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Ahn, Youngmee,Sohn, Min,Lee, Sangmi Blackwell Pub 2014 JAPAN JOURNAL OF NURSING SCIENCE Vol.11 No.4
<P>The physical growth of mild preterm infants (<32?weeks of gestation at birth) needs to be explored in terms of bio-sociocultural factors considering the sociocultural aspects of child-care practice.</P>
Growth patterns and their implications for preterm infants in a culture of rapid modernization
Ahn, Youngmee,Sohn, Min,Jun, Yonghoon,Lee, Sangmi SAGE Publications 2013 Journal of child health care Vol.17 No.3
<P>This prospective longitudinal study explored the growth patterns of preterm infants and the implications of rearing them in an advancing culture. The study measured the weight, length, and head circumference of 343 Korean preterm infants over 12 months corrected age. Data were analyzed using a generalized estimation equation for growth patterns of preterm infants by the degree of prematurity (mild, moderate, or severe). Results showed that the early ‘catch-up phenomenon’, accelerated growth rate, occurred around 11 months corrected age, although the mild preterm group weighed less, was shorter, and had a smaller head circumference than the moderate and severe preterm groups. This may reflect the Asian culture’s preference for big babies and draws special attention to the influence of cultural values and childrearing practices in the growth of preterm infants. Pediatric nurses should be alert to accelerated growth in preterm infants in societies in cultural transition.</P>
고위험신생아의 생후 초기 표피 pH, 온·습도와 산성덮개 형성 요인
안영미(Ahn, Youngmee),손민(Sohn, Min),이상미(Lee, Sangmi),이미진(Lee, Mijin) 한국간호과학회 2013 Journal of Korean Academy of Nursing Vol.43 No.1
Purpose: The study was done to explore variations in physiologic parameters of the stratum corneum (SC) of the dorsal hand and cord area during early days of life in high-risk newborns. Methods: In this longitudinal study, a total of 77 high-risk newborns were assessed for pH, temperature and hydration of the SC of the dorsal hand and the cord area on the 1st, 2nd, 3rd, 5th and 7th days of life. Results: Results showed that an acid mantle (AM) was formed in 57.1% for dorsal hand and 35.1% for cord area, implying significant delay regardless of decrease in pH (F=103.60, p<.001), and hydration (F=4.00, p=.003) across days in both areas. Peripheral hypothermia with low hydration level was also observed in both areas. There was a positive relation between hydration and temperature (.14<r<.27, p<.010), and negative relation between hydration and pH in both areas (-.23<r< -.15, p<.010). Antibiotics may play a positive role in AM formation. Conclusion: High-risk newborns may experience delay in acid mantle formation on SC, hypothermia and decreases in hydration on peripheral sites during the first 7 days of life.
Ahn, Jeonghyun,Jee, Youngmee,Seo, Ilseon,Yoon, Seung Yong,Kim, DongHou,Kim, Yoo Kyum,Lee, Heuiran Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of medical virology Vol.80 No.3
<P>Coxsackievirus B (CVB) is one of the major pathogens of aseptic meningitis and meningioencephalitis, particularly in newborn infants. To analyze the influence of neural maturation on susceptibility to CVB infection, we prepared immature and mature neurons from 16-day-old BALB/c embryonic cortex. In contrast to immature neurons, mature neurons were less susceptible to CVB5 infection, as indicated by the decrease of cytopathic features. In mature neurons, progeny virus production was significantly hindered, and virus capsid protein VP1 synthesis and virus genome amplification were concomitantly reduced. In addition, the expression of coxsackievirus and adenovirus receptor (CAR), the major receptor of CVB5, was down-regulated in mature neurons. The antibody treatment specific to CAR significantly attenuated CVB5 susceptibility of immature neurons. These findings demonstrate that mature neurons become less susceptible to CVB by the decrease of CAR level. Thus, the data strongly support the idea that the level of virus receptor in neurons is one of the crucial determinants in the age-dependency of CVB virulence in central nervous system. J. Med. Virol. 80:434–440, 2008. © 2008 Wiley-Liss, Inc.</P>
비만 생쥐모델의 폐약(肺弱)을 유발하기 위한 Bleomycin의 농도 결정 연구.
