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Byun, Min Soo,Kim, Hyun Jung,Yi, Dahyun,Choi, Hyo Jung,Baek, Hyewon,Lee, Jun Ho,Choe, Young Min,Sohn, Bo Kyung,Lee, Jun-Young,Lee, Younghwa,Ko, Hyunwoong,Kim, Yu Kyeong,Lee, Yun-Sang,Sohn, Chul-Ho,Woo PERGAMON PRESS LTD 2017 NEUROBIOLOGY OF AGING Vol. No.
<P><B>Abstract</B></P> <P>We tested the hypothesis that lower insulin or higher glycated hemoglobin (HbA1c) levels in blood are associated with increased cerebral beta amyloid (Aβ) deposition and neurodegeneration in nondiabetic cognitively normal (CN) older adults. A total of 205 nondiabetic CN older adults underwent comprehensive clinical assessment, [<SUP>11</SUP>C]Pittsburgh compound B (PiB)-positron emission tomography (PET), [<SUP>18</SUP>F]fluorodeoxyglucose-PET, magnetic resonance imaging, and blood sampling for fasting insulin and HbA1c measurement. Lower blood insulin was significantly associated with increased Aβ positivity rates and decreased cerebral glucose metabolism in the AD-signature region. In contrast, higher HbA1c levels were not associated with Aβ positivity rates but were significantly associated with higher rates of having neurodegeneration in the AD-signature regions. Our results suggest different roles of insulin and HbA1c in AD pathogenesis, in that decreased blood insulin below optimal levels may contribute to increasing cerebral Aβ deposition and neurodegeneration whereas impaired glycemic control may aggravate neurodegeneration through a nonamyloid mechanism in nondiabetic CN older adults.</P>
Normative Data of the Phonemic Fluency Test in Korean Middle-Aged and Elderly Population
Dahyun Yi,Younghwa Lee,Haejung Joung,Hakyoung Kim,Hyejin Ahn,Min Soo Byun,Jun Ho Lee,Gi Hwan Byeon,Dong Young Lee 대한노인정신의학회 2020 노인정신의학 Vol.24 No.1
Objective:The available normative data for the phonemic fluency test in Korean older adults have concerns for its utility. The aim of the currently study is to provide the normative data that overcome the issues of the previous norms. Methods:Total of 443 middle- and old-aged non-demented adults participated in this study. All participants underwent comprehensive assessments conducted by trained psychiatrists and psychologists. Diagnosis was made based on formal guidelines prior to administering the phonemic fluency test. Results:The norms on two age groups (50-59 and 60-90 years) with different strata of the education levels for the age groups are provided. Conclusion:The goal of the current study, which was to overcome the shortcomings of the previously published normative data and establish an updated reference for the Korean version of the phonemic fluency test, is achieved.
Lee, Jun Ho,Byun, Min Soo,Yi, Dahyun,Choe, Young Min,Choi, Hyo Jung,Baek, Hyewon,Sohn, Bo Kyung,Lee, Jun-Young,Kim, Hyun Jung,Kim, Jee Wook,Lee, Younghwa,Kim, Yu Kyeong,Sohn, Chul-Ho,Woo, Jong Inn,Lee PERGAMON PRESS LTD 2017 NEUROBIOLOGY OF AGING Vol. No.
