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Crocetin Induces Cytotoxicity in Colon Cancer Cells Via p53-independent Mechanisms
Li, Cai-Yan,Huang, Wen-Feng,Wang, Qun-Li,Wang, Fan,Cai, E.,Hu, Bing,Du, Jia-Cheng,Wang, Jing,Chen, Rong,Cai, Xiao-Jing,Feng, Jing,Li, Hui-Hui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Objective: Crocin has been proposed as a promising candidate for cancer chemoprevention. The purpose of this investigation was to investigate the chemopreventive action and the possible mechanisms of crocin against human colon cancer cells in vitro. Methods: Cell proliferation was examined using MTT assay and the cell cycle distribution fractions were analyzed using fow cytometric analysis after propidium iodide staining. Apoptosis was detected using theTUNEL Apoptosis Detection Kit with laser scanning confocal microscope. DNA damage was assessed using the alkaline single-cell gel electrophoresis assay, while expression levels of p53, cdk2, cyclinA and P21 were examined by Western blot analysis. Results: Treatment of SW480 cells with crocetin (0.2, 0.4, 0.8 mmol/L) for 48 h signifcantly inhibited their proliferation in a concentration-dependent manner. Crocetin (0.8 mmol/L) signifcantly induced cell cycle arrest through p53-independent mechanisms accompanied by P21 induction. Crocetin (0.8 mmol/L) caused cytotoxicity in the SW480 cells by enhancing apoptosis and decreasing DNA repair capacity in a time-dependent manner. Conclusions: This report provides evidence that crocetin is a potential anticancer agent, which may be used as a chemotherapeutic drug.
Mannich reaction catalyzed by a novel catalyst under solvent-free conditions
Cai Bo Yue,Ting Feng Yi,Chuan Bing Zhu,Gang Liu 한국공업화학회 2009 Journal of Industrial and Engineering Chemistry Vol.15 No.5
An acidic catalyst [Py][CF3COO] (pyridinium trifluoroacetate) was synthesized and used in the Mannich reaction of various kinds of aromatic aldehydes, aromatic ketones and aromatic amines. b-Amino carbonyl compounds were obtained in reasonable yields when the Mannich reaction was carried out at room temperature under solvent-free conditions. The products could be separated from the catalyst simply via washing with water and after removing water, the catalyst could be recycled and reused for up to four times without noticeably decreasing in catalytic activity.
Creation of Consistent Burn Wounds: A Rat Model
Cai, Elijah Zhengyang,Ang, Chuan Han,Raju, Ashvin,Tan, Kong Bing,Hing, Eileen Chor Hoong,Loo, Yihua,Wong, Yong Chiat,Lee, Hanjing,Lim, Jane,Moochhala, Shabbir M.,Hauser, Charlotte A.E.,Lim, Thiam Chye Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.4
Background Burn infliction techniques are poorly described in rat models. An accurate study can only be achieved with wounds that are uniform in size and depth. We describe a simple reproducible method for creating consistent burn wounds in rats. Methods Ten male Sprague-Dawley rats were anesthetized and dorsum shaved. A 100 g cylindrical stainless-steel rod (1 cm diameter) was heated to $100^{\circ}C$ in boiling water. Temperature was monitored using a thermocouple. We performed two consecutive toe-pinch tests on different limbs to assess the depth of sedation. Burn infliction was limited to the loin. The skin was pulled upwards, away from the underlying viscera, creating a flat surface. The rod rested on its own weight for 5, 10, and 20 seconds at three different sites on each rat. Wounds were evaluated for size, morphology and depth. Results Average wound size was $0.9957cm^2$ (standard deviation [SD] 0.1845) (n=30). Wounds created with duration of 5 seconds were pale, with an indistinct margin of erythema. Wounds of 10 and 20 seconds were well-defined, uniformly brown with a rim of erythema. Average depths of tissue damage were 1.30 mm (SD 0.424), 2.35 mm (SD 0.071), and 2.60 mm (SD 0.283) for duration of 5, 10, 20 seconds respectively. Burn duration of 5 seconds resulted in full-thickness damage. Burn duration of 10 seconds and 20 seconds resulted in full-thickness damage, involving subjacent skeletal muscle. Conclusions This is a simple reproducible method for creating burn wounds consistent in size and depth in a rat burn model.
Jixiang Cai,Bing Huang,Qikun Ma,Wenwen Zhang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6
We propose a novel process for the preparation of silica and concentrated hydrochloric acid using chlorosilane residual liquid originating from the polysilicon production process. The process was designed and optimized after conducting pilot plant tests. The effects of circulating acid concentration, flow rate, chlorosilane residual liquid treatment load and other factors on silica products were studied. The results showed that the circulating acid flowrate can effectively control the formation of gel, and the amount of chlorosilane residual liquid has significant influence on the hydrolysis efficiency and operation of the hydrolysis tower. The prepared silica was characterized using XRD, XRF, FTIR, SEM, DLS, TG-MS and N2 adsorption/desorption experiments. The results indicated that silica consisted of amorphous particles, which were spherical, had surface hydroxyl, and showed heterogeneous distribution. The average particle size was 50-80 μm and had high specific surface area (565.049m2g−1), large pore volume (0.449 cm3g−1), and a narrow pore size distribution (3.419 nm). The new technology provides a simple, efficient and environmentally friendly way for treating chlorosilane residual liquid, as well as a cost-effective method for the preparation of silica.
