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조영곤,반일환,유미경 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.3
본 연구는 상아질에 2단계와 단일 단계 자가 산부식 접착제를 적용하여 복합레진을 접착한 후 저장기간에 따른 미세 인장 결합강도와 접착계면의 변화를 상호 비교하기 위하여 시행하였다. 발거된 상 ·하악 대구치 48개의 교합면측 상아질을 노출시켜 12개씩 4개의 군으로 분류하였다 사용된 접착제의 종류에 따라 SE Bond 군, AdheSE 군, Adper 군, Xeno III 군으로 분류하여 접착제를 적용한 후, 동일 회사의 복합레진 을 4 mm두께로 접착시켰다. 각 군당 4개의 치아를 선택하여 증류수가 담겨진 용기에 집어넣고 37℃의 항온기에 각각 1일 15일, 30일 동안 저장한 후 시편을 제작하여 각각 미세인장 결합강도의 측정과 주사전자 현미경 관찰 하여 다음과 같은 결과를 나타내었다. 2단계 자가 산부식 접착제는 1일에서 30간의 저장기간 동안 결합강도가 점차적으로 감소하였지만 통계학적으로 유의한 차이를 나타내지 않았고, 상아질과 접착제 간에 긴밀한 접착관계를 보였다. 반면에 단일 단계자가 산부식 접착제는 1일의 저장기간에 비해 30일의 저장기간에서 통계학적인 결합강도의 감소를 나타내었으며, 상아질과 접착제 간에 넓은 간극이 관찰되었다. 따라서 본 연구에서 나타난 두 종류의 30일 동안의 접착내구성은 2단계 자가 산부식 접착제가 단일 단계 자가 산부식 접착제보다 우수한 것으로 나타났다. This study compared the microtensile bond strength (μTBS) and microscopic change of two 2-step and two 1-step self-etching adhesives to dentin according to storage times in distilled water. Occlusal dentin was exposed in 48 human molars. They were divided to four groups by different adhesives: SE Bond group (Clearfil SE Bond), AdheSE group (AdheSE). Adper group (Adper Prompt L-Pop), and Xeno group (Xeno III). Each group was stored in 37℃ distilled water for 1, 15, and 30 days. Resin-bonded specimens were sectioned into beams and subjected to μTBS testing with a crosshead speed of 1 mm/minute. For SEM observation, one specimen was selected and sectioned in each group after each stroage time. Resin-dentin interface was observed under FE-SEM. In all storage times, mean μTBS of SE group was significantly higher than those of other groups (p < 0.05). There was no significant difference between mean μTBS of SE group and AdheSE group among all storage times, but significant difference between 1- and 30-day storage in mean μTBS of Adper group and Xeno group (p > 0.05). For 1-and 15-day storage, all groups showed the close adaptation between resin-dentin interfaces. For 30-day storage, resin-dentin interfaces showed wide gap in Adper group and separate pattern in Xeno III group. Resin-bonded specimens were sectioned into beams and subjected to μTBS testing with a crosshead speed of 1 mm/minute. For SEM observation, one specimen was selected and sectioned in each group after each stroage time. Resin-dentin interface was observed under FE-SEM. In all storage times, mean μTBS of SE group was significantly higher than those of other groups (p < 0.05). There was no significant difference between mean μTBS of SE group and AdheSE group among all storage times, but significant difference between 1- and 30-day storage in mean μTBS of Adper group and Xeno group (p > 0.05). For 1-and 15-day storage, all groups showed the close adaptation between resin-dentin interfaces. For 30-day storage, resin-dentin interfaces showed wide gap in Adper group and separate pattern in Xeno III group.
Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng
Young-Hwan Ban,Yeseul Cha,Jieun Choi,Eun Suk An,Ji Young Lee,Nu Ry Han,Da Woom Seo,Gooyoung Jung,Da-Hye Jeong,Man Hee Rhee,Ehn-Kyoung Choi,Yun-Bae Kim 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg3 improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.
