콜로이드 골드 나노입자의 단백질 수송성 평가법

김미영,노상명,김정목,최한곤,김정애,오유경 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

Colloidal gold nanoparticles might be of use as nano scale delivery systems of various therapeutic materials in the firture. Recent studies have reported the feasibility of colloidal gold nanoparticles as gene delivery systems or protein delivery systems. In this study, we aimed to develop a short-step method useful for screening the optimal coating conditions of colloidal gold nanoparticles with proteins. We observed that colloidal gold nanoparticles have properties of changing its unique color when they were exposed to NaCl solution. Taking advantage of the color changing properties of colloidal gold nano-particles, we applied the color testing method of colloidal gold nanoparticles solutions for evaluating the protein coating nature. Using bovine senim albumin as a model protein, we tested the protein coating of colloidal gold nanoparticles via the color change upon NaCl addition. The optimal coating concentration and coating conditions of colloidal gold nanoparticles with bovine serum albumin were fixed using the color testing methods. We suggest that the color testing method might be applied to optimize the coating condition of colloidal gold nanoparticles with other therapeutic proteins.

양지면 전원주택단지 프로젝트 계획

김신원,정유홍,노희곤,도의성,최기왕 경희대학교 디자인연구원 2006 예술· 디자인학연구 Vol.9 No.2

This plan of rural housing-development is to present a new orientation for the residential culture that can meet the shifting demands of modern people as their attitudes toward naturalistic life. In this plan, sites of possible, a new housing complex is designed to supplement the site partition problem of existing housing complex by using attractiveness that the site has as a residence environment in housing planning. The conclusion can be summarized as follows. 1. Currently, most residential developments on slopes are planned with excessive slope cutting or filling on existing natural slopes rather than utilizing existing contours. In consideration of this, this proposed plan uses the existing contours of the slope to the maximum capacity in site planning. 2. The majority of the home site buyers are between the ages 30's to 50's of middle to high level incomes. Reflecting the financial needs of these families, home construction was planned by using building methods that require lower costs. 3. Reflected open-space furtherance maximum at design of community equipment for party's offer to sale in lots persons, from site purchase recognition of construction to in package sale in lots way select. 4. Considered to preserve existing natural-food life in way financial world stroke maximum, and accomplish creation with existing vegetation. Also, did planting considering privacy, and considered vegetation's environment adaptation degree because using midland style vegetation. 5. Garden wished to offer an opportunity that can make by oneself directly depending on each fondness and character to tenants. If is this intuition, wished to design, and maintained spur of housing development because housing development uses maximum natural history style comparing with other power jars all. Also, because considering people who move in housing-development, designed, and tried to make housing-development that want to live most offering the convenience.

전북대학교병원 소아치과에 내원한 교정환자 보호자들의 의삭에 관한 설문조사

소유려,백병주,김재곤,양연미,이용훈 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

최근 치의학의 눈부신 발전과 소득의 증가에 따른 일반인의 의식 변화로 외모에 대한 관심도가 높아지고 있다. 본 연구에서는 대학병원에 내원한 동기와 교정치료를 시작하게 된 동기,치료방법 및 치료기간을 파악하여,이를 토대로 보호자와 보다 적절한 의사소통을 위한 정보를 파악하고,보호자들의 교정치료에 대한 기대를 파악하고자 본 연구를 시행하였다. 이를 위해 전북대학교 치과병원 소아치과에 내원한 교정환자의 보호자 150명을 대상으로 조사 연구한 결과 다음과 같은 결론을 얻었다. 1. 본 병원의 소아치과를 찾게 된 이유 중 대학병원이 좋을 것 같아서가 52.1%. 친지나 아는 사람의 권유가 25%. 다른 치과병원의 소개가 16.7%로 나타났다. 2. 내원 전 예상하였던 치료기간 중 2년 이상이 37.5%. 12∼18개월이 12.5%로 나타났다. 3. 교정치료를 받으려는 이유 중 부모가 부정교합을 발견하고 걱정스러워서가 58.3%, 주위사람들의 지적이 12.5%로 나타났다. 4. 소아치과 내원 환자의 치료방법은 구강 내 고정성장치가 41.7%, 가철성장치가 29.2% 구외 장치가 2.1%를 차지했다. 5. 예약 후 치료를 위해 기다리는 시간 중 5∼10분이 39.6%, 15∼30분이 4.1%로 나타났으며,기다리는 시간은 어느 정도까지 괜찮다고 생각하는가에 대해 5∼10분이 60.4%, 15∼30분이 2.1%로 나타났다. Recently, in proportion to the remarkable development of dentistry and income increases it is growing more and more a concern about changed awareness in appearance, In this study, it had a grasp of the purpose for university hospital visiting, the motive of the commencement for orthodontic treatment and a method of the treatment as well as term. Based on these, the aim of this study is to keep more of the information between parent and doctors for mutual understanding and to grasp the characteristics for the needs of orthodontic treatment. In order to conduct researches, there has made a survey of 150 persons among orthodontic patients' parents who visit CBNU hospital, the pediatric dentistry. The study has found the results like these. 1. There was a question about the reason to visit CBNU hospital in the department of pediatric dentistry for orthodontic treatment. 52.1% of respondents, the survey found, were more likely to receive a good medical service. 25% of them were counselled from a relative or an acquaintance. 16.7% of them were recommended by another dental clinic. 2. There was a question about the expected orthodontic treatment period, when at first hospital visiting. 37.5% of the respondents answered that it was a 'more than 2 years', 12.5% of them said 'from 12 months to 18 months'. 3. There was a question about the reason to receive orthodontic treatment. 58.3% of the respondents, the survey found, answered the reason was parents' concern about the malocclusion of their children, 12.5% of them said a the orthodontic problem pointed out by entourages. 4. There was a question about the method of orthodontic treatment for patients who visit the department in pediatric dentistry. 41.7% of the respondents said that it was used as 'an intra-oral fixed appliance', 29.2% of them said 'an intra-oral removable appliance', 2.1% of them said 'an extra-oral appliance'. 5. There was a question about the waiting time for treatment after a dental appointment. 60.4% of the respondents said 'from 5 minutes to 10 minutes', 4.1% of them said 'from 15 minutes to 30 minutes'. There was a question about the extent of an acceptable waiting time. It was answered to 'from 5 minutes to 10 minutes' by 60.4% of them, 2.1% of them said 'from 15 minutes to 30 minutes'.

