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BALB/c 생쥐에서 천식 발생에 대한 dehydroepiandrosterone의 억제효과
최용,최인선,고영일,고영아,이현철 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : Dehydroepiandrosterone(DHEA). and adrenal androgen, may regulate Th1/Th2 cytokines. Objective : To determine whether DHEA have a preventive effect against the development of asthma, a Th2-associated disease. Materials and methods : Female BALB/c mice were fed with a standard diet incorporated with 0.1% (w/w) of DHEA for 1 week before sensitization with ovalbumin(OVA. 20㎍ i.p. twice with 2-week intervals). Enhanced pause (Penh) was monitored after 1% OVA inhalations for 3 successive days, and then the methacholine bronchoprovocation tests were performed using a whole-body plethysmography system. Analyses of inflammatory cells, cytokines, and OVA-specific IgE were carried out. Results : Both the excessive airway narrowing (maximum Penh) and the airway hypersensitivity (PC200, ㎎/mL) to methacholine were significantly suppressed with the DHEA pretreatment (F<.05 and F<.01, respectively). However, the numbers of the inflammatory cells and the levels of interleukin(IL)-4, IL-5, and IFN-γ in the bronchoalveolar lavage fluid, the production of IL-4, IL-5, and IFN-γ by Con A-stimulated splenocytes, and the serum IgE level in DHEA group were not significantly different from those in asthma group. Conclusion : DHEA pretreatment could suppress the development of asthmatic airway hyperresponsiveness without suppression of Th2 cytokines and airway inflammation. (J. Asthma Allergy Clin Immunol 24 : 116-26, 2004)
천명이 있으면서 정상 폐환기 기능 성적을 보인 천식 환자의 임상 분석
최인선,임호,고영일,정세웅 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : Wheezing is one of the characteristics of asthma. Intensity of wheezing is correlated with the severity of airway obstruction. However, some asthmatic patients may show wheezing despite normal ventilatory function. Objective : To determine the cause of wheezing in asthmatic patients with normal ventilatory function. Methods : Thirty-eight consecutive asthmatic patients with wheezing despite FEV 180% of predicted value were retrospectively examined for clinical data. Results : Twenty-seven patients (71.1%) were women. Sixteen patients (42.1%) showed airway obstruction based on the Intermountain Thoracic Society criteria. Patients with airway obstruction had significantly lower FEF50% than did those without it (F<.001). When the patients with no wheezing were re-examined by the pulmonary function test, 14 patients (48.3%) showed a significant bronchodilation. In patients without airway obstruction, FEF50/FIF50 was significantly higher than in those with it(F<.01). and FEF50/FIF50 >1 suggesting upper airway obstruction was observed in 7 of 16 (43.8%) patients. Associated diseases were rhinitis in 21 (55.3%) patients, sinusitis in 18 (47.4%), and postnasal drip syndrome in 3 (7.9%). Conclusions : Wheezing despite normal ventilatory function in asthma occurs more often in women. It may be related to reversible airway obstruction in nearly half patients and to upper airway obstruction such as rhinitis, in considerable numbers of the remaining patients. (J Asthma Allergy Clin Immunol 24 : 85-93, 2004)
Case Reports : Lactic acidosis associated with the usual theophylline dose in a patient with asthma
Youngil I. Koh,Inseon S. Choi 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.2
Metabolic and electrolyte abnormalities, including hypokalemia, hyperglycemia and lactic acidosis, are associated with theophylline overdose. However, we report an unusual case of sinus tachycardia, lactic acidosis, hypokalemia and hyperglycemia associated