http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
백서 잔여 신장에서 TGF- β 수용체 발현에 관한 연구
강명재(Myoung Jae Kang),윤현상(Hyun Sang Yoon),정명자(Myoung JA Chung),문우성(Woo Sung Moon),이동근(Dong Geun Lee) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.1
N/A TGF-β1 plays a major role in the regulation of extracellular matrix synthesis and degradation. TGF-β1 exerts its biological effects by interacting with specific cell surface receptors including type I and II receptors(TGFβ RI and RII). The purpose of this study is to investigate the expression of TGF β RI and RII proteins in the kidney during the development of glomerulosclerosis and renal fibrosis in rats with subtotal nephrectomy. Forty male Sprague-Dawley rats weighing 200 to 220 grams were divided into two groups: 25 rats were subjected to 5/6 renal ablation and 15 to sham operation. The animals were sacrificed 1, 2, 4, 8, and 16 weeks following operation and the kidneys were removed for histological and immunohistochemical studies for TGF-β1, TGFβRI, and TGFβRII. The results showed increased glomerulosclerosis, interstitial fibrosis, and mononuclear cellular infiltration with time and progressively higher immunohistochemical TGF-β1, TGF βRI, and TGFβRII staining in rats with subtotal nephrectomy. We conclude that increase in TGFβRI and RII expression in remnant kidney rats may be causally related with the development of renal fibrosis.
경부에 전이한 Sex Cord Tumor with Annular Tubules의 세침흡인 세포소견 - 1예 보고 -
오소영,강명재,정명자,문우성,이동근,Oh, So-Yeong,Kang, Myoung-Jae,Chung, Myoung-Ja,Moon, Woo-Sung,Lee, Dong-Geun 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
A sex cord tumor with annnular tubules is a relatively rare ovarian neoplasm. The cytologic findings from a fine needle aspiration biopsy of neck metastasis of a sex cord tumor with annnular tubules are described. The origin of the neck metastasis was the right ovary, and the tumor was diagnosed six years ago. The cytologic findings were characterized by tumor cells arranged in solid or follicular patterns. The tumor cells formed rosette-like or complex tubular structures with central rounded or coalesced hyaline materials. It was difficult to distinguish this tumor cytologically from granulosa cell tumor, thyroid follicular neoplasm, Sertoli-Leydig cell tumor, and Brenner tumor, but complex tubular structures were helpful in discriminating between these tumors.
박호성,강명재,이동근,정명자,Park, Ho-Sung,Kang, Myoung-Jae,Lee, Dong-Geun,Chung, Myoung-Ja 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1
Pilomatrixoma is a benign tumor which usually occur as a solitary, firm nodule in the head and neck, and upper extremities of young people. This tumor is occasionally encountered during aspiration biopsy of subcutaneous masses, but only a small number of cases are correctly diagnosed prior to excision. We report five cases of pilomatrixoma. Four cases occurred in the neck and one case in the back. The characteristic fine needle aspiration cytologic features are shadow cells and basaloid cells in the background of inflammatory cells, including some multinucleated giant cells. The shadow cells were recognized in all five cases. These cells were pale, anucleated cells with relatively distinct cell borders. $May-Gr\ddot{u}nbald-Giemsa$ stain is useful for the identification of shadow cells. The recognition of shadow cells appears to be essential for accurate diagnosis of pilomatrixoma.
부신피질암종의 세침흡인 세포학적 검색 - 1례 보고 -
정명자,이호,강명재,이동근,최호열,김상호,Jeong, Myoung-Ja,Lee, Ho,Kang, Myoung-Jae,Lee, Dong-Geun,Choi, Ho-Yeul,Kim, Sang-Ho 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1
Fine-needle aspiration (FNA) biopsy has become the procedure of choice for initial diagnosis of adrenal masses. However, there have been relatively few reports discussing the FNA cytologic features of adrenal cortical carcinoma. Recently, we experienced a case of FNA cytology of bilateral adrenal cortical carcinoma in a 61-year old man. The smear revealed loosely cohesive pleomorphic tumor cells with hemorrhagic and necrotic background. The tumor cells showed oval to spindle hyperchromatic nuclei and prominent nucleoli with frequent mitotic figures. The cytoplasm of tumor cells was relatively abundant and sometimes vacuolated. These cytologic findings were interpreted as an ad renal cortical carcinoma, undifferentiated pattern.