Broccoli sprout extracts improve alcoholic gastric ulcers via antioxidative activities
YOUNG-HWAN BAN,YESEUL CHA,HAIYU GUO,JIEUN CHOI,EUN SUK AN,JI YOUNG LEE,NU RY HAN,EUN SU JEON,EUN SANG CHO,DA WOOM SEO,JUNG-MIN YON,TAE-SU KIM,SUNG-PYO LEE,EHN-KYOUNG CHOI,YUN-BAE KIM 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08
조소영 ( So Young Jo ),김나영 ( Nayoung Kim ),이정원 ( Jung Won Lee ),임지환 ( Ji Hwan Lim ),최치언 ( Chiun Choi ),전일영 ( Il Young Chon ),길호 ( Ho Kil ),민보영 ( Bo Young Min ),변영상 ( Young Sang Byoun ),이반석 ( Ban Seok Lee 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6
Background/Aims: The aim of this study was to compare polyethylene glycol (PEG) 4 L, split method of PEG 4 L and PEG 2 L plus sodium phosphate (NaP) in the aspect of bowel preparation quality, safety, patients` compliance and preference. Methods: Total 249 subjects were prospectively enrolled and received bowel preparation for colonoscopy from August to October in 2010; PEG 4 L (93 subjects), split method of 4 L PEG (74 subjects) and PEG 2 L plus NaP 90 mL group (82 subjects). To investigate the completion, preference for bowel preparation and safety, a questionnaire survey was conducted before colonoscopy. Results: There were no significant intergroup differences in the aspect of completion of preparation, cecal intubation time and success rate. Satisfaction and preference were higher in PEG 2 L plus NaP 90 mL and split method of 4 L PEG compared with PEG 4 L. In the aspect of the bowel preparation quality PEG 4 L showed significantly higher quality in the morning colonoscopy (p<0.001). However, in the afternoon colonoscopy PEG 2 L plus NaP 90 mL showed better result than PEG 4 L (p=0.009). Hyperphosphatemia was most frequently observed in PEG 2 L plus NaP 90 mL, but no severe adverse events occurred (p<0.001). Conclusions: PEG 4 L showed better result than split method of 4 L PEG or PEG 2 L plus NaP 90 mL in the aspect of bowel preparation quality and safety. (Korean J Gastroenterol 2012;59:414-422)
( Hye Ryun Ban ),( Kyung Mo Kim ),( Joo Young Jang ),( Gu Hwan Kim ),( Han Wook You ),( Kyung Eun Kim ),( Eun Sil Yu ),( Dae Yeon Kim ),( Ki Hun Kim ),( Young Joo Lee ),( Sung Gyu Lee ),( Young Nyun P The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.1
Glycogen storage disease type IV (GSD-IV) is an autosomal recessive disease caused by a deficient glycogen branching enzyme (GBE), encoded by the GBE1 gene, resulting in the accumulation of abnormal glycogen deposits in the liver and other tissues. We treated a 20-month-old girl who presented with progressive liver cirrhosis and was diagnosed with GSD-IV, as confirmed by GBE1 gene mutation analysis, and underwent living related heterozygous donor liver transplantation. Direct sequencing of the GBE1 gene revealed that the patient was compound heterozygous for a known c.1571G>A (p.Gly264Glu) mutation a novel c.791G>A (Arg524Gln) mutation. This is the first report of a Korean patient with GSD-IV confirmed by mutation analysis, who was treated successfully by liver transplantation. (Gut and Liver 2009;3:60-63)
Ban, Ju-Yeon,Cho, Soon-Ock,Jeon, So-Young,Song, Kyung-Sik,Bae, Ki-Hwan,Seong, Yeon-Hee The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.5
Sanguisorbae radix (SR) from Sanguisorba officinalis L. (Losaceae) is widely used in Korea and China due to its various pharmacological activity. The present study aims to investigate the effect of the methanol extract of SR on amyloid ${\beta}$ Protein(25-35) $(A{\beta}\;(25-35))$, a synthetic 25-35 amyloid peptide, -induced neurotoxicity using cultured rat cortical neurons. SR, over a concentration range of $10-50\;{\mu}g/ml$, inhibited the $A{\beta}$ (25-35) $(10\;{\mu}M)-induced$ neuronal cell death, as assessed by a 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and the number of apoptotic nuclei, evidenced by Hoechst 33342 staining. Pretreatment of SR $(50\;{\mu}g/ml)$ inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced} elevation of cytosolic calcium concentration $([Ca^{2+}]c)$, which was measured by a fluorescent dye, fluo-4 AM. SR $(10\;and\;50\;{\mu}g/ml)$ inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}(25-35)$, which was measured by HPLC, and generation of reactive oxygen species. These results suggest that SR prevents $A{\beta}$ (25-35)-induced neuronal cell damage in vitro.
Ban, Jung Ok,Kim, Dae Hwan,Lee, Hee Pom,Hwang, Chul Ju,Shim, Jung-Hyun,Kim, Dae Joong,Kim, Tae Myoung,Jeong, Heon-Sang,Nah, Seong Su,Chen, Hanyong,Dong, Zigang,Ham, Young Wan,Kim, Youngsoo,Han, Sang-B Wiley (Blackwell Publishing) 2014 British journal of pharmacology Vol.171 No.11
<P>Products of Maillard reactions between aminoacids and reducing sugars are known to have anti-inflammatory properties. Here we have assessed the anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal and its possible mechanisms of action.</P>