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Yongkeun Song,Seunguk Heo,Gyuseok Cho,Sanghyun Choi,Moojae Han,Jikoon Park 한국방사선학회 2017 한국방사선학회 논문지 Vol.11 No.6
꿈의 암치료기라고 불리는 중입자 치료는 환자의 암세포에 입사하여 암세포만을 사멸하고 사라지는데 이때 중성자 및 감마선이 발생되어 치료실 내 영상장비, 그 밖의 전자장비에 영향을 미치게 된다. 중입자 치료시설을 구축하기 위해서는 약 2,000억 원 가량의 예산이 필요하며 구축기간도 5년 이상 소요된다. 따 라서 구축 전 몬테카를로 시뮬레이션을 이용하여 치료실 내 선량 분포에 대해 관찰하여 적절한 대비를 하 는 것이 중요하다. 본 연구에서는 몬테카를로 시뮬레이션 툴인 FLUKA를 이용하여 중입자 치료 시 치료실 내 선량분포에 대해 알아보았으며 1분 치료 시 치료실 내에는 약 0.1 mSv에서 2 pSv 정도의 영향이 있을 것으로 파악되었다. The purpose of this study was to comparison of measure signal to noise ratio (SNR) according to change of kernel size from region of interest (ROI) of heart shadow in chest image. We examined images of chest image of 100 patients in a University-affiliated hospital, Seoul, Korea. Chest images of each patient were calculated by using ImageJ. We have analysis socio-demographical variables, SNR according to images, 95% confidence according to SNR of difference in a mean of SNR. Differences of SNR among change of equalization were tested by SPSS Statistics21 ANOVA test for there was statistical significance 95%(p<0.05). In SNR results, with the quality of distributions in the order of kernel size 9*9 image, kernel size 7*7 image and original chest image, kernel size 3*3 image (p<0.001). In conclusion, this study would be that quantitative evaluation of heart shadow on chest image can be used as an adjunct to the kernel size chest image.
Management of Patients with Long QT Syndrome
Yongkeun Cho 대한심장학회 2016 Korean Circulation Journal Vol.46 No.6
Long QT syndrome (LQTS) is a rare cardiac channelopathy associated with syncope and sudden death due to torsades de pointes and ventricular fibrillation. Syncope and sudden death are frequently associated with physical and emotional stress. Management of patients with LQTS consists of life-style modification, ß-blockers, left cardiac sympathetic denervation (LCSD), and implantable cardioverterdefibrillator (ICD) implantation. Prohibition of competitive exercise and avoidance of QT-prolonging drugs are important issues in life-style modification. Although ß-blockers are the primary treatment modality for patients with LQTS, these drugs are not completely effective in some patients. Lifelong ICD implantation in young and active patients is associated with significant complications. LCSD is a relatively simple and highly effective surgical procedure. However, LCSD is rarely used.
Yongkeun Kim(김용근) 대한전기학회 2019 전기학회논문지 P Vol.68 No.3
Network function virtualization (NFV) is a big trend for network operators because it can give lots of benefits to the operators for logistics, cost reduction, quick service launch, flexibility with rapid service scale up/down, efficient resource use by sharing the resources with multiple applications, etc. This article reviews the overall NFV architecture, its benefits and challenges, and checks the performance bottlenecks of each layer in NFV infrastructure (NFVI) and possible solutions, then, considers ways to reduce the performance bottlenecks of virtual machine (VM) to VM communications for service chaining within a physical server.
( Yongkeun Park ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Although gross vascular invasion (VI) has prognostic value for patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection, few studies have investigated the relationship between gross VI and the aberrant expression of microRNAs. This study identified microRNAs selectively expressed in HCC with gross VI and investigated their prognostic roles. Methods: Clinical data and microRNA expression profiles for 372 HCC patients were extracted from The Cancer Genome Atlas database. MicroRNAs that were differentially expressed in the patients with gross VI and those without VI were identified and investigated as potential prognostic factors for HCC. Results: MicroRNA-338 and microRNA-582 were upregulated more (log2 FC of 1.34 with FDR = 0.014 and log<sub>2</sub> FC of 1.09 with FDR = 0.015, respectively), and microRNA-100 and microRNA-99a were downregulated to a greater extent in gross VI group (log<sub>2</sub> FC of -1.45 with FDR < 0.001 and log<sub>2</sub> FC of -1.12 with FDR = 0.009, respectively). Receiver operating characteristic curve analysis showed the discriminatory power of these microRNAs in predicting MVI(figure). Multivariate survival analysis revealed that the types of surgery (HR 1.676, 95% CI 1.205-2.332, P=0.002), advanced TNM stage (HR 1.795, 95% CI 1.266-2.547, P=0.001) and under-expression of microRNA-100 (HR 1.511, 95% CI 1.041-2.194, P=0.029) were independently associated with tumor recurrence, and that the types of surgery, advanced TNM stage, under-expression of microRNA-100 and over-expression of microRNA-582 were independent risk factors for overall survival after hepatic resection for HCC (HR 1.844, 95% CI 1.110-3.065, P=0.018; HR 2.401, 95% CI 1.433-4.024, P<0.001; HR 2.652, 95% CI 1.519-4.629, P<0.001; HR 2.016, 95% CI 1.109-3.663, P=0.021, respectively). PLK1 was considered a target gene of microRNA-100 with strong evidence. Conclusions: Under-expression of microRNA-100 and over-expression of microRNA-582 were associated with gross VI and poor survival of patients after hepatic resection for HCC.
A Comparison Study of the Ridge Filter Parameter by Using FLUKA and GEANT4 Simulation Codes
Yongkeun Song,Jaeik Shin,Sungho Cho,Seunghoon Yoo,Ilsung Cho,Eunho Kim,Wongyun Jung,Sanghyoun Choi,오경민 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.1
We investigated the parameter optimization of the ridge filter’s thickness for carbon-ion therapy by using a Monte Carlo simulation. For this study, a ridge filter was designed for the spreadout Bragg peak (SOBP) by considering the relative biological effectiveness (RBE). The thickness, height, and width of the ridge filter were designed by using the FLUKA and the GEANT4 codes, and we analyzed and compared the results of the physical dose distributions for the FLUKA and the GEANT4 codes. The results showed that the minimum width of the groove for the ridge filter should be at least 0.5 cm for an appropriate biological dose. The SOBP sections were 8 cm, 9 cm, and 10 cm, respectively, when the heights were 3.5 cm, 4.0 cm, and 4.5 cm. The height of the ridge filter was designed to be associated with the SOBP width. Also, the results for the FLUKA and the GEANT4 codes showed that the average value of the difference was 3% and that the maximum error was 5%; however, the trends were similar. Therefore, the height and the width of the groove for the ridge filter are important parameters for deciding the length and the plateau of the SOBP.
A Technical Trend and Prospect of I/O Virtualization
Yongkeun Kim(김용근) 대한전기학회 2019 전기학회논문지 P Vol.68 No.3
Virtualization technology has been widely used and it is a broad topic. As the universe of I/O devices is large and diverse, this article focuses on I/O virtualization. The I/O virtualization gives many advantages, such as better I/O device utilization, seamless portability of virtual machines across servers, live migration, dynamic device management while virtual machines are running, virtual views over multiple I/O devices, additional new feature support not provided by hardware, etc. There are many techniques developed so far, which are software-based, hardware-based and hybrid one. This article reviews the benefits and characteristics of the I/O virtualization, current available technologies in software and hardware perspective, then, checks their status and trends.