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국화(Chrysanthemum morifolium)꽃으로부터 Flavonoid의 분리 및 동정
김형근 ( Hyoung-geun Kim ),고정환 ( Jung-hwan Ko ),이영근 ( Yeong-geun Lee ),박하승 ( Ha-seung Pak ),김동찬 ( Dong-chan Kim ),손국성 ( Kuk-seong Son ),백윤수 ( Yun-su Baek ),권오근 ( Oh-keun Kwon ),신학기 ( Hak-ki Shin ),백남인 ( 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.4
국화(C. morifolium)의 꽃을 80 % MeOH 수용액으로 추출한뒤, 감압농축한 추출물을 EtOAc, n-butyl alcohol 및 물분획으로 나누었다. EtOAc 분획과 n-butyl alcohol 분획에 대하여SiO2 및 ODS column chromatography를 반복 실시하여 4종의 flavonoid를 분리, 정제하였다. Nuclear magnetic resonance, infrared spectrometry 및 FAB-MS data를 해석하여, 화합물 1-4를 각각 apigenin, acacetin, cosmetin (apigenin-7-O-β-Dglucopyranoside), acacetin-7-O-β-D-glucoside으로 구조 동정 하였다. Chrysanthemum morifolium flowers were extracted with 80 % aqueous MeOH, and the concentrated extract was partitioned into EtOAc, n-butyl alcohol (n-BuOH), and water fractions. The repeated silica gel and octadecyl silica gel column chromatographies for the EtOAc and n-BuOH fractions led to isolation of four flavonoids. The chemical structures of the compounds were determined as acacetin (1), apigenin (2), apigenin- 7-O-β-D-glucopyanoside (3), acacetin-7-O-β-D-glucopyranoside (4) based on spectroscopic data analyses including nuclear magnetic resonance, mass spectrometry, and infrared spectrometry.
투과선량을 이용한 생체내 (in vivo) 선량측정을 위한 알고리즘
윤형근,지의규,허순녕,이형구,우홍균,신교철,김시용,하성환 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.3
연구 목적 : 각종 암 환자의 방사선치료시 환자에 조사되는 방사선량을 매 치료시마다 간편하게 확인하기 위한 생체내(in vivo) 선량측정의 한 방법으로 투과선량을 이용하는 새로운 시스템에 필요한 알고리즘을 개발하고자 하였다. 이를 위하여 본 교실에서 이미 개발한 바 있는 알고리즘을 개선하고자 하였다. 연구 재료 및 방법 : 알고리즘은 투과선량의 기본 측정치를 A/P (area-perimeter ratio)의 4차 함수로 회귀한 후에 각 계수들을 PCD (phantom-chamber distance)의 3차 함수로 회귀하여 구성하였다. 또한 기본 측정조건들의 감소 가능성을 확인하기 위하여 각각의 PCD 및 Tp(phantom thickness)당 조사야를 8개만 사용한 경우와 15개를 사용한 경우에서 측정치와 계산치를 비교하였다. 임의의 방사선조사조건에서의 알고리즘의 정확도를 확인하기 위하여 기본 측정 조건에 포함되지 않은 장방형의 방사선조사야, 기본 측정에 포함되지 않은 임의의 팬톰 두께, 임의의 PCD 조건에서 측정을 시행하고 알고리즘을 이용한 계산치와 비교하였다. 연구 결과 : 기본 측정치와 알고리즘을 이용한 계산치 간의 오차를 분석한 결과 기존의 알고리즘에 비하여 정확도가 크게 향상되었으며 정방형 개방 조사야의 경우 오차의 범위를 ±0.5% 이내로 제안할 수 있었다. 또한 기본 측정조건을 약 2분의 1로 감소시킬 수 있었다. 임의의 개방조사야의 방사선조사조건에서 측정을 시행하고 알고리즘을 이용한 계산치와 비교한 경우도 대부분의 경우 ±1.0% 이하의 오차를 나타내었다. 결론 : 악성종양환자의 방사선치료시 투과선량을 이용하여 환자에 조사되는 방사선량을 실시간으로 측정하기 위한 생체내 선량측정시스템에 필요한 개선된 알고리즘은 기본 측정자료를 약 2분의 1로 축소한 경우에도 정방형 개방 조사야의 경우 ±0.5% 이하의 오차 범위, 장방형의 개방 조사야에서는 ±1.0% 이하의 오차 범위로 정확히 투과선량을 계산할 수 있음을 확인하였다. Purpose : Measurement of transmission dose is useful for in vivo dosimetry of QA purpose. The objective of this study is to develope an algorithm for estimation of tumor dose using measured transmission dose for open radiation field. Materials and Methods : Transmission dose was measured with various field size (FS), phantom thickness (Tp), and phantom chamber distance (PCD) with a acrylic phantom for 6MV and 10 MV X-ray. Source to chamber distance (SCD) was set to 150 cm, Measurement was conducted with a 0.6 cc Farmer type ion chamber. Using measured data and regression analysis, an algorithm was developed for estimation of expected reading of transmission dose. Accuracy of the algorithm was tested with flat