Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

크릴분말이 콜레스테롤 및 카드뮴 식이 흰쥐의 간 및 심장 지질에 미치는 영향

조영숙,박석규,박정로,손미예,문주석,곽수동 순천대학교 기초과학연구소 1992 基礎科學硏究誌 Vol.3 No.-

In order to investigate effects of krill on lipid components of liver and heart in cholesterol and cadmium-fed rats, male Sprague-Dawley rats were raised for 4 weeks with 8 experimental diets. Krill used in this experiment contained 65.4%(w/w) of protein and 16.7% of lipid. Krill contained 35% of polyunsaturated fatty acids and more unsaturated fatty acids than saturated fatty acids by 2 times. Amino acid content of krill was high in order of Glu, Asp, Tyr and Lys. Rats fed krill diet showed more food intake and weight gain compared with control group. However, food efficiency ratio and weight of liver and heart were not significantly different. The ingestion of cadmium resulted in a severe restriction in growth rate with normal or mild reduction of liver and heart weight. Cadmium also caused a significant decrease in food efficiency ratio. The contents of total and free cholesterol of liver and heart in rats fed krill diets were similar or slightly higher than those fed control diet. Dietary krill also showed no significant difference in liver and heart cholesterol levels in rats with cadmium ingestion. The contents of phospholipid and triglyceride in liver and heart of krill group were slightly higher than those of control group. Supplement of krill reduced triglyceride content of liver in rats ingested with cadmium without any effect on the level of phospholipid and heart lipids. The concentration of cadmium in plasma significantly increased with dietary krill. However, the krill supplement did not influence the concentration of cadmium in liver or heart. A significant accumulation of lipid in liver tissue was observed in all dietary groups but standard group. However, no difference in degree of lipid accumulation was found among the dietary groups. Necrosis and hemolysis of liver in all dietary groups were not shown.

生長調節劑 및 揷木用土가 切花薔薇 揷木에 미치는 影響

蔡潤錫,孫玲杰,李相雨 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-

생장조절제 및 揷木용토를 이용하여 薔薇 揷木苗 생산기술을 정립하기 위하여 몇가지 상토를 계절별로 揷木하고 發根率 및 苗 생산상태를 조사하였다. 춘계揷木의 경우 'Koffectti', 'Rote Rose'에서 토실이 培地의 68%, 64%의 發根率보다 岩綿培地의 82%, 78%로 發根率이 높았지만, 신초 발아율은 岩綿培地는 58%, 56%에 비하여 토실이가 63%, 61%로 높았다. 발근후 苗의 생육은 토실이 揷木苗가 岩綿 揷木苗에 비하여 좋았다. 配合土에서는 發根率 및 생육상태가 두 品種 공히 매우 낮았다. 夏季 揷木의 경우 'Koffectti', 'Rote Rose'에서 岩綿培地에서의 發根率이 각 68%, 63%로 토실이 培地의 54%, 51%에 비하여 높았으며, 생육상태는 토실이 培地가 좋았는데 이는 유기질함량의 영향이었다. 발근제처리에서는 두 品種 모두 NAA 1000, 1500ppm과 IBA 1500ppm에서 發根率이 높았고, 신초발아율 및 신초생장도 좋았다. For the establishment of producing technique in cutting seedling of rose, rooting ratio and condition of seedling in case of each seasonal cutting seedling in several soil were investigated using growth regulators and media of cutting. In case of cutting in spring, rooting ratio in 'Koffectti' and 'Rote Rose' in rockwool were higher(82% and 78%) than in tosilee (68% and 64%), respectively. However, shoot emergency in 'Koffectti' and 'Rote Rose' were lower(58% and 56%) in rockwool than in tosilee (63% and 61%), respectively. Seedling quality was better in cutting seedling grown in tosilee than grown in rockwool after rooting. The rooting condition and growing condition in both variaties were very low in miting media. In case of cutting in summer, although rooting ratio in 'Koffectti' and 'Rote Rose' in rockwool were higher(68% and 63%) than in tosilee (54% and 51%), respectively, the condition of growth was better in tosilee because of the effect of organic materials. In treatment of growth regulators were better in 1,000ppm and 1,500ppm NAA abnd 1,500ppm of IBA on shooting emergency, rooting ratio and seedling growth in both variaties.

