Serum Talin-1 is a Potential Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in Egyptian Patients

Youns, Mahmoud M.,Abdel Wahab, Abdel Hady A.,Hassan, Zeinab A.,Attia, Mohamed S. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide. The outcome of HCC depends mainly on its early diagnosis. To date, the performance of traditional biomarkers is unsatisfactory. Talins were firstly identified as cytoplasmic protein partners of integrins but Talin-1 appears to play a crucial role in cancer formation and progression. Our study was conducted to assess the diagnostic value of serum Talin-1 (TLN1) compared to the most feasible traditional biomarker alpha-fetoprotein (AFP) for the diagnosis of HCC. Methods: TLN1 was detected using enzyme linked immunosorbent assay (ELISA) in serum samples from 120 Egyptian subjects including 40 with HCC, 40 with liver cirrhosis (LC) and 40 healthy controls (HC). Results: ROC curve analysis was used to create a predictive model for TLN1 relative to AFP in HCC diagnosis. Serum levels of TLN1 in hepatocellular carcinoma patients were significantly higher compared to the other groups (p<0.0001). The diagnostic accuracy of TLN1 was higher than that of AFP regarding sensitivity, specificity, positive predictive value and negative predictive value in diagnosis of HCC. Conclusions: The present study showed for the first time that Talin-1 (TLN1) is a potential diagnostic marker for HCC, with a higher sensitivity and specificity compared to the traditional biomarker AFP.

디젤엔진개량에 의한 천연가스차량전환에 관한 연구

한영출(Youns-Chool Han),오용석(Yong-Suk Oh),나완용(Wan-Yong Rha) 한국공작기계학회 1999 한국공작기계학회지 Vol.8 No.2

TALENs Construction: Slowly but Surely

Hegazy, Wael Abdel Halim,Youns, Mahmoud Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Cancer is thought to be a direct result of transcriptional misregulation. Broad analysis of transcriptional regulatory elements in healthy and cancer cells is needed to understand cancer development. Nucleases regulatory domains are recruited to bind and manipulate a specific genomic locus with high efficacy and specificity. TALENs (transcription activator-like effector nuclease) fused to endonuclease FokI have been used widely to target specific sequences to edit several genes in healthy and cancer cells. This approach is promising to target specific cancer genes and for this purpose it is needed to pack such TALENs into viral vectors. There are some considerations which control the success of this approach, targeting appropriate sequences with efficient construction of TALENs being crucial factors. We face some obstacles in construction of TALENs; in this study we made a modification to the method of Cermk et al 2011 and added one step to make it easier and increase the availability of constructs.

사료(史料)로 살펴본 윤성덕(尹聖德)의 삶과 음악 활동

장정윤 ( Chang Jeong Youn ) 한국음악학학회 2021 음악학 Vol.29 No.1

본 논문은 근대 시기 음악유학을 경험한 여성 음악가 윤성덕(尹聖德, 1903~1968)에 대한 연구로서 지금껏 알려지지 않은 그녀의 삶을 당시의 신문기사, 잡지, 유학 기관에서의 기록, 미국 이민국 서류 등 새롭게 발굴한 1차 자료를 통해 구체화하고 음악 활동을 살펴보는 것에서 출발한다. 윤성덕의 삶과 음악 활동은 크게 세 시기로 나누어 살펴볼 수 있다. 첫 번째 시기는 평양의 기독교 가정에서 자라고 이화학당에서 교육을 받으며 음악에 대한 꿈을 키운 시기이며, 두 번째 시기는 선교사들의 전폭적인 지원을 받아 미국 유학을 경험하고 이후 이화여전의 교수로 부임하여 음악 교육시스템의 발전에 헌신한 시기이다. 그리고 세 번째 시기는 미국의 발전된 최신 음악 교육시스템을 경험하고 조선으로 도입하기 위해 이화여전 교수의 신분으로 다시 미국으로 건너간 이후이다. 윤성덕의 삶과 활동 전반에 나타난 음악에 대한 소명은 개인적인 성공과 명성을 위한 자아실현보다는 당시의 기독교와 여성 교육정책이라는 강력한 영향 아래에서 음악교육자의 모습으로 발현되었다. 또한 그녀는 김애식 이후 이화학당출신 미국음악유학생으로 김메리, 김영의같이 보다 많은 여성 음악가들이 선교사들의 네트워크와 지원을 통해 미국 유학을 경험하고 귀국하여 이화에 교육자로 투입되는 연장선의 시작점에 있다. 본 연구는 윤성덕이라는 인물의 삶과 음악 활동을 보다 구체화하고 관련 인물들을 밝힘으로써 한국 근대 초기에 활동한 여성 음악가의 갈등과 욕망을 심도 있게 살펴볼 수 있는 계기를 마련할 것이다. This paper is a fundamental study on Mary Sungduk Youn (尹聖德, 1903~1968), a female musician who studied abroad in early modern Korea, and starts to discover her life and her musical activities based on primary sources and historical records such as newspapers, magazines, copies of personal documents and the records from the universities and the archives in the U.S. Based on them, Youn’s life can be divided into 3 periods. The first period is the time when she was raised and educated under the Christian family and Ewha Haktang. And the second is the time when she went abroad to study music in the U.S., supported by several missionaries involved in Ewha College and the time she devoted herself as a professor to improve the music educational system of Ewha College after coming back from America. The last is the time after she revisited the U.S. for having experience on the latest music educational system and for introducing it to Ewha College. The vocation for music that appeared throughout Youn’s life and activities was manifest as a music educator under the strong influence of Christianity and women’s education policy rather than self-actualization for personal success and fame. And Youn was an important figure after Alice Kim (1890~1951) who was the first music educator going abroad to study in the U.S., and as a pioneer Youn was at the beginning of studying abroad of female musicians such as Mary Chesik Kim (1906~2005) and Youngyi Kim (1908~1986), supported by missionaries within their strong network. By discovering Youn’s life and musical activities with the people involved, this study will provide the opportunity to examine the conflicts and desires of female musicians who were active in the early modern Korea.