solid phantom with various settings. Results : The algorithm consisted of quadratic function of log(A/P) (where A/P is area-perimeter ratio) and tertiary function of PCD. The algorithm could estimate dose with very high accuracy for open square field, with errors within ±0.5%. For elongated radiation field, the errors were limited to ±1.0%. Conclusion : The developed algorithm can accurately estimate the transmission dose in open radiation fields with various treatment settings.
Hyoung-joo Ham,Geun-ho Kang,Yun-sang Choi,Tae-jun Jeong,Ko-eun Hwang,Cheon-jei Kim 한국축산식품학회 2016 한국축산식품학회지 Vol.36 No.5
The objective of this study was to evaluate effects of Gaeddongssuk powder (GP) on quality characteristics and shelf stability of emulsion sausages during storage. Proximate composition properties showed no significant differences in all treatment (p>0.05). Control showed the highest cooking loss while the treatment with GP showed decreased cooking loss depending on increasing GP content (p< 0.05). Apparent viscosity of batter was increased as the amount of GP increased, whereas hardness of emulsion sausages was decreased with increasing GP level. In sensory evaluation, emulsion sausage with 0.1% GP resulted in the highest score in overall acceptability. The pH values of all treatments decreased at the early storage stage, followed by gradual increase. The lightness and redness of treatments were decreased when the level of GP was increased. However, the yellowness of sausages with GP were higher than that of control (p0.05). Therefore, Gaeddongssuk powder up to 0.1% has a potential as a natural antioxidant for meat products because it can inhibit lipid oxidation of sausages without decreasing their sensory properties.
Transmission Dose Estimation Algorithm for in vivo Dosimetry
Yun, Hyong-Geun,Huh, Soon-Nyung,Lee, Hyoung-Koo,Woo, Hong-Gyun,Shin, Kyo-Chul,Ha, Sung-Whan The Korean Association for Radiation Protection 2003 방사선방어학회지 Vol.28 No.1
Purpose : Measurement of transmission dose is useful for in vivo dosimetry of QA purpose. The objective of this study is to develope an algorithm for estimation of tumor dose using measured transmission dose for open radiation field. Materials and Methods : Transmission dose was measured with various field size (FS), phantom thickness (Tp), and phantom chamber distance (PCD) with a acrylic phantom for 6 MV and 10 MV X-ray Source to chamber distance (SCD) was set to 150 cm. Measurement was conducted with a 0.6 cc Farmer type ion chamber. Using measured data and regression analysis, an algorithm was developed for estimation of expected reading of transmission dose. Accuracy of the algorithm was tested with flat solid phantom with various settings. Results : The algorithm consisted of quadratic function of log(A/P) (where A/P is area-perimeter ratio) and tertiary function of PCD. The algorithm could estimate dose with very high accuracy for open square field, with errors within ${\pm}0.5%$. For elongated radiation field, the errors were limited to ${\pm}1.0%$. Conclusion : The developed algorithm can accurately estimate the transmission dose in open radiation fields with various treatment settings.
