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      • KCI등재

        Voltage Prediction in Transient Connection for Power Battery Modules: Experimental Results

        You Xu,Qiang Wu,Limin Yu,Jiehao Li 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.9

        This paper mainly focuses on the safe maintenance of power systems and the use of secondary batteries for electric vehicles from the experimental scenarios. In engineering, the power battery module of series connection or parallel connection is conducive to the fast combination and unloading of high-voltage energy systems in the electric vehicles. However, the parallel connection is affected by inconsistency and generally uses the powerful resistance to solve the current shock. In this paper, an improved RC network lithium-iron-phosphate battery model based on parallel hysteretic voltage is proposed to achieve a safe parallel sequence and solve the high current impact in this process. Furthermore, the voltage oscillation standard deviations at different voltage levels and voltage differences are carried out, which obtains the hysteretic curve map of oscillating voltage distribution. At last, the voltage oscillation model is established by discussing the oscillating parallel characteristics, and the control strategy of the pre-charging circuit can be applied to the voltage optimization. Comparative experimental results using 32650 lithium-ion phosphate battery can effectively achieve satisfactory predicting performance with a reasonable voltage range.

      • Luciferase Assay to Screen Tumour-specific Promoters in Lung Cancer

        Xu, Rong,Guo, Long-Jiang,Xin, Jun,Li, Wen-Mao,Gao, Yan,Zheng, You-Xian,Guo, You-Hong,Lin, Yang-Jun,Xie, Yong-Hua,Wu, Ya-Qing,Xu, Rui-An Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        Objective: Specific promoters could improve efficiency and ensure the safety of gene therapy. The aim of our study was to screen examples for lung cancer. Methods: The firefly luciferase gene was used as a reporter, and promoters based on serum markers of lung cancer were cloned. The activity and specificity of seven promoters, comprising CEACAM5 (carcinoembryonic antigen, CEA), GRP (Gastrin-Releasing Peptide), KRT19 (cytokeratin 19, KRT), SFTPB (surfactant protein B, SP-B), SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA), SELP (Selectin P, Granule Membrane Protein 140kDa, Antigen CD62, GMP) and DKK1 (Dickkopf-1) promoters were compared in lung cancer cells to obtain cancer-specific examples with strong activity. Results: The CEACAM5, DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB promoters were cloned. Furthermore, we successfully constructed recombinant vector pGL-CEACAM5 (DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB) contained the target gene. After cells were transfectedwith recombinant plasmids, we found that the order of promoter activity from high to low was SERPINB3, DKK1, SFTPB, KRT19, CEACAM5, SELP and GRP and the order for promoters regarding specificity and high potential were SERPINB3, DKK1, SELP, SFTPB, CEACAM5, KRT19 and GRP. Conclusion: The approach adopted is feasible to screen for new tumour specific promoters with biomarkers. In addition, the screened lung-specific promoters might have potential for use in lung cancer targeted gene therapy research.

      • Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis

        Xu, Lu,Ju, Xiao-Bing,Li, Pu,Wang, Jue,Shi, Zhu-Mei,Zheng, Ming-Jie,Xue, Dan-Dan,Xu, Yan-Jie,Yin, Yong-Mei,Wang, Shui,You, Yong-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

        Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).

      • SCIESCOPUSKCI등재

        One-Cycle Control Strategy for Dual-Converter Three-Phase PWM Rectifier under Unbalanced Grid Voltage Conditions

        Xu, You,Zhang, Qingjie,Deng, Kai The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.1

        In this paper, a dual-converter three-phase pulse width modulation (PWM) rectifier based on unbalanced one-cycle control (OCC) strategy is proposed. The proposed rectifier is used to eliminate the second harmonic waves of DC voltage and distortion of line currents under unbalanced input grid voltage conditions. The dual-converter PWM rectifier employs two converters, which are called positive-sequence converter and negative-sequence converter. The unbalanced OCC system compensates feedback currents of positive-sequence converter via grid negative-sequence voltages, as well as compensates feedback currents of negative-sequence converter via grid positive-sequence voltages. The AC currents of positive- and negative-sequence converter are controlled to be symmetrical. Thus, the workload of every switching device of converter is balanced. Only one conventional PI controller is adopted to achieve invariant power control. Then, the parameter tuning is simplified, and the extraction for positive- and negative-sequence currents is not needed anymore. The effectiveness and the viability of the control strategy are demonstrated through detailed experimental verification.