Effect of oxidation states of vanadium precursor solution in V₂O₅/TiO₂ catalysts for low temperature NH₃ selective catalytic reduction

Youn, S.,Jeong, S.,Kim, D.H. Elsevier Science Publishers 2014 CATALYSIS TODAY - Vol.232 No.-

In this study, we aimed at finding the optimum condition to prepare V<SUB>2</SUB>O<SUB>5</SUB>/TiO<SUB>2</SUB> catalyst for the selective catalytic reduction with NH<SUB>3</SUB> (NH<SUB>3</SUB>-SCR) by changing oxidation states in vanadium precursor solution. Using three precursor solutions with different oxidation states (V<SUP>3+</SUP>, V<SUP>4+</SUP> and V<SUP>5+</SUP>), TiO<SUB>2</SUB> supported V<SUB>2</SUB>O<SUB>5</SUB> catalysts (1, 3, 5 and 7wt%) were prepared by applying wet impregnation method. We utilized various analytical techniques, such as N<SUB>2</SUB> adsorption-desorption with BET method, inductively coupled plasma (ICP), X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance spectroscopy (UV-Vis DRS) and temperature programmed reduction with hydrogen (H<SUB>2</SUB> TPR) to investigate the physicochemical properties of V<SUB>2</SUB>O<SUB>5</SUB>/TiO<SUB>2</SUB> catalysts. In addition, the SCR reactivity of these catalysts was evaluated to obtain a structure-activity relationship. It was found that V<SUB>2</SUB>O<SUB>5</SUB>/TiO<SUB>2</SUB> catalysts prepared from the precursor solution of V<SUP>3+</SUP> oxidation state (VT(3+)) has good activity over wide temperature range and selective to N<SUB>2</SUB> production, respectively. Also, they produced the least amount of N<SUB>2</SUB>O during SCR reaction, which is beneficial from the view point of greenhouse gas emission. The superiority of low temperature Such desirable reaction behavior of the VT(3+) catalyst is attributed to the formation of highly coordinated polymeric vanadyl species on the sample.

