아파트 居住者의 入浴패턴과 衛生空間의 構成欲求에 관한 硏究

윤정근,권영민 慶南專門大學 1997 論文集 Vol.25 No.1

C-means 알고리즘을 이용한 마이크로 엔드밀의 상태 감시

권동희,정연식,강익수,김전하,김정석 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

Recently, the advanced industries using micro parts are rapidly growing. Micro end milling is one of the prominent technology that has wide spectrum of application field ranging from macro to micro parts. Also, the method of micro-grooving using micro end milling is used widely owing to many merit, but has problems of precision and quality of products due to tool wear and tool fracture. This study deals with condition monitoring using acoustic emission(AE) signal in the micro-grooving. First, the feature extraction of AE signal directly related to machining process is executed. Then, the distinctive micro end mill state according to the each tool condition is classified by using the fuzzy C-means algorithm, which is one of the methods to recognize data patterns. These result is effective monitoring method of micro end mill state by the AE sensing techniques which can be expected to be applicable to micro machining processes in the future.

意思決定論序說 : 規範的 理論模型

權寧贊,朴英熙,尹正吉 건국대학교 1975 學術誌 Vol.19 No.1

Decision making is one of the most important functions of administrators and it is a key element of management functions which is "to determine what you want people to accomplish, to check periodically on flow well they are accomplishing it, and to develop methods by which they well perform more effectively". In other words, deciding what to do, and how to do it, is then, the heart of the management function. The purpose of this paper is writing the teat book of the theory and the pratice in decision-making. But we only paid the attention on introducing and analysing some normative models of public policy making because of limiting time and volume here. An important thought relatively new and less developed addition to the formal line of organizational analysis is the study of organizational decision-making. The theory of decision-making is at present largely a non-organizational theory that deaths with decisions made by individuals, disregarding whether the individuals are card players, shoppers in a supermarket, or executive. Moreover, like the classical administrative approach, decision-makings theory in large part is prescriptive ; i.e., it indicates-often on the basis of mathematical analysis and logical reasoning, sometimes on the basis of "distilled common sense"-what steps a decision-mailer should follow if he wishes to make rational decision. However, in recent years there has been growing interest in a descriptive theory of decision-making which reports and analyzes how people actually make decisions, what prevents them from making rational ones, and under what conditions they will make comparatively rational decisions. The descriptive approach still requires considerable development and needs to be extended from the individual to the organization level. According to Yehezkel Dror's classification in this paper, we concentrated on six main normative models that deal with phases of policy-making: (1) the pure-rationality model: (2) the "economically rational" model; (3) the sequential-decision model; (4) the incremental-change model: (5) the satisfying model; and (6) the extrarational-processes model. In this paper, we have described and critically analyze these six nomative models one by one, paying special attention to the assumptions on which they are based, to their domains of validity, and to their major limitations. To bun up, Dror analyzed the previous sirs normative models and he constructed his own optimal normative model of policy-making which had mixed the "economically" rational model and the extrarational model. The optimal model of public policy making tries to reject pure rationality on the one hand, and to provide an optimal goal that is more than an incrementally improved extrapolation of the present situation on the other hand. Dror intended the optimal model to be both an analytical tool for understanding policy-making and a goal that actual public policy making can approximate if the policymakers are willing to try. It should be judged not as an end in itself, but only as an operational tool, that is, by its usef71ness for analyzing, evaluating, and improving public policy-making. All five of the normative models except the extrarational model discussed above share one basic assumption, namely, that purse rationality, when it can be achieved at a reasonable cost, is the best method for decisionmaking and policymaking. The differences between the pure-rationality model and the other four are not in their basic assumptions but in the way they estimate the practicality and justification for a pure-rationality policy in terms of benefits arid costs. The economically rational model deviates from pure rationality because it accepts the restraints that limited resources put on trying to achieve pure rationality. The sequential-decision model in effect proposes a new type of policy making strategy to be considered by pure-rationality and economic피Iy rational standards. The incremental change model deviates from pure rationality on the grounds that innovative policies are necessarily risky and unpredictable, and that the unexpected results of such policies will likely be very costly. The satisfying model deviates from pure rationality on the grounds that, fur social-psychological reasons, policymakers do not look for new alternatives after they have found one they consider satisfactory. But all these models are clearly derived from the pure-rationality model, are themselves justified in terms of "pure rationality," and are presented as realistic second-bests to the unachievable ideal, pure rationality. The model that is exactly opposite to the pure-rationality model is therefore not one of these four models. It is rather the extrarational model, whose various forma are based on some acceptance of extrarational processes as an optimal method for decisionmaking and policymaking. A normative model of public policymaking exists as a tool for systematically analyzing public policymaking, as a basis for the criteria and standards needed to evaluate policymaking, and as a guide for formulating effective proposals for any improvements that are found to be desirable. Such a model should be normative, not in the sense of setting forth final goals, but in the instrumental sense of establishing processes and structures whereby a maximum net output of whatever coals and values are desired can be achieved. In contrast, a non-normative behavioral model is good enough for analyzing policymaking, but to make improvements in policymaking, one needs a model which is suitable not only for scientific analysis of actual behavior, but also for evaluating that behavior, and for deriving suggestions for improving that behavior. The normative model must therefore also be idealistic enough that it can stimulate consistent, through-going proposals for innovative improvements based on the best available knowledge. Insofar as the normative model used to evaluate public policymaking is either too utopian or too realistic, it will lead to a picture that is either too dark or too bright, respectively, neither picture being much good for deciding how to improve the situation. Dror's optimal model of public policymaking has a characteristics of avoiding both extremes deseribed above.