돌산갓 전처리 중의 산도, 항균선 및 색도 변화

박석규,서권일,이상원,조영수,손미혜 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.1

In order to use leaf mustard Dolsan food preservative ingradient, acidity, antimicrobial activity and colors were investigated during pretreatment of leaf mustard Dolsan. pH was remarkably decreased after 8 hours to pretreatment(extracted on shaking) of leaf mustard Dolsan, and no changes were observed after that time. pH of leaf part was higher than stalk after 8 hours storage. Titratable acidity was opposite tendency to the pH, pH was gradually decreased than initial stage during pretreatment: of leaf mustard Dolsan at 30, 40 and 50℃. After 16 hours pretreatment, the higher pretreatment temperature was, the higher pH was, but after pretreatment for 48 hours, pH of sample pretreated at 50℃ was lower than that of sample pretreated at 40℃. Antimicrobial activity of leaf mustard Dolsan extract pretreated at 30℃ was the strongest of the samples pretreated at 30, 40 and 50℃, and that of stalk part was stronger than that of leaf part. L and b value in colors was gradually decreased, and a value was increased with the passage of pretreatment time. L and b value was higher in the order of samples pretreated at 40, 50 and 30℃, and the lower pretreatment temperature was, the higher a value was. L value of stalk part was higher than that of leaf part, but a and b value of of leaf part was higher than that of stalk part.

Lithium-Pilocarpine으로 유발된 중첩경련 흰쥐 모델에서 Ketamine의 항경련 및 신경 보호 효과

고석범,박성경,손영민,김영인 대한간질학회 2004 대한간질학회지 Vol.8 No.1

원료콩의 증자조건을 달리한 검정콩 간장의 유리당, 유기산 및 지방산의 변화

권선화,최재훈,고영란,손미예,박석규 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3

콩의 증자조건에 따른 검정콩 전통간장의 숙성 후 유리당, 유기산, 지방산조성을 조사하였다. pH 값은 5.04~5.32로 시험구간의 큰 차이를 나타내지 않았고, 원료 콩을 상압증자한 검정콩 간장이 가압이나 스팀보다는 약간 높은 수치를 나타내었다. 적정산도는 4.26~7.73mL로 나타났으며, 가압증자한 검정콩 간장(4.26~5.61mL)이 가장 높았으며, 다음으로 상압(7.32mL), 스팀(5.99~6.96mL)의 순으로 나타났다. 환원당은 25.18~194.81㎎%로 나타났고, 상압이 25.18㎎%로 가장 낮았으며, 가압이나 스팀증자한 검정콩 간장의 경우 상호간에는 큰 차이가 없지만, 상압한 것보다는 7~8배 높은 함량을 나타내었다. 주요 유리당은 glucose, fructose, xylose였으며, 스팀증자한 검정콩 간장이 상압이나 가압보다 각각의 유리당 모두가 많았고, 상압증자는 유리당이 극히 미량으로 검출되었다. 주요 유기산은 succinic acid, oxalicaicd, tartaric aic, malic acid, citric acid였고, 총 유기산은 스팀증자 (40.38~76.96 ㎎%)한 검정콩 간장이 상압(55.85㎎%)이나 가압(27.78~34.21)한 것보다 많았다. 증자 처리시간이 길수로 가압과 스팀으로 처리하여 제도된 검정콩 간장은 약간씩 감소되는 경향을 나타내었다. 주요 지방산은 palmitic acid(33.28~43.51%), stearic a창(14.15~19.16%), myristic acid(5.03~19.14%)였으며, 전체 지방산 중에 55.97~72.85% 비율을 차지하였고, 원료 콩에 존재하지 myristic acid가 상당히 많이 존재하였다. pH values in all samples were in the range of 5.04 to 5.32. pH of kanjang prepared with normal pressure(HPK) was higher than that of kanjang prepared with high pressure(HPK) and kanjang prepared with steam(SPK). Titratable acidity(TA) in all samples were found to be 4.26∼7.72 mL. TA in HPK(5.99∼6.96 mL) was lower than that in SPK(4.26∼5.61 mL) and NPK(7.32 mL). Reducing sugar(RS) contents in all samples were in the range of 25.48 to 194.81 ㎎%. Rs contents of HPK and SPK were a similar pattern and were higher than that of NPK. Major free sugars(FS) were glucose, fructose and xylose. In total FS, SPK was higher than that of NPK and HPK. Major organic acids(OA) were succinic acid, oxalic acid, tartaric acid, malic acid citric acid. OA contents in HPK and SPK were decreased slightly according to the heating time of whole black bean. The highest percentage of fatty acid(FA) in all samples was palmitic acid(33.28∼43.51% as area % of GC chromatogram), followed in a decreasing order by stearic acid(14.15∼19.16%) and myristic acid(5.93∼19.14%). The composition ratios of three FA to total FA ranged from 55.97 to 72.85%. In all samples, there was myristic acid that was not contained in raw soybean.

