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속단의 dichloromethane 분획물이 마우스 두개골 세포의 분화에 미치는 영향
김동진,윤정호,정의원,유윤정,김윤철,유형근,김종관,최성호,Kim, Dong-Jin,Yun, Jeong-Ho,Jung, Ui-Won,Yoo, Yun-Jung,Kim, Yun-Chul,You, Hyung-Keun,Kim, Chong-Kwan,Choi, Sung-Ho 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.4
The purpose of this study was to evaluate the effects of DFPR on differentiation of mouse calvarial cell in vitro, to examine the possibility for periodontal regeneration. $10{\mu}g/ml$ of DFPR was used as experimental concentration. osteogenic medium only was assigned as control, Experimental 1 was supplemented with 10nM dexamethasone, Experimental 2 with $10{\mu}g/ml$ DFPR and Experimental 3 with l0nM dexamethasone + $10{\mu}g/ml$ DFPR. cellular activity was evaluated by MTT method at 8, 12, 16 days, expression of mRNA of ALP, osteopontin, osteocalcin, collagen type-l was detected by RT-PCR method at 4, 8, 12, 16 days of culture. extent of mineralization was observed by Von Kossa staining at 16 day of culture. The results are as follows 1)Any acceleration of differentiation was not observed at expression of differentiation marker, 2) Decrease in expression of extracelluar matrix and in bone nodule formation was observed The results suggested that DFPR have negative effect on the rate of differentiation on rat calvarial cell, decrease extracelluar matrix formation ,decrease bone nodule formation. Ongoing studies are necessary in order to determine effect of DFPR on periodontal regeneration.
오수목과탕(吳茱木瓜湯)의 자유(自由)라디칼 소거활성(演去活性) 및 肝(간) 세포(細胞) 보호효과(保護效果)
정옥삼,윤용갑,김윤철,Jeong, Ok-Sam,Yun, Young-Gab,Kim, Youn-Chul 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.2
In order to find the new hepatoprotective agents preliminary screening of twelve prescriptions which have been used for the treatment of hepatic disease in Oriental traditional medicine has been carried out. Both DPPH free radical scavenging and hepatoprotective effect on tacrine-induced cytotoxicity in Hep G2 cells are performed. Osumokkya-tang which is one of the prescription belongs to interior-warming properties showed the DPPH free radical scavenging effect as well as hepatoprotective activity significantly. It is also suggested that its hepatoprotective effect is derived from Chaenomelis Fructus.
속단의 dichloromethane 분획물이 태아골모세포의 골형성 유도에 미치는 효과
이영준,최희인,김윤철,신형식,유형근,Lee, Young-Joon,Choi, Hee-In,Kim, Yun-Chul,Shin, Hyung-Shik,You, Hyung-Keun 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2
The ideal goal of periodontal therapy is the regeneration of periodontal tissue repair of function. Although is very difficult to attain the goal, recent advances in periodontal wound healing concepts encourage hope reaching it. Recently many efforts are concentrated on the regeneration potential of material used in traditional Korean medicine. Phlomidis Radix has been used for the treatment of blood stasis, bone fracture and osteoporosis in traditional Korean medicine. The purpose of this study is to examine effects of dichloromethane fraction Phlomidis Radix on Bone Formation in Human Fetal Osteoblasts. Human fetal osteoblastic cell line(hFOB1 1.19 ;American Type Culture Collection, Manassas, VA) were used and cells were cultured containing DMEM and dichloromethane fraction Phlomidis Radix(100 ng/ml , 1 ${\mu}$/ml, 10 ${\mu}$/ml) at 34$^{\circ}C$ with 5% $CO_2$ in 100% humidity. MTT was performed to examine the viability of the cell, and alkaline phosphatase activity was analyzed to examine the mineralization. Also bone calcification nodules were evaluated. The cellular activity of hFOB1 was increased in 100 ng/ml, 1 ${\mu}$/ml , 10 ${\mu}$/ml of dichloromethane fraction of Phlomidis Radix and especially significant increation was showed in 100 ng/ml of dichloromethane fraction of Phlomidis Radix at 6days (p <0.05). ALP level of hFOB1 was significantly increased in 100 ng/ml , 1 ${\mu}$/ml, 10 ${\mu}$/ml of dichloromethane fraction of Phlomidis Radix and especially more increation was showed in 10 ${\mu}$/ml of dichloromethane fraction of Phlomidis Radix (p <0,05). Calcification nodules of hFOB1 significantly increased in 10 ${\mu]$/ml of dichloromethane fraction of Phlomidis Radix at 21 days of incubation(p<0.05). The results indicate that dicholoromethane fraction of Phlomidis Radix has excellent effects on mineralization of hFOB1.
김민겸 ( Min-kyeom Kim ),김승현 ( Seunghyun Kim ),윤재원 ( Jae-won Yun ),정효균 ( Jeong-hyo Gyun ),곽민준 ( Min-jun Kwak ),안예린 ( Yea-lin Ahn ),박찬욱 ( Chan-wook Park ),김윤철 ( Youn-chul Kim ),서종환 ( Jonghwan Suhr ) 한국복합재료학회 2021 Composites research Vol.34 No.4
적층제조 기술의 발전으로 복잡한 구조의 제조가 용이해짐에 따라, 기존에 존재하지 않은 특성을 지닌 메타물질에 대한 관심이 커지고 있다. 기존에 존재하지 않은 기계, 음향, 열, 전자기 및 광학 특성을 지닌 메타물질은 높은 공학응용(Engineering applications) 가능성을 보여, 새로운 메타물질 개발 및 설계방안에 대한 연구를 지속적으로 진행하고 있다. 이에 본 논문에서는 메타물질의 여러 특성 중 기존에 존재하지 않은 기계적 특성을 지닌 메타물질의 특성, 거동 및 물성을 소개하고 설계방안을 제시하고자 한다. 또한 설계한 메타물질을 제조하기 위해 여러 적층제조 방식별 메타물질 제조특성 들을 검토하여, 메타물질의 산업에서의 활용 가능성을 제시하고자 한다. As an additive manufacturing achieves technological advances, it enables to manufacture complex structures with saving a cost and time. Therefore, metamaterials, which has geometric complexity, have gradually gathered attention due to the unprecedented properties: the unprecedented mechanical, thermal, electromagnetic, and optical properties. The metamaterials could exhibit a high potential in engineering applications, and thus it has been steadily investigated to design or/and develop novel metamaterials. Here, mechanical metamaterials, which had been reported, were reviewed to suggest the way to design and fabricate the metamaterials for industrial applications.