현대건축의 Context적 디자인방법에 관한 연구

권영민,윤정근 慶南專門大學 1997 論文集 Vol.25 No.1

흰쥐에서의 카르복시메칠셀룰로오스나트륨과 겔란검 혼합겔의 유착방지 효과

권윤환,이시범,이정권,박용덕,박정숙,황성주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomv. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomv. The animals (60 female Sprague-Dawlev rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4. 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4. 8. and 12 weeks. The mean adhesion scores were 0.75. 125. and 1.38 at 4. 8. and 12 weeks in the gel-treated group. respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomv model without affecting the healing of operation wound and other complications. Therefore. the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.

카페인 약리작용에 민감한 지원자와 둔감한 지원자 및 뚱뚱한 쥐와 마른 쥐에 대한 카페인 약물동태 비교

유정옥,권광일 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

To determine the reason of individual variation of the effect of caffeine. the absorption and the disposition of caffeine were studied in caffeine sensitive and caffeine nonsensitive volunteers. And also to study the effect of obesity on caffeine pharmacokinetics, the caffeine disposition in the obese rat and in the lean rat were investigated respectively. In result the caffeine sensitive group showed a longer terminal half-life of caffeine(7.35±0.71 hr:5.49±0.73 hr) and a larger AUC (55.42±9.09㎍·㎖^-1·hr:440.0±7.81㎍·㎖^-1·hr) than that of caffeine non-sensitive group without statistical significance. The obese rat showed a longer terminal half-life (3.47hr : 2.31hr) and a larger AUC(35.3㎍·㎖^-1·hr:26.97㎍·㎖^-1·hr) than that of the lean rat. But there was no correlation in the amount of daily caffeine consumption and obesity. In conculusion, we suggest that the individual variation of the effect of caffeine are being caused from the individual differances of caffeine susceptibility or tolerance rather than the differances of the genetic metabolic capacity or metabolic tolerance.

과학적 규칙성 지식의 생성 과정 : 경향성 지식의 생성을 중심으로 Focused on the Generation of Scientific Pattern-Knowledge

권용주,박윤복,정진수,양일호 한국초등과학교육학회 2004 초등과학교육 Vol.23 No.1

The purpose of this study was to suggest a grounded theory on the process of undergraduate students' generating pattern-knowledge about scientific episodes. The pattern-discovery tasks were administered to seven college students majoring in elementary education. The present study found that college students show five types of procedural knowledge represented in the process of pattern-discovery, such a s element, elementary variation, relative prior knowledge, predictive-pattern, and final pattern-knowledge. Furthermore, subjects used seven types of thinking ways, such as recognizing objects, recalling knowledges, searching elementary variation, predictive-pattern discovery, confirming a predictive-pattern, combining patterns, and selecting a pattern. In addition, pattern-discovering process involves a systemic process of element, elementary variation, relative prior knowledge, generating and confirming predictive-pattern, and selecting final pattern-knowledge. The processes were shown the abductive and deductive reasoning as well as inductive reasoning. This study also discussed the implications of these findings for teaching and evaluating in science education.

