베체트병에서 비스테로이드성 소염진통제에 의해 발생한 대량 소장출혈 1예

강인숙,류연주,장지은,정성애,이지수,조영주,이경은,이지희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Bechet's disease(BD) is a chronic inflammatoroy condition involving several organs inclu-ding gastrointestinal tract. Gastrointestinal tracts involvement in BD has been identified throughout the entire alimentary tract and commonly accompanies ulcerative lesions in the small and large bowel. It is debatable whether BD could be included among seronegative spondyloarthropathy (SPA).SPA usually occurs without overt sign of intestinal inflammation, but significant number of patients have asymptomatic intestinal inflammation, usually affecting ileum. Since most patients with SPA in-cluding BD are treated with NSAIDS. However, NSAID may play a role in aggravation or provo-cation of intestinal inflammation. Special attention to asymptomatic intestinal inflammation is needed, especially when NSAIDs are used for management of arthritic symptom in SpA. We experienced a case of BD which was complicated by a massive small bowel bleeding precipitated by NSAID use. 저자들은 베체트병 환자에서 비스테로이드성 소염진통제 사용 후 발생한 대량 소장 출혈의 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet

Young-Rye Kang,Hak-Yong Lee,Jung-Hoon Kim,Dea-In Moon,Min-Young Seo,Sang-Hoon Park,Kwang-Ho Choi,Chang-Ryong Kim,Sang-Hyun Kim,Ji-Hyun Oh,Seong-Wan Cho,Sun-Young Kim,Min-Gul Kim,Soo-Wan Chae,Okjin Kim 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.1

Yerba Mate, derived from the leaves of the tree, Ilex paraguariensis, is widely-used as a tea or as an ingredient in formulated foods. The aim of the present study was to evaluate the effects of Yerba Mate extract on weight loss, obesity-related biochemical parameters, and diabetes in high-fat diet-fed mice.To this end, by using in vivo animal models of dietary-induced obesity, we have made the interesting observations that Yerba Mate has the ability to decrease the differentiation of pre-adipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity. Our data from in vivo studies revealed that Yerba Mate treatment affects food intake, resulting in higher energy expenditure, likely as a result of higher basal metabolism in Yerba Mate-treated mice. Furthermore, in vivo effects of Yerba Mate on lipid metabolism included reductions in serum cholesterol, serum triglycerides, and glucose concentrations in mice that were fed a high fat diet. In conclusion, Yerba Mate can potentially be used to treat obesity and diabetes.

Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles

Hong-Geun Oh,Hak-Yong Lee,Min-Young Seo,Young-Rye Kang,Jung-Hoon Kim,Jung-Woo Park,Ok-Jin Kim,Hyang-Im Back,Sun-Young Kim,Mi-Ra Oh,Soo-Hyun Park,Min-Gul Kim,Ji-Young Jeon,Min-Ho Hwang,Sook-Jeong Shin 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.4

Constipation is one of the most common functional digestive complaints worldwide. We investigated the laxative effects of figs (Ficus carica L) in a beagle model of constipation induced by high protein diet and movement restriction. The experiments were consecutively conducted over 9 weeks divided into 3 periods of 3 weeks each. All 16 beagles were subjected to a non-treatment (control) period, a constipation induction period, and a fig paste treatment period. We administered fig paste (12 g/kg daily, by gavage) for 3 weeks following a 3-week period of constipation induction in dogs. Segmental colonic transit time (CTT) was measured by counting radiopaque markers (Kolomark) using a radiograph performed every 6 h after feeding Kolomark capsules, until capsules were no longer observed. Fig paste significantly increased fecal quantity in constipated dogs, and segmental CTT was also reduced following fig paste administration. There were no significant differences in feed intake, water intake, body weight, or blood test results, between the constipation and fig paste administration periods. Our results demonstrate that fig is an effective treatment for constipation in beagles. Specifically, stool weight increased and segmental CTT decreased. Fig pastes may be useful as a complementary medicine in humans suffering from chronic constipation.