<P><B>Abstract</B></P> <P>This study aimed to examine the sex-specific association between serum sex hormones and gonadotropins and the cerebral beta-amyloid (Aβ) burden and hippocampal neurodegeneration in subjects with normal cognition and impaired cognition. Two hundred sixty-five older subjects received clinical assessments, serum measurements of sex hormones, gonadotropins, <SUP>11</SUP>C-Pittsburgh compound B-positron emission tomography, and magnetic resonance imaging. In females, higher free testosterone and gonadotropin levels were associated with lower cerebral Aβ positivity. In males, free testosterone was positively related to hippocampal volume with significant interaction with cognitive status. Further subgroup analyses showed that the association was significant only in impaired cognition but not in normal cognition. Free estradiol was not associated with Aβ burden or hippocampal neurodegeneration in either sex. These results suggest that testosterone might inhibit the early pathological accumulation of Aβ in females and delay neurodegeneration in males.</P>
Haejung Joung,Dahyun Yi,Hyejin Ahn,Younghwa Lee,Min Soo Byun,Kiyoung Sung,Dongkyun Han,Dong Young Lee,KBASE Research Group 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.6
Objective The Block Design Test (BDT) is known to be an effective measure in diagnosing age-related cognitive decline of visuospatial function. The goal of this study is to investigate the effects of age, education years, and gender on the performance of the BDT and to provide normative data in Korean community-dwelling participants who are 55 to 90 years old.Methods The participants were 432 non-demented adults aging from 55 to 90 years old. The BDT was administered to participants according to its manual. Multiple linear regressions and analyses of variance were conducted, including age, gender, and educations were used as covariates.Results Age, educational years, and gender were found to be significantly associated with performance on the BDT. As age increased, BDT performance decreased. Educational years were associated with BDT performance. Men showed higher performance (29.9±10.3) compare to women (26.1±8.7). The BDT is influenced by age, educational years, and gender.Conclusion Unlike the previous study, the current study shows that gender has a significant influence in visuospatial ability in the old population. Present normative data will be useful for clinicians in evaluating aging participants with cognitive impairment.
NUMERICAL SIMULATION OF INTERPLAY BETWEEN ECOSYSTEM AND THE ASIAN MONSOON CLIMATE
Jinkyu HONG,Kyung-Hee SEOL,Younghwa BYUN,Chunho CHO,Taeyoung HA,Joon KIM 한국산업응용수학회 2010 한국산업응용수학회 학술대회 논문집 Vol.5 No.2
The monsoon system is an important natural driver of ecosystem carbon and water exchanges in Asia and is being altered by anthropogenic forcings. This system is accompanied by heavy rainfall and typhoons in the main growing season, thus causing alterations of environmental conditions such as rainfall, wind, and temperature; therefore, it acts as a natural disturbance to forests in Asia. Therefore, degradation of ecosystem service by monsoon activity reinforced by anthropogenic factors in a changing climate is of great concern. In this study, we presented observational evidences for the interplay of terrestrial carbon and water dynamics with the Asian monsoon and their implication in ecosystem modeling. Our analysis showed strong coupling between ecosystem functioning and temporal variations of monsoon climate. Further scrutiny on the model outputs showed that the model did not accurately reproduce the observed plant phenology and thus ecosystem carbon and water exchanges disturbed by monsoon activities. Our findings suggest that under projected climate scenarios, terrestrial carbon sinks in monsoon Asia will decline if the monsoon disturbance will exceed its natural range of variation and if there is no enhancement in the robustness of the ecosystem in this region.
Validation of the Korean Version of the Anosognosia Questionnaire for Dementia
Gi Hwan Byeon,Woo Jin Kim,Min Soo Byun,Jun Ho Lee,So Yeon Jeon,Kang Ko,Kiyoung Sung,Dongkyun Han,Haejung Joung,Younghwa Lee,Gijung Jung,Han Na Lee,Dahyun Yi,Dong Young Lee 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.4
Objective Anosognosia is a common phenomenon in individuals with dementia. Anosognosia Questionnaire for dementia (AQ-D) is a well-known scale for evaluating anosognosia. This study aimed to establish a Korean version of the AQ-D (AQ-D-K) and to evaluate the reliability and validity of the AQ-D-K in patients with Alzheimer’s disease (AD) dementia. Methods We translated the original English version of AQ-D into Korean (AQ-D-K). Eighty-four subjects with very mild or mild AD de-mentia and their caregivers participated. Reliability of AQ-D-K was assessed by internal consistency and one-month test-retest reliability. Construct validity and concurrent validity were also evaluated. Results Internal consistencies of the AQ-D-K patient form and caregiver form were high (Cronbach alpha 0.95 and 0.93, respectively). The test-retest reliability of AQ-D-K measured by intra-class correlation coefficient was 0.84. Three factors were identified: 1) anosognosia of instrumental activity of daily living; 2) anosognosia basic activity of daily living; and 3) anosognosia of depression and disinhibition. AQ-D-K score was significantly correlated with the clinician-rated anosognosia rating scale (ARS), center for epidemiological studies-de-pression scale (CES-D) and state-trait anxiety inventory (STAI). Conclusion The findings suggest that the AQ-D-K is a reliable and valid scale for evaluating anosognosia for AD dementia patients us-ing Korean language. Psychiatry Investig 2021;18(4):324-331