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Grace G.L. Yue,Sau-Wan Cheng,Hua Yu,Zi-Sheng Xu,Julia K.M. Lee,Po-Ming Hon,Mavis Y.H. Lee,Edward J. Kennelly,Gary Deng,Simon K. Yeung,Barrie R. Cassileth,Kwok-Pui Fung,Ping-Chung Leung,Clara B.S. Lau 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
The rhizome of Curcuma longa (turmeric) is often used in Asia as a spice and as a medicine. Its most wellstudied component, curcumin, has been shown to exhibit poor bioavailability in animal studies and clinical trials. We hypothesized that the presence of lipophilic components (e.g., turmerones) in turmeric extract would affect the absorption of curcumin. The effects of turmerones on curcumin transport were evaluated in human intestinal epithelial Caco-2 cells. The roles of turmerones on P-glycoprotein (P-gp) activities and mRNA expression were also evaluated. Results showed that in the presence of a- and aromatic turmerones, the amount of curcumin transported into the Caco-2 cells in 2 hours was significantly increased. a-Turmerone and verapamil (a P-gp inhibitor) significantly inhibited the efflux of rhodamine-123 and digoxin (i.e.,inhibited the activity of P-gp). It is interesting that aromatic turmerone significantly increased the rhodamine-123 efflux and Pgp (MDR1 gene) mRNA expression levels. The effects of a- and aromatic turmerones on curcumin transport as well as P-gp activities were shown here for the first time. The presence of turmerones did affect the absorption of curcumin in vitro. These findings suggest the potential use of turmeric extract (including curcumin and turmerones), rather than curcumin alone, for treating diseases.
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( Huatuo Zhu ),( Xinyong Wan ),( Wenguo Chen ),( Chaohui Yu ),( Min Yue ),( Yining Dai ),( Lihua Chen ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: It was recently reported that epigenetics might play an essential role in IBD. Bromo adjacent homology domain 1 (BAHD1), which involved in category of epigenetics maintains homeostasis by promoting heterochromatin formation. Our study aimed to investigate the underlying mechanism of BAHD1 in gut inflammation including IBD, seeking a new therapeutic target for the inflammation-associated colon disease. Methods: Experimental colitis was induced in C57BL/6 mice by dextran sulfate sodium administration. To simulate the intestinal inflammation microenvironment for epithelial cells, Caco-2 cells were exposed to a mixture of LPS, TNF-a, IL-1ß, and IFN-. BAHD1 expression was detected by quantitative PCR(qPCR), western blot and immunohistochemistry in both UC patients and mice model. Small interfering RNA was used to knock down BAHD1 level(siBAHD1) in Caco-2 cells and associated cytokines(CKs) expression were detected by either qPCR or ELISA. Possible mechanism involving in- flammatory pathways activation were addressed by western blot. Results: Murine model of UC-like inflammation was successfully established. And we found that BAHD1 existed in the normal internal crypt and surface epithelial cells ubiquitously. Compared with control group, BAHD1 expression in colon tissue were significantly decreased in both UC patients and mice model. In the vitro model system, we found that the protein level of BAHD1 was decreased in the stimulated Caco-2 cells. In addition, consistent with mRNA level of associated CKs enhanced in the siBAHD1 group within stimulatory factors, the interference group secreted more IL-6 and MCP-1 contents in the culture supernatant. As for potential mechanisms of BAHD1 in colitis, increased expression of TNFR1 was found in Caco-2 cells pre-treated with siBAHD1 in gut inflammation model, accompanying with the activation of IKK/ NF-κB and JNK/AP-1 pathways. Conclusions: Collectively, those findings provide evidence that BAHD1 might act as an indispensable safeguard to keep intestine immunological homeostasis.
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Yueh-Ming Tai,Chih-Yuan Ko,Chen-Cheng Lin,Yu-Yue Wan,Jing-Yi Chung,Yia-Ping Liu 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.2
Objective Central 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role is not clearly defined in developmentally social deprived (isolation rearing, IR) rats featured with impaired sensorimotor gating ability. We therefore aimed to examine the effects of 5HT1A activation on acoustic startle response (ASR) and prepulse inhibition (PPI) in IR rats in a condition of compromised presynaptic 5-HT functions. Methods Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletor, 5,7-DHT. Seven days later rats entered a protocol of 8-OH-DPAT, a 5-HT1A agonist, in which locomotor activity, ASR and PPI and their tissue levels of 5-HT were measured. Results Our results found that both IR and 5,7-DHT decreased the tissue concentration of 5-HT. IR-induced hyperactivity and gating impairment were unaffected by 5-HT depletion. 8-OH-DPAT strengthened the ASR in IR but not SOC rats and the drug-reduced PPI could be adjusted by 5,7-DHT pretreatment. 8-OH-DPAT at 100 μg/kg enhanced PPI in 5-HT-depleted SOC rats. However for IR rats, 8-OH-DPAT strengthened PPI in sham rats but downgraded it in depletion condition. Conclusion The integrity of central 5-HT system is important to 5-HT1A-modulated sensorimotor gating in isolation-reared rats.
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