su,Yuping Tang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.8
A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraceae), along with ten known compounds, including atractylenolide II (2), ϕ-taraxasteryl acetate (3), taraxerol acetate (4), β-sitosterol (5), stigmasterol (6), β-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-β-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and an isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.