      • KCI등재

        One-Cycle Control Strategy for Dual-Converter Three-Phase PWM Rectifier under Unbalanced Grid Voltage Conditions

        You Xu,Qingjie Zhang,Kai Deng 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.1

        In this paper, a dual-converter three-phase pulse width modulation (PWM) rectifier based on unbalanced one-cycle control (OCC) strategy is proposed. The proposed rectifier is used to eliminate the second harmonic waves of DC voltage and distortion of line currents under unbalanced input grid voltage conditions. The dual-converter PWM rectifier employs two converters, which are called positive-sequence converter and negative-sequence converter. The unbalanced OCC system compensates feedback currents of positive-sequence converter via grid negative-sequence voltages, as well as compensates feedback currents of negative-sequence converter via grid positive-sequence voltages. The AC currents of positive- and negative-sequence converter are controlled to be symmetrical. Thus, the workload of every switching device of converter is balanced. Only one conventional PI controller is adopted to achieve invariant power control. Then, the parameter tuning is simplified, and the extraction for positive- and negative-sequence currents is not needed anymore. The effectiveness and the viability of the control strategy are demonstrated through detailed experimental verification.

      • Evolution of ALPPS: The Simpler, Safer and Effective One---TELPP

        ( Shu You Peng ),( Xu An Wang ),( Cong Yun Huang ),( You Yong Zhang ),( Jiang Tao Li ),( De Fei Hong ),( Xiu Jun Cai ),( Yi Fang Wang ),( Xiao Liang ),( Jian Wei Wang ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: The characteristic of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) carries high mortality and morbidity. There is room for improvement. We suggest Terminal Branches Portal Vein Embolization (TBPVE) as a way to compart the liver. As a result, only a single surgical operation is required.This method is termed Terminal branches portal vein Embolization Liver Partition Planned hepatectomy (TELPP). Methods: Patients with unresectable primary or metastatic liver tumor were performed with TELPP. The procedure of TELPP was that in addition to PVE, embolization agent was infused to the terminal branches of portal vein of S5,S8 or S4. CT scan was taken one or two weeks later, and standard liver volume(SLV), FLR and FLR/SLV are calculated. Two weeks later when the FLR and liver function is appropriate, open or laparoscopic hepatectomy is performed. Results: The study included 11patients including hepatocellular carcinoma: n =8, intrahepatic cholangiocarcinoma: n = 1, hilarcholangiocarcinoma: n =1, colorectal liver metastasis: n =1. After a waiting period of 14 days, the volume of theFLR had increased from 382mlto 578ml, representing a median volume increase of 51% (range =32.5%-86.7%). Of the 11patients with hepatectomy, right hemihepatectomy (n=2), extended right hemihepatectomy (n=5), right trisecmentectomy(2), extended left hemihepatectomy (n=1) and left trisecmentectomy(1). No patient died, and no serve perioperative morbidity occurred. Conclusions: ALPPS and all modifications need two-stage operations with a high morbidity and mortality rate. It seems that TELPP is very promising. It has the merit of ALPPS as extraordinarily rapid increasement of FLRvolume, yet the morbidity and mortality is much lower, owing to the fact that unlike ALPPS, there is no two liver raw surfaces left behind in the abdominal cavity to produce bile leak, as only single surgical operation is required

      • Capturing Wetting States in Nanopatterned Silicon

        Xu, XiuMei,Vereecke, Guy,Chen, Chang,Pourtois, Geoffrey,Armini, Silvia,Verellen, Niels,Tsai, Wei-Kang,Kim, Dong-Wook,Lee, Eunsongyi,Lin, Chang-You,Van Dorpe, Pol,Struyf, Herbert,Holsteyns, Frank,Moshc American Chemical Society 2014 ACS NANO Vol.8 No.1

