中醫學과 體質醫學

匡調元 圓光大學校 韓醫學硏究所 1994 원광한의학 Vol.4 No.1

The constitution of human is a stable state with the specificity of function and metabolism, which can distinguish one from another during the process that he is born, grow up and senile. This state may usually decide the specialty of physical response, sensitivity to the cause and type of disease. In Western medicine, there is a middle zone between that of disease and that of normal state, whether it can be disease or not. Based on these concept, the constitutional pathology is suggested. The constitution of human is classified into five types in the part of pathology. In this study, a experiment was designed for the scientific access of Chinese constituion theory and constitutional food therapy.

A Distributed LT Codes-based Data Transmission Technique for Multicast Services in Vehicular Ad-hoc Networks

( Yuan Zhou ),( Zesong Fei ),( Gaishi Huang ),( Ang Yang ),( Jingming Kuang ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.4

In this paper, we consider an infrastructure-vehicle-vehicle (I2V2V) based Vehicle Ad-hoc Networks (VANETs), where one base station multicasts data to d vehicular users with the assistance of r vehicular users. A Distributed Luby Transform (DLT) codes based transmission scheme is proposed over lossy VANETs to reduce transmission latency. Furthermore, focusing on the degree distribution of DLT codes, a Modified Deconvolved Soliton Distribution (MDSD) is designed to further reduce the transmission latency and improve the transmission reliability. We investigate the network behavior of the transmission scheme with MDSD, called MDLT based scheme. Closed-form expressions of the transmission latency of the proposed schemes are derived. Performance simulation results show that DLT based scheme can reduce transmission latency significantly compared with traditional Automatic Repeat Request (ARQ) and Luby Transform (LT) codes based schemes. In contrast to DLT based scheme, the MDLT based scheme can further reduce transmission latency and improve FER performance substantially, when both the source-to-relay and relay-to-sink channels are erasure channels.

STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro

( Hai Xiao Wang ),( Kuang Jie Wu ),( Yuan Sun ),( Yan Dong Li ),( Ming Yu Wu ),( Qian Qiao ),( Yuan Jiang Wei ),( Ze Guang Han ),( Bing Cai ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.11

The human glycoprotein, stanniocalcin 2 (STC2) plays multiple roles in several tumor types, however, its function and clinical significance in hepatocellular carcinoma (HCC) remain unclear. In this study, we detected STC2 expression by quantitative real-time PCR and found STC2 was upregulated in HCC tissues, correla ed with tumor size and multiplicity of HCC. Ectopic expression of STC2 markedly promoted HCC cell proliferation and colony formation, while silencing of endogenous STC2 resulted in a reduced cell growth by cell cycle delay in G0/G1 phase. Western blot analysis demonstrated that STC2 could regulate the expression of cyclin D1 and activate extracellular signal-regulated kinase 1/2 (ERK1/2) in a dominant-positive manner. Transwell chamber assay also indicated altered patterns of STC2 expression had an important effect on cell migration. Our findings suggest that STC2 functions as a potential oncoprotein in the development and progression of HCC as well as a promising molecular target for HCC therapy.

The Supply Chain Analysis of Hakka Restaurants and Food Industry in Liutui Area of Taiwan

Chen Jui Ling,Yuan-Kuang Guu,Shiunn-Der Kuo 세계문화관광학회 2010 Conference Proceedings Vol.11 No.0

This study adopted the concept of supply chain analysis to establish 6 major and 18 secondary attributes for evaluating the Hakka food industry in the area of Liutui (six major clusters of the Hakka villages distributed in Kaohsiung and Pingtung counties, which functioned as 6 allied military forts when encountered with invading enemies), Taiwan, through literature review and on-site interviews of the business owners on the aspects of cost, quality, innovation, customer service, marketing, and flexibility. Analytical Hierarchy Process (AHP) was applied to weight the 6 major and 18 secondary attributes from the data of interviews. The objectives were to find out the weaknesses of business development of the Liutui Hakka restaurants and food industry via competition analysis of the business supply chain. These findings would be used as references for suggesting a “Blue Ocean Strategy” to the future sustainable operation and an uncontested market of the Hakka restaurants and food industry in the Liutui area. The research showed that the top three priorities of the 6 major attributes were quality, customer service and marketing (equally weighted), and flexibility. The most important secondary attribute under the major attribute quality was product safety and wholesomeness. These findings would be provided to the business holders and governments as bases for making development policies and strategies for future sustainable Hakka restaurants and food industry.

Effects of repeated tuberculin skin testings on immune responses in experimental monkeys

Min, Fangui,Wang, Jing,Yuan, Wen,Kuang, Huiwen,Zhao, Weibo Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.8

Though many alternative methods to tuberculin skin testing (TST) have been established and evaluated in recent years, sensitivities and specificities of most methods could not meet the requirements of golden standards. In this study, we sought to identify whether repeated TSTs could affect the immune responses in experimental monkeys. Nine natural tuberculosis (TB) monkeys receiving repeated TSTs biweekly were used to demonstrate the effect on TST responsiveness. Two healthy monkeys were administrated with repeated TSTs to analyze the immune response profiling. Intrapalpebral reactions in TB infections gradually weakened or presented intermittent positive reactions. The leukocyte counts, cytokine responses, and antibody responses to all antigens except Old tuberculin (OT) and MPT64L showed no specific changes for TB in healthy monkeys. Positive antibody responses to OT and MPT64L emerged during the first half experimental period, which may cause by their cross-reactivity with mycobacterial species. Results showed that repeated TSTs had no significant effects on immune responses in healthy monkeys but a progressive reduction in TST responsiveness in TB infections.

