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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
Study on the Thermal Decomposition of Waste Polystyrene in Motor Oil Using Microwave Energy
Liu, Xiao Yun,Kang, Tae Won 公州大學校 工學硏究院 生産技術硏究所 2003 論文集 Vol.11 No.-
A novel microwave-induced pyrolysis of waste polystyrene in motor oil was performed in quartz tube reactor. Different pyrolysis conditions were investigated, such as time range from 30 minutes to 1 hour and effective microwave power range from 180 to 250 watt. The distillate components were analyzed with GC-MS, and styrene, 1-methyl styrene, toluene, ethyl benzene were the four main products. Among these distillate products, styrene took over 70 percentages. Temperature of pyrolysis suing microwave was much lower than that of conventional thermal pyrolysis method.
Yun-Jung Lee,Tae Joon Won,Kyeong Eun Hyung,Mi Ji Lee,Young-hye Moon,Ik Hee Lee,Byung Sung Go,Kwang Woo Hwang 대한생리학회-대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.1
Cell death and survival are tightly controlled through the highly coordinated activation/inhibition of diverse signal transduction pathways to insure normal development and physiology. Imbalance between cell death and survival often leads to autoimmune diseases and cancer. Death receptors sense extracellular signals to induce caspase-mediated apoptosis. Acting upstream of CED-3 family proteases, such as caspase-3, Bcl-2 prevents apoptosis. Using short hairpin RNAs (shRNAs), we suppressed Bcl-2 expression in Jurkat T cells, and this increased TCR-triggered AICD and enhanced TNFR gene expre-ssion. Also, knockdown of Bcl-2 in Jurkat T cells suppressed the gene expression of FLIP, TNF receptor-associated factors 3 (TRAF3) and TRAF4. Furthermore, suppressed B
( Tae Won Goo ),( Seong Wan Kim ),( Kwang Ho Choi ),( Seong Ryul Kim ),( Seok Woo Kang ),( Seung Won Park ),( Eun Young Yun ) 한국잠사학회 2013 International Journal of Industrial Entomology Vol.26 No.2
The insect baculovirus expression vector system (BEVS) is useful for producing biologically active recombinant proteins. However, the overexpression of heterologous proteins using this system often results in misfolded proteins and the formation of protein aggregates. To overcome this limitation, we developed a versatile baculovirus expression and secretion system using Bombyx mori protein disulfide isomerase (bPDI) as a fusion partner. bPDI gene fusion was found to improve the secretions and antibacterial activities of recombinant nuecin and enbocin proteins. Thus, we conclude that bPDI gene fusion is a useful addition to BEVS for the large-scale production of bioactive recombinant proteins.
Neurovascular Manifestation of Loeys-Dietz Syndrome : A Case Report
Yun-Jeong Lee,Mi-Sun Yum,Eun-Hee Kim,Hae-Won Choi,Beom Hee Lee,Han-Wook Yoo,Tae-Sung Ko 대한의학유전학회 2013 대한의학유전학회지 Vol.10 No.1
Loeys-Dietz syndrome (LDS) is an autosomal dominant disorder caused by heterozygous mutations in the genes encoding transforming growth factor-β receptor type 1 or 2. It is typically characterized by a triad of hypertelorism, cleft palate or bifid uvula, and arterial tortuosity with aneurysm or dissection. Characteristic vascular abnormalities such as tortuosity, aneurysms, dissections, and stenosis are the most severe complications of LDS and can occur in the neurovascular system. We report a 5-year-old boy who presented with headaches and neurovascular abnormalities and was diagnosed with LDS with a novel mutation of the TGFBR1 gene. It is the first Korean report of neurovascular abnormalities in LDS.
( Yun Won Jo ),( Seung Suk Yoo ),( Sung Soo Kim ),( Jeong Mi Lee ),( Hyun Ju Min ),( Chang Yoon Ha ),( Hong Jun Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hyun Jin Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Colonoscopic polypectomy is a commonly performed procedure in Korea, subsequently prevents colon cancer. The increase of therapeutic colonoscopy, polypectomy, results in inevitably various complications including bowel perforation that is rare and requires emergent decision of treatment modalities and timely treatment. The bowel perforation is usually diagnosed on the basis of pneumoperitoneum on simple X-ray images. Surgery is the treatment of choice for most cases of colonic perforation. A 58-year-old woman was referred to the gastroenterologist for endoscopic mucosal resection (EMR) of laterally spreading flat adenoma in the sigmoid colon. The EMR was performed with flexible and insulated tip knives. The patient was hospitalized for close observation of post-EMR complications. On the day of the polypectomy, simple X-ray images were taken to rule out colonic perforation, which revealed a large amount of intracolonic gas, but no free air in the subphrenic area. The next day of the procedure, subcutaneous emphysema was observed by the clinicians. Then abdomen computed tomography (CT) scan was performed, which showed diffuse bilateral retroperitoneal air extending to the mediastinum without intraperitoneal gas. The patient was discharged from the hospital after medical treatment and supportive care. We herein report a case of colonoscopic perforation in which pneumomediastinum, subcutaneous emphysema and peumoretroperitoneum occurred in the absence of pneumoperitoneum. The perforation was successfully treated with medical treatment and endoscopic clipping. Colonoscopists should not exclude colonic perforation even though free air on simple X-ray images is not visible.
A case of colovesical fistula complicated by sigmoid diverticulitis
( Yun Hyuk Yim ),( Hyo Keun Lee ),( June Sung Lee ),( Kyung Ah Kim ),( Nam Hoon Kim ),( Tae Jun Song ),( Won Ki Bae ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Colovesical fistula is a rare complication of inflammatory or neoplastic disease, and traumatic or iatrogenic injuries. Among them, sigmoid diverticulitis is the most frequent cause of colovesical fistula. There are few reported cases of the colovesical fistula in Korean literature, that is probably because the left colonic diverticulum is not common in Korea. We present here a case of patient with colovesical fistula complicated by sigmoid diverticulitis. A 66-year-old male patient was transferred to our hospital due to complaining of abdominal pain and mucoid stool. An abdominal and pelvic CT scan revealed diverticulitis and peridiverticular abscess in sigmoid colon. The patient was admitted and treated with intravenous antibiotic agents for four weeks, followed by oral antibiotic therapy. Six weeks after being discharged from the hospital, he was admitted again with complaints of pneumaturia, fecaluria, and dysuria. Follow up CT scan demonstrated fistula between sigmoid colon and bladder dome portion. Under the diagnosis of colovesical fistula due to diverticulitis of sigmoid colon, low anterior resection and partial cystectomy with cystostomy were performed.
Drug resistance of bladder cancer cells through activation of ABCG2 by FOXM1
( Yun-gil Roh ),( Mi-hye Mun ),( Mi-so Jeong ),( Won-tae Kim ),( Se-ra Lee ),( Jin-woong Chung ),( Seung Il Kim ),( Tae Nam Kim ),( Jong Kil Nam ),( Sun-hee Leem ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.2
Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer. [BMB Reports 2018; 51(2): 98-103]