        <P>Spectacular progress in developing advanced Si circuits with reduced size, along the track of Moore’s law, has been relying on necessary developments in wet cleaning of nanopatterned Si wafers to provide contaminant free surfaces. The most efficient cleaning is achieved when complete wetting can be realized. In this work, ordered arrays of silicon nanopillars on a hitherto unexplored small scale have been used to study the wetting behavior on nanomodulated surfaces in a substantial range of surface treatments and geometrical parameters. With the use of optical reflectance measurements, the nanoscale water imbibition depths have been measured and the transition to the superhydrophobic Cassie–Baxter state has been accurately determined. For pillars of high aspect ratio (about 15), the transition occurs even when the surface is grafted with a hydrophilic functional group. We have found a striking consistent deviation between the contact angle measurements and the straightforward application of the classical wetting models. Molecular dynamics simulations show that these deviations can be attributed to the long overlooked atomic-scale surface perturbations that are introduced during the nanofabrication process. When the transition condition is approached, transient states of partial imbibition that characterize intermediate states between the Wenzel and Cassie–Baxter states are revealed in our experiments.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-1/nn405621w/production/images/medium/nn-2013-05621w_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn405621w'>ACS Electronic Supporting Info</A></P>

      • SCIESCOPUSKCI등재

        Metabolic Characteristic of the Liver of Dairy Cows during Ketosis Based on Comparative Proteomics

        Xu, Chuang,Wang, Zhe,Liu, Guowen,Li, Xiaobing,Xie, Guanghong,Xia, Cheng,Zhang, Hong You Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.7

        The objective of the present study was to identify differences in the expression levels of liver proteins between healthy and ketotic cows, establish a liver metabolic interrelationship of ketosis and elucidate the metabolic characteristics of the liver during ketosis. Liver samples from 8 healthy multiparous Hostein cows and 8 ketotic cows were pooled by health status and the proteins were separated by two-dimensional-electrophoresis (2D-E). Statistical analysis of gels was performed using PDQuest software 8.0. The differences in the expression levels of liver proteins (p<0.05) between ketotic and healthy cows were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF-TOF) tandem mass spectrometry. Five enzymes/proteins were identified as being differentially expressed in the livers of ketotic cows: expression of 3-hydroxyacyl-CoA dehydrogenase type-2 (HCDH), acetyl-coenzyme A acetyltransferase 2 (ACAT) and elongation factor Tu (EF-Tu) were down-regulated, whereas that of alpha-enolase and creatine kinase were up-regulated. On the basis of this evidence, it could be presumed that the decreased expression of HCDH, which is caused by high concentrations of acetyl-CoA in hepatic cells, in the livers of ketotic cows, implies reduced fatty acid ??oxidation. The resultant high concentrations of acetyl-CoA and acetoacetyl CoA would depress the level of ACAT and generate more ??hydroxybutyric acid; high concentrations of acetyl-CoA would also accelerate the Krebs Cycle and produce more ATP, which is stored as phosphocreatine, as a consequence of increased expression of creatine kinase. The low expression level of elongation factor Tu in the livers of ketotic cows indicates decreased levels of protein synthesis due to the limited availability of amino acids, because the most glucogenic amino acids sustain the glyconeogenesis pathway; thus increasing the level of alpha-enolase. Decreased protein synthesis also promotes the conversion of amino acids to oxaloacetate, which drives the Krebs Cycle under conditions of high levels of acetyl-CoA. It is concluded that the livers of ketotic cows possess high concentrations of acetyl-CoA, which through negative feedback inhibited fatty acid oxidation; show decreased fatty acid oxidation, ketogenesis and protein synthesis; and increased gluconeogenesis and energy production.

      • SCIESCOPUSKCI등재

        Association of Tyrosinase (TYR) and Tyrosinase-related Protein 1 (TYRP1) with Melanic Plumage Color in Korean Quails (Coturnix coturnix)

        Xu, Ying,Zhang, Xiao-Hui,Pang, You-Zhi Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.11

        TYR (Tyrosinase) and TYRP1 (Tyrosinase-related protein 1) play crucial roles in determining the coat color of birds. In this paper, we aimed to characterize the relationship of TYR and TYRP1 genes with plumage colors in Korean quails. The SNPs were searched by cDNA sequencing and PCR-SSCP in three plumage color Korean quails (maroon, white and black plumage). Two SNPs ($367T{\rightarrow}C$ and $1153C{\rightarrow}T$) were found in the coding region of TYRP1 gene, but had no significant association with plumage phenotype in Korean quails. The expression of TYR was higher in black plumage quails than that in maroon plumage quails. In contrast, the expression of TYRP1 was lower in black plumage quails than that in maroon plumage quails. This study suggested that the melanic plumage color in Korean quails may be associated with either increased production of TYR or decreased production of TYRP1.

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