시판되는 생수 내 무기물 함량에 관한 연구

소유려,백병주,김재곤,양연미,김하나 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

생수 내에는 많은 미네랄이 포함하고 있으며, 이 중 칼슘, 나트륨, 칼륨, 마그네슘, 불소는 생수통에 반드시 표기해야 할 무기물이다. 칼슘, 마그네슘, 불소와 같은 무기물은 치아형성에 관여하며, 적절하게 섭취시 치아우식증을 예방할 수 있다. 현행 먹는 샘물 수질기준에 따르면 무해무기물질인 칼슘과 마그네슘에 대한 기준치는 없으며, 유해무기물질인 불소와 같은 무기물은 2 mgF/L 이하로 규정하고 있다. 본 연구는 국내에서 판매되고 있는 생수 15종을 대상으로 칼슘, 마그네슘, 불소의 농도를 측정하였고, 생수 내 무기물 함량의 표기 여부 및 무기물 농도를 비교, 검토하여 다음과 같은 결론을 얻었다. 1. 15개의 생수 중 1개의 생수를 제외하고 모두 칼슘함량을 표기하였다. 평균 칼슘농도는 34.68±31.84 mg/L, 최대 12.891±1.85 mg/L, 최소 2.0±0.02 mg/L이었다. 2. 15개의 생수 중 2개의 생수를 제외하고 모두 마그네슘 함량을 표기하였다. 평균 마그네슘 농도는 9.22±11.06 mg/L, 최대 30.43±0.75 mg/L, 최소 0.0 mg/L이었다. 3. 15개의 생수 중 4개의 생수를 제외하고 모두 불소 함량을 표기하였다. 평균 불소 농도는 0.25±0.33 mg/L, 최대 1.13±0.04 mg/L, 최소 0.01±0.03 mg/L이었다. 모두 생수는 현행 먹는 샘물 기준치인 2 mgF/L 이하에는 만족시켰다. Drinking water has lots of minerals, especially calcium, sodium, kalium, magnesium, and fluoride must be labelled on the bottle about their contents. Minerals like calcium, magnesium, and fluoride have influence to the tooth development. Appropriately taking some minerals, dental caries can be prevented somewhat degree. There is no guide line about innoxious minerals like calcium and magnesium, however, noxious mineral like fluoride, should be contained less than 2 mgF/L according to the current drinking water standard. Hereupon, it is necessary to recognize the concentration of fluoride in drinking water, so I studied 15 samples of domestic drinking water on sale about the concentration of calcium and magnesium, fluoride. The results obtained were as follows ; 1. 14 drinking waters in 15 samples showed various Ca concentration. The average Ca concentration is 34.68±31.84 mg/L. the highest is 128.91±1.85 mg/L and the lowest is 2.0±0.02 mg/L. 2. 13 drinking waters in 15 samples indicate the Mg concentration. The average concentration is 9.22±11.06 mg/L. the highest is 30.43±0.75 mg/L and the lowest is 0.0 mg/L. 3. 11 drinking waters in 15 samples indicate the F concentration. The average concentration is 0.25±0.33 mg/L, the highest is 1.13±0.04 mg/L and the lowest is 0.01±0.03 mg/L. All samples are satisfied the current drinking water standard, 2 mg F/L.

탄소섬유 프리프레그 외부 표면 적층방법에 따른 하이브리드 샤프트 진동특성

홍동표,김현식,홍용,고유곤,유청환 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Studies on carbon fiber epoxy composite is being conducted broadly in industries because of its specific stiffness, specific strength and good fatigue resistance. Because carbon fiber epoxy composite has high vibration characteristics, if existing metal material is alternated by carbon fiber epoxy composite, structure will be low weight, satisfy 1st bending natural frequency and have high fatigue resistance. In this study, research on to manufacture hybrid propeller-shaft using carbon fiber epoxy composite instead of current steel propeller shaft of rear wheel drive vehicle. For this, change of 1st bending natural frequency by the number of layers of carbon fiber epoxy composite on the outer surface of aluminum shaft was observed. Compared the change of 1st bending natural frequency by FEA with computer simulation and vibration test. Through this, the amount of increase in 1st bending natural frequency of hybrid shaft by the increase in number of layers of carbon fiber epoxy composite and high vibration characteristics of hybrid shaft was acknowledged.

마이크로 프레스 구동을 위한 기어시스템 개발

홍용,김현식,고유곤,홍동표,김성욱 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

In this paper, gear system for Micro-press actuator parts is developed. The micro-press system consists of AC geared servo motor, gear system and high precision ball screw. Herein, the micro-press gear system not only forms the micro thin foil valve but also forms the hydro dynamic bearing for a high precision rotational equipment, we analyzed the transmitted power capacity of gear system and torque, angular velocity of ball screw, because we are to select the appropriate servo motor and then we apply result of analysis to the micro press system. For the next step, we plan to study for the development of forming speed for a productivity with high precision.

마이크로 프레스 구동을 위한 기어시스템 개발

홍용,김현식,고유곤,홍동표,김성욱 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

In this paper, gear system for Micro-press actuator parts is developed. The micro-press system consists of AC geared servo motor, gear system and high precision ball screw. Herein, the micro-press gear system not only forms the micro thin foil valve but also forms the hydro dynamic bearing for a high precision rotational equipment. we analyzed the transmitted power capacity of gear system and torque, angular velocity of ball screw, because we are to select the appropriate servo motor and then we apply result of analysis to the micro press system. For the next step, we plan to study for the development of forming speed for a productivity with high precision.

初等學敎의 建築的 特性에 관한 硏究

나상훈,김유곤 서강대학 지역발전연구소 1999 지역발전연구 : 서강전문대 Vol.5 No.2

This study based upon theoretical contemplation has tried to analyze the composition of open school spaces of the elementary schools in Kwang-ju whose designs have been chosen by competition since 1990, and thereby to suggest both its problems and basic materials necessary for the construction of new type of school buildings. The results of this study are as follows: The school buildings are usually separated and arranged according to higher classes and lower classes, special classrooms and general classrooms, and classrooms and control offices. But there are usually pilots on the first floor, the other floors are connected directly and often there are arranged special rooms in connecting passages. School buildings, a gymnasium, and a play ground are common factors in every school. And there are small play grounds for lower class students or kindergarteners who have some difficulty in using play grounds, and these spaces are separated and arranged for higher class students, lower class students, and kindergarteners each. In many schools, the size of a unit classroom is the standard size of 67.5㎡. But it seems that a size of each unit classroom must be enlarged to utilize small spaces and to provide some spaces for open education.

漢文 敎科書 內의 漢詩 分析 硏究 : 第7次 高等學校 漢文 敎科書를 중심으로

박완식,김창용,김상곤,김유태,정인덕 전주대학교 교육문제연구소 2001 敎育論叢 Vol.16 No.-

폴록사머를 이용한 디클로페낙 고형 좌제의 개발

용철순,오유경,김정애,김용일,박상만,양준호,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

To develop a poloxamer-based solid suppository with poloxamer mixtures, the melting points of various formulations composed of P 124 and P 188 were investigated. To investigate the effect of poloxamer to the dissolution and dissolution mechanism of diclofenac sodium from the suppository the dissolution of diclofenac sodium delivered by the poloxamer-based suppository was performed. Furthermore, to investigate the mucoadhesive property of the poloxamer-based solid suppository, the identification test in the rectum was carried out after its rectal administration in rats. The poloxamer mixtures composed of P 124 and P 188 were homogeneous. Very small amounts of P 188 affected the melting points of poloxamer mixtures. In particular, the poloxamer mixture [P 124/P 188 (97/3%)] with the melting point of about 32℃ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, very small amounts of P 188 in the poloxamer-based suppository hardly affected the dissolution rates of diclofenac sodium from the suppository. Dissolution mechanism analysis showed the dissolution of diclofenac sodium was proportional to the time. At 4 h after administration, the blue color of poloxamer-based suppository [diclofenac sodium/poloxamer mixture (2.5/97.5%)] with the P 124/P 188 ratio of (97/3%) and blue lake in the rectum was faded. However, the position of suppository in the rectum did not significantly change with time. Thus, it retained in the rectum for at least 4 h. Our results indicated that the poloxamer-based solid suppository with P 124 and P 188 would be a candidate of rectal dosage from for diclofenac sodium.