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Kwon, Soonbum,Kwon, Dah In,Jung, Youngeun,Kim, Ju Hee,Lee, Yeongcheol,Lim, Bumhee,Kim, Ikyon,Lee, Jeeyeon Elsevier 2017 Sensors and actuators. B, Chemical Vol.252 No.-
<P><B>Abstract</B></P> <P>Live cell imaging using small organic fluorophores has emerged as a powerful non-invasive approach to visualizing a variety of cellular processes. We recently reported the design and synthesis of indolizino[3,2-<I>c</I>]quinolines (IQs), a fused heterocyclic system, as a potential candidate for novel fluorescent probes. Here, we explored the environment-sensitive features of the IQs in a cellular context using fluorescent microscopy to achieve no-wash live cell imaging with precise spatial control. Elucidating the cellular targets of IQs based on their chemical structures has enabled us to develop organelle-specific fluorophores that target DNA (3C2), RNA (3B1 and 3H1), and lysosomes (IQ-MP1 and IQ-MP2) in live cells. These compounds exhibit good cell membrane permeability, high photostability, and low cytotoxicity with good compatibility in aqueous systems, properties that are rarely encountered together. 3H1, with a large Stokes shift, exhibits counterstain compatibility when combined with DNA probes (Hoechst 33258) in live cells. The properties of the IQs described here suggest that these compounds may serve as important tools for investigating dynamic processes in live cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The optical properties and live cell imaging properties of indolizino[3,2-<I>c</I>]quinolines (IQs) were explored. </LI> <LI> The environment-sensitive features of IQs yielded desirable properties for no-wash live cell imaging. </LI> <LI> Organelle-specific IQ fluorophores that target DNA, RNA, and lysosomes in live cells were developed. </LI> </UL> </P>
A1B 시나리오 자료를 이용한 우리나라 아열대 기후구 전망
권영아(Young-Ah Kwon),권원태(Won-Tae Kwon),부경온(Kyung-On Boo),최영은(Youngeun Choi) 대한지리학회 2007 대한지리학회지 Vol.42 No.3
지구 온난화의 영향으로 임업 뿐 아니라 농업, 수산업, 보건 등 여러 분야에서 피해가 발생하고 있어, 사회·경제 전분야에 걸쳐 기후변화에 대한 적응 대책이 필요하다. 기후변화의 영향을 평가하고 적응 방안을 마련하기 위해서는 미래 기후가 어떻게 변할 것인지 미리 전망하는 일은 필수적이다. 본 연구에서는 트레와다의 기후 지역 구분 기준(최한월 평균기온이 18℃ 이하이면서 월평균기온 10℃ 이상인 달이 8-12개월)을 적용하여 아열대 기후 지역을 정의하고 A1B 시나리오에 근거한 아열대 기후구의 변화를 전망하기 위하여 기온 관측 자료와 모델 시나리오자료를 분석하였다. 아열대 기후에 관한 트레와다의 정의를 적용하여 현재 아열대 기후구와 미래 아열대 기후구의 변화를 전망해 본 결과 현재는 제주도를 포함한 남해안 일부 지역(부산, 통영, 거제, 여수, 완도, 목포)에 해당하던 것이 2100년에는 태백산맥과 소백산맥을 중심으로 한 산지 주변을 제외하고는 대부분 아열대 기후에 포함된다. 즉, 현재의 온난화가 지속된다면 제주도와 울릉도를 포함한 도서지역은 물론, 동해안으로는 속초, 서해안으로는 강화에 이르기까지 해안지역을 모두 포함하며, 서울, 인천, 수원 등 대도시 지역도 아열대 기후 지역에 포함될 것이다. As the global warming has been influenced on various sectors including agriculture, fisheries and health, it is essential to project more accurate future climate for an assessment of climate change impact and adaptation strategy. The purpose of this study is to examine the boundary changes in the subtropical climate region in South Korea using observed 30-year(1971-2000) data and projected 100-year data based on the IPCC SRES A1B emission scenario. We have selected Trewartha’s climate classification among various climate classification, defining the subtropical climate region as the region with monthly mean temperature 10℃ or higher during 8-12 months. By observed data, the subtropical climate region was only limited in Jeju-do and the farmost southern coastal area(Busan, Tongyeong, Geoje, Yeosu, Wando, Mokpo) of South Korea. The future projected climate region for the period of 2071-2100 included have shown that subtropical climate region extended to most of stations except for the ares of Taebaeksan and Sobaeksan Mountains.
Past and Future Regional Climate Change in Korea
Kwon, Won-Tae,Park, Youngeun,Min, Seung-Ki,Oh, Jai-Ho Korea Association For Quaternary Research 2003 제사기학회지 Vol.17 No.2
During the last century, most scientific questions related to climate change were focused on the evidence of anthropogenic global warming (IPCC, 2001). There are robust evidences of warming and also human-induced climate change. We now understand the global, mean change a little bit better; however, the uncertainties for regional climate change still remains large. The purpose of this study is to understand the past climate change over Korea based on the observational data and to project future regional climate change over East Asia using ECHAM4/HOPE model and MM5 for downscaling. There are significant evidences on regional climate change in Korea, from several variables. The mean annual temperature over Korea has increased about 1.5∼$1.7^{\circ}C$ during the 20th century, including urbanization effect in large cities which can account for 20-30% of warming in the second half of the 20th century. Cold extreme temperature events occurred less frequently especially in the late 20th century, while hot extreme temperature events were more common than earlier in the century. The seasonal and annual precipitation was analyzed to examine long-term trend on precipitation intensity and extreme events. The number of rainy days shows a significant negative trend, which is more evident in summer and fall. Annual precipitation amount tends to increase slightly during the same period. This suggests an increase of precipitation intensity in this area. These changes may influence on growing seasons, floods and droughts, diseases and insects, marketing of seasonal products, energy consumption, and socio-economic sectors. The Korean Peninsular is located at the eastern coast of the largest continent on the earth withmeso-scale mountainous complex topography and itspopulation density is very high. And most people want to hear what will happen in their back yards. It is necessary to produce climate change scenario to fit forhigh-resolution (in meteorological sense, but low-resolution in socio-economic sense) impact assessment. We produced one hundred-year, high-resolution (∼27 km), regional climate change scenario with MM5 and recognized some obstacles to be used in application. The boundary conditions were provided from the 240-year simulation using the ECHAM4/HOPE-G model with SRES A2 scenario. Both observation and simulation data will compose past and future regional climate change scenario over Korea.