두개강내 출혈을 동반한 불응성 특발성 혈소판감소성 자반증의 CYCLOPHOSPHAMIDE 치험 1예

서정철,양태영,최연수,박유환,김완중,허경,정원영,정춘해 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Idiopathic thrombocytopenic purpura(ITP) is an autoimmune bleeding disorder characterized by the development of antibodies to one's own platelets, which are then destroyed by phagocytosis in the spleen and liver. Its clinical manifestations are characterized by bleeding and the most serious complication is hemorrhage into the central nervous system, but which is rarely seen below 1%. In treating IPT, the therapy of first chice is administration of adrenocorticosteroid and r-globuline. If satisfactory results are not obtained, then splenectomy is recommended. If this also proves inadequate, then administration of immunosuppressants is carried out. 16-year-old male was admitted with complaints of left hemiplegia and nasal bleeding. This case may be developed spontaneous intracerebral hemorrhage causing thrombocytopenia and was treated by steroid, r-globuline and splenectomy, but satisfactory results are not obtained. After all, the paient was successfully treated with cyclophosphamide.

좌측흉수로 발현된 Boerhaave 증후군 1예

이준,변유미,조민근,조주연,원경준,김영대,박찬국,김만우,유재근,서홍주,이석기 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

구토 후 발생한 토혈을 주소로 내원한 환자에서 좌측 늑막 삼출 동반 시 식도 파열의 가능성을 고려하여 흉수 천자 및 지속적인 흉부 단순 촬영의 추적관찰이 필요하며 식도 파열이 배제된 후 환자의 생체 징후 및 토혈 양을 파악하여 내시경 검사 시기를 신중히 결정하는 것이 좋을 것으로 생각된다. 본 증례는 토혈을 주소로 내원하여 Mallory-Weiss 증후군 의심 하에 내시경을 통한 치료 시행 후 추적 관찰에 의해 진단된 Boerhaave 증후군을 경험하였기에 보고하는 바이다. Boerhaave's syndrome is a spontaneous perforation of the esophagus most commonly resulting from a sudden increase in intraesophageal pressure combined with negative intrathoracic pressure caused by straining or vomiting. Surgery should generally be performed within 24 hours because mortality approached 30 to 50 percent in which surgery was delayed. Therefore, early diagnosis and prompt surgical repair are critical for survival. We have experienced a case of Boerhaave's syndrome in a patient presenting with hematemesis with left pleural effusion without any signs or symptoms of pneumomediastinum or pneumothorax.

간경변 환자에서 Oro-cecal Transit Time의 측정

원경준,이준,변유미,조민근,조주연,서정균,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background: Neurotransmitter like substances in the gut have been proposed to contribute to the overall portal systemic encephalopathy (PSE). The source of the ammonia in patients with PSE is mainly the small bowel, as a result of the conversion of glutamine in the diet to glutamate and ammonia. PSE is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides such as lactulose. This study was performed to evaluate the relationship between PSE and oro-cecal transit time. In addition, performed to evaluate the effect of severity, cause, complications of liver cirrhosis on oro-cecal transit time. Methods: Between August 2006 and February 2007, 48 cirrhotic patients consecutively was enrolled in study their oro-cecal transit time after informed consent was obtained. A non-invasive hydrogen breath test was used to study oro-cecal transit time (OCTT). Result: The OCTT were delayed in cirrhotic patients with PSE compared without PSE (123.3 ± 42.7 min vs 170.0 ± 58.3 min, p<0.05). OCTT tended to prolongate further as the damage in the liver got worse, nevertheless the result was statistically meaningless (p<0.111). Neither presence of ascites or cause of PSE had any influence on gastrointestinal transit. Conclusions: Cirrhotic patients with PSE have more delayed OCTT than without PSE. Further research is needed to find out the relationship between OCTT and severity of liver cirrhosis.