고영미,장순우,안택원 大田大學校 附屬 韓方病院 2020 惠和醫學 Vol.29 No.1
Objectives : The objectives of this study is to develop a mouse model similar to Taeeum-type by inducing Lung fibrosis with bleomycin, and to determine adequate concentration of bleomycin. Methods : The subjects were divided into six groups: normal, obesity induced group, and bleomycin administered 0.015U, 0.03U, 0.06U, and 0.09U(U/100g bw) concentrations respectively. Each concentration of bleomycin was dissolved in distilled water, and administered through Intra-Nazal-Trachea injection method. Food intake and body weight were measured at regular time weekly. At the end of the experiment, blood was gathered by cardiac puncture for biochemical examinations, organs were removed for histological examinations, and weigh and mRNA genes was analyzed. Result : Mice administered with bleomycin at 0.015U and 0.03U showed body and fat weight gain, and increased blood total cholesterol, LDL-cholesterol, glucose, and free fatty acid level. Fat related genes also showed higher level than the control group. Obesity was most strongly induced in the mice administered with 0.03U of bleomycin. On the other hand, when bleomycin was administered at concentrations above 0.06U, a model of obesity mouse was not created due to rapid emphysema inflammation and weakness. Conclusions : Mice were most vulnerable to obesity when bleomycin was administered at a concentration of 0.3 to cause liver damage. Bleomycin concentration over 0.06U did not cause obesity-induced mice, due to severe damage in liver.
지영미,천두성,최우영,안정배,김기순,정윤석,이지원,이강범,노효송,박귀성,이선화,김성한,조경순,김은선,정재근,윤재득,조해월 대한감염학회 2004 감염과 화학요법 Vol.36 No.5
Purpose : We identified the causative viruses from patients with aseptic meningitis, acute hemorrhagic conjunctivitis and other enterovirus-related diseases to understand the epidemiological patterns and prevailing strains of enterovirus infections each year. Materials and Methods : During 1999-2003, we examined 3,260 specimens from 2,939 patients with aseptic meningitis or other clinical manifestations for the presence of enteroviruses by using both cell culture/ neutralisation test and reverse transcription-polymerse chain reaction-sequencing. To investigate the etiological agents which caused an epidemic of acute haemorrhagic conjunctivitis, conjunctival swab samples from acute haemorrhagic conjunctivitis patients showing cytopathic effects in HEp2 cells were tested by enteroviral specific PCR. Results : We identified 603 isolates of enteroviruses (20.5%) among 2,939 cases and 22 serotypes of human enteroviruses were isolated during this 5 year period. Echovirus 13 and coxsackievirus A24 in 2002 and coxsackievirus A9 in 2003 were the first enterovirus to be indentified in Korea since we began the enterovirus surveillance in 1993. While an epidemic of echovirus 13 infection in Korea began in Gwangju and Jeolla province in 2002 and spread to Seoul, Gyunggi, Busan, Ulsan and other regions, echovirus 6 isolates in 2002 were mainly detected in Busan specimens and some Gwangju samples. From the nucleotide sequencing of enteroviral PCR products of conjunctival swab specimens, we found 85% nucleotide homology to coxsackievirus A24 (D90457). Conclusions : We isolated 603 enteroviral isolates among 2939 cases during 1999-2003. Echovirus 13 and coxsackievirus A24 were the first enterovirus to be identified in Korea and caused nationwide epidemics in 2002. 목적 : 1999-2003년 기간 중 국내의 무균성 수막염, 수족구병, 포진성구협염, 급성 출혈성 결막염 등 엔테로바이러스 감염 의심환자로부터 엔테로바이러스 검출하고 유전자 분석을 실시하여 국내에서 유행하는 엔테로바이러스의 형을 확인하고자 하였다. 재료 및 방법 : 동 기간 중 총 2,939건으로부터 3,260개의 검체가 의뢰되었으며 바이러스 분리를 위한 세포배양/중화시험과 유전자 분석을 병행하여 수행하였다. 결과 : 총 2,939건 중 603건(20.5%)에서 바이러스가 분리되었으며 2000년에 엔테로바이러스 71형과 2002년 중 에코바이러스 13형, 콕사키바이러스 A24형 등을 분리하였으며 분리주간 상동성도 99-100%로 같은 유전자형의 바이러스가 국내유행을 일으킨 것을 확인하였다. 결론 : 1999-2003년 중 총 2,939건 중 603건에서 엔테로바이러스를 분리하였으며 특히 2002년 중 무균성 수막염과 급성출혈성 결막염 환자로부터 에코바이러스 13형과 콕사키바이러스 A24형을 국내에서 최초로 분리하였다