白耕 金茂圭의 風流 硏究

具潤國(Koo Youn-Kook) 한국전통음악학회 2005 한국전통음악학 Vol.- No.6

필자가 1962년부터 국립국악원에 부임 이후 오늘날까지 절실히 느낀 점은 명인들이 세상을 떠나면 그 유품은 물론 귀중한 자료들도 같이 사라진다는 사실이었다. 그래서 시작한 것이 거문고 명인들의 유음이나 악보 등을 찾아야 되겠다는 일념으로 오늘에 이르고 있다. 생존해 있는 분들은 직접 녹음이나 비디오로 촬영을 하였고, 작고한 분들은 유음이나 악보 등을 구하려고 노력하였으나 얻은 것은 별로 없다. 지난날들이 그렇고, 지금도 우리민족의 정신이요 우리의 귀중한 문화유산이 이 땅에서 영원히 사라져 가고 있음은 실로 안타까운 일이 아닐 수 없다. 백경 김무규 선생은 일찌기 추산 전용선 선생께 단소풍류를 배워 후계 양성과 개인 발표도 하였으나 얼마나 원형대로 전수되었고 전승되고 있는지 필자는 잘 알지 못하고 있다. 또한 조선 정악전습소에서 우당 김윤덕에게 배운 거문고 풍류는 전승자가 없는 것으로 알고 있다. 조선 정악 전습소가 설립된 지 100년이 다 되어 가고 있지만 당시의 거문고 교수인 김경남, 조이순, 고익상, 김윤덕 등등… 이들의 가락은 물론, 이력사항, 생몰연대까지 찾을 수 없는 것이 현실이다. 한편 국악기의 개량, 국악의개선 국악의 현대화 등등이 물결치고 있는 것이 지금 국악계의 현실임을 간과할 수 없다. 그러나 이러한 상황을 인정하지 않는 것은 아니다. 다만 우리의 전통음악이 변질 되고 원형을 잃어 가는 현싯점에서 원형을 잃은 개량과, 개선 그리고, 현대화는 개악과 변질에 이르러 결국 국적 없는 음악으로 전락할 가능성이 높다는 것이 필자의 생각이다. 그리하여 늦었지만 닞혀진 옛 금사들의 유음을 다시 보존 전수해야한다는 일념에서 拙稿(졸고) “백경 김무규의 풍류 연구”라는 글을 쓰게 된 것이다. 풍류는 크게 2가지로 나눌 수 있다. 하나는 국립국악원 계통의 음악이고 또 하나는 정악원 계통의 음악이다. 국립국악원 계통의 풍류와 정악원 계통의 풍류는 서로 같거나 비슷한 것 같으나 상당부분 다른 점을 발견할 수 있다. 몇 가지 차이점만을 골라 보면 다음과 같다. 1) 악곡명은 다른 점이 별로 없고 비슷한 이름을 쓰는데 이는 같다고 보아진다. 2) 연주 순서는 현행 가진 회상과 같다. 3) 각 악곡별 악장 구분 및 악장의 각 수가 서로 다르다 4) 각 가락에서 음을 한음씩 나누어 비교해 보면 음이 서로 다른 경우가 많다. 5) 뜰동이 서로 다르고 출현회수도 다르게 내는 경우가 많다. 6) 정악원계통은 음을 생략하는 경우가 많은데 주로 동음 생략, 장2도 하행 생략, 그리고 단3도와 완전 4도 하행음의 생략이 많다. 7) 정악원 계통은 첨가음(잔가락)이 많은데 1)동음의 첨가 2)완전 4도 상행음과, 하행음 첨가 단3도, 장2도의 첨가 등을 들 수 있다. 8) 박의 한배가 다르다 국악원 계통이 1박을 낼 때 1/3을 낸다던가 2/3를 내는 경우 등등이다. 9) 리듬이 세분화되어 있는 경우가 많다. 10) 리듬에 있어 같은 음으로 구성되어 있거나 전연 다른 음으로 구성 된 경우가 많다. 11) 영산회상을 연주 할 때는 현행 다스름과 다른 21박정도의 다스름을 반드시 연주한다. 이상 국립국악원 계통의 풍류와 정악원 계통 풍류를 비교하여 본 결과 차이점이 많음을 발견 할 수 있다. 또한 같은 정악원 계통의 풍류라고 해도 지방에 따라 그 곡태가 다른데 중부지방과 전라도 지방의 차이가 바로 그것이다. 전라도 지방의 풍류는 그 흐름과 떠는음(bivrato) 농현 등에서 거의가 산조풍의 음악이라는 점이다.(초숙자, 경주 이말량) Since I have been appointed to Kungrip Kugawon (The National Center for Korean Traditional Performing Arts) in 1962, it makes my heart hurt to see after a master died, all their articles and precious things are disappeared with their death. That's why I decided to find the musical notes of the masters of Korean harp. So I took a photograph of living experts with sound recording and videotapes, also tried to get musical notes of past masters. But it wasn't that easy and I couldn't get satisfactory results. It makes me feel sorry to see disappearing all our cultural heritages which also means spirits of Nations in this country. Baekyoung Mu-Kyu Kim learned a short bamboo flute from Choosan Yong-Sun, Cheon and trained students and presented. But I don't know if it is being inherited well or not. Also Poongliu of Korean harp from Woodang Youn-Duck Kim in Chosun Classical Music Institute hasn't been taught anyone. About 100 years have passed after Chosun Classical Music Institute had found, but nowadays it is very hard to find their melodies, career and period of master Kyung-Nam Kim, E-Soon Cho, Ik-Sang Go, Youn-Duck Kim and so on.. In Korean Classical Music society, Korean Classical Music and instruments are developing and Korean Classical Music is being modernized. But if we lost our original form, the more we change our music the more our music will be in the state of disorder and chaos and lose nationality. In this reason I begin to write this “A Study on Poongliu of Baekyoung Mu-Kyu Kim”. Poongliu can be divided into two kinds. One is the kind of Kungrip Kugawon and the other is Jeongakwon. Both seem the same but there are some differences as followings : 1) Both of them use same names as the titles of musical compositions. 2) Both of them have the same performing order of the current Kazunhoesang. 3) However, dividing section and the numbers in each movement are different. 4) If analysing one note in terms of one beat, a lot of different notes are noticed. 5) ‘Teuldong’ is different and doesn't appear the same. 6) In Jeongakwon, a note is usually left out when it is the same note, the major 2degree one, the minor 3 degree one, or the perfect 4 degree one, etc. 7) In Jeongakwon, adds a note when it is the same note, the perfect 4 degree one, the minor 3 degree one, the major 2 degree one. 8) The length of one beat is different, too. 9) Rhythms are subdivided frequently. 10) Rhythms are made of same notes or entirely different notes. 11) When play Youngsanhoesang, play 21 beats surely. There are lots of differences between Kungrip Kugawon Poongliu and Jeongakwon Poongliu. Besides same kind of Kungrip Kugawon Poongliu differs from place to place ; Central province and Ch?lla-do province. Poongliu of Ch lla-do is kind of Sanjo style in each current and vibrato Nonghyun.