Morphological transformation of gold nanoparticles on graphene oxide: effects of capping ligands and surface interactions

Young-Seok Shon,Bingli Wa,Nisala Weerasuriya,Serena Low,Hanqing Pan 나노기술연구협의회 2019 Nano Convergence Vol.6 No.2

This article presents the influence of capping ligand and surface interaction types on the coarsening or reshaping behavior of surface-immobilized gold nanoparticles with different core size and shape. The morphological transformation of gold nanoparticles and nanorods on graphene oxide upon heating at temperatures ranging from 50 to 200 °C was investigated. The aggregation and coarsening behaviors of spherical nanoparticles on graphene oxide were slightly affected by the core size of nanoparticles (~ 1, 3, and 10 nm). The comparison of two different surface ligands revealed that glutathione ligands provide much better protection than cetyltrimethylammonium bromide ligands against the morphological transformation of nanoparticles. In addition, the evaluation of surface binding interactions indicated that the attachment of nanoparticles and nanorods onto graphene oxide with additional thiol functional groups could improve the immobilization of particles and therefore decelerate coarsening and reshaping of nanoparticle and nanorods.

Heat-induced coarsening of layer-by-layer assembled mixed Au and Pd nanoparticles

Shon, Young-Seok,Shon, Dayeon Judy,Truong, Van,Gavia, Diego J.,Torrico, Raul,Abate, Yohannes Techno-Press 2014 Advances in nano research Vol.2 No.1

This article shows the coarsening behavior of nanoparticle multilayers during heat treatments which produce larger metallic nanostructures with varying shapes and sizes on glass slides. Nanoparticle multilayer films are initially constructed via the layer-by-layer self-assembly of small and monodispersed gold and/or palladium nanoparticles with different compositions (gold only, palladium only, or both gold and palladium) and assembly orders (compounding layers of gold layers over palladium layers or vice versa). Upon heating the slides at $600^{\circ}C$, the surface nanoparticles undergo coalescence becoming larger nanostructured metallic films. UV-Vis results show a clear reliance of the layering sequence on the optical properties of these metal films, which demonstrates an importance of the outmost (top) layers in each nanoparticle multilayer films. Topographic surface features show that the heat treatments of nanoparticle multilayer films result in the nucleation of nanoparticles and the formation of metallic cluster structures. The results confirm that different composition and layering sequence of nanoparticle multilayer films clearly affect the coalescence behavior of nanoparticles during heat treatments.

Time-dependent periimplant bone reaction of acidic monomer-treated injection molded zirconia implants in rabbit tibiae.

Shon, Won-Jun,Woo, Kyung Mi,Kim, Hong-Kyun,Kwon, Ho Beom,Shin, Seung-Yun,Park, Young-Seok Published for the International Congress of Oral I 2015 Implant dentistry Vol.24 No.3

<P>The aim of this study was to evaluate and compare the osseointegration of zirconia implants in rabbit tibiae with and without 10-methacryloyloxydecyl dihydrogen phosphate (MDP) treatment.</P>

Development and Operational Practices of Hankyeong/Sungsan Wind Farm and Future Direction

Young-Chul Park(박영철),Sang-Soo Moon(문상수),Hyo-Soo Shon(손효수),Kyung-Hwa Kim(김경화),Seung-Il Lee(이승일),Seok-Hyun Lee(이석현),Gunsu Kim(김근수) 한국신재생에너지학회 2015 한국신재생에너지학회 학술대회논문집 Vol.2015 No.6