Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Yu-Hsiang Hsu,Hsing-Hui Li,Junne-Ming Sung,Wei-Yu Chen,Ya-Chin Hou,Yun-Han Weng,Wei-Ting Lai,Chih-Hsing Wu,Ming-Shi Chang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-β1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-β1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy.

Cooperative Learning in Small EFL Early Reading Groups

( Yu Ju Lan ),( Kuo En Chang ),( Yao Ting Sung ) 범태평양응용언어학회 2005 범태평양응용언어학회지 Vol.9 No.2

The purpose of this study is to explore the interactive behaviors and intra-group discourse in a cooperative reading group when students were asked to do meaning-based reading tasks with their group mates cooperatively. The subjects were 52 third graders from an elementary school of Taipei, Taiwan. For ten weeks, both video and audio data were collected. Based on the finding of qualitative data analysis, we found four main types of group interactive behavior which we called Ardent, Be-forced, Supervisory, and Wait-on. According to the intra-group discourse, we also found that peer-assisted learning existed in cooperative reading groups and most of the peer discourse provided essential scaffolding, modeling, and direct instruction dialogs that help children with lower reading abilities do meaning-based reading.

Numerical investigation of the mechanical component design of a hexacopter drone for real-time fine dust monitoring

Yu-Ting Wu,Zhen Qin,Amre Eizad,Sung-Ki Lyu 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.7

Multi-rotor unmanned aerial vehicles (UAVs) are being widely used in various military and civilian fields because they can replace manned systems in the performance of a variety of difficult and/or hazardous tasks. Various UAV designs have been developed to fulfill the requirements of various applications. The current work investigates the design of a hexacopter drone with foldable arms to support the six propulsion units that is designed for realtime fine dust monitoring. The propeller and foldable arm are the key mechanical power transmission components in this design, so their propulsion performance and safety reliability have been numerically investigated in this research. The finite volume method (FVM) based aerodynamic characteristics simulation is utilized to calculate and observe the operational performance of eight different proposed propeller blade designs. The optimal design was obtained through a series of comparisons of the simulation outcomes. The flow field force acting on the propeller blade was analyzed using the fluid-structure interaction (FSI) based simulation method. In addition, the design philosophy of using carbon fiber composite material to replace the traditional aluminum alloy in the manufacture of the foldable arm is presented. The rationality of this design philosophy is verified through finite element method (FEM) based structural analysis. The design experience gained from this study provides a theoretical basis for the development of components for multi-rotor UAVs.

Numerical Investigation of Flow Characteristics in a Viscous Damping System with Symmetrical Hydraulic Cylinders

Yu-Ting Wu,Zhen Qin,Amre Eizad,Sung-Ki Lyu,Choon-Man Lee 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.4

Hydraulic dampers are widely applied due to their characteristics of absorbing huge impact energy, stable and reliable working performance, and easy on-demand design. The hydraulic cylinder is an important part of the hydraulic damping system and the flow conditions inside the cylinder significantly affect its performance. However, only a few researches related to the flow field inside the hydraulic cylinder have been reported. In this study, a novel viscous damping system with opposing symmetrical hydraulic cylinders that can guarantee the smoothness of vibration absorption in a single degree of freedom is proposed. The advantage of this design is that the damping characteristic can be regulated using the external flow valve provided in the external hydraulic loop. The hydraulic damping system is simulated using the commercial software ANSYS Fluent software environment, different strokes and frequencies are applied to observe the internal flow characteristics. As can be seen from the results of numerical investigation, when the piston on one side moves, the piston on the other side also moves, and the pressure change in the cylinder is caused by the collective effect of the cavity volume change and the flow change of the hydraulic oil. In addition, by comparing the streamline and velocity distribution in the cavity under different strokes and frequencies, the relationship between vortex and velocity and compression distance is summarized. These results provide valuable information to facilitate the design of viscous damping system with symmetrical hydraulic cylinders

새로운 케이블 감쇠 시스템의 이론 모델에 관한 연구

우위팅(Yu-Ting Wu),진진(Zhen Qin),류성기(Sung-Ki Lyu) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12

Robust Tracking Design Based on Adaptive Fuzzy Control of Uncertain Nonlinear MIMO Systems with Time Delayed States

Tzu-Sung Wu,Mansour Karkoub,Chien-Ting Chen,Wen-Shyong Yu,Ming-Guo Her,Jui-Yiao Su 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.6

It is proposed here to use a robust tracking design based on adaptive fuzzy control technique to control a class of multi-input-multi-output (MIMO) nonlinear systems with time delayed uncertainty in which each uncertainty is assumed to be bounded by an unknown gain. This technique will overcome modeling inaccuracies, such as drag and friction losses, effect of time delayed uncertainty, as well as parameter uncertainties. The proposed control law is based on indirect adaptive fuzzy control. A fuzzy model is used to approximate the dynamics of the nonlinear MIMO system; then, two on-line estimation schemes are developed to overcome the nonlinearities and identify the gains of the delayed state uncertainties, simultaneously. The advantage of employing an adaptive fuzzy system is the use of linear analytical results instead of estimating nonlinear system functions with an online update law. The adaptive fuzzy scheme uses a Variable Structure (VS) scheme to resolve the system uncertainties, time delayed uncertainty and the external disturbances such that H∞ tracking performance is achieved. The control laws are derived based on a Lyapunov criterion and the Riccati-inequality such that all states of the system are uniformly ultimately bounded (UUB). Therefore, the effect can be reduced to any prescribed level to achieve H∞ tracking performance. A two-connected inverted pendulums system on carts and a two-degree-of-freedom mass-spring-damper system are used to validate the performance of the proposed fuzzy technique for the control of MIMO nonlinear systems.