非營利機關會計

尹允錫 光云大學校 1984 論文集 Vol.13 No.-

Until the 1920s, nonbusiness accounting was approximately the same as business accounting, although both were fairly crude compared with today's business accounting. In the 1920s, nonbusiness organizations become enamored of the concept that is now called fund accounting. But, in recent years, governments and other nonbusiness organizations have experienced dramatic growth and have emerged as major economic, political and social forces in our society. A nonbusiness organization is a accounting entity which is operated for the benefit of society. Nonbusiness accounting is the process of identifying, measuring and communicating economic information to permit informed judgements and decisions by users of information in nonbusiness organizations. A fund is a independent fiscal and accounting entity with a self-balancing set of accounts recording cash or other resources which are segregated for the purpose of carrying on specific activities in accordance with special limitations. The accural basis used in the enterprises accounting is not completely applied in nonbusiness accounting area. This is caused by the fact that income determination is not needed in nonbusiness accounting. In many nonbusiness organizations, the fixed assets are not capitalized by cash basis but this makes it impossible to allocate the cost used. It is needed to capitalize the fixed assets and to depreciate them. FASB has published the Statement of Financial Accounting Concepts. No. 4 (Objectives of Financial Reporting by Nonbusiness Organizations) Objectives of financial reporting are as follows : The objectives begin with a broad focus on information that is useful to resource providers and other users in making rational decisions about allocating resources to nonbusiness organizations. Financial reporting by nonbusiness organizations should provide information that is useful to present and potential resource providers and other users in making rational decisions about the allocation of resources to those organizations. They are interested in that information because the services are the end for which the resources are provided. Financial reporting should provide information that is useful to present and potential resource providers and other users in assessing how managers of a nonbusiness organization have discharged their stewardship responsibilities and about other aspects of their performance. Financial reporting should provide information about the economic resources, obligations, and net resources of an organization and the effects of transactions, events and circumstances that charge resources and interests in those resources. The accomplishments of nonbusiness organizations generally cannot be measured in terms of sales, profit or return on investment. The primary purpose of this paper is to outline the framework of nonbusiness accounting in the United States, and to promote this area in our nation. The results of study reveal that nonbusiness accounting is neglected discussing areas which have been covered accounting fields, in both the United States and our nation. As nonbusiness accounting principles and procedures are absent or insufficient, accountants will cover new principles, theory, managerial techniques of nonbusiness accounting.

國際的 租稅回避와 規制에 관한 硏究

윤윤석 光云大學校 1990 論文集 Vol.19 No.-

International tax avoidance has been a pervading economic and political issue in recent years. Under the contemporary economic environment in Korea, various researches on international tax avoidance are to be implemented. Korea requires the oversea business activities in advanced forms by opening the liaison offices, branch offices, subsidiary companies in foreign countries. Objectives of this study is to detect a probable way of tax avoidances in oversea business activities and searches for the alternatives of regulations to prevent tax avoidance. The types of international tax avoidance are transfer pricing, treaty shopping, tax havens. International double taxation is caused by conflicts of taxation laws between countries. Tax convention means the treaty concluded between two nations or multi-nations. The purpose of such a tax convention lies in solving disputes arising in taxation by taking close connections between the parties of the convention and preventing tax avoidance. It is the intent- ion of tax convention to adjust the competing taxation rights of the parties by concluding the tax convention and setting up international taxation regulations.