Kim, Yun-Gon,Gil, Geun-Cheol,Jang, Kyung-Soon,Lee, Sukmook,Kim, Hyoung-Il,Kim, Jung-Sik,Chung, Junho,Park, Chung-Gyu,Harvey, David J.,Kim, Byung-Gee John Wiley Sons, Ltd. 2009 Journal of mass spectrometry Vol.44 No.7
<P>N-glycan structures released from miniature pig endothelial and islet cells were determined by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF), negative ion electrospray ionization (ESI) MS/MS and normal-phase high performance liquid chromatography (NP-HPLC) combined with exoglycosidase digestion. Totally, the identified structures were 181 N-glycans including 129 sialylated and 18 α-galactosylated glycans from pig endothelial cells and 80 N-glycans including 41 sialylated and one α-galactosylated glycans from pig islet cells. The quantity of the α-galactosylated glycans from pig islet cells was certainly neglectable compared to pig endothelial cells. A number of NeuGc-terminated N-glycans (80 from pig endothelial cells and 13 from pig islet cells) are newly detected by our mass spectrometric strategies. The detailed structural information will be a matter of great interest in organ or cell xenotransplantation using α 1,3-galactosyltransferase gene-knockout (GalT-KO) pig. Copyright © 2009 John Wiley & Sons, Ltd.</P>
플라이오메트릭 운동이 BMI 23 이상 성인 남녀의 심폐기능에 미치는 영향
권근아(Geun-A Kwon),윤형근(Hyoung-Gun Yun),이리라(Ri-Ra Yi),임나윤(Na-Yoon Lim),장영호(Young-Ho Jang),정선민(Sun-Min Jung),이건철(Keon-Cheol Lee),배원식(Won-Sik Bae) 대한심장호흡물리치료학회 2015 대한심장호흡물리치료학회지 Vol.3 No.1
Purpose : The purpose of this study was to investigate for the effect of rope-jumping and plyometric exercise on the cardiopulmonary function to overweight people. Method : This study was performed on overweight 18 males and 15 females subjects. They were divided in to 3 groups(11 subjects per 1 group) using random sampling and rope-jumping and plyometric exercise, respectively. In order to compare the difference of VO2max, AT, RER, HRmax before and after applying progressive rope-jumping and plyometric exercise. Cardiopulmonary function was examined using CS-200 ERGO-SPIRO. Results : 1. VO2max, AT, RER, HRmax function before and after exercise in non exercise group A and rope-jumping and plyometric exercise in group C significantly different(p<.05) 2. VO2max, AT, RER, HRmax function before and after exericse in non exercise group A and rope-jumping exercise in group B significantly different(p<.05) 3. VO2max, AT, RER, HRmax function before and after exericse in rope-jumping exercise in group B and rope-jumping and plyometric exercise group C non-significantly different(p<.05) Conclusion : Rope-jumping exercise and plyometric exercise is improve exercise in cardiopulmonary function that combined areobic exercise and plyometric exercise is more effective increasing cardiopulmonary function.
Klinefelter 증후군 환자에서 진단된 전신성 홍반성 루프스 1예
곽형종 ( Hyoung Jong Kwak ),장규윤 ( Kyu Yun Jang ),정명자 ( Myoung Ja Chung ),문우성 ( Woo Sung Moon ),강명재 ( Myoung Jae Kang ),이동근 ( Dong Geun Lee ),박호성 ( Ho Sung Park ) 전북대학교 의과학연구소 2011 全北醫大論文集 Vol.35 No.1
저자들은 전신성홍반성루푸스와 Klinefelter증후군을 동시에 진단하였던 1예를 경험하였기에 보고하는 바이다. We report a case of SLE related epistaxis(due to thrombocytopenia) in a 16 year-old man with Klinefelter`s syndrome. Clinical outcome was favorable with low doses of corticosteroids. The incidence of systemic lupus erythematosus(SLE) is known to be affected by sex hormone. Patients with Klinefelter`s syndrome were reported to have abnormal sex hormonal metabolism and their chronic estrogenic stimulation seems to affect the pathogenesis of SLE. Therefore, association of SLE and Klinefelter`s syndrome has been considered as a clue of the effect of sex hormone on SLE.