Single institute experience of pancreatico-enteric anastomosis failure after pancreaticoduodenectomy

Yoonkyung Woo,유영경,한재현,최호중,Yumi Kim,Bongjun Kwak,홍태호,Donggoo Kim 대한종양외과학회 2019 Korean Journal of Clinical Oncology Vol.15 No.1

Purpose: We have summarized the experience of our institution related to what treatment has been performed in patients with pancreatic fistula and their outcome. Methods: Seventy-eight pancreatico-enteric anastomosis failure (PEAF) patients of 403 pancreaticoduodenectomy (PD) were included for this retrospective study. PEAF was defined by the presence of rich amylase (over 10,000 IU/L) in drainage fluid at postoperative day 5 to 7 and radiographic demonstration of the anastomotic breakdown and associated local fluid collection. The management was analyzed by observation group (O group), intervention (I group) and surgery group (S group). Results: Preoperative clinical status of the PEAF group and non-PEAF group was similar. Bile duct cancer was the highest risk subgroup of the PEAF (P=0.001) and the pancreatic adenocarcinoma showed the least risk for the PEAF (P<0.001). Among the 78 PEAF patients, 50 were managed as a conservative treatment, 15 patients were received radiologic intervention and 13 patients performed rescue surgery. Among these three subgroups, there was no statistical significance in the patient’s demographics, clinical status, surgical factors and disease nature. However, mortality was significantly higher in the S group (P<0.001). The mortality cases were developed one and six patients in O and S group, respectively. Surgical procedures in S group were completion total pancreatectomy with or without splenectomy (n=12) and pancreatectomy preserving spleen in four (28.6%). Pancreaticogastrostomy repair and Roux-en-Y pancreaticojejunostomy reconstruction were performed each case, respectively. Conclusion: Proper drainage catheter indwelling during the PD or postoperative radiological intervention can effectively manage the PEAF without surgical interventional treatment.

Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells.

Woo, Yoonkyung,Shin, Soon Young,Hyun, Jiye,Lee, Sung Dae,Lee, Young Han,Lim, Yoongho D.A. Spandidos 2012 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.29 No.3

<P>Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin?E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer activities of flavanone derivatives have rarely been reported, we examined the effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results suggest that flavanone derivatives control the expression of cell cycle regulatory proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity of HCT116 cells. In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined.</P>

Complete assignments of NMR data of salens and their cobalt (III) complexes

Woo, Yoonkyung,Koh, Dongsoo,Lim, Yoongho John Wiley Sons, Ltd. 2009 Magnetic resonance in chemistry Vol.47 No.2

<P>Salens, derived from 1,2-ethylenediamine and salicylaldehydes, have been widely used as ligands for metal complexes which have been showing enormous potential in chemical properties of asymmetric catalysts as well as biological properties such as anticancer agents. Almost all of the salen–metal complexes with their corresponding metal (II)-complexes show the evidences of chelation of two oxygens in salens. However, several metal (II) complexes, especially cobalt (II) complexes, could not show NMR spectra due to their paramagnetism. Recently, it has been reported that one of the cobalt (III) complexes was used for NMR spectroscopy to evaluate its stereoselectivity as a catalyst. Even though many salen ligands are known, their NMR data are not assigned completely. It was possible that modification in northern part of salen with 2-hydroxyphenyl group afforded another oxygen chelation site in salen ligand. Here we report that synthesis and full NMR assignment of new salen ligands, which form meso 1,2-bis(2-hydroxyphenyl)ethylenediamine) and their cobalt (III) complexes. The assignments of <SUP>1</SUP>H and <SUP>13</SUP>C NMR data obtained in this experiment can help us to predict the NMR data of other salen ligands. Copyright © 2008 John Wiley & Sons, Ltd.</P> <B>Graphic Abstract</B> <P>Even though many salen ligands are known, their NMR data are not assigned completely. It was possible that modification in northern part of salen with 2-hydroxyphenyl group afforded another oxygen chelation site in salen ligand. Here we report synthesis and full NMR assignment of new salen ligands, which form meso 1,2-bis(2-hydroxyphenyl)ethylenediamine) and their cobalt (III) complexes. <img src='wiley_img/07491581-2009-47-2-MRC2372-gra001.gif' alt='wiley_img/07491581-2009-47-2-MRC2372-gra001'> </P>

Perioperative outcomes of sinusoidal obstruction syndrome underwent liver resection for colorectal metastases after neoadjuvant chemotherapy

Yoonkyung WOO,Yoonyoung CHOI,Haneol PARK,Chang Ho SEO,Sung Eun PARK,Joseph AHN,Ho Joong CHOI,Tae Ho HONG,Young Kyoung YOU 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

소비자 상품테스트지의 상품품질정보에 대한 국제간 비교분석

우윤재(Woo Yuh Jae),여윤경(Yuh Yoonkyung),차은영(Chah Eun-Young) 한국소비문화학회 2004 소비문화연구 Vol.7 No.2