Effects of male silkworm pupa powder on the erectile dysfunction by chronic ethanol consumption in rats

Hong-Geun Oh,Hak-Yong Lee,Jung-Hoon Kim,Young-Rye Kang,Dea-In Moon,Min-Young Seo,Hyang-Im Back,Sun-Young Kim,Mi-Ra Oh,Soo-Hyun Park,Min-Gul Kim,Ji-Young Jeon,Sook-Jeong Shin,Kang-Sun Ryu,Soo-Wan Chae 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.2

Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men worldwide. ED is now considered an early manifestation of atherosclerosis, and consequently, a precursor of systemic vascular disease. This study was designed to investigate the effects of male silkworm pupa powder (SWP) on the levels of nitric oxide synthase (NOS) expression, nitrite, and glutathione (GSH); lipid peroxidation; libido; and erectile response of the corpus cavernosum of the rat penis. We induced ED in the study animals by oral administration of 20% ethanol over 8 weeks. The SWP-treated male rats were divided into 3 groups that were orally administered 200, 400, and 800 ㎎/㎏. The libido of the SWP-administered male rats was higher than that of the ethanol control group. In addition, the erectile response of the corpus cavernosum was restored in males on SWP administration, to a level similar to that of the normal group without ED. The testosterone concentration did not increase significantly. The lipid peroxidation in the corpus cavernosum of the male rats administered SWP decreased significantly. In contrast, compared to the ethanol group, SWP-administered male rats showed increased GSH levels in the corpus cavernosum. The level of nitrite and NOS expression in the corpus cavernosum of SWP-administered male rats increased significantly. These results indicated that SWP effectively restored ethanol-induced ED in male rats.

20~30대 직장여성의 피부관리실 이용실태에 관한 조사연구

강성례, 최숙경 김천대학교 2007 김천대학교 논문집 Vol.28 No.-

This study aims at providing statistical and valuable information on skincare. This was done by studying the method, approach and expense of salaried women at their age of 20s to 30s who receive any from services on skincare. The research was conducted from June 15 to 30,2007, distributing questionnaires among the subjects, to the age groups of 20s and 30s, salaried women, lives in seoul. 166 adequately answered questionnaires were returned. It was analyzed using SPSSWIN 12.0 program. Followings are the results of the study 1.By the classification of age, women at age group of 30s hed the most experi-ences of skincare service and in contrast, age of 20-24 had the least experience. For self-skincare, women at age of 20 to 24 have the most experiences, and ages over 35 had the least. however, subjects aged from 25 to 29 have the most expe-rience of both ‘skincare service’ and ‘self-skincare combined’ with 27.9%, fol-lowed by subjects aged over 35 with 24.0%, showing p<.05. 2. By frequency classification , ‘once a week ’ was the dominant response with 55%, followed by ‘once a month’ and ‘twice a week’ with any from of skin care. As a whole, aged 20 to 35 had experience of ‘once a week’ with statistical differ-ence p.<05. 3.By expenses on skincare classification, the most subjects spent between 10.000 to 30.000won per expenditure. By age, 20 and 24 years old spent less than 10.000won at a time with 36.4% However, on average subjects spent 10.000 to 30.000won for skincare per expenditure. age group in 30s spent between 30.000 to 50.000won the most. contrastively age group of 20s spent between 50.000 to 100.000 won the most. Over 100.000won, age group over 35 with showing similar statistical difference p<.050. fromm this study, it is strongly evident that salaried –women showed great inter- est with their skincare and regularly receive services from skincare shops and even self perfrom . most perobable that there are more statistical & systemed mea-sures are required to ensure and fulfill women’s desire to beauty.

PCR detection of Y-specific sequences in Turner syndrome

Kang, Young-Roon,Chung, Woo-Yeong,Lee, Jeong-Nye,Kim, Rye-Ra 인제대학교 2009 仁濟醫學 Vol.30 No.-

배경 : Turner 증후군 환자의 약 6% 에서 Y 염색체 혹은 Y 특이유전물질을 보유하고 이들 중 약 15-25% 에서 성선모세포종이 발생하는 것으로 추정되고 있다. 본 연구에서 저자들은 터너증후군 환자에서 고식적인 세포유전학 검사에서 검출하지 못한 Y 특이유전 물질을 중합효소연쇄반응을 이용하여 검출하고자 한다. 대상 빛 방법 : Turner 증후군이 확진된 28명의 환자를 대상으로 염색체검사는 환자의 말초혈액 림프구를 phytohaemagglutinin(PHA)으로 자극한 후 G-분염법으로 염색하여 분석하였다. 중합효소연쇄반응을 수행하기 위해 모든 환자의 말초 혈액을 이용하여 DNA 를 분리하였으며 Y 특이 표지자는 Y 염색체의 장완과 단완, 그리고 중심절 상의 위치를 고려하여 SRY, ZFY, TSPY, DYZ3, DYF49S1, RBM, DYZ1 등 총 7종을 사용하였다. 결과 : 중합효소연쇄반응으로 Y 특이염기서열이 증명된 경우는 28예 중 4예 였다 (14.3%). 이들 중 2예는 염색체 검사에서 Y 염색체가 관찰되었던 경우로 이들의 핵형은 각각 45,X/47,XYY와 45,X/46,XY였다. 나머지 2 예는 염색체 검사에서는 Y 염색제를 관찰할 수 없었던 경우로서 DYZ3 에 증폭이 되었다. 결론 : Turner 증후군 환자에서 Y 특이유전물질의 존재를 중합효소연쇄반응을 이용하여 선별하는 것이 유용하다고 생각된다.