Yao Cai,Huidong Liu,Ye Ma,Qiang Wan,Hao Cheng,Yan Liu,Yanming Chen,Qingsong Mei,Bing Yang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.5
Cr-containing diamond-like carbon (Cr-DLC) nanocomposite coatings were synthesized by ion beam-assisted arc ion plating with varying hollow cathode ion source (HCIS) currents. The morphologies, compositions and microstructures were characterized by scanning electronic microscopy (SEM), atomic force microscopy (AFM), X-Ray photoelectron spectrometer (XPS), Raman spectroscopy, grazing incidence X-ray diffraction (GIXRD) and high-resolution transmission electron microscopy (HRTEM). Hardness and friction coefficient were investigated by using nanoindentation and ball-on-disc tribometer, respectively. With no HCIS current, the coating exhibits the maximal growth rate and a rough surface, as well as lower hardness and elastic modulus. With the increasing HCIS current from 40 A to 80 A, the growth rate and the content of chromium carbide decrease obviously, the sp3/sp2 ratio increases initially to the maximum at the HCIS current of 60 A, the highest hardness and elastic modulus are obtained at the HCIS current of 50 A. It is also revealed that moderate HCIS current can reduce surface roughness obviously and promote tribological properties. The correlation of the HCIS current with the microstructure and performance of Cr-DLC coating has been established.
Yang Lin,Cai Yongheng,Dan Lin,Huang He,Chen Bing 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.6
Background: Mechanical ventilation, particularly one-lung ventilation (OLV), can cause pulmonary dysfunction. This meta-analysis assessed the effects of dexmedetomidine on the pulmonary function of patients receiving OLV. Methods: The Embase, PubMed, MEDLINE, Cochrane Library, ClinicalTrials.gov, and Chinese Clinical Trial Registry databases were systematically searched. The primary outcome was oxygenation index (OI). Other outcomes including the incidence of postoperative complications were assessed. Results: Fourteen randomized controlled trials involving 845 patients were included in this meta-analysis. Dexmedetomidine improved the OI at 30 (mean difference [MD]: 40.49, 95% CI [10.21, 70.78]), 60 (MD: 60.86, 95% CI [35.81, 85.92]), and 90 min (MD: 55, 95% CI [34.89, 75.11]) after OLV and after surgery (MD: 28.98, 95% CI [17.94, 40.0]) and improved lung compliance 90 min after OLV (MD: 3.62, 95% CI [1.7, 5.53]). Additionally, dexmedetomidine reduced the incidence of postoperative pulmonary complications (odds ratio: 0.44, 95% CI [0.24, 0.82]) and length of hospital stay (MD: −0.99, 95% CI [−1.25, −0.73]); decreased tumor necrosis factor-α, interleukin (IL)-6, IL-8, and malondialdehyde levels; and increased superoxide dismutase levels. However, only the results for the OI and IL-6 levels were confirmed by the sensitivity and trial sequential analyses.Conclusions: Dexmedetomidine improves oxygenation in patients receiving OLV and may additionally decrease the incidence of postoperative pulmonary complications and shorten the length of hospital stay, which may be related to associated improvements in lung compliance, anti-inflammatory effects, and regulation of oxidative stress reactions. However, robust evidence is required to confirm these conclusions.
One-Pot Synthesis of α-Fe2O3 Nanospindles as High-Performance Lithium-Ion Battery Anodes
Yanhua Ding,Bing Liu,Rongsheng Cai,Tuo Xin,Chen Li,Linhua Xia,Yiqian Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.2
Hematite nanospindles with a uniform size of ~270 nm in length and ~90 nm in width are prepared using a facile one-step hydrothermal method. Polyvinylpyrrolidone (PVP) serves as a structure-directing agent to control the primary morphology and aggregations. When evaluated as anode materials for lithium-ion batteries (LIBs), the electrode of sodium alginate (SA) binder exhibits a much better electrochemical performance than that with the polyvinylidene fluoride (PVDF) binder. Remarkably, the electrode using SA binder can deliver a high reversible specific capacity of 979mAh · g -1 after 50 cycles and prominent rate capability. The microstructural evolution of the nanospindles after the electrochemical cycling is investigated by scanning transmission electron microscopy (STEM). Our results may provide important mechanistic insights for the design of nanostructured anode materials for LIBs.