뇨세포검사로 진단된 방광의 배아성 횡문근육종 - 1 증례 보고 -
김주헌,이호,강명재,이동근,김상호,Kim, Joo-Heon,Lee, Ho,Kang, Myoung-Jae,Lee, Dong-Geun,Kim, Sang-Ho 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.1
Rhabdomyosarcomas are found mainly in young patients, but rare in adults. A correlated cytological and histologic study of one case of embryonal rhabdomyosarcoma is presented. The cytologic appearance of the urine smear corresponded well with the histologic findings. Cytologically, two main cell types were distinguished ; a predominant primitive, small round cell with scant cytoplasm and a large cell with abundant cytoplasm. The cytologic feature proving rhabdomyoblastic differentiation, such as cross-striation, was absent.
골격외 간엽성 연골육종의 세침흡인 세포학적 소견 - 1예 보고 -
정명자,오소영,강명재,이동근,최호열,김상호,Chung, Myoung-Ja,Oh, So-Yeong,Kang, Myoung-Jae,Lee, Dong-Geun,Choi, Ho-Yeul,Kim, Sang-Ho 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
Extraskeletal mesenchymal chondrosarcoma is a relatively rare tumor and its cytologic findings have rarely been reported. We experienced a case of mesenchymal chondrosarcoma of soft tissue of the right lateral neck diagnosed by fine needle aspiration biopsy in a 59 year-old man. Cytologic findings showed two cell components. One was an undifferentiated, small cell component with moderate amount of cytoplasm and spindle nuclei. The second population was a chondroid component. These cytologic findings were diagnostic to mesenchymal chondrosarcoma.
Carrageenin에 의하여 유발된 백서 슬관절염의 활액막세포에 관한 형태학적 검색
이혜수,심용식,강명재,김상호,Lee, Hye-Soo,Shim, Yong-Shik,Kang, Myoung-Jae,Kim, Sang-Ho 한국현미경학회 1994 Applied microscopy Vol.24 No.3
To investigate the morphology of the synovial lining cells, synovitis was induced by carrageenin injection into the rat knee joint cavities. Synovial membranes were excised at 1, 3, 5, 7 and 14 days, and histologic, electron microscopic, histochemical (periodic acid Schiff: PAS, toluidine blue), and enzyme histochemical (acid phosphatase: ACP, nonspecific esterase: NSE and endogenous peroxidase) studies were performed. The results are as follows: Carrageenin induced synovial membrane hypertrophy with synovial cell proliferation and granuloma formation. The proliferated synovial lining cells and macrophages in the granulomatous lesion had round to oval nuclei and large, plump cytoplasm with many phagocytotic materials and vacuoles. Electron microscopically, these cells had small number of granular endoplasmic reticulum and many lysosomes, phagosomes and vaculoes. Mitotic figures were observed at early stage of experiment. PAS and toluidine blue stains showed strongly positive reaction in the cytoplasm of the proliferated lining cells and macrophages in granulomatous lesion. ACP and NSE activities were strong positive in the cytoplasm of the proliferated synovial lining cells and macrophages in the granulomatous lesion. But endogenous peroxidase stains were negative in all prolifeative lining cells and macrophages in granulomatous lesion. Conclusively, carrageenin-induced synovitis showed proliferation of synovial lining cells and granuloma formation in deep layer. The macrophages, which consisted of the lesions and have active phagocytic function, were speculated to proliferate by mitosis of superficial synovial A cells and histiocytes in the deep layer of the synovial membrane.
장간막에서 발생한 염증성 근섬유모세포종의 세침흡인 세포학적 소견 - 1예 보고 -
손현진,김주헌,문우성,최호열,강명재,Son, Hyun-Jin,Kim, Joo-Heon,Moon, Woo-Sung,Choi, Ho-Yeul,Kang, Myoung-Jae 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1
Since inflammatory myofibroblastic turner was initially recognized in the lung, this tumor has been described in other extrapulmonary sites. In spite of relatively uniform histologic findings in various organs, a rarity in extrapulmonary sites and highly vascular characteristics frequently lead to a misdiagnosis in preoperative radiology and fine needle aspiration cytology. We present a case of inflammatory myofibroblastic tumor occurring in the mesentery of a 4-month-old girl. Fine needle aspiration cytology smear disclosed characteristic spindle cells intermixed with prominent mature plasma cells and lymphocytes. According to the immunohistochemical staining, we recognized that the intervening spindle cells are myofibroblasts which have reactivity for the both actin and vimentin.