한국의 수출과 실질소득 및 인적자본 간의 동태적 인과관계

정용석 동아대학교 동아시아연구원 2007 동아시아 : 비교와 전망 Vol.6 No.2

한국은 전통적으로 매우 높은 교육열과 수출지향공업화의 정책이 서로 상승작용을 하면서 높은 경제성장률을 이끌어 낸 국가로 인식되어 있다. 본고의 목적은 한국의 1968-2006년의 기간 동안 이들 3변수간의 인과관계의 존재를 살펴보고자 한 것이다. 이를 위해 본고는 한국의 실질소득과 수출 및 인적자본간의 공적분과 인과관계를 검정해 보고, 이를 확장하여 모형의 적합성과 안정성을 검토해 보았으며, 그 변수들 간의 외생성의 정도를 분산분해와 충격반응함수로써 고찰해 본 것이다. 공적분검정과 인과관계 검정의 결과는 다음과 같다. (1) 수출 혹은 인적자본이 종속변수일 때 실질소득과 수출과 인적자본 간에는 각각 공적분이 존재하였다. 하지만 인적자본이 종속변수일 때는 공적분 관계는 존재하지 않았다. (2) 장기에는 실질소득과 실질수출은 양방향 인과관계가 나타났으며, 인적자본은 수출과 실질소득 양자에 대해 인과관계를 나타내었다. (3) 단기에는 실질수출이 실질소득과 양방향 인과관계를 나타내었다. 그러나 수출과 실질소득 모두 인적자본에 대해서는 중립적으로 나타났다. The aim of this paper is to test the causal relationship between exports, real income and human capital using data for Korea over the period 1968?2006. For it, this paper used cointegration and error-correction modeling and extended this analysis to variance decomposition analysis and impulse response functions. The results of the test suggest that (1) real exports, human capital and real income are cointegrated when real exports or human capital is the dependent variable, but are not cointegrated when human capital is the dependent variable. (2) In the long- run, there is bi-directional Granger causality between real income and real exports. And there is uni-directional Granger causality running from human capital to real exports and real income. (3) In the short-run there is bi-directional Granger causality between real exports and real income.

Sedimentation Rate and Transport Features of Suspended Matter in the Changjiang Estuary and Adjacent Continental Shelf

윤정수,박상운,고윤영,오윤근 제주대학교 해양연구소 2000 해양자원연구소연구보고 Vol.24 No.-

The study area is situated between 31˚00' ~ 33˚30' N and 122˚30' ~126˚00' E as a part of the East China Sea continental shelf. The distribution of sediment in the study area can be classified three sedimentary types. Modern land derived muddy sediments consisting of silt and mud are distributed at mouth of the Changjiang River. and are also observed the southwest offshore of the Cheju Island. The sandsilt-clay miadre sediments are presented in the outer shelf area. The relict sand are distributed between the mordern and mixture sediment. The inner-shelf mud consisted of 8.89% sand. 59.05% silt. 32.06% clay and mean size of 6.90Φ. The offshore mud composed of 5.83% sand. 34.54% silt. 59.63% clay and mean size of 8.32). and also have higher water content and organic carbon. The C/N ratio showed higher in the inner-shelf mud (10.14) rather than that of the offshore mud (8.68). Most of the Changiiang River suspended matter is entrapped in the area around the Changjiang Estuary to the west of 123˚30' E. Only a small part of the suspended matter can be moved by Changjiang Diluted Plume to the southeastern and northeastern middle shelf. The higher suspended matter concentration gradient zone are observed in the northwest central region, and this plume zone separated from Changjiang Estuary by a low oncentration of less than 5 mg/ l or 15 mg/ l. The sediment accumulation rate in the inner shelf mud deposit near the mouth of the Changjiang River is 1.70 cm/yr and characterized by physical stratified mud. The sedimentation rate in the offshore mud deposit to the southwest of Cheju Island shows 0.28 cm/yr and characterized by homogenous mud. The difference in fine-scale stratigraphy is explained by the ratio of mixing rate to accumulation rate, which is much larger for the offshore mud deposit (27.34) than for the inner shelf mud deposit (1.65). these larger ratio allows biological mixing to destroy physical stratification.