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A Compound Isolated from Rumex japonicus Induces Early Growth Response Gene-1 Expression
Geunhyeong Jo,신순영,Younggiu Lee,Jiye Hyun,Kwang Sik Dong,Jun Cheol Park,Hyun Su Kim,이영한,임융호 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.
A Peptide Produced by Pseudomonas tolaasi, Tolaasin Binds to Metal Ions
Geunhyeong Jo,Doseok Hwang,Yoonkyung Woo,Younggiu Lee,Yeonjoong Yong,강경래,Jiye Hyun,Young-Kee Kim,Dong-Woon Kim,Yoongho Lim 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
Brown blotch disease in mushrooms is caused by Pseudomonas tolaasin, which produces a peptide toxin, tolaasin I, and zinc ion inhibits the channel formed by tolaasin I. NMR experiments revealed that zinc, sodium, and calcium ions can bind to tolaasin I and their binding position on tolaasin I is the lactone ring.
Jo, Geunhyeong,Hyun, Jiye,Hwang, Doseok,Lee, Young Han,Koh, Dongsoo,Lim, Yoongho John Wiley Sons, Ltd. 2011 Magnetic resonance in chemistry Vol.49 No.6
<P><B>Abstract</B></P><P>Resveratrol is a polyphenol isolated from many natural sources including grapes, mulberries, eucalyptus, spruce, lilies, and peanuts. The hydroxyl groups in polyphenols can be substituted with various functional groups, allowing production of multiple derivatives. NMR spectroscopy is used to identify new derivatives. Since the complete NMR data of the known derivatives can be useful for identification of the newly isolated derivatives, here, we report the synthesis of 14 methoxylated stilbenes and four 1,2‐diphenylethanes and their NMR data. Copyright © 2011 John Wiley & Sons, Ltd.</P>
Synthesis of methoxybenzoflavones and assignments of their NMR data
Hwang, Doseok,Jo, Geunhyeong,Hyun, Jiye,Lee, Sung Dae,Koh, Dongsoo,Lim, Yoongho John Wiley Sons, Ltd 2012 Magnetic resonance in chemistry Vol.50 No.1
<P>A phytotoxic root exudate from <I>Acroptilon repens</I> was identified as 7,8‐benzoflavone, an inhibitor of cytochrome P450 1A2 and activator of cytochrome P450 3A4. The synthetic 5,6‐benzoflavone also is a potent phytotoxin. Six 7,8‐benzoflavones and eight 5,6‐benzoflavones were synthesized in this study. The NMR data for a few of these compounds have been previously reported; however, the NMR data for most of them have not been reported. For reference purposes, the complete NMR data for the 14 benzoflavones are described. Copyright © 2012 John Wiley & Sons, Ltd.</P>
Synthesis and complete assignment of NMR data of 20 chalcones
Hwang, Doseok,Hyun, Jiye,Jo, Geunhyeong,Koh, Dongsoo,Lim, Yoongho John Wiley Sons, Ltd. 2011 Magnetic resonance in chemistry Vol.49 No.1
<P><B>Abstract</B></P><P>Chalcones, intermediates in flavonoid biosynthesis, can exhibit antibacterial, antiproliferative, and anti‐inflammatory properties. Chalcones contain two benzene rings and both hydroxylated and methoxylated analogs are frequently produced by hydroxylases and <I>O</I>‐methyltransferases in plant biosynthetic pathways. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of <SUP>1</SUP>H and <SUP>13</SUP>C NMR spectra. Copyright © 2010 John Wiley & Sons, Ltd.</P>