LC/MS/MS 분석법을 이용한 Amlodipine의 약물동태연구

서정원,윤민혁,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

The aim of this study were to confirm the analysis method and also to estimate the pharmacokinetic parameters of amlodipine in human volunteers. In an open-label single-dose pharmacokinetic study, a group, consisting of 24 healthy volunteers, received single oral dose of 5mg amlodipine. Blood sample were taken for up to 120 hours. The concentration of amlodipine in these body fluids was determinated using a validated high-performance liquid chromatography(HPLC) method with tandem mass spectrometry. Amlodipine and ketoconazole, an internal standard, were extracted from plasma using ethyl acetate in the presence of 0.1M sodium carbonate. After drying the organic layer, the residue was reconstituted in mobile phase(acetonitrile : water = 70 : 30 v/v (0.1% formic acid)) and injected onto a Zorvax C18 column (2.1 × 100 mm, 3.5 ㎛ particles). The isocratic mobile phase was eluted at 0.2ml/min. The ion transitions monitored in multiple reaction-monitoring mode were m/z 410.10 → 294.95 and 532.11 → 81.95, respectively. The coefficient of variance of the assay precision was less than 12%, and the accuracy exceeded 99.1%. The limit of quantification was 0.1 ng/ml. The pharmacokinetic parameters were calculated with non-compartmental(AUC, C_(max), T_(max), CL_(t), V/F) and compartmental(K_(el), K_(a), t_(lag)) pharmacokinetic analysis using WinNonlin program. The estimated means of AUC_(0-120hr), C_(max) and T_(max) were 196.90 ± 5.02 ng·hr/ml, 3.36 ± 0.09 ng/ml and 10.44 ± 0.61 hr, respectively. The means of other pharmacokinetic parameters(V/F, CL_(t), K_(el), K_(a) and t_(lag)) were 1208.06 ± 50.61 L, 25.39 ± 0.65 L/hr, 0.2806 ± 0.0294 hr^(-1), 0.0210 ± 0.0008 hr-1 and 0.4574 ± 0.0635 hours, respectively.

殺蟲性 結晶蛋白質 特異的인 抗體의 生産

김기윤,이정민,유형진,백길현,권무식 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.3 No.1

Bacillus thuringiensis is a gram-positive soil bacterium characterized by its ability to produce crystalline inclusions during sporulation. These parasporal bodies consist of protoxins known as crystal proteins exhibiting highly specific insecticidal activities. The Lepidoptera-specific protoxin, Cry IAc, was purified from E.coli JM103 harboring the cry IAc gene. The gene was isolated from Bacillus thuringiensis kurstaki HD-73 and subcloned into an expression vector, pKK223-3. The recombinant DNA(pOS4201) was transformed into E.coli JM103. The Cry I Ac protoxin overexpressed in the E.coli was isolated from the total proteins by differential solubility. The protoxin were trypsinized to obtain activated toxin. The proteins was resolved on SDS gel. The molecular weights of the pro-and toxin were resistered about 130,000 and 65,000 Daltons respectively. The Cry IAc toxin was used as immunogen to produce anti-Cry IAc antiserum in a rabbit. The immunogen (200㎍/ 200㎕) was mixed with an equal volume of Freund's complete adjuvant, and the mixture was hypodermically injected to the hide back (30 spots) and paws (2 spots) of the rabbit. The immunization was performed four times every two weeks. The dosage of the immunogen was decreased by half, and incomplete adjuvant was substituted for the complete one from the second immunization. The serum was prepared from the blood as described elsewhere. Immunoreactivity of the serum was examined by dot-blotting with the aid of GAR-HRP indirect immunoassay kit. It has been found that the anti-Cry I Ac antiserum recognized nano-gram quantity of antigen under these experimental conditions. The antiserum will he used for the development of immunochemical mean(s) to screen transgenic plants transformed by the insecticidal characteristics of Cry I Ac.

잔류응력 완화 중 나노접촉 형상의 천이거동 모델링을 통한 DLC 박막의 잔류응력 평가

李潤熙,池源宰,鄭增鉉,權東一 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.7

Assessment of residual stress is an important point to prevent the failures of thin film devices. Nanoindentation technique was proposed as a stress-measuring method of thin film in a previous research. However, the stress-analyzing model used at the previous research had the problems of a partial deformation-irrelative stress interaction concept and no consideration of the change in the contact area during continuous stress relaxation. Therefore, we modified the model by analyzing a new residual stress-induced normal load based on deformation-dependent shear stress component and by calculating the continuous relaxation procedure as an integration method. The modified model was applied to evaluate the residual stresses in two diamond-like carbon films. The evaluated residual stresses from the newly modified model were more consistent with the results from the conventional curvature method than those from the earlier model.