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Yang, Zhen-Hai,Zhou, Chun-Lin,Zhu, Hong,Li, Jiu-Hong,He, Chun-Di Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: The MDM2 oncogene, a negative regulator of p53, has a functional polymorphism in the promoter region (SNP309) that is associated with multiple kinds of cancers including non-melanoma skin cancer. SNP309 has been shown to associate with accelerated tumor formation by increasing the affinity of the transcriptional activator Sp1. It remains unknown whether there are other factors involved in the regulation of MDM2 transcription through a trans-regulatory mechanism. Methods: In this study, SNP309 was verified to be associated with overexpression of MDM2 in tumor cells. Bioinformatics predicts that the T to G substitution at SNP309 generates a stronger E2F1 binding site, which was confirmed by ChIP and luciferase assays. Results: E2F1 knockdown downregulates the expression of MDM2, which confirms that E2F1 is a functional upstream regulator. Furthermore, tumor cells with the GG genotype exhibited a higher proliferation rate than TT, correlating with cyclin D1 expression. E2F1 depletion significantly inhibits the proliferation capacity and downregulates cyclin D1 expression, especially in GG genotype skin fibroblasts. Notably, E2F1 siRNA effects could be rescued by cyclin D1 overexpression. Conclusion: Taken together, a novel modulator E2F1 was identified as regulating MDM2 expression dependent on SNP309 and further mediates cyclin D1 expression and tumor cell proliferation. E2F1 might act as an important factor for SNP309 serving as a rate-limiting event in carcinogenesis.
THE LOG-CONVEXITY OF ANOTHER CLASS OF ONE-PARAMETER MEANS AND ITS APPLICATIONS
Zhen-Hang Yang 대한수학회 2012 대한수학회보 Vol.49 No.1
In this paper, the log-convexity of another class one-para-meter mean is investigated. As applications, some new upper and lower bounds of logarithmic mean, new estimations for identric mean and new inequalities for power-exponential mean and exponential-geometric mean are first given.
Yang Zhen,Xie Jiqin,Huang Feiyun,Yang Yu,Zhang Xiuyue,Yue Bisong 한국곤충학회 2022 Entomological Research Vol.52 No.2
Edible insects are alternative sources of high protein. Southeast Asia, South America, Africa, and Europe have recorded edible insects and, especially in Europe and America, there are factories that produce insects as food. In some areas of China, there has also been the habit of eating insects since ancient times. Periplaneta americana is an insect with the homology of medicine and food. In recent years, its medicinal and nutritional functions have attracted extensive attention and research. Its adult powder has been certified as a health product. It not only contains a variety of proteins but also is rich in fatty acids. The composition and antioxidant function of adult powder extract was analyzed in this study. Using adult P. americana powder as the raw material, it was extracted with n-Hexane, dichloromethane, and ethyl acetate, respectively. Gas chromatography–mass spectrometry (GC–MS) removed a total of 60 compounds, and many active components were extracted from P. americana powder for the first time. The parts and relative content of each extracted sample were obtained, and the total antioxidant capacity (T-AOC) of each extracted piece was determined, among which the antioxidant activity of ethyl acetate was the highest.
Schur power convexity of Gini means
Zhen-Hang Yang 대한수학회 2013 대한수학회보 Vol.50 No.2
In this paper, the Schur convexity is generalized to Schur f-convexity, which contains the Schur geometrical convexity, harmonic convexity and so on. When f : R+ → R is defined as f(x) = (xm −1)/m if m 6≠0 and f(x) = ln x if m = 0, the necessary and sufficient conditions for f-convexity (is called Schur m-power convexity) of Gini means are given, which generalize and unify certain known results.
The Effects of Flipped Vocabulary Learning on Chinese College Students' Listening Achievement
( Zhen Yang ),( Chang-in Lee ) 한국멀티미디어언어교육학회 2018 멀티미디어 언어교육 Vol.21 No.1
This study looked at the correlation between improved listening skills and flipped vocabulary learning on low-level EFL learners in a Chinese context. Thirty-one college students participated in a listening practice course for 20 weeks. The first three weeks focused on training on flipped learning and course preparation. The actual implementation of the real listening practice took place between weeks four and nineteen. During the listening practice course, 26 listening practice sections were covered. An alternating treatment design was used with two flipped vocabulary learning methods, learning words by teacher-made videos or by an online dictionary before the listening practice. For every listening practice section, students learned 20 target words before class. A vocabulary activity helped to enhance the effects of flipped learning in class before the start of listening practice. Data sources included pre-tests, repeated tests, and post-tests. The findings are as follows: 1) flipped learning of vocabulary had positive effects on listening improvement, and there was an overall increase in listening test scores. 2) With the two vocabulary learning methods, vocabulary learning with videos was more effective on students' listening practice than the method using an online dictionary.
THE LOG-CONVEXITY OF ANOTHER CLASS OF ONE-PARAMETER MEANS AND ITS APPLICATIONS
Yang, Zhen-Hang Korean Mathematical Society 2012 대한수학회보 Vol.49 No.1
In this paper, the log-convexity of another class one-parameter mean is investigated. As applications, some new upper and lower bounds of logarithmic mean, new estimations for identric mean and new inequalities for power-exponential mean and exponential-geometric mean are first given.
Effect of bFGF on the MCF-7 Cell Cycle with CD44+/CD24-: Promoting the G0/G1→G2/S Transition
Zhen-lin Yang,Kai Cheng,Zhao-dong Han 한국유방암학회 2012 Journal of breast cancer Vol.15 No.4
Purpose: Few cells with stem cell characteristics possess capabilities of self-renewal and differentiation, which leads to high tumorigenesis and resistance to standard chemotherapeutic agents. These cells are mostly quiescent, and arrest occurs at the mitotic G0/G1 phase in mitosis. We explored the effects of basic fibroblast growth factor (bFGF) on the MCF-7 cell cycle with CD44+/CD24-. Methods: Cancer-initiating cells were propagated as mammospheres. The CD44+/CD24- subpopulation was sorted by a fluorescence activating cell sorter-Vantage flow cytometer. A cell cycle analysis was performed with different bFGF concentrations. Results: Differences in the CD44+/CD24- cell proliferation under different bFGF concentrations were observed (p=0.001). When the bFGF concentration was increased, the proportion of CD44+/CD24- at G0/G1 decreased (p=0.023). Conclusion: We conclude that bFGF may sustain CD44+/CD24- cell proliferation and could promote cell progression through the G0/G1→G2/S phase transition.