강의 평가용 웹 기반 설문정보시스템의 설계 자동화 및 구현

강민숙,조동섭,박영례 한국컴퓨터교육학회 2001 컴퓨터교육학회 논문지 Vol.4 No.2

인터넷의 보급으로 확산되고 있는 가상교육이 교육의 효과를 내기 위해서는 적절한 강의평가가 요구된다. 웹 기반 교육에서는 설문지를 이용한 평가가 가장 보편적으로 이루어지고 있는데, 이는 간단한 텍스트 형태의 설문지나, CGI나 ASP를 이용하여 인터넷에서 바로 설문에 응할 수 있는 형태 등으로 비교적 다양하게 구성되어 있다. 본 논문에서는 현재 인터넷상에서 이루어지고 있는 설문 시스템을 비교 분석하여 그 특징과 제한점을 알아본 후 그 제한점을 극복할 수 있도록 ASP를 이용하여 설문지를 인터넷상에서 편리하게 만들 수 있고 만들어진 설문을 관리하며 그 설문을 통해 나타난 결과를 교육자에게 피드백하는 시스템을 설계 및 구현한다.

목질진흙버섯에 대한 항산화 및 주름개선 효과 : 강성례

강성례, 최은영 김천대학교 2013 김천대학교 논문집 Vol.34 No.-

The purpose of this study was to examine the anti-oxidant activity and anti-wrin- kle effect of mushroom Phellinus linteus. The anti-oxidant activity was determined by using DPPH radical scavenging activ- ity, ABTS radical inhibiton activity and hydrogen peroxide inhibition activity, DPPH radical scavenging ability of Phellinus linteus were increased concentration-dependent in water extract and showed 80, 87 and 87.6% at the 10,50 and 100,4g/mL in ethanol extract. Especially it was more effective than BHA of possitive control in ethanol extract. The result of ABTS radical inhibition activity was showed 81.4,99 and 100% and 75.6. 98.9 and 99% at the 100,500 and 1000g/mL in water and ethanol extracts, which were appeared very high inhibition effects compared to BHA of possitive control. In the test of hydrogen peroxide inhibition activity, water and ethanol extracts of Phellinus liteus were more than 90% at the 500g/mL, which were also similar activity in comparison to vitamin C. The anti-wrinkle effect was experimented by measuring inhibition ability of colla-genase and elastase. The collagenase inhibition ability was appeared to be 47.1% at the1000g/mL in ethanol extract. The elastase inhibition ability was increased slightly.

소엽 (Perilla frutescens var. acuta)의 화장품 천연소재 응용을 위한 생리활성 기능 검증

강성례(Kang Sung-Rye),최은영(Choi Eun-Young) 한국인체미용예술학회 2004 한국인체미용예술학회지 Vol.5 No.2

  In this study, in order to apply Perilla frutescens which is a kind of herb cultivated in Korea to the natural materials of cosmetics, the Perilla frutescens"s physiological activities function in enzymology and its antibacterial activity against skin resident flora were researched.<BR>  As a result of testing electron donating ability, at over 500ppm both water and ethanol extracts of Perilla frutescens showed relatively high donating ability by more than 70%. And as a result of measuring SOD like activity, both water and ethanol extracts showed the effect by more than 80% at 5,000ppm and the like activity showed dose dependent increase. From the test of inhibitory effect of tyrosinase, both water and ethanol extracts showed insufficient inhibitory rate. As a result of antibacterial activity test, water extract showed clear zone against staphylococcus epidermidis as 9.3mm at 0.5mg/disc and 11.8mm at 1mg/disc and ethanol extract showed clear zone of 11.6mm at 1mg/disc.<BR>  From the above results, it was confirmed that Perilla frutescens being a kind of herb has a sufficient potentiality applying itself to industry and also the Perilla frutescens can be utilized as cosmetics natural materials.

Mannosylphosphorylation by Heterologous Expression of YIMPO1, Yarrowia lipolytica Homologue of Saccharomyces cerevisiae MNN4

Jin Young Kil,Jeong-Nam Park,Kyung Jin Lee,Ohsuk Kwon,Rye-Shin Chung,Hyun Ah Kang,Doo-Byoung Oh 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1