평면식 유압 커플링 시스템의 유동 특성에 관한 수치적 연구

류성기(Sung-Ki Lyu),우위팅(Yu-Ting Wu),진진(Zhen Qin),조용민(Yong-Min Cho) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.6

한국과 중국의 국가수준 유아교육과정 비교분석: 2019 개정 누리과정, 3-6세 아동학습 및 발달지침 중심으로

한상미 ( Han Sang Mi ),양옥정 ( Yang Yu ting ),서현아 ( Seo Hyun Ah ) 한국유아교육학회 2021 유아교육연구 Vol.41 No.6

본 연구의 목적은 한국과 중국의 국가수준 유아교육과정을 비교 분석하여 양국이 지향하는 유아교육의 방향을 가늠해보고, 향후 유아교육과정 개선에 기초자료를 제공하는 데 의의가 있다. 연구대상은 한국의 2019 개정 누리과정과 중국의 3-6세 아동학습 및 발달지침이며 교육과정 구성체계, 목적 및 목표, 영역별 내용 범주와 내용, 교육과정 특징으로 비교하였다. 연구 결과 첫째, 누리과정과 발달지침의 교육과정은 각국의 독자적인 특성을 반영한 유사한 구성체계를 가지고 있다. 둘째, 누리과정의 목적은 올바른 인성과 민주 시민의 기초를 형성하는 데 있으며, 발달지침의 목적은 소양 교육과 전인 발달에 강조를 두고 있다. 셋째, 누리과정과 발달지침의 영역별 내용은 각국의 5개 영역별 명칭은 다르나 의미와 내용은 영역별로 매칭되는 특성을 보였다. 넷째, 누리과정과 발달지침 교육과정 특징은 국가수준의 공통성과 다양성, 유아 중심과 놀이 중심의 가치 추구, 5개 영역별 내용이 통합적 운영, 함께 실현하는 교육과정 4가지 공통점으로 나타났다. The purpose of this study is to make a comparative analysis of the national level early childhood education curriculum in South Korea and China and to measure the direction of early childhood education in the two countries, so as to provide basic data for the improvement of early childhood education curriculum in the future. The objects of this study were the Nuri curriculum revised in 2019 in South Korea and the Guideline to the Learning and Development of Children Aged 3-6 in China. The comparisons were made in the aspects of composition system, aims and objectives, content category, and specific content in various fields and educational curriculum characteristics of early childhood education curriculum in the two countries. The results show that, first, the Nuri curriculum and Guideline educational curricula have similar compositional systems that reflect each country’s own characteristics. Second, the purpose of the Nuri curriculum is to lay the foundation for proper personality and democratic citizenship, while the purpose of the Guideline is to emphasize quality education and the all-around development of young children. Third, although the names and contents of the five fields in Nuri curriculum and Guideline are different, the meanings and contents of each field are matched by fields. Fourth, the common characteristics of the Nuri curriculum and Guideline are reflected in the following 4 aspects: commonness and diversity at the national level, child-centered and play-centered value pursuit, comprehensive operation of five fields, and joint realization of the curriculum.

Advancement of Mechanical Engineering in Extreme Environments

Zhen Qin,Yu-Ting Wu,Amre Eizad,Sung-Ki Lyu,이춘만 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.6

With the continuing increase in the use of technology in the modern world, the environmental demands placed on mechanical products have become increasingly harsh, especially in the fields of industrial equipment, vehicles, robotics, medical equipment, and weapons . For the development of mechanical engineering, it is essential to ensure reliable performance, high efficiency, and long durability in extreme environments (extremes of temperature, pressure, corrosion, vibration, etc. ). The mechanical properties of the materials used to manufacture the components directly influence the component’s characteristics in extreme environments. Mechanical design and manufacturing processes are also key factors that affect the reliability of mechanisms. With the development of composite materials, computer technology, and the 4th industrial revolution, extreme environment technology has also progressed rapidly. Engineering for extreme environments is considered as a very important field in the green and environmental-friendly technology. This is because the shortened working life of machinery under such extremely harsh environments leads to higher energy consumption and more non-recyclable wastes. This paper reviews the developments related to novel extreme environment technologies in terms of materials, design, and manufacturing that have come about in recent years. Moreover, an analysis of related articles, patents, and the economy of this field is carried out and a perspective on the developmental trend is put forward.

Towards an Omni-directional Orientation Manipulation of Spherical Piezoelectric Motor: A Torque Vector Composition Method

Tai-Chi Hwang,Yu-Ting Sung,Yu-Hsi Huang,Chi-Ying Lin 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10

This paper presents the application of a torque vector composition method realizing omni-directional rotor orientations for a novel standing wave spherical piezoelectric motor (SPM). The developed SPM system comprises four stators where each stator can provide three fundamental orientations or torque vectors implemented with the technique of electrode configuration. The concept of vector composition applied to the SPM system is illustrated with two stator actuation configurations: symmetrical and adjacent actuation stator pairs. The proposed method has the advantage of easy generation of new rotor orientations by adjusting the magnitude ratio of the excitation signals given to the stators. Composited vector analysis shows that the use of all stator pairs is able to offer omni-directional rotor orientations in the xy, yz, and xz planes. The estimated orientations in the experiments demonstrate the feasibility of the proposed torque vector composition method and the potentials of expanding omni-directional orientations to the whole 3D space with more than two actuating units.