발프로산나트륨과 페니토인과의 약물상호작용

최준식,유재신,박용채,이진환 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4. 8. 16 ㎎/㎏. i.v.) and phenytoin (4 ㎎/㎏. i.v) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (4. 8. 16 ㎎/㎏) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (8. 16 ㎎/㎏) in rabbit. From the results of this experiment. it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.

취약계층 권리보호에 관한 고려요소와 지향점 : 통합 지식관리시스템 구축을 중심으로

배유진,최승원 梨花女子大學校 法學硏究所 2017 法學論集 Vol.21 No.4

우리 공동체를 위한 좋은 복지를 위해서 취약계층의 권리보호 대한 촘촘한 정치망이 필요한 시점이다. 한편, 인터넷혁명 및 IT기술의 발달은 모든 제반영역에서 혁명을 이끌 수 있는 원동력이 되고 있다. 따라서, 여러 생활영역에서 취약계층의 낙오방지 시스템으로도 작용할 수 있는 수요자 중심의 통합 지식관리시스템의 구현이 중요하다. 본 연구는 취약계층의 실질적인 권리보호를 위하여 사각지대, 중복누수방지를 위 한 통합 지식관리시스템 구축을 위한 고려요소와 미래 지향점을 고찰하였다. 우선, 기존의 좁은 개념의 테두리를 벗어나 여러 생활영역에서의 취약계층에 대한 개념의 확대와 이에 따른 입법유형화 필요성을 제시하였다. 다음으로, 수요자 중심의 원스톱 통합서비스의 제공 및 사례관리화, 전자문서기반의 지식관리와 모든 주체가 참여할 수 있는 지식관리시스템의 중요성을 강조하였다. 그리고 시스템 구축 시 고려사항으로 기술적인 관점에서 모바일 중심의 표준화･구조화･자동화 등을 언급하였다. 한편, 권리실현을 위한 취약계층의 권리성 강화와 구제수단을 법적으로 살피면서, 개인 서비스를 위한 여러 법률에 흩어져 있는 취약계층의 내용을 수요자의 입장에서 통합법으로서의 제정필요성을 강조하였다. 큰 틀에서 취약계층 권리보호 통합법안은 여러 사회생활영역의 취약계층의 인권과 복지 및 권리 실현의 실효성･수월성을 확보하고, 통합 개인화 서비스를 통한 복지효율화를 도모하는 것을 주요 내 용으로 담아야 할 것임을 제시하였다. 궁극적으로 아직까지 취약계층의 권리보호가 미흡한 상황에서 수요자 중심의 법적･제도적･기술적･종합체계적인 정치망 지식관리시스템을 구축･고도화하여 취약계층의 보호시스템이 제대로 작동되는 것을 지향방향으로 제시하였다. It is a time that we need a tight political network to protect the rights of vulnerable groups for good welfare for our community. However, the Internet revolution and the development of IT technology are driving the revolution in all areas. Therefore, it is important to implement a consumer- centered integrated knowledge management system that can function as a fall prevention system for vulnerable classes in various living areas. This study examines the factors and future directions for building an integrated knowledge management system to prevent blind spots and duplicate leaks in order to protect the actual rights of vulnerable groups. First, it proposed the necessity of extending the concept of vulnerable groups in various living areas beyond the narrow boundaries of existing ones and to formulate legislation accordingly. Next, it emphasized the importance of the provision of one-stop integrated services and customer-centered case management, the knowledge management based on electronic documents, and the knowledge management system that can participate in all subjects. In addition, the mobile-centered standardization, structuring, and automation are mentioned from the technical point of view as a consideration in system construction. On the other hand, while looking for the means of strengthening the rights of vulnerable groups and realizing the right of remedies for the realization of rights, it emphasized the necessity of enacting contents of vulnerable groups scattered in various laws for personal service as an integrated law from the viewpoint of consumers. In a large frame, it proposed that the integrated legislation on the protection of the rights of the vulnerable class should contain the main contents such as securing the human rights, welfare and the realiztion of the rights of vulnerable groups in various social life areas along with promoting welfare efficienc through integrated personaliztion service. Ultimately, in the situation where the protection of the rights of the vulnerable groups is still insufficient, it suggested that the protection system of vulnerable groups should be operated properly by building and improving the client-centered legal, institutional, technical, and comprehensive systematic political network knowledge-based management system.

요로결석 환자에 대한 응급실에서의 진단방법

유지영,최옥경,유진현,정구영 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

Nephrolithiasis is one of the most common disease seen in the Emergency Department. Among the patients who visited in the Emergency Department with acute abdominal pain, many people were suspected urolithiasis. Because of limitation of diagnostic method on Emergency Department we planned this study in order to confirm the our accuracy of diagnosis and the possibility of misdiagnosis. During 5 months from April 1996 to August 1996, the 189 patients was suspected the urolithiasis. Among this patient, 51 cases was excluded due to incomplete study. After performing P/Ex, U/A, KUB in the Emergency Department, they were followed out patients department of Urology and perfomed Intravenous Pyelogram. The sensitivity and specificity for KUB were 84.5% and 94.0%, respectively. The positive predictive value was 93.8%, the nagative predictive value was 93.8%. Diagnostic accuracy of urolithiasis in our Emergency Department is 89.1%. There was no relationship between urinary occult blood and KUB or IVP. There was no relationship between degree of occult blood and diagnosis of urolithiasis. For differential diagnosis of urolithisis, emergency ultrasound and IVP will be available. So combination of this diagnostic methods will improve accuracy and safty of diagnosis and treatment of urolithiasis.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

방사선조사가 설의 개방성창상치유에서 섬유아세포의 재형성에 미치는 영향에 관한 연구

최순철,박태원,유동수,이진구 大韓口腔顎顔面 放射線學會 1997 Imaging Science in Dentistry Vol.27 No.1

Radiation-impaired wound healing in animal experiments was believed to be an another logical experimental model to understand the wound healing mechanism in patients. The purpose of this study was to reveal the block point which would result in impaired healing. Twenty four rats(Sprague-Dawley strains) were divided into two groups according to the time interval between irradiation and wounding. Group I, observing the healing effect on the lst day and GroupⅡ are the healing effects on the 7th days after irradiation to the wound of the rat tongue. Experimental animals were sacrificed 3, 6, 12, and 24 hours after wounding. The specimens were examined by the light microscope and transmission electron microscope. The following results were obtained 1. Fibroblasts in both groups showed degenerative changes which were dilated mitochondria and rER, reduced microorganelle, vacuoles and little cytoplasmic process. 2. Average length between bands and quantity of the newly produced collagen fibers around fibroblasts remained unchanged against control group. 3. The severity of degenerative change of the fibroblast and impairment of wound healing including shortening of the thickness of collagen fibers were more severe in the group Ⅱ than in the group I.

『三國遺事』 紀事와 讚 연구

최재남,최유진,김재현 경남대학교 인문과학연구소 1999 人文論叢 Vol.12 No.-

『金剛三昧經論』에 나타난 원효의 一心

최유진 慶南大學校 人文科學硏究所 1998 人文論叢 Vol.11 No.-

원효의 열반관

최유진 慶南大學校 人文科學硏究所 2002 人文論叢 Vol.15 No.-

한국 불교의 21세기적 과제

최유진 새한철학회 1998 哲學論叢 Vol.15 No.-

급성충수돌기염으로 발현된 방선균증 2예

조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.