Mycophenolic Acid와 Rapamycin이 흰쥐 사구체 혈관간세포증식과 세포외기질 생성에 미치는 영향

김명수,박제현,하헌주,허규하,서지연,김유선,김혜진,박기일 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14

Background: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such as vascular smooth muscle cells (VSMC) and glomerular mesangial cells cause chronic allograft nephropathy showing transplant vascular sclerosis and glomerulosclerosis. Mycophenolic acid (MPA) and rapamycin (RPM) are well known as strong inhibitors of VSMC proliferation, but their effects on the glomerular mesangial cells are not yet clearly understood. This study examined the effects of MPA or RPM on PDGF-induced proliferation and ECM accumulation in rat glomerular mesangial cells. Methods: Mesangial cells isolated from the glomeruli of Sprague-Dawley rats were cultured with DMEM containing 20% fetal bovine serum. Growth arrested and synchronized cells were administered with test drugs (MPA10 nM-10μM, RPM 0.1 nM-1μM) before the addition of PDGF 10 ng/mL. Cell proliferation was assessed by [³H]thymidine incorporation, collagen by [³H]proline incorporation, and fibronectin, ERK, and p38 MAPK by Western blot analysis. Results: PDGF increased mesangial cell proliferation by 4.64-fold. Compared to stimulated control, MPA above 500 nM and RPM above 10nM showed a significant inhibitory effect in a dose-dependent manner. The IC_(50) of MPA and RPM against PDGF-induced mesangial cell proliferation were around 500 nM and 100 nM, respectively. The collagen synthesis was also inhibited by MPA and RPM, but the fibronectin secretion was inhibited by MPA alone. The proliferation of mesangial cell correlated with activation of ERK and. p38 MAPK. MPA, but not RPM, inhibited ERK and p38 MAPK activation. Conclusion: This study demonstrated that MPA and RPM significantly inhibited PDGF-induced proliferation and ECM production in rat glomerular mesangial cells. The inhibitory effects of MPA, but not RPM, are correlated with ERK and p38 MAPK.

Immunohistochemical distributions of ClC-2 expression in the GABAergic interneurons following Febrile seizures (FS)

Yeon Hee Yu,Ji-Heon Jeong,Kahyun Lee,Shin Young Kim,Seo Yeon Kim,Ki Dam Kim,Dae-Kyoon Park,Kyung-Ho Park,Duk-Soo Kim 대한체질인류학회 2015 대한체질인류학회 학술대회 연제 초록 Vol.58 No.-

Associations of autism-like behavior and hippocampus functional disorder following hyperthermic convulsions

Yeon Hee Yu,Hyuna Im,Yejin Song,Seo Jeong Kim,Yu Ran Lee,Gun Woo Kim,Changmin Hwang,Hankyu Kim,Jeong-Oh Shin,Dae-Kyoon Park,Duk-Soo Kim 대한체질인류학회 2022 대한체질인류학회 학술대회 연제 초록 Vol.65 No.-

Positive Feedback Loop between Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-Beta1 during Renal Fibrosis in Diabetes

Seo, Ji Yeon,Park, Jehyun,Yu, Mi Ra,Kim, Yu Seun,Ha, Hunjoo,Lee, Hi Bahl S. Karger AG 2009 American journal of nephrology Vol.30 No.6

<P><I>Background/Aims:</I> Plasminogen activator inhibitor (PAI)-1 is increasingly recognized as a profibrotic factor but the mechanisms are not entirely clear. The present study examined the profibrotic mechanism of PAI-1 focusing on its effect on transforming growth factor (TGF)-β1 in experimental diabetes. <I>Methods:</I> PAI-1 knockout (KO) mesangial cells cultured under high glucose (HG) in addition to streptozotocin-induced diabetic PAI-1 KO mice were used. <I>Results:</I> PAI-1 deficiency did not affect plasma glucose significantly but reduced the fractional mesangial area, fibronectin and collagen I expression in the renal cortex after 20 weeks of diabetes as well as in HG-stimulated mesangial cells along with suppression of TGF-β1 mRNA expression. PAI-1 deficiency also reduced HG-induced βig-h3, a TGF-β1-induced gene product, mRNA expression. All these losses-of-function in PAI-1 KO mesangial cells were effectively gained by recombinant PAI-1. Recombinant PAI-1-induced fibronectin and collagen I expression was abrogated by TGF-β1 receptor inhibitor or anti-TGF-β antibody suggesting that the effect of PAI-1 was mediated by TGF-β1. In a similar context, recombinant PAI-1 stimulated TGF-β1 promoter activity to the same extent as TGF-β1 itself. <I>Conclusion:</I> Since TGF-β1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-β1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