본 연구는 상품테스트 정보가 어떠한 형식과 내용으로 소비자에게 제공되어야 효율적인가에 대하여 바람직한 모델을 제시하는데 연구의 목적이 있다. 이러한 연구목적을 위해서 한국, 미국, 영국, 호주의 대표적인 상품테스 트지를 선정하여 Manies 의 소비자정보의 바람직한 기준에 근거하여 상품의 품질정보를 비교하고 각국 상품테스 트지 품질정보의 특징과 장 · 단점을 분석하였다. 분석결과, 품질속성의 수는〈소비자시대〉가 가장 많았고 〈 Consumer Reports 〉지가 가장 적었으며, 제품수 및 모델수는 〈 Consumer Reports 〉지가 가장 많았고 〈소비자시대〉가 가장 적었다. 속성에 대한 종합평가는〈소비자 시대〉를 제외한 모든 상품테스트지에서 제공되는 것으로 나타났으며, 가중치는 〈Choice 〉지와 〈 Which 〉지에만 제 공되고 있었고 품질점수의 수치화는 〈 Choice 〉지에서만 표시되고 있었다. 정보의 이용가능성은 〈 Which 〉지가 가 장 우수한 것으로 나타났고 정보의 최신성은 〈소비자 시대〉가 가장 떨어지는 것으로 나타났다. 상품테스트내용 의 평가 결과, Maynes 가 주장하였던 소비자 정보원의 바람직한 속성에 가장 근접하고 있는 상품 테스트지는 〈 Choice 〉지와〈 Which 〉지로 나타났다. 결론적으로 소비자에게 보다 많은 효용을 제공하기 위해서 〈소비자시대〉 는 소비자 상품품질정보의 내용측면과 정보의 수치화, 적시성, 최신성 등에서 보완될 필요가 있다. This study was to examine the actual condition of product test institutions to look deep into the cause of lack of product test information in Korea, and to suggest a desirable model with effective form and content of product test information to be provided to consumers. As a method of this study, comparative study was performed with reference to the data of several consumer magazines and reports of organizations. For comparison of product test quality information, the subjects - Korea Consumer Protection Board of a government organization and Consumer Union of a private organization - were compared to examine whether any difference in quantity and management of product tests exists, and merit and demerit of product test management in Korea were analyzed. Consumer information magazines used in this study were 'Consumer Age' of Korea, 'Consumer Reports' of U.S., 'Which' of U.K., and 'Choice' of Australia. For quality comparison of product tests, items of the same kind were selected and they were assessed according to the assessment standard of consumer infonnation sources among the product comparison tests performed in 2000-2001 in Korea. U.S., Australia, and U.K. The 'Consumer Age' had the largest number of product characteristics while the 'Consumer Reports' had the smallest. In terms of the number of products and models, the 'Consumer Reports' provided the largest while the 'Consumer Age' provided the smallest. All three magazines except for the 'Consumer Age' provided the overall measure of quality information, information flexibility measured of each characteristic's weight was provided in the 'Choice' and the 'Which', cardinal information was provided only in the 'Choice'. The 'Which' provided the most portable information and the 'Consumer Age' provided the least timely information among those consumer information magazines. Based on results of this study, a desirable product test model is suggested in each aspect of management and contents. First, general quality assessment shall be performed so that consumers can easily understand the content of product test, and quality marks shall be expressed numerically so that any distinct difference in the same grade can be recognized. Second, any objection shall not be raised and there shall be any problem against the test result so that product test information obtain high reliability. For this, result of product test shall be notified to the manufacturer, and if any objection is raised, reinspection shall be performed. Third, weight of each product test institution by properties shall be indicated so that consumers can compare them with their weight. Weight shall be selected in consideration of the importance of performance. For specialization of information and differentiation from other information on the basis of such assessment and improvement measures, if the 'Consumer Age' of Korea Consumer Protection Board secures supplement and reliability of product test information by increasing articles of product test beyond the current feature of general information magazine, it will have a great effect on the market. In future studies, comparative analysis shall be performed for the test information of products made by our consumer organizations. As this study performed comparison among product test information of a single product, test for diverse products is needed for more comprehensive analysis.

호소 수질 예측을 위한 Delft3D 모델과 딥러닝 모델의 연계 적용

김영우(Young Woo Kim),신지훈(Jihoon Shin),김낙겸,박태승(Taeseong Park),차윤경(Yoonkyung Cha) 대한환경공학회 2022 대한환경공학회 학술발표논문집 Vol.2022 No.11

위성영상을 활용한 전국 호소 부유물질 및 투명도 예측모델의 개발

김영우 ( Young Woo Kim ),이건형 ( Gun Hyung Lee ),박태승 ( Tae Seung Park ),차윤경 ( Yoonkyung Cha ) 한국물환경학회 2021 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2021 No.-

Effect of Malformin on Ethylene Production in rimary Roots of Maize

Kim, Soon Young,Kim, Yoonkyung,Kwon, Ki-Sang,Kim, Kon-Woo 안동대학교 기초과학연구소 1998 基礎科學 硏究論文集 Vol.9 No.1

Malformun is an active plant growth regulator isolated from the fungus Aspergillus niger. IAA-and 1-aminocyclopropane-l-carboxylic acid (ACC)-induced ethylene production was measured in the primary roots of maize in the presence of malformin. ACC-dependent ethylene production was stimulated by the treatment of 10^(-6) M malformin within 2 hr. The increased ethylene production maintained until 24 hr. IAA-induced ethylene production was not stimulated within 2 hr, but ethylene production slightly stimulated and maintained until 24 hr. In the presence of ACC, Co^(2+) inhibited the ethylene production, but this inhibition did not observed within 4 hr by the treatment of malformin.

Relationships between Structure and Anti-oxidative Effects of Hydroxyflavones

Younghee Park,Sunhee Lee,Yoonkyung Woo,Yoongho Lim 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.6

A Peptide Produced by Pseudomonas tolaasi, Tolaasin Binds to Metal Ions

Geunhyeong Jo,Doseok Hwang,Yoonkyung Woo,Younggiu Lee,Yeonjoong Yong,강경래,Jiye Hyun,Young-Kee Kim,Dong-Woon Kim,Yoongho Lim 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4

Brown blotch disease in mushrooms is caused by Pseudomonas tolaasin, which produces a peptide toxin, tolaasin I, and zinc ion inhibits the channel formed by tolaasin I. NMR experiments revealed that zinc, sodium, and calcium ions can bind to tolaasin I and their binding position on tolaasin I is the lactone ring.