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Genome Architecture and Transcriptome Analysis of Marine Cyanobacteria Synechocystis sp. PCC 7338
Yujin JEONG,Seong-Joo HONG,Sang-Hyeok CHO,Seonghoon YOON,Hookeun LEE,Hyung-Kyoon CHOI,Dong-Myung KIM,Choul-Gyun LEE,Suhyung CHO,Byung-Kwan CHO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4
Cyanobacteria producing various bio-products are considered promising microbial cell factories. The marine cyanobacterium Synechocystis sp. PCC 7338 has the advantage of growing in seawater, rather than requiring arable land or freshwater. However, how this marine cyanobacterium grows under the high salt stress condition remains unknown. Here, we determined the 3.70 Mbp complete genome of Synechocystis sp. PCC 7338. Differential RNA-seq and Term-seq data provided genome-wide information on genetic regulatory elements. Comparison with freshwater Synechocystis sp. strains revealed that Synechocystis sp. PCC 7338 genome encodes additional genes, which facilitate the adaptation to high salt and high osmotic pressure. A cyclic electron transport through photosystem I actively used by Synechocystis sp. PCC 7338 satisfied the demand for ATP under high salt environment. Our comprehensive analyses provide valuable information to discover the various genomic functions and regulations available for engineering Synechocystis sp. PCC 7338.
The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
( Yujin Jeong ),( Seong Ran Jeon ),( Hyun Gun Kim ),( Jung Rock Moon ),( Tae Hee Lee ),( Jae Young Jang ),( Jun-hyung Cho ),( Jun Seok Park ),( Heesu Park ),( Ki-hun Lee ),( Jin-oh Kim ),( Joon Seong 대한장연구학회 2021 Intestinal Research Vol.19 No.1
Background/Aims: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods: We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results: To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944-11.339; area under the curve [AUC] 0.774, 95% CI, 0.690-0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821-7.838; AUC 0.654, 95% CI 0.556-0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 μg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions: NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions. (Intest Res 2021;19:62-70)
Mixed application of Bt products against three species of moths
Jeong Jun Kim,Hong Zhu,Heo Seon,Yujin Song,Sang Guei Lee 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
The first commercial bioinsecticide in Korea was registered in 2003 to control diamond back moth and beet armyworm in Chinese cabbage using Bacillus thuringiensis subsp. aizawai. Currently, fourteen microbial pesticides have registered in Korean market. The Korean government is aiming for 40% reduction (from the 2004 value) in the use of chemical pesticides by 2013. To increase the use of microbial pesticides as an alternative of chemicals, we conducted in vitro bioassay with Bt products. Bt products were treated alone and in combination against larvae of beet armyworm, diamond back moth and tobacco cutworm. Five Bt products shown high mortality against diamond back moth in recommended concentration, but had low control effects against beet armyworm and tobacco cutworm. Mixed Bt products had no synergic effects against the tested three moths. When Bt products were sprayed with higher concentration than recommended dose, those mortality was similar with lower concentration.