The Supply Chain Analysis of Hakka Restaurants Industry for Hakka Liutui Regions in Taiwan

Chen,Jui-Ling,Guu,Yuan-Kuang,Kuo,Shiunn-Der 한국문화관광학회 2010 문화관광연구 Vol.12 No.2

Analytical Hierarchy Process (AHP) was applied to weight the 6 major and 18 secondary attributes from the data of interviews. The objectives were to find out the weaknesses of business development of the Liutui Hakka restaurants and food industry via competition analysis of the business supply chain. These findings would be used as references for suggesting a “Blue Ocean Strategy” to the future sustainable operation and an uncontested market of the Hakka restaurants and food industry in the Liutui area. The research showed that the top three priorities of the 6 major attributes were quality, customer service and marketing (equally weighted), and flexibility. The most important secondary attribute under the major attribute quality was product safety and wholesomeness. These findings would be provided to the business holders and governments as bases for making development policies and strategies for future sustainable Hakka restaurants and food industry.

The Supply Chain Analysis of Hakka Restaurants Industry for Hakka Liutui Regions in Taiwan

( Jui Ling Chen ),( Yuan Kuang Guu ),( Shiunn Der Kuo ) 한국문화관광학회 2010 문화관광연구 Vol.12 No.2

Analytical Hierarchy Process (AHP) was applied to weight the 6 major and 18 secondary attributes from the data of interviews. The objectives were to find out the weaknesses of business development of the Liutui Hakka restaurants and food industry via competition analysis of the business supply chain. These findings would be used as references for suggesting a "Blue Ocean Strategy" to the future sustainable operation and an uncontested market of the Hakka restaurants and food industry in the Liutui area. The research showed that the top three priorities of the 6 major attributes were quality, customer service and marketing (equally weighted), and flexibility. The most important secondary attribute under the major attribute quality was product safety and wholesomeness. These findings would be provided to the business holders and governments as bases for making development policies and strategies for future sustainable Hakka restaurants and food industry.

On the direct insulator-quantum Hall transition in two-dimensional electron systems in the vicinity of nanoscaled scatterers

Liang, Chi-Te,Lin, Li-Hung,Kuang Yoa, Chen,Lo, Shun-Tsung,Wang, Yi-Ting,Lou, Dong-Sheng,Kim, Gil-Ho,Yuan-Huei, Chang,Ochiai, Yuichi,Aoki, Nobuyuki,Chen, Jeng-Chung,Lin, Yiping,Chun-Feng, Huang,Lin, Sh Springer 2011 Nanoscale research letters Vol.6 No.1

<P>A direct insulator-quantum Hall (I-QH) transition corresponds to a crossover/transition from the insulating regime to a high Landau level filling factor ν > 2 QH state. Such a transition has been attracting a great deal of both experimental and theoretical interests. In this study, we present three different two-dimensional electron systems (2DESs) which are in the vicinity of nanoscaled scatterers. All these three devices exhibit a direct I-QH transition, and the transport properties under different nanaoscaled scatterers are discussed.</P>

Distinct Inflammation Biomarkers in Healthy Individuals and Patients with Schizophrenia: A Reliability Testing of Multiplex Cytokine Immunoassay by Bland-Altman Analysis

Ta-Chuan Yeh,Hsuan-Te Chu,Chia-Kuang Tsai,Hsin-An Chang,Fu-Chi Yang,San-Yuan Huang,Chih-Sung Liang 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.8

Objective Since the inflammatory process has been implicated in the pathophysiology of psychiatric disorder, an important issue emerging is to assess the test-retest reliability of cytokine measurement in healthy individuals and patients with schizophrenia. The objective of the present study was to investigate the test-retest reliability of bead-based multiplex immunoassay technology (BMIT) for cytokine measurement by using a Bland-Altman plot (BAP). Methods Twenty healthy individuals and twenty patients with schizophrenia were enrolled, and a 17-plex cytokine assay was used to measure inflammatory biomarkers at baseline and two weeks later. The test-retest reliability was examined by BAP, 95% limits of agreement (LOA), intraclass correlation coefficient (ICC), and coefficient of repeatability (CoR). Results In the healthy controls, only interleukin (IL)-2, IL-13, IL-10, IL-17, and macrophage inflammatory protein-1β showed excellent ICC. The BAP with 95% LOA determined that 13 cytokines showed acceptable 95% LOA for a 2-week test-retest reliability, and only IL-1β, IL-12 and tumor necrosis factor (TNF)-α had significant test-retest bias. The CoR of cytokines varied significantly, ranging from 1.72 to 218.1. Compared with healthy controls, patients with schizophrenia showed significantly higher levels of IL-5, IL-13, and TNF-α and significantly lower levels of IL-4, IL-12, and interferon-gamma (IFN-γ). Of these six cytokines, IL-12 and TNF-α were considered suboptimal reliability. Conclusion The findings from ICC and CoR implied that the test-retest reliability of BMIT for cytokine measurement were suboptimal. However, the BAP with 95% LOA confirmed that BMIT can reliably distinguish schizophrenia from healthy individuals in cytokine measurement, while significant within-subject variation and between-group overlapping were evident in cytokine expression.

Antiproliferative and Antitumorigenic Activity of Toona sinensis Leaf Extracts in Lung Adenocarcinoma

Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1

Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.