Mental Health Nurses’ Experiences with Violence and Emotional Labor and Their Impact on Intent to Change Jobs: Mediating Effect of Resilience

Seo Yeon Yu,Ji Young Kim,Hye Young Kim 한국간호과학회 2019 한국간호과학회 학술대회 Vol.2019 No.10

운전자의 지역간 도로이미지에 의한 경로선택 요인분석

徐採演(Seo Chae-Yeon),李有玉(Lee Yu-Ok),成水鍊(Seong Su-Yeon) 대한국토·도시계획학회 1997 國土計劃 Vol.32 No.3

국내 모바일 오픈마켓의 사용성 평가항목 도출에 관한 연구

유서연(Yu, Seo Yeon),김관배(Kim, Kwan Bae) 한국디지털디자인협의회 2015 디지털디자인학연구 Vol.15 No.2

본 논문은 국내 모바일 오픈마켓 어플리케이션 인터페이스에서 고려되어야 할 사항과 불편사항을 알아보고, 사용성과 인터페이스에 관한 선행연구의 문헌조사를 토대로 모바일과 오픈마켓의 특성에 맞는 사용성 원칙과 평가 요소를 도출하며, 모바일 오픈마켓 어플리케이션의 사용성 평가항목을 작성하는 데 연구목적이 있다. 과거 온라인 쇼핑 시장의 거래는 대부분 PC에서 이루어진 반면, 현재는 모바일 기기로 쇼핑을 즐기는 모바일 커머스 시장이 화두로 떠오르고 있다. 모바일 쇼핑은 PC환경과 다른 화면구성 및 작은 화면, 서툰 입력 등의 주요 사용성 문제로 모바일 기기에 적절한 인터페이스 디자인이 요구된다. 이에 본 논문에서는 국내 오픈마켓 시장을 조사하여 이용자가 가장 많은 네 곳을 연구 대상으로 선정하였고, 이 네 곳의 모바일 오픈마켓 어플리케이션에 대하여 사용측면에서의 UI 고려사항과 불편사항을 설문조사를 통해 알아보았다. 그리고 설문조사 결과와 인터페이스 관련 선행연구의 분석을 통해 전문가 집단토론을 진행하여 모바일 오픈마켓 사용성 평가원칙을 체계화 하였다. 결론에서는 앞의 연구 내용을 토대로 사용성 평가원칙에 따른 모바일 오픈마켓 어플리케이션 인터페이스 디자인 사용성 평가항목을 도출하였다. 이는 현재 모바일 오픈마켓 어플리케이션의 문제점에 대한 보완 및 개선 방향을 제시한 것으로 향후 기존 어플리케이션의 사용성 향상에 기초기반 자료가 될 수 있을 것이다. In this thesis, we examine the matter and discomfort that should be considered in the application interface of mobile open market of domestic country, on the basis of the literature review of previous research on the ease interface of use is ongoing, and the characteristics of the mobile and open market derived the appropriate principles and evaluation elements of usability. In addition, there is an object of the present invention is to create a usability evaluation checklist of open market application of mobile. While the past of online shopping market transactions were carried out on most of the PC, currently mobile commerce market to enjoy shopping on mobile devices has become a hot topic. Mobile shopping, PC environment and other screen configuration and a small screen, the design of the appropriate interface is required to major mobile devices to usability problems such as poor input. Therefore, in this paper, to investigate the domestic open market, and to select the most often 4 locations by the user as a research subject, conduct a primary survey, the UI considerations in the use surface of the open market of mobile have examined the inconvenience. And, by proceeding the expert group discussion through the analysis of relevant prior research to the interface between the primary questionnaire survey results, codified the valuation principles of mobile open market usability. Conclusion was derived the design usability checklist of application interface of mobile open market in accordance with the principles of usability evaluation on the basis of the previous research. This is a problem with current mobile open market application solution and improvements, it is considered in developing applications with improved future usability can be the underlying basis of the data.