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PCDH8 protects MPP+-induced neuronal injury in SH-SY5Y cells by inhibiting MAPK pathway
Wei Huaming,Wu Yuping,Zhuang Huanxia,Su Hongyi 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background Parkinson's disease (PD) is a common degenerative disease of the nervous system in the elderly. Objectives To investigate the eff ect of protocadherin 8 (PCDH8) on PD and explore the underlying mechanism. Results PCDH8 was down-regulated in PD. Silencing PCDH8 inhibited cell viability, increased cell cytotoxicity and apoptosis, but overexpression of PCDH8 acted the opposed eff ects. Then, silencing PCDH8 increased the levels of IL-1β, IL-8, TNF-α and ROS production, but decreased SOD and CAT activity, while up-regulation of PCDH8 acted the opposed eff ects. In addition, down-regulation of PCDH8 activated MAPK pathway, but up-regulation of PCDH8 inhibited MAPK pathway. Furthermore, in SH-SY5Y cells treated by MPP + , SB203580 reversed cell injuries induced by silencing PCDH8. Conclusion PCDH8 was down-regulated in PD, and PCDH8 protected MPP + -induced neuronal injury in SH-SY5Y cells via